Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo

Strahlentherapie und Onkologie

Volumn 189, Issue 8, 2013, Pages 684-692

  Zwicker, F ^a,b   Kirsner, A ^a   Peschke, P ^b   Roeder, F ^a,b   Debus, J ^a,b   Huber, P E ^a,b   Weber, K J ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Apoptosis; Citric acid cycle; Glycolysis; Hypoxia; Irradiation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHEMICAL COMPOUND; DICHLOROACETIC ACID; KI 67 ANTIGEN; LACTIC ACID; PIMONIDAZOLE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVIC ACID;

ANAEROBIC GLYCOLYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER PROGNOSIS; CANCER SURVIVAL; CELL SURVIVAL; CLONOGENIC ASSAY; COLON ADENOCARCINOMA; CONTROLLED STUDY; FLOW CYTOMETRY; GLUCOSE OXIDATION; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROBLAST; LYMPHOBLASTOID CELL; MOUSE; NICK END LABELING; NONHUMAN; RADIATION; RADIOSENSITIVITY; RADIOSENSITIZATION; TUMOR CELL LINE; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DICHLOROACETIC ACID; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RATS; TREATMENT OUTCOME;

EID: 84881261950     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-013-0354-x     Document Type: Article

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