RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway

Breast Cancer Research and Treatment

Volumn 126, Issue 3, 2011, Pages 555-563

  Cao, Xi Xi ^a   Xu, Jing Da ^a   Xu, Jia Wen ^a   Liu, Xiao Li ^a   Cheng, Yuan Yuan ^a   Li, Qing Quan ^a   Xu, Zu De ^a   Liu, Xiu Ping ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Breast carcinoma; Metastasis; Migration; Rack1; RhoA Rho kinase

Indexed keywords

RECEPTOR FOR ACTIVATED C KINASE 1; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ADULT; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOMA CELL; CELL STRAIN MCF 7; CELL STRAIN T 47D; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; UPREGULATION;

BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; NEOPLASM METASTASIS; NEOPLASM PROTEINS; RECEPTORS, CELL SURFACE; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; TREATMENT OUTCOME;

EID: 79958706977     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0955-3     Document Type: Article

References (35)

1. McPherson K, Steel CM, Dixon JM (1994) ABC of breast diseases. Breast cancer epidemiology, risk factors and genetics. BMJ 309:1003-1006
2. Tjan-Heijnen VCG, Bult P, de Widt-Levert LM, Ruers TJ, Beex LVAM (2001) Micro-metastases in axillary lymph nodes: an increasing classification and treatment dilemma in breast cancer due to the introduction of the sentinel lymph node procedure. Breast Cancer Res Treat 70:81-88 (Pubitemid 33139665)
3. Cao XX, Xu JD, Xu JW, Liu XL, Cheng YY, Wang WJ, Li QQ, Chen Q, Xu ZD, Liu XP (2009) RACK1 promotes breast carcinoma proliferation and invasion/metastasis in vitro and in vivo. Breast Cancer Res Treat. doi:10.1007/s10549-009-0657-x (Epub ahead of print)
4. Cao XX, Xu JD, Liu XL, Xu JW, Wang WJ, Li QQ, Chen Q, Xu ZD, Liu XP (2009) RACK1: a superior independent predictor for poor clinical outcome in breast cancer. Int J Cancer. doi: 10.1002/ijc.25120 (Epub ahead of print)
5. Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (1994) Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci USA 91:839-843 (Pubitemid 24048462)
6. McCahill A, Warwicker J, Bolger GB, Houslay MD, Yarwood SJ (2002) The RACK1 scaffold protein: a dynamic cog in cell response mechanisms. Mol Pharmacol 62:1261-1273 (Pubitemid 35403822)
7. Kubota T, Yokosawa N, Yokota S, Fujii N (2002) Association of mumps virus V protein with RACK1 results in dissociation of STAT-1 from the alpha interferon receptor complex. J Virol 76:12676-12682 (Pubitemid 35386952)
8. Hermanto U, Zong CS, Li W, Wang LH (2002) RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol 22:2345-2365 (Pubitemid 34224638)
9. Wu Di, Asiedu Michael, Wei Qize (2009) MyoGEF regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene 28:2219-2230
10. Pillé JY, Denoyelle C, Varet J, Bertrand JR, Soria J, Opolon P, Lu H, Pritchard LL, Vannier JP, Malvy C, Soria C, Li H (2005) Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther 11:267-274
11. Simpson KJ, Dugan AS, Mercurio AM (2004) Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res 64:8694-8701 (Pubitemid 39552085)
12. van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD (2000) RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 60:5832-5838
13. Davies R, Budworth J, Riley J, Snowden R, Gescher A, Gant TW (1996) Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF7/ADR cell line subclones. Br J Cancer 73:307-315 (Pubitemid 26047508)
14. McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2006) Reporting recommendations for tumor marker prognostic studies (REMARK). Breast Cancer Res Treat 100:229-235 (Pubitemid 44631925)
15. Boettner B, Van Aelst L (2002) The role of Rho GTPases in disease development. Gene 286:155-174 (Pubitemid 34273873)
16. Buensuceso CS, Woodside D, Huff JL, Plopper GE, O'Toole TE (2001) The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration. J Cell Sci 114:1691-1698 (Pubitemid 32454667)
17. Schechtman D, Mochly-Rosen D (2001) Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20:6339-6347 (Pubitemid 32977843)
18. Sklan EH, Podoly E, Soreq H (2006) RACK1 has the nerve to act: structure meets function in the nervous system. Prog Neurobiol 78:117-134 (Pubitemid 43290718)
19. Imai Y, Suzuki Y, Tohyama M, Wanaka A, Takagi T (1994) Cloning and expression of a neural differentiation-associated gene, p205, in the embryonal carcinoma cell line P19 and in the developing mouse. Brain Res Mol Brain Res 24:313-319 (Pubitemid 24202868)
20. Berns H, Humar R, Hengerer B, Kiefer FN, Battegay EJ (2000) RACK1 is up-regulated in angiogenesis and human carcinomas. FASEB J 14:2549-2558
21. Yoshiji H, Kuriyama S, Ways DK, Yoshii J, Miyamoto Y, Kawata M, Ikenaka Y, Tsujinoue H, Nakatani T, Shibuya M, Fukui H (1999) Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res 59:4413-4418 (Pubitemid 29418762)
22. Bouzahzah B, Albanese C, Ahmed F, Pixley F, Lisanti MP, Segall JD, Condeelis J, Joyce D, Minden A, Der CJ, Chan A, Symons M, Pestell RG (2001) Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med 7:816-830 (Pubitemid 34175305)
23. Denoyelle C, Vasse M, Körner M, Mishal Z, Ganné F, Vannier JP, Soria J, Soria C (2001) Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer celllines: an in vitro study. Carcinogenesis 22:1139-1148 (Pubitemid 32737327)
24. Bourguignon LY (2001) CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression. J Mammary Gland Biol Neoplasia 6:287-297
25. Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116:167-179 (Pubitemid 38167310)
26. Nobes CD, Hall A (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62
27. Caron E, Hall A (1998) Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282:1717-1721 (Pubitemid 28549289)
28. Pertz O, Hodgson L, Klemke RL, Hahn KM (2006) Spatiotem-poral dynamics of RhoA activity in migrating cells. Nature 440:1069-1072
29. Narumiya S, Tanji M, Ishizaki T (2009) Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 28:65-76
30. Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Mastuura Y, Kaibuchi K (1997) Formation of actin stress fibers and focal adhesion enhanced by Rho-kinase. Science 275:1308-1311 (Pubitemid 27114159)
31. Ishizaki T, Uehata M, Tamechika I, Keel J, Nonomura K, Maekawa M, Narumiya S (2000) Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinase. Mol Pharmacol 57:976-983 (Pubitemid 30253382)
32. Sahai E, Ishizaki T, Narumiya S, Treisman R (1999) Transformation mediated by Rho requires activity of ROCK kinases. Curr Biol 9:136-145 (Pubitemid 29087543)
33. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S (1999) An essential part for Rho-associated kinase in the trans-cellular invasion of tumor cells. Nat Med 5:221-225 (Pubitemid 29068531)
34. Del Re DP, Miyamoto S, Brown JH (2008) Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem 283:35622-35629
35. Nakaya Y, Sukowati EW, Wu Y, Sheng G (2008) RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation. Nat Cell Biol 10:765-775 (Pubitemid 351927706)