-
1
-
-
0007015743
-
On a New Kind of Rays
-
Rontgen WC (1896) On a New Kind of Rays. Science 3: 227-231.
-
(1896)
Science
, vol.3
, pp. 227-231
-
-
Rontgen, W.C.1
-
2
-
-
4544384318
-
Radiation oncology: A century of achievements
-
Bernier J, Hall EJ and Giaccia A (2004) Radiation oncology: a century of achievements. Nat Rev Cancer 4: 737-747.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 737-747
-
-
Bernier, J.1
Hall, E.J.2
Giaccia, A.3
-
3
-
-
2942590732
-
Exploiting tumour hypoxia in cancer treatment
-
Brown JM and Wilson WR (2004) Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4: 437-447.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
4
-
-
84966192535
-
The histological structure of some human lung cancers and the possible implications for radiotherapy
-
Thomlinson RH and Gray LH (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9: 539-549.
-
(1955)
Br J Cancer
, vol.9
, pp. 539-549
-
-
Thomlinson, R.H.1
Gray, L.H.2
-
7
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
Moeller BJ, et al (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
-
(2004)
Cancer Cell
, vol.5
, pp. 429-441
-
-
Moeller, B.J.1
-
8
-
-
33745517944
-
HIF-1 and tumour radiosensitivity
-
Moeller BJ and Dewhirst MW (2006) HIF-1 and tumour radiosensitivity. Br J Cancer 95: 1-5.
-
(2006)
Br J Cancer
, vol.95
, pp. 1-5
-
-
Moeller, B.J.1
Dewhirst, M.W.2
-
9
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
Moeller BJ, et al (2005) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8: 99-110.
-
(2005)
Cancer Cell
, vol.8
, pp. 99-110
-
-
Moeller, B.J.1
-
11
-
-
0004967036
-
Radiation Response of Mammalian Cells Grown in Culture. V. Temperature Dependence of the Repair of X-Ray Damage in Surviving Cells (Aerobic and Hypoxic)
-
Elkind MM, et al (1965) Radiation Response of Mammalian Cells Grown in Culture. V. Temperature Dependence of the Repair of X-Ray Damage in Surviving Cells (Aerobic and Hypoxic). Radiat Res 25: 359-376.
-
(1965)
Radiat Res
, vol.25
, pp. 359-376
-
-
Elkind, M.M.1
-
12
-
-
0014344261
-
Application of radiobiologic principles to radiation therapy
-
Suit HD (1968) Application of radiobiologic principles to radiation therapy. Cancer 22: 809-815.
-
(1968)
Cancer
, vol.22
, pp. 809-815
-
-
Suit, H.D.1
-
13
-
-
0019942560
-
Experimental results and clinical implications of the four R's in fractionated radiotherapy
-
Trott KR (1982) Experimental results and clinical implications of the four R's in fractionated radiotherapy. Radiat Environ Biophys 20: 159-170.
-
(1982)
Radiat Environ Biophys
, vol.20
, pp. 159-170
-
-
Trott, K.R.1
-
14
-
-
0033955922
-
Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers
-
Mohan R, et al (2000) Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 46: 619-630.
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.46
, pp. 619-630
-
-
Mohan, R.1
-
15
-
-
27244433455
-
Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
-
Harada H, Kizaka-Kondoh S and Hiraoka M (2005) Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol Imaging 4: 182-193.
-
(2005)
Mol Imaging
, vol.4
, pp. 182-193
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Hiraoka, M.3
-
16
-
-
50949104613
-
Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors
-
Harada H, et al (2008) Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors. Biochem Biophys Res Commun 373: 533-538.
-
(2008)
Biochem Biophys Res Commun
, vol.373
, pp. 533-538
-
-
Harada, H.1
-
17
-
-
64149112403
-
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
-
Harada H, et al (2009) The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem 284: 5332-5342.
-
(2009)
J Biol Chem
, vol.284
, pp. 5332-5342
-
-
Harada, H.1
-
18
-
-
61749090849
-
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
-
Harada H, et al (2009) Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy. Br J Cancer 100: 747-757.
-
(2009)
Br J Cancer
, vol.100
, pp. 747-757
-
-
Harada, H.1
-
19
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D and Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
20
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
Vaupel P, Kallinowski F and Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465.
-
(1989)
Cancer Res
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
21
-
-
0003605672
-
-
Fourth Edition, J. B. Lippincott Company, Philadelphia
-
Hall EJ (1994) Radiobiology for the Radiologists. Fourth Edition, J. B. Lippincott Company, Philadelphia.
-
(1994)
Radiobiology For the Radiologists
-
-
Hall, E.J.1
-
22
-
-
0018760476
-
Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
-
Brown JM (1979) Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 52: 650-656.
-
(1979)
Br J Radiol
, vol.52
, pp. 650-656
-
-
Brown, J.M.1
-
23
-
-
70549102512
-
Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
-
Dewhirst MW (2009) Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 172: 653-665.
-
(2009)
Radiat Res
, vol.172
, pp. 653-665
-
-
Dewhirst, M.W.1
-
24
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst MW, Cao Y and Moeller B (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 425-437
-
-
Dewhirst, M.W.1
Cao, Y.2
Moeller, B.3
-
25
-
-
84960987950
-
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
-
Gray LH, et al (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638-648.
-
(1953)
Br J Radiol
, vol.26
, pp. 638-648
-
-
Gray, L.H.1
-
26
-
-
0347029631
-
Tumor hypoxia: A target for selective cancer therapy
-
Kizaka-Kondoh S, et al (2003) Tumor hypoxia: a target for selective cancer therapy. Cancer Sci 94: 1021-1028.
-
(2003)
Cancer Sci
, vol.94
, pp. 1021-1028
-
-
Kizaka-Kondoh, S.1
-
27
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold DM, et al (2001) Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916.
-
(2001)
Cancer Res
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
-
28
-
-
3142672781
-
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1
-
Irie N, Matsuo T and Nagata I (2004) Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathol 21: 1-6.
-
(2004)
Brain Tumor Pathol
, vol.21
, pp. 1-6
-
-
Irie, N.1
Matsuo, T.2
Nagata, I.3
-
29
-
-
4544276339
-
Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma
-
Ishikawa H, et al (2004) Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. Int J Radiat Oncol Biol Phys 60: 513-521.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.60
, pp. 513-521
-
-
Ishikawa, H.1
-
30
-
-
8544229943
-
Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
-
Zhang X, et al (2004) Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res 64: 8139-8142.
-
(2004)
Cancer Res
, vol.64
, pp. 8139-8142
-
-
Zhang, X.1
-
31
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, et al (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510-5514.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
-
32
-
-
27544504817
-
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
-
Hirota K and Semenza GL (2005) Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun 338: 610-616.
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 610-616
-
-
Hirota, K.1
Semenza, G.L.2
-
33
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
-
Semenza GL (2001) HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3.
-
(2001)
Cell
, vol.107
, pp. 1-3
-
-
Semenza, G.L.1
-
34
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, et al (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
35
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
36
-
-
34547125574
-
Hypoxia, gene expression, and metastasis
-
Chan DA and Giaccia AJ (2007) Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 26: 333-339.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 333-339
-
-
Chan, D.A.1
Giaccia, A.J.2
-
37
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler JT, et al (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226.
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
-
38
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
-
40
-
-
0034037286
-
Microenvironment-induced cancer metastasis
-
Rofstad EK (2000) Microenvironment-induced cancer metastasis. Int J Radiat Biol 76: 589-605.
-
(2000)
Int J Radiat Biol
, vol.76
, pp. 589-605
-
-
Rofstad, E.K.1
-
41
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Liu YV, et al (2007) RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25: 207-217.
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
-
42
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, et al (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
-
43
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, et al (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14: 391-396.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
-
44
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
Feldser D, et al (1999) Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 59: 3915-3918.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
-
45
-
-
0033181324
-
Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
-
Hellwig-Burgel T, et al (1999) Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 94: 1561-1567.
-
(1999)
Blood
, vol.94
, pp. 1561-1567
-
-
Hellwig-Burgel, T.1
-
46
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT
-
Zelzer E, et al (1998) Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 17: 5085-5094.
-
(1998)
EMBO J
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
-
47
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, et al (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
-
48
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K and Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
49
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
-
Richard DE, et al (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 274: 32631-32637.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
-
50
-
-
0034282553
-
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha
-
Sodhi A, et al (2000) The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res 60: 4873-4880.
-
(2000)
Cancer Res
, vol.60
, pp. 4873-4880
-
-
Sodhi, A.1
-
51
-
-
0033564974
-
Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
-
Gorski DH, et al (1999) Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59: 3374-3378.
-
(1999)
Cancer Res
, vol.59
, pp. 3374-3378
-
-
Gorski, D.H.1
-
52
-
-
55449136468
-
TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
-
Zeng L, et al (2008) TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis. Cancer Sci 99: 2327-2335.
-
(2008)
Cancer Sci
, vol.99
, pp. 2327-2335
-
-
Zeng, L.1
-
53
-
-
34047272690
-
Regulation of HIF-1alpha stability through S-nitrosylation
-
Li F, et al (2007) Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell 26: 63-74.
-
(2007)
Mol Cell
, vol.26
, pp. 63-74
-
-
Li, F.1
-
54
-
-
69549122382
-
Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy
-
Ou G, et al (2009) Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy. Int J Radiat Oncol Biol Phys 75: 463-467.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.75
, pp. 463-467
-
-
Ou, G.1
-
55
-
-
0034566045
-
Changes in tumor hypoxia measured with a double hypoxic marker technique
-
Ljungkvist AS, et al (2000) Changes in tumor hypoxia measured with a double hypoxic marker technique. Int J Radiat Oncol Biol Phys 48: 1529-1538.
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.48
, pp. 1529-1538
-
-
Ljungkvist, A.S.1
-
56
-
-
4344707313
-
Quantifying transient hypoxia in human tumor xenografts by flow cytometry
-
Bennewith KL and Durand RE (2004) Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res 64: 6183-6189.
-
(2004)
Cancer Res
, vol.64
, pp. 6183-6189
-
-
Bennewith, K.L.1
Durand, R.E.2
-
57
-
-
0023107539
-
Intermittent blood flow in a murine tumor: Radiobiological effects
-
Chaplin DJ, Olive PL and Durand RE (1987) Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 47: 597-601.
-
(1987)
Cancer Res
, vol.47
, pp. 597-601
-
-
Chaplin, D.J.1
Olive, P.L.2
Durand, R.E.3
-
58
-
-
33846850493
-
Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers
-
Ljungkvist AS, et al (2007) Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat Res 167: 127-145.
-
(2007)
Radiat Res
, vol.167
, pp. 127-145
-
-
Ljungkvist, A.S.1
-
59
-
-
37049004518
-
Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer
-
Nehmeh SA, et al (2008) Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer. Int J Radiat Oncol Biol Phys 70: 235-242.
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.70
, pp. 235-242
-
-
Nehmeh, S.A.1
-
61
-
-
0029969331
-
Reoxygenation after single irradiation in rodent tumors of different types and sizes
-
Murata R, et al (1996) Reoxygenation after single irradiation in rodent tumors of different types and sizes. Int J Radiat Oncol Biol Phys 34: 859-865.
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.34
, pp. 859-865
-
-
Murata, R.1
-
62
-
-
34447565882
-
The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
-
Harada H, et al (2007) The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun 360: 791-796.
-
(2007)
Biochem Biophys Res Commun
, vol.360
, pp. 791-796
-
-
Harada, H.1
-
63
-
-
18044364816
-
Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts
-
Liu J, et al (2005) Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts. J Radiat Res (Tokyo) 46: 93-102.
-
(2005)
J Radiat Res (Tokyo)
, vol.46
, pp. 93-102
-
-
Liu, J.1
-
64
-
-
0031742542
-
Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes
-
Shibata T, et al (1998) Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys 42: 913-916.
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, pp. 913-916
-
-
Shibata, T.1
-
65
-
-
0026022660
-
Pathophysiological approaches to identifying tumor hypoxia in patients
-
Mueller-Klieser W, et al (1991) Pathophysiological approaches to identifying tumor hypoxia in patients. Radiother Oncol 20 Suppl 1: 21-28.
-
(1991)
Radiother Oncol
, vol.20
, Issue.SUPPL. 1
, pp. 21-28
-
-
Mueller-Klieser, W.1
-
66
-
-
0025807618
-
Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
-
Vaupel P, et al (1991) Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51: 3316-3322.
-
(1991)
Cancer Res
, vol.51
, pp. 3316-3322
-
-
Vaupel, P.1
-
67
-
-
0032170012
-
Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
-
Raleigh JA, et al (1998) Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker. Cancer Res 58: 3765-3768.
-
(1998)
Cancer Res
, vol.58
, pp. 3765-3768
-
-
Raleigh, J.A.1
-
68
-
-
0027376264
-
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts
-
Lord EM, Harwell L and Koch CJ (1993) Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res 53: 5721-5726.
-
(1993)
Cancer Res
, vol.53
, pp. 5721-5726
-
-
Lord, E.M.1
Harwell, L.2
Koch, C.J.3
-
69
-
-
0038724686
-
Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: In vitro and xenograft studies
-
Vordermark D and Brown JM (2003) Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies. Int J Radiat Oncol Biol Phys 56: 1184-1193.
-
(2003)
Int J Radiat Oncol Biol Phys
, vol.56
, pp. 1184-1193
-
-
Vordermark, D.1
Brown, J.M.2
-
70
-
-
0035418586
-
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
-
Loncaster JA, et al (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61: 6394-6399.
-
(2001)
Cancer Res
, vol.61
, pp. 6394-6399
-
-
Loncaster, J.A.1
-
72
-
-
34250712408
-
Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond
-
Mankoff DA, et al (2007) Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond. Clin Cancer Res 13: 3460-3469.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3460-3469
-
-
Mankoff, D.A.1
-
73
-
-
60549083256
-
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
-
Semenza GL (2009) Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 19: 12-16.
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 12-16
-
-
Semenza, G.L.1
-
74
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen C, et al (2001) Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 276: 9519-9525.
-
(2001)
J Biol Chem
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
-
75
-
-
43549121719
-
The warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen?
-
Lopez-Lazaro M (2008) The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med Chem 8: 305-312.
-
(2008)
Anticancer Agents Med Chem
, vol.8
, pp. 305-312
-
-
Lopez-Lazaro, M.1
-
76
-
-
0033954168
-
Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1
-
Evans SM, et al (2000) Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1. J Nucl Med 41: 327-336.
-
(2000)
J Nucl Med
, vol.41
, pp. 327-336
-
-
Evans, S.M.1
-
77
-
-
0030811565
-
Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential
-
Fujibayashi Y, et al (1997) Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med 38: 1155-1160.
-
(1997)
J Nucl Med
, vol.38
, pp. 1155-1160
-
-
Fujibayashi, Y.1
-
78
-
-
0023638854
-
Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells
-
Rasey JS, et al (1987) Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiat Res 111: 292-304.
-
(1987)
Radiat Res
, vol.111
, pp. 292-304
-
-
Rasey, J.S.1
-
79
-
-
70349655722
-
Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET
-
Wang K, et al (2009) Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET. Med Phys 36: 4400-4408.
-
(2009)
Med Phys
, vol.36
, pp. 4400-4408
-
-
Wang, K.1
-
80
-
-
33645773136
-
Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI
-
Egeland TA, et al (2006) Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI. Magn Reson Med 55: 874-882.
-
(2006)
Magn Reson Med
, vol.55
, pp. 874-882
-
-
Egeland, T.A.1
-
81
-
-
77957717869
-
Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI
-
Magat J, et al (2010) Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI. Med Phys 37: 5434-5441.
-
(2010)
Med Phys
, vol.37
, pp. 5434-5441
-
-
Magat, J.1
-
82
-
-
78650387484
-
Imaging cycling tumor hypoxia
-
Matsumoto S, et al (2010) Imaging cycling tumor hypoxia. Cancer Res 70: 10019-10023.
-
(2010)
Cancer Res
, vol.70
, pp. 10019-10023
-
-
Matsumoto, S.1
-
83
-
-
77955761645
-
Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice
-
Yasui H, et al (2010) Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice. Cancer Res 70: 6427-6436.
-
(2010)
Cancer Res
, vol.70
, pp. 6427-6436
-
-
Yasui, H.1
-
84
-
-
0023262969
-
Radiation therapy and the role of red blood cell transfusion
-
Poskitt TR (1987) Radiation therapy and the role of red blood cell transfusion. Cancer Invest 5: 231-236.
-
(1987)
Cancer Invest
, vol.5
, pp. 231-236
-
-
Poskitt, T.R.1
-
85
-
-
11344268695
-
Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts
-
Pinel S, et al (2004) Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts. Int J Radiat Oncol Biol Phys 59: 250-259.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.59
, pp. 250-259
-
-
Pinel, S.1
-
87
-
-
0021953023
-
Hypoxic cell radiosensitizers: Expectations and progress in drug development
-
Coleman CN (1985) Hypoxic cell radiosensitizers: expectations and progress in drug development. Int J Radiat Oncol Biol Phys 11: 323-329.
-
(1985)
Int J Radiat Oncol Biol Phys
, vol.11
, pp. 323-329
-
-
Coleman, C.N.1
-
88
-
-
0019967261
-
Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers
-
Stratford IJ (1982) Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers. Int J Radiat Oncol Biol Phys 8: 391-398.
-
(1982)
Int J Radiat Oncol Biol Phys
, vol.8
, pp. 391-398
-
-
Stratford, I.J.1
-
89
-
-
0024957873
-
The treatment of hepatic metastases from colorectal cancer with radiation therapy alone or combined with chemotherapy or misonidazole
-
Minsky BD and Leibel SA (1989) The treatment of hepatic metastases from colorectal cancer with radiation therapy alone or combined with chemotherapy or misonidazole. Cancer Treat Rev 16: 213-219.
-
(1989)
Cancer Treat Rev
, vol.16
, pp. 213-219
-
-
Minsky, B.D.1
Leibel, S.A.2
-
90
-
-
0024322637
-
Radiation therapy alone or combined with misonidazole in the treatment of locally advanced non-oat cell lung cancer: Report of an RTOG prospective randomized trial
-
Simpson JR, et al (1989) Radiation therapy alone or combined with misonidazole in the treatment of locally advanced non-oat cell lung cancer: report of an RTOG prospective randomized trial. Int J Radiat Oncol Biol Phys 16: 1483-1491.
-
(1989)
Int J Radiat Oncol Biol Phys
, vol.16
, pp. 1483-1491
-
-
Simpson, J.R.1
-
91
-
-
0024343498
-
Positive clinical experience with misonidazole in brachytherapy and external radiotherapy
-
Baillet F, et al (1989) Positive clinical experience with misonidazole in brachytherapy and external radiotherapy. Int J Radiat Oncol Biol Phys 16: 1073-1075.
-
(1989)
Int J Radiat Oncol Biol Phys
, vol.16
, pp. 1073-1075
-
-
Baillet, F.1
-
92
-
-
0031909654
-
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
-
Overgaard J, et al (1998) A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 46: 135-146.
-
(1998)
Radiother Oncol
, vol.46
, pp. 135-146
-
-
Overgaard, J.1
-
93
-
-
27744520254
-
Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo
-
Yahiro T, et al (2005) Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo. J Radiat Res (Tokyo) 46: 363-372.
-
(2005)
J Radiat Res (Tokyo)
, vol.46
, pp. 363-372
-
-
Yahiro, T.1
-
94
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman EM, et al (1986) SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 12: 1239-1242.
-
(1986)
Int J Radiat Oncol Biol Phys
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
-
95
-
-
0023689603
-
Metabolism of SR 4233 by Chinese hamster ovary cells: Basis of selective hypoxic cytotoxicity
-
Baker MA, et al (1988) Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Res 48: 5947-5952.
-
(1988)
Cancer Res
, vol.48
, pp. 5947-5952
-
-
Baker, M.A.1
-
96
-
-
0042348003
-
A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates
-
Zagorevskii D, et al (2003) A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates. J Am Soc Mass Spectrom 14: 881-892.
-
(2003)
J Am Soc Mass Spectrom
, vol.14
, pp. 881-892
-
-
Zagorevskii, D.1
-
97
-
-
0037105653
-
Tirapazamine: A hypoxia-activated topoisomerase II poison
-
Peters KB and Brown JM (2002) Tirapazamine: a hypoxia-activated topoisomerase II poison. Cancer Res 62: 5248-5253.
-
(2002)
Cancer Res
, vol.62
, pp. 5248-5253
-
-
Peters, K.B.1
Brown, J.M.2
-
98
-
-
16644377045
-
Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
-
Rischin D, et al (2005) Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J Clin Oncol 23: 79-87.
-
(2005)
J Clin Oncol
, vol.23
, pp. 79-87
-
-
Rischin, D.1
-
99
-
-
0034104328
-
Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors
-
von Pawel J, et al (2000) Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors. J Clin Oncol 18: 1351-1359.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1351-1359
-
-
von Pawel, J.1
-
100
-
-
34547660100
-
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading
-
Shin DH, et al (2007) Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading. Cancer Lett 255: 107-116.
-
(2007)
Cancer Lett
, vol.255
, pp. 107-116
-
-
Shin, D.H.1
-
101
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo EJ, et al (2003) YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95: 516-525.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
-
102
-
-
70449580319
-
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
-
Lee K, et al (2009) Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci USA 106: 17910-17915.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 17910-17915
-
-
Lee, K.1
-
103
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder PK, et al (2004) mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10: 594-601.
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
-
104
-
-
60549083336
-
Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha
-
Kim WY, et al (2009) Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha. Cancer Res 69: 1624-1632.
-
(2009)
Cancer Res
, vol.69
, pp. 1624-1632
-
-
Kim, W.Y.1
-
105
-
-
34347256360
-
Structural basis for depletion of heat shock protein 90 client proteins by deguelin
-
Oh SH, et al (2007) Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst 99: 949-961.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 949-961
-
-
Oh, S.H.1
-
106
-
-
0030968939
-
Targeting gene expression to hypoxic tumor cells
-
Dachs GU, et al (1997) Targeting gene expression to hypoxic tumor cells. Nat Med 3: 515-520.
-
(1997)
Nat Med
, vol.3
, pp. 515-520
-
-
Dachs, G.U.1
-
107
-
-
0034017489
-
Development of a hypoxia-responsive vector for tumor-specific gene therapy
-
Shibata T, Giaccia AJ and Brown JM (2000) Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 7: 493-498.
-
(2000)
Gene Ther
, vol.7
, pp. 493-498
-
-
Shibata, T.1
Giaccia, A.J.2
Brown, J.M.3
-
108
-
-
0345257217
-
How to overcome (and exploit) tumor hypoxia for targeted gene therapy
-
Greco O, et al (2003) How to overcome (and exploit) tumor hypoxia for targeted gene therapy. J Cell Physiol 197: 312-325.
-
(2003)
J Cell Physiol
, vol.197
, pp. 312-325
-
-
Greco, O.1
-
109
-
-
34250350316
-
Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts
-
Liu J, et al (2007) Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts. Br J Cancer 96: 1871-1878.
-
(2007)
Br J Cancer
, vol.96
, pp. 1871-1878
-
-
Liu, J.1
-
110
-
-
21244497803
-
A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas
-
Ogura M, et al (2005) A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas. Cancer Sci 96: 288-294.
-
(2005)
Cancer Sci
, vol.96
, pp. 288-294
-
-
Ogura, M.1
-
111
-
-
0036328116
-
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours
-
Patterson AV, et al (2002) Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours. Gene Ther 9: 946-954.
-
(2002)
Gene Ther
, vol.9
, pp. 946-954
-
-
Patterson, A.V.1
-
112
-
-
0036145795
-
Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy
-
Shibata T, Giaccia AJ and Brown JM (2002) Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 4: 40-48.
-
(2002)
Neoplasia
, vol.4
, pp. 40-48
-
-
Shibata, T.1
Giaccia, A.J.2
Brown, J.M.3
-
113
-
-
20244364373
-
Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: Final analysis of a randomized trial of the EORTC cooperative group of radiotherapy
-
Horiot JC, et al (1992) Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 25: 231-241.
-
(1992)
Radiother Oncol
, vol.25
, pp. 231-241
-
-
Horiot, J.C.1
-
114
-
-
0020064973
-
Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships
-
Thames HD Jr, et al (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 8: 219-226.
-
(1982)
Int J Radiat Oncol Biol Phys
, vol.8
, pp. 219-226
-
-
Thames Jr, H.D.1
-
115
-
-
0029113269
-
Intensity-modulated arc therapy with dynamic multileaf collimation: An alternative to tomotherapy
-
Yu CX (1995) Intensity-modulated arc therapy with dynamic multileaf collimation: an alternative to tomotherapy. Phys Med Biol 40: 1435-1449.
-
(1995)
Phys Med Biol
, vol.40
, pp. 1435-1449
-
-
Yu, C.X.1
-
116
-
-
0023370208
-
An integrated radiotherapy treatment system and its clinical application
-
Aoki Y, et al (1987) An integrated radiotherapy treatment system and its clinical application. Radiat Med 5: 131-141.
-
(1987)
Radiat Med
, vol.5
, pp. 131-141
-
-
Aoki, Y.1
-
117
-
-
77956266565
-
A review of the clinical evidence for intensity-modulated radiotherapy
-
Staffurth J (2010) A review of the clinical evidence for intensity-modulated radiotherapy. Clin Oncol (R Coll Radiol) 22: 643-657.
-
(2010)
Clin Oncol (R Coll Radiol)
, vol.22
, pp. 643-657
-
-
Staffurth, J.1
-
118
-
-
40949088260
-
Current concepts on imaging in radiotherapy
-
Lecchi M, et al (2008) Current concepts on imaging in radiotherapy. Eur J Nucl Med Mol Imaging 35: 821-837.
-
(2008)
Eur J Nucl Med Mol Imaging
, vol.35
, pp. 821-837
-
-
Lecchi, M.1
|