Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?

British Journal of Cancer

Volumn 89, Issue 5, 2003, Pages 870-876

  Cooper, R ^a   Sarioglu S ^a   Sokmen S ^a   Fuzun M ^a   Kupelioglu A ^a   Valentine, H ^c   Gorken I B ^a   Airley, R ^b   West, C ^c  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

GLUT 1; Hypoxia; Rectal cancer

Indexed keywords

BIOLOGICAL MARKER; GLUCOSE TRANSPORTER 1;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECTUM CARCINOMA; TISSUE DISTRIBUTION; TISSUE SECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CELL HYPOXIA; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; NECROSIS; PROGNOSIS; RECTAL NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 0141618460     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601202     Document Type: Article

References (42)

1. Aebersold DM, Burri P, Beer KT, Laissure J, Djonov V, Greiner R, Semenza GL (2001) Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916
2. Airley R, Loncaster J, Davidson S, Bromley M, Roberts S, Patterson A, Hunter R, Stratford I, West C (2001) Glucose transporter Glut-1 expression correlates with tumour hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 7: 928-934
3. Airley RE, Loncaster J, Raleigh JA, Harris AL, West CML, Stratford IJ (2003) Glut-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding. Int J Cancer 104: 85-91
4. Behrooz A, Isail-Beigi F (1997) Dual control of glut-1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation. J Biol Chem 272: 5555-5562
5. Brown JM, Giaccia AJ (1998) The unique physiology of solid tumours: opportunities (and problems) for cancer therapy. Cancer Res 58: 1408-1416
6. Brizel DM, Sculley SP, Harrelsons JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW (1996) Tumour oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943
7. Brizel DM, Sibley GS, Prosnitz LR, Scher RL, Dewhirst MW (1997) Tumour hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38: 285-289
8. Cantuaria G, Fagotti A, Ferrandina G, Magalhaes A, Nadji M, Angioli R, Penalver M, Mancuso S, Scambia G (2001) Glut-1 expression in ovarian carcinoma. Association with survival and response to chemotherapy. Cancer 92: 1144-1150
9. Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A (2001) Regulation of glut-1 mRNA by hypoxia-inducible factor-1. J Biol Chem 276: 9519-9525
10. Dachs GU, Chaplin DJ (1998) Microenvironmental control of gene expression: implications for tumour angiogenesis, progression and metastasis. Semin Radiant Oncol 8: 208-216
11. Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL (1999) Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 59: 3915-3918
12. Flier JS, Mueckler MM, Usher P, Lodish HF (1987) Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235: 1492-1495
13. Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP (2002) Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 20: 680-687
14. Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, Hill RP (1998) Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48: 149-156
15. Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff C, Gatter KC, Harris AL (2001) Expression of hypoxia inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res 61: 7992-7998
16. Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A, Burstein DE (1998) Glut1 glucose transporter expression in colorectal carcinoma* A marker for poor prognosis. Cancer 83: 34-40
17. Hakimian J, Ismail-Beigi F (1991) Enhancement of glucose transport in clone 9 cells by exposure to alkaline pH: studies on potential mechanisms. J Membr Biol 120: 29-39
18. Haugland HK, Vukovic V, Pintilie M, Fyles AW, Milosevic M, Hill RP, Hedley DW (2002) Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: correlation with tumor oxygenation. Int J Radiat Oncol Biol Phys 53: 854-861
19. Haustermans K, Hofland I, Van de Pavert I, Geboes K, Varia Mahesh, Raleigh J, Begg AC (2000) Diffusion limited hypoxia estimated by vascular image analysis: comparison with pimonidazole staining in human tumors. Radiother Oncol 55: 325-333
20. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P (1996) Association between tumour hypoxia and malignant progression in advanced carcinoma of the uterine cervix. Cancer Res 56: 4509-4515
21. Isslbacher KJ (1972) Sugar and amino acid transport by cells in culture: differences between normal and malignant cells. N Engl J Med 286: 929-933
22. Janssen HL, Haustermans KM, Sprong D, Blommestijin G, Hofland I, Hoebers FJ, Blijweert E, Raleigh JA, Semenza GL, Varia MA, Balm AJ, van Velthuysen ML, Delaere P, Sciot R, Begg AC (2002) HIF-1alpha, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. Int J Radiat Oncol Biol Phys 54: 1537-1549
23. Jiang BHH, Agani F, Passaniti A, Semenza GL (1997) V-SRC inuces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumour progression. Cancer Res 57: 5328-5335
24. Kennedy AS, Raleigh JA, Perez GM, Calkins DP, Thrall DE, Novotny DB, Varia MA (1997) Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays. Int J Radiat Oncol Biol Phys 37: 897-905
25. Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos C, Pastorek J, Wykoff CC, Gatter KC, Harris AL (2001) Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularisation and resistance of squamous cell head and neck cancer to chemoradiotherapy. Clin Cancer Res 7: 3399-3403
26. Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos C, Turley H, Talks K, Gatter KC, Harris AL (2002) Hypoxia-inducible factor (HIFIA and HIF1B), angiogenesis, and chemoradiotherapy outcome of squamous cell head and neck cancer. Int J Radiat Oncol Biol Phys 53: 1192-1202
27. Kuruvilla AK, Perez C, Ismail-Beigi F, Leob JN (1991) Regulation of glucose transport in clone 9 cells by thyroid hormone. Biochem Biophys Acta 1094: 300-308
28. Loncaster JA, Cooper RA, Logue JP, Davidson SE, Hunter RD, West CML (2000) Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. Br J Cancer 83: 620-625
29. Loncaster JL, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CML (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumour oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61: 6394-6399
30. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Rarcliffe PJ (1997) Proc Natl Acad Sci USA 94: 8104-8109
31. Mueckler M, Caruso C, Baldwin SA, Pancio M, Blench I, Morris H, Allard Wj, Lienhard GE, Lodis HF (1985) Sequence and structure of a human glucose transporter. Science 229: 941-945
32. Nordsmark M, Loncaster J, Chou SC, Havsteen H, Lindegaard JC, Davidson SE, Varia M, West C, Hunter R, Overgaard J, Raleigh JA (2001) Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma. Int J Radiat Oncol Biol Phys 49: 581-586
33. Nordsmark M, Overgaard M, Overgaard J (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39
34. Olive PL, Aquino-Parsons C, MacPhail SH, Liao SY, Raleigh JA, Lerman MI, Stanbridge EJ (2001) Carbonic anhydrase 9 as an endogenous marker for hypoxia cells in cervical cancer. Cancer Res 61: 8924-8929
35. Pitson G, Fyles A, Milosevic M, Wylie J, Pintilie M, Hill R (2001) Tumor size and oxygenation are independent predictors of nodal diseases in patients with cervix cancer. Int J Radiat Oncol Biol Phys 51: 699-703
36. Semenza GL (2000) Hypoxia clonal selection, and the role of HIF-1 in tumour progression. Crit Rev Biochem Mol Biol 35: 71-103
37. Shetty M, Loeb JN, Ismail-Beigi F (1992) Enhancement of glucose transport in response to inhibition of oxidative phosphorylation: pre- and posttranslational mechanisms. Am J Physiol 262: C527-C532
38. Wendling P, Manz R, Thews G, Vaupel P (1984) Heterogenous oxygenation of rectal carcinomas in humans: critical parameter for preoperative irradiation. Adv Exp Med Biol 180: 293-300
39. Younes M, Brown RS, Stephenson M, Gondo M, Cagle PT (1997) Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 80: 1046-1051
40. Younes M, Lechago LV, Somoana JR, Mosharaaf M, Lechago J (1996) Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res 56: 1164-1167
41. Zhang JZ, Behrooz A, Ismail-Beigi F (1999) Regulaion of glucose transport by hypoxia. Am J Kidney Dis 34: 189-202
42. Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL (2000) Modulation of hypoxia-inducible factor 1α exspression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumour angiogenesis. Cancer Res 60: 1541-1545