Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts

Journal of Molecular Medicine

Volumn 91, Issue 6, 2013, Pages 749-758

  Kumar, Krishan ^a   Wigfield, Simon ^b   Gee, Harriet E ^b,c   Devlin, Cecilia M ^a   Singleton, Dean ^b   Li, Ji Liang ^b   Buffa, Francesca ^b   Huffman, Melanie ^a   Sinn, Anthony L ^a   Silver, Jayne ^a   Turley, Helen ^b   Leek, Russell ^b   Harris, Adrian L ^b   Ivan, Mircea ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

Bevacizumab; Dichloroacetate; Glycolysis; Hypoxia; Oxidative phosphorylation

Indexed keywords

BEVACIZUMAB; DICHLOROACETIC ACID;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER MODEL; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; GLIOBLASTOMA; GLIOMA CELL; GLYCOLYSIS; HYPOXIA; IN VIVO STUDY; MICROARRAY ANALYSIS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; TREATMENT DURATION; TUMOR ESCAPE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR RESISTANCE; TUMOR VOLUME; TUMOR XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; ANOXIA; ANTIBODIES, MONOCLONAL, HUMANIZED; CELL LINE, TUMOR; DICHLOROACETIC ACID; DRUG RESISTANCE, NEOPLASM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MICE; MICE, SCID; NEOPLASMS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878620894     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-0996-2     Document Type: Article

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