Transcriptional response to hypoxia in human tumors

Journal of the National Cancer Institute

Volumn 93, Issue 17, 2001, Pages 1337-1343

  Lal, Anita ^a   Peters, Hans ^b   St Croix, Brad ^c   Haroon, Zishan A ^a   Dewhirst, Mark W ^a   Strausberg, Robert L ^d   Kaanders, Johannes H A M ^b   Van Der Kogel, Albert J ^b   Riggins, Gregory J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; GLYCOPROTEIN; HYPOCALCIN; MITOGENIC AGENT; OXYGEN; PIMONIDAZOLE; TENASCIN; VASCULOTROPIN;

ADAPTATION; ANGIOGENESIS; ARTICLE; BLOOD VESSEL; BREAST CANCER; CALCIUM HOMEOSTASIS; CANCER CELL; CARCINOMA; CELL DAMAGE; CELL DEATH; CELL PROTECTION; COLON CANCER; CONTROLLED STUDY; DRUG RESISTANCE; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALIGNANT NEOPLASTIC DISEASE; MEASUREMENT; NUCLEOTIDE SEQUENCE; ORGAN GROWTH; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SOLID TUMOR; TIME; TUMOR CELL LINE; VASCULARIZATION;

EID: 0035812284     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.17.1337     Document Type: Article

References (41)

1. Hypoxia marker labeling in tumor biopsies: Quantification of labeling variation and criteria for biopsy sectioning
2. The hypoxic cell: A target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture
3. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
4. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
5. Microenvironment-induced cancer metastasis
6. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
7. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
8. Vascular-specific growth factors and blood vessel formation
9. Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors
10. Glioblastoma
11. Serial analysis of gene expression
12. Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber
13. Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas
14. A public database for gene expression in human cancers
15. Analysis of human transcriptomes
16. Identifying potential tumor markers and antigens by database mining and rapid expression screening
17. Genes expressed in human tumor endothelium
18. Gene expression profiles in normal and cancer cells
19. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
20. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
21. The role of carbonic anhydrases in tumors
22. MN/CA IX/G250 as a potential target for immunotherapy of renal cell carcinomas
23. Hypoxia-inducible expression of tumor-associated carbonic anhydrases
24. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
25. Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
26. The fibrinogen globe of tenascin-C promotes basic fibroblast growth factor-induced endothelial cell elongation
27. Expression of tenascin is related to histologic malignancy and angiogenesis in b-cell non-Hodgkin's lymphomas
28. Tenascin-C expression in the cyst wall and fluid of human brain tumors correlates with angiogenesis
29. Tenascin expression and angiogenesis in breast cancers
30. Evidence that tenascin and thrombospondin-1 modulate sprouting of endothelial cells
31. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease
32. Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: A possible role in luteal development and rescue
33. Gene expression profiling in an in vitro model of angiogenesis
34. An antibody for macrophage migration inhibitory factor suppresses tumour growth and inhibits tumour-associated angiogenesis
35. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
36. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom
37. Carcinogenic nickel induces genes involved with hypoxic stress
38. Candidate genes for the hypoxic tumor phenotype
39. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
40. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
41. Exposure of cultured primary rat astrocytes to hypoxia results in intracellular glucose depletion and induction of glycolytic enzymes