메뉴 건너뛰기




Volumn 52, Issue 5, 2011, Pages 545-556

How Can We Overcome Tumor Hypoxia in Radiation Therapy?

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DISEASES; RADIATION; TUMORS;

EID: 80053355093     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.11056     Document Type: Article
Times cited : (154)

References (118)
  • 1
    • 0007015743 scopus 로고
    • On a New Kind of Rays
    • Rontgen WC (1896) On a New Kind of Rays. Science 3: 227-231.
    • (1896) Science , vol.3 , pp. 227-231
    • Rontgen, W.C.1
  • 2
    • 4544384318 scopus 로고    scopus 로고
    • Radiation oncology: A century of achievements
    • Bernier J, Hall EJ and Giaccia A (2004) Radiation oncology: a century of achievements. Nat Rev Cancer 4: 737-747.
    • (2004) Nat Rev Cancer , vol.4 , pp. 737-747
    • Bernier, J.1    Hall, E.J.2    Giaccia, A.3
  • 3
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM and Wilson WR (2004) Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4: 437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 4
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH and Gray LH (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9: 539-549.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 7
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • Moeller BJ, et al (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1
  • 8
    • 33745517944 scopus 로고    scopus 로고
    • HIF-1 and tumour radiosensitivity
    • Moeller BJ and Dewhirst MW (2006) HIF-1 and tumour radiosensitivity. Br J Cancer 95: 1-5.
    • (2006) Br J Cancer , vol.95 , pp. 1-5
    • Moeller, B.J.1    Dewhirst, M.W.2
  • 9
    • 23644453277 scopus 로고    scopus 로고
    • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
    • Moeller BJ, et al (2005) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8: 99-110.
    • (2005) Cancer Cell , vol.8 , pp. 99-110
    • Moeller, B.J.1
  • 11
    • 0004967036 scopus 로고
    • Radiation Response of Mammalian Cells Grown in Culture. V. Temperature Dependence of the Repair of X-Ray Damage in Surviving Cells (Aerobic and Hypoxic)
    • Elkind MM, et al (1965) Radiation Response of Mammalian Cells Grown in Culture. V. Temperature Dependence of the Repair of X-Ray Damage in Surviving Cells (Aerobic and Hypoxic). Radiat Res 25: 359-376.
    • (1965) Radiat Res , vol.25 , pp. 359-376
    • Elkind, M.M.1
  • 12
    • 0014344261 scopus 로고
    • Application of radiobiologic principles to radiation therapy
    • Suit HD (1968) Application of radiobiologic principles to radiation therapy. Cancer 22: 809-815.
    • (1968) Cancer , vol.22 , pp. 809-815
    • Suit, H.D.1
  • 13
    • 0019942560 scopus 로고
    • Experimental results and clinical implications of the four R's in fractionated radiotherapy
    • Trott KR (1982) Experimental results and clinical implications of the four R's in fractionated radiotherapy. Radiat Environ Biophys 20: 159-170.
    • (1982) Radiat Environ Biophys , vol.20 , pp. 159-170
    • Trott, K.R.1
  • 14
    • 0033955922 scopus 로고    scopus 로고
    • Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers
    • Mohan R, et al (2000) Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 46: 619-630.
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 619-630
    • Mohan, R.1
  • 15
    • 27244433455 scopus 로고    scopus 로고
    • Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
    • Harada H, Kizaka-Kondoh S and Hiraoka M (2005) Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol Imaging 4: 182-193.
    • (2005) Mol Imaging , vol.4 , pp. 182-193
    • Harada, H.1    Kizaka-Kondoh, S.2    Hiraoka, M.3
  • 16
    • 50949104613 scopus 로고    scopus 로고
    • Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors
    • Harada H, et al (2008) Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors. Biochem Biophys Res Commun 373: 533-538.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 533-538
    • Harada, H.1
  • 17
    • 64149112403 scopus 로고    scopus 로고
    • The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
    • Harada H, et al (2009) The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem 284: 5332-5342.
    • (2009) J Biol Chem , vol.284 , pp. 5332-5342
    • Harada, H.1
  • 18
    • 61749090849 scopus 로고    scopus 로고
    • Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
    • Harada H, et al (2009) Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy. Br J Cancer 100: 747-757.
    • (2009) Br J Cancer , vol.100 , pp. 747-757
    • Harada, H.1
  • 19
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D and Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 20
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F and Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 21
    • 0003605672 scopus 로고
    • Fourth Edition, J. B. Lippincott Company, Philadelphia
    • Hall EJ (1994) Radiobiology for the Radiologists. Fourth Edition, J. B. Lippincott Company, Philadelphia.
    • (1994) Radiobiology For the Radiologists
    • Hall, E.J.1
  • 22
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • Brown JM (1979) Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 52: 650-656.
    • (1979) Br J Radiol , vol.52 , pp. 650-656
    • Brown, J.M.1
  • 23
    • 70549102512 scopus 로고    scopus 로고
    • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    • Dewhirst MW (2009) Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 172: 653-665.
    • (2009) Radiat Res , vol.172 , pp. 653-665
    • Dewhirst, M.W.1
  • 24
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst MW, Cao Y and Moeller B (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437.
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 25
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray LH, et al (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638-648.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1
  • 26
    • 0347029631 scopus 로고    scopus 로고
    • Tumor hypoxia: A target for selective cancer therapy
    • Kizaka-Kondoh S, et al (2003) Tumor hypoxia: a target for selective cancer therapy. Cancer Sci 94: 1021-1028.
    • (2003) Cancer Sci , vol.94 , pp. 1021-1028
    • Kizaka-Kondoh, S.1
  • 27
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold DM, et al (2001) Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916.
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1
  • 28
    • 3142672781 scopus 로고    scopus 로고
    • Protocol of radiotherapy for glioblastoma according to the expression of HIF-1
    • Irie N, Matsuo T and Nagata I (2004) Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathol 21: 1-6.
    • (2004) Brain Tumor Pathol , vol.21 , pp. 1-6
    • Irie, N.1    Matsuo, T.2    Nagata, I.3
  • 29
    • 4544276339 scopus 로고    scopus 로고
    • Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma
    • Ishikawa H, et al (2004) Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. Int J Radiat Oncol Biol Phys 60: 513-521.
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , pp. 513-521
    • Ishikawa, H.1
  • 30
    • 8544229943 scopus 로고    scopus 로고
    • Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
    • Zhang X, et al (2004) Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res 64: 8139-8142.
    • (2004) Cancer Res , vol.64 , pp. 8139-8142
    • Zhang, X.1
  • 31
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, et al (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510-5514.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1
  • 32
    • 27544504817 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
    • Hirota K and Semenza GL (2005) Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun 338: 610-616.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 610-616
    • Hirota, K.1    Semenza, G.L.2
  • 33
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza GL (2001) HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 34
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P, et al (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 35
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1
  • 36
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • Chan DA and Giaccia AJ (2007) Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 26: 333-339.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 37
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • Erler JT, et al (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226.
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1
  • 38
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1
  • 39
    • 34547130302 scopus 로고    scopus 로고
    • Effects of hypoxia on tumor metabolism
    • Kim JW, Gao P and Dang CV (2007) Effects of hypoxia on tumor metabolism. Cancer Metastasis Rev 26: 291-298.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 291-298
    • Kim, J.W.1    Gao, P.2    Dang, C.V.3
  • 40
    • 0034037286 scopus 로고    scopus 로고
    • Microenvironment-induced cancer metastasis
    • Rofstad EK (2000) Microenvironment-induced cancer metastasis. Int J Radiat Biol 76: 589-605.
    • (2000) Int J Radiat Biol , vol.76 , pp. 589-605
    • Rofstad, E.K.1
  • 41
    • 33846254999 scopus 로고    scopus 로고
    • RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    • Liu YV, et al (2007) RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25: 207-217.
    • (2007) Mol Cell , vol.25 , pp. 207-217
    • Liu, Y.V.1
  • 42
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, et al (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1
  • 43
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel W, et al (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14: 391-396.
    • (2000) Genes Dev , vol.14 , pp. 391-396
    • Zundel, W.1
  • 44
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D, et al (1999) Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 59: 3915-3918.
    • (1999) Cancer Res , vol.59 , pp. 3915-3918
    • Feldser, D.1
  • 45
    • 0033181324 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
    • Hellwig-Burgel T, et al (1999) Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 94: 1561-1567.
    • (1999) Blood , vol.94 , pp. 1561-1567
    • Hellwig-Burgel, T.1
  • 46
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT
    • Zelzer E, et al (1998) Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 17: 5085-5094.
    • (1998) EMBO J , vol.17 , pp. 5085-5094
    • Zelzer, E.1
  • 47
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, et al (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1
  • 48
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K and Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686.
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 49
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard DE, et al (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 274: 32631-32637.
    • (1999) J Biol Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1
  • 50
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha
    • Sodhi A, et al (2000) The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res 60: 4873-4880.
    • (2000) Cancer Res , vol.60 , pp. 4873-4880
    • Sodhi, A.1
  • 51
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski DH, et al (1999) Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59: 3374-3378.
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1
  • 52
    • 55449136468 scopus 로고    scopus 로고
    • TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
    • Zeng L, et al (2008) TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis. Cancer Sci 99: 2327-2335.
    • (2008) Cancer Sci , vol.99 , pp. 2327-2335
    • Zeng, L.1
  • 53
    • 34047272690 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha stability through S-nitrosylation
    • Li F, et al (2007) Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell 26: 63-74.
    • (2007) Mol Cell , vol.26 , pp. 63-74
    • Li, F.1
  • 54
    • 69549122382 scopus 로고    scopus 로고
    • Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy
    • Ou G, et al (2009) Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy. Int J Radiat Oncol Biol Phys 75: 463-467.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 463-467
    • Ou, G.1
  • 55
    • 0034566045 scopus 로고    scopus 로고
    • Changes in tumor hypoxia measured with a double hypoxic marker technique
    • Ljungkvist AS, et al (2000) Changes in tumor hypoxia measured with a double hypoxic marker technique. Int J Radiat Oncol Biol Phys 48: 1529-1538.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 1529-1538
    • Ljungkvist, A.S.1
  • 56
    • 4344707313 scopus 로고    scopus 로고
    • Quantifying transient hypoxia in human tumor xenografts by flow cytometry
    • Bennewith KL and Durand RE (2004) Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res 64: 6183-6189.
    • (2004) Cancer Res , vol.64 , pp. 6183-6189
    • Bennewith, K.L.1    Durand, R.E.2
  • 57
    • 0023107539 scopus 로고
    • Intermittent blood flow in a murine tumor: Radiobiological effects
    • Chaplin DJ, Olive PL and Durand RE (1987) Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 47: 597-601.
    • (1987) Cancer Res , vol.47 , pp. 597-601
    • Chaplin, D.J.1    Olive, P.L.2    Durand, R.E.3
  • 58
    • 33846850493 scopus 로고    scopus 로고
    • Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers
    • Ljungkvist AS, et al (2007) Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat Res 167: 127-145.
    • (2007) Radiat Res , vol.167 , pp. 127-145
    • Ljungkvist, A.S.1
  • 59
    • 37049004518 scopus 로고    scopus 로고
    • Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer
    • Nehmeh SA, et al (2008) Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer. Int J Radiat Oncol Biol Phys 70: 235-242.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 235-242
    • Nehmeh, S.A.1
  • 61
    • 0029969331 scopus 로고    scopus 로고
    • Reoxygenation after single irradiation in rodent tumors of different types and sizes
    • Murata R, et al (1996) Reoxygenation after single irradiation in rodent tumors of different types and sizes. Int J Radiat Oncol Biol Phys 34: 859-865.
    • (1996) Int J Radiat Oncol Biol Phys , vol.34 , pp. 859-865
    • Murata, R.1
  • 62
    • 34447565882 scopus 로고    scopus 로고
    • The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
    • Harada H, et al (2007) The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun 360: 791-796.
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 791-796
    • Harada, H.1
  • 63
    • 18044364816 scopus 로고    scopus 로고
    • Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts
    • Liu J, et al (2005) Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts. J Radiat Res (Tokyo) 46: 93-102.
    • (2005) J Radiat Res (Tokyo) , vol.46 , pp. 93-102
    • Liu, J.1
  • 64
    • 0031742542 scopus 로고    scopus 로고
    • Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes
    • Shibata T, et al (1998) Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys 42: 913-916.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 913-916
    • Shibata, T.1
  • 65
    • 0026022660 scopus 로고
    • Pathophysiological approaches to identifying tumor hypoxia in patients
    • Mueller-Klieser W, et al (1991) Pathophysiological approaches to identifying tumor hypoxia in patients. Radiother Oncol 20 Suppl 1: 21-28.
    • (1991) Radiother Oncol , vol.20 , Issue.SUPPL. 1 , pp. 21-28
    • Mueller-Klieser, W.1
  • 66
    • 0025807618 scopus 로고
    • Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
    • Vaupel P, et al (1991) Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51: 3316-3322.
    • (1991) Cancer Res , vol.51 , pp. 3316-3322
    • Vaupel, P.1
  • 67
    • 0032170012 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
    • Raleigh JA, et al (1998) Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker. Cancer Res 58: 3765-3768.
    • (1998) Cancer Res , vol.58 , pp. 3765-3768
    • Raleigh, J.A.1
  • 68
    • 0027376264 scopus 로고
    • Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts
    • Lord EM, Harwell L and Koch CJ (1993) Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res 53: 5721-5726.
    • (1993) Cancer Res , vol.53 , pp. 5721-5726
    • Lord, E.M.1    Harwell, L.2    Koch, C.J.3
  • 69
    • 0038724686 scopus 로고    scopus 로고
    • Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: In vitro and xenograft studies
    • Vordermark D and Brown JM (2003) Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies. Int J Radiat Oncol Biol Phys 56: 1184-1193.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 1184-1193
    • Vordermark, D.1    Brown, J.M.2
  • 70
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, et al (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61: 6394-6399.
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1
  • 72
    • 34250712408 scopus 로고    scopus 로고
    • Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond
    • Mankoff DA, et al (2007) Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond. Clin Cancer Res 13: 3460-3469.
    • (2007) Clin Cancer Res , vol.13 , pp. 3460-3469
    • Mankoff, D.A.1
  • 73
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • Semenza GL (2009) Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 19: 12-16.
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 74
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, et al (2001) Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 276: 9519-9525.
    • (2001) J Biol Chem , vol.276 , pp. 9519-9525
    • Chen, C.1
  • 75
    • 43549121719 scopus 로고    scopus 로고
    • The warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen?
    • Lopez-Lazaro M (2008) The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med Chem 8: 305-312.
    • (2008) Anticancer Agents Med Chem , vol.8 , pp. 305-312
    • Lopez-Lazaro, M.1
  • 76
    • 0033954168 scopus 로고    scopus 로고
    • Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1
    • Evans SM, et al (2000) Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1. J Nucl Med 41: 327-336.
    • (2000) J Nucl Med , vol.41 , pp. 327-336
    • Evans, S.M.1
  • 77
    • 0030811565 scopus 로고    scopus 로고
    • Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential
    • Fujibayashi Y, et al (1997) Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med 38: 1155-1160.
    • (1997) J Nucl Med , vol.38 , pp. 1155-1160
    • Fujibayashi, Y.1
  • 78
    • 0023638854 scopus 로고
    • Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells
    • Rasey JS, et al (1987) Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiat Res 111: 292-304.
    • (1987) Radiat Res , vol.111 , pp. 292-304
    • Rasey, J.S.1
  • 79
    • 70349655722 scopus 로고    scopus 로고
    • Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET
    • Wang K, et al (2009) Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET. Med Phys 36: 4400-4408.
    • (2009) Med Phys , vol.36 , pp. 4400-4408
    • Wang, K.1
  • 80
    • 33645773136 scopus 로고    scopus 로고
    • Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI
    • Egeland TA, et al (2006) Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI. Magn Reson Med 55: 874-882.
    • (2006) Magn Reson Med , vol.55 , pp. 874-882
    • Egeland, T.A.1
  • 81
    • 77957717869 scopus 로고    scopus 로고
    • Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI
    • Magat J, et al (2010) Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI. Med Phys 37: 5434-5441.
    • (2010) Med Phys , vol.37 , pp. 5434-5441
    • Magat, J.1
  • 82
    • 78650387484 scopus 로고    scopus 로고
    • Imaging cycling tumor hypoxia
    • Matsumoto S, et al (2010) Imaging cycling tumor hypoxia. Cancer Res 70: 10019-10023.
    • (2010) Cancer Res , vol.70 , pp. 10019-10023
    • Matsumoto, S.1
  • 83
    • 77955761645 scopus 로고    scopus 로고
    • Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice
    • Yasui H, et al (2010) Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice. Cancer Res 70: 6427-6436.
    • (2010) Cancer Res , vol.70 , pp. 6427-6436
    • Yasui, H.1
  • 84
    • 0023262969 scopus 로고
    • Radiation therapy and the role of red blood cell transfusion
    • Poskitt TR (1987) Radiation therapy and the role of red blood cell transfusion. Cancer Invest 5: 231-236.
    • (1987) Cancer Invest , vol.5 , pp. 231-236
    • Poskitt, T.R.1
  • 85
    • 11344268695 scopus 로고    scopus 로고
    • Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts
    • Pinel S, et al (2004) Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts. Int J Radiat Oncol Biol Phys 59: 250-259.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 250-259
    • Pinel, S.1
  • 86
    • 0036898268 scopus 로고    scopus 로고
    • ARCON: A novel biology-based approach in radiotherapy
    • Kaanders JH, Bussink J and van der Kogel AJ (2002) ARCON: a novel biology-based approach in radiotherapy. Lancet Oncol 3: 728-737.
    • (2002) Lancet Oncol , vol.3 , pp. 728-737
    • Kaanders, J.H.1    Bussink, J.2    van der Kogel, A.J.3
  • 87
    • 0021953023 scopus 로고
    • Hypoxic cell radiosensitizers: Expectations and progress in drug development
    • Coleman CN (1985) Hypoxic cell radiosensitizers: expectations and progress in drug development. Int J Radiat Oncol Biol Phys 11: 323-329.
    • (1985) Int J Radiat Oncol Biol Phys , vol.11 , pp. 323-329
    • Coleman, C.N.1
  • 88
    • 0019967261 scopus 로고
    • Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers
    • Stratford IJ (1982) Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers. Int J Radiat Oncol Biol Phys 8: 391-398.
    • (1982) Int J Radiat Oncol Biol Phys , vol.8 , pp. 391-398
    • Stratford, I.J.1
  • 89
    • 0024957873 scopus 로고
    • The treatment of hepatic metastases from colorectal cancer with radiation therapy alone or combined with chemotherapy or misonidazole
    • Minsky BD and Leibel SA (1989) The treatment of hepatic metastases from colorectal cancer with radiation therapy alone or combined with chemotherapy or misonidazole. Cancer Treat Rev 16: 213-219.
    • (1989) Cancer Treat Rev , vol.16 , pp. 213-219
    • Minsky, B.D.1    Leibel, S.A.2
  • 90
    • 0024322637 scopus 로고
    • Radiation therapy alone or combined with misonidazole in the treatment of locally advanced non-oat cell lung cancer: Report of an RTOG prospective randomized trial
    • Simpson JR, et al (1989) Radiation therapy alone or combined with misonidazole in the treatment of locally advanced non-oat cell lung cancer: report of an RTOG prospective randomized trial. Int J Radiat Oncol Biol Phys 16: 1483-1491.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 1483-1491
    • Simpson, J.R.1
  • 91
    • 0024343498 scopus 로고
    • Positive clinical experience with misonidazole in brachytherapy and external radiotherapy
    • Baillet F, et al (1989) Positive clinical experience with misonidazole in brachytherapy and external radiotherapy. Int J Radiat Oncol Biol Phys 16: 1073-1075.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 1073-1075
    • Baillet, F.1
  • 92
    • 0031909654 scopus 로고    scopus 로고
    • A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
    • Overgaard J, et al (1998) A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 46: 135-146.
    • (1998) Radiother Oncol , vol.46 , pp. 135-146
    • Overgaard, J.1
  • 93
    • 27744520254 scopus 로고    scopus 로고
    • Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo
    • Yahiro T, et al (2005) Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo. J Radiat Res (Tokyo) 46: 363-372.
    • (2005) J Radiat Res (Tokyo) , vol.46 , pp. 363-372
    • Yahiro, T.1
  • 94
    • 0022493495 scopus 로고
    • SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
    • Zeman EM, et al (1986) SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 12: 1239-1242.
    • (1986) Int J Radiat Oncol Biol Phys , vol.12 , pp. 1239-1242
    • Zeman, E.M.1
  • 95
    • 0023689603 scopus 로고
    • Metabolism of SR 4233 by Chinese hamster ovary cells: Basis of selective hypoxic cytotoxicity
    • Baker MA, et al (1988) Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Res 48: 5947-5952.
    • (1988) Cancer Res , vol.48 , pp. 5947-5952
    • Baker, M.A.1
  • 96
    • 0042348003 scopus 로고    scopus 로고
    • A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates
    • Zagorevskii D, et al (2003) A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates. J Am Soc Mass Spectrom 14: 881-892.
    • (2003) J Am Soc Mass Spectrom , vol.14 , pp. 881-892
    • Zagorevskii, D.1
  • 97
    • 0037105653 scopus 로고    scopus 로고
    • Tirapazamine: A hypoxia-activated topoisomerase II poison
    • Peters KB and Brown JM (2002) Tirapazamine: a hypoxia-activated topoisomerase II poison. Cancer Res 62: 5248-5253.
    • (2002) Cancer Res , vol.62 , pp. 5248-5253
    • Peters, K.B.1    Brown, J.M.2
  • 98
    • 16644377045 scopus 로고    scopus 로고
    • Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
    • Rischin D, et al (2005) Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J Clin Oncol 23: 79-87.
    • (2005) J Clin Oncol , vol.23 , pp. 79-87
    • Rischin, D.1
  • 99
    • 0034104328 scopus 로고    scopus 로고
    • Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors
    • von Pawel J, et al (2000) Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors. J Clin Oncol 18: 1351-1359.
    • (2000) J Clin Oncol , vol.18 , pp. 1351-1359
    • von Pawel, J.1
  • 100
    • 34547660100 scopus 로고    scopus 로고
    • Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading
    • Shin DH, et al (2007) Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading. Cancer Lett 255: 107-116.
    • (2007) Cancer Lett , vol.255 , pp. 107-116
    • Shin, D.H.1
  • 101
    • 0037414180 scopus 로고    scopus 로고
    • YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
    • Yeo EJ, et al (2003) YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95: 516-525.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 516-525
    • Yeo, E.J.1
  • 102
    • 70449580319 scopus 로고    scopus 로고
    • Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
    • Lee K, et al (2009) Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci USA 106: 17910-17915.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17910-17915
    • Lee, K.1
  • 103
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, et al (2004) mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10: 594-601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1
  • 104
    • 60549083336 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha
    • Kim WY, et al (2009) Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha. Cancer Res 69: 1624-1632.
    • (2009) Cancer Res , vol.69 , pp. 1624-1632
    • Kim, W.Y.1
  • 105
    • 34347256360 scopus 로고    scopus 로고
    • Structural basis for depletion of heat shock protein 90 client proteins by deguelin
    • Oh SH, et al (2007) Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst 99: 949-961.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 949-961
    • Oh, S.H.1
  • 106
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • Dachs GU, et al (1997) Targeting gene expression to hypoxic tumor cells. Nat Med 3: 515-520.
    • (1997) Nat Med , vol.3 , pp. 515-520
    • Dachs, G.U.1
  • 107
    • 0034017489 scopus 로고    scopus 로고
    • Development of a hypoxia-responsive vector for tumor-specific gene therapy
    • Shibata T, Giaccia AJ and Brown JM (2000) Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 7: 493-498.
    • (2000) Gene Ther , vol.7 , pp. 493-498
    • Shibata, T.1    Giaccia, A.J.2    Brown, J.M.3
  • 108
    • 0345257217 scopus 로고    scopus 로고
    • How to overcome (and exploit) tumor hypoxia for targeted gene therapy
    • Greco O, et al (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. J Cell Physiol 197: 312-325.
    • (2003) J Cell Physiol , vol.197 , pp. 312-325
    • Greco, O.1
  • 109
    • 34250350316 scopus 로고    scopus 로고
    • Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts
    • Liu J, et al (2007) Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts. Br J Cancer 96: 1871-1878.
    • (2007) Br J Cancer , vol.96 , pp. 1871-1878
    • Liu, J.1
  • 110
    • 21244497803 scopus 로고    scopus 로고
    • A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas
    • Ogura M, et al (2005) A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas. Cancer Sci 96: 288-294.
    • (2005) Cancer Sci , vol.96 , pp. 288-294
    • Ogura, M.1
  • 111
    • 0036328116 scopus 로고    scopus 로고
    • Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours
    • Patterson AV, et al (2002) Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours. Gene Ther 9: 946-954.
    • (2002) Gene Ther , vol.9 , pp. 946-954
    • Patterson, A.V.1
  • 112
    • 0036145795 scopus 로고    scopus 로고
    • Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy
    • Shibata T, Giaccia AJ and Brown JM (2002) Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 4: 40-48.
    • (2002) Neoplasia , vol.4 , pp. 40-48
    • Shibata, T.1    Giaccia, A.J.2    Brown, J.M.3
  • 113
    • 20244364373 scopus 로고
    • Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: Final analysis of a randomized trial of the EORTC cooperative group of radiotherapy
    • Horiot JC, et al (1992) Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 25: 231-241.
    • (1992) Radiother Oncol , vol.25 , pp. 231-241
    • Horiot, J.C.1
  • 114
    • 0020064973 scopus 로고
    • Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships
    • Thames HD Jr, et al (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 8: 219-226.
    • (1982) Int J Radiat Oncol Biol Phys , vol.8 , pp. 219-226
    • Thames Jr, H.D.1
  • 115
    • 0029113269 scopus 로고
    • Intensity-modulated arc therapy with dynamic multileaf collimation: An alternative to tomotherapy
    • Yu CX (1995) Intensity-modulated arc therapy with dynamic multileaf collimation: an alternative to tomotherapy. Phys Med Biol 40: 1435-1449.
    • (1995) Phys Med Biol , vol.40 , pp. 1435-1449
    • Yu, C.X.1
  • 116
    • 0023370208 scopus 로고
    • An integrated radiotherapy treatment system and its clinical application
    • Aoki Y, et al (1987) An integrated radiotherapy treatment system and its clinical application. Radiat Med 5: 131-141.
    • (1987) Radiat Med , vol.5 , pp. 131-141
    • Aoki, Y.1
  • 117
    • 77956266565 scopus 로고    scopus 로고
    • A review of the clinical evidence for intensity-modulated radiotherapy
    • Staffurth J (2010) A review of the clinical evidence for intensity-modulated radiotherapy. Clin Oncol (R Coll Radiol) 22: 643-657.
    • (2010) Clin Oncol (R Coll Radiol) , vol.22 , pp. 643-657
    • Staffurth, J.1
  • 118
    • 40949088260 scopus 로고    scopus 로고
    • Current concepts on imaging in radiotherapy
    • Lecchi M, et al (2008) Current concepts on imaging in radiotherapy. Eur J Nucl Med Mol Imaging 35: 821-837.
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 821-837
    • Lecchi, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.