메뉴 건너뛰기




Volumn 37, Issue 9, 2012, Pages 364-372

Passing the baton: The HIF switch

Author keywords

Angiogenesis; Cancer; Development; Hypoxia; Hypoxia inducible factor; Stem cells

Indexed keywords

AGGRECAN; ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN 3; ANGIOPOIETIN 4; COLLAGEN TYPE 2; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR 3ALPHA; MATRIX METALLOPROTEINASE; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; RECEPTOR FOR ACTIVATED C KINASE 1; SIRTUIN 1; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 84865429409     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2012.06.004     Document Type: Review
Times cited : (442)

References (82)
  • 1
    • 79957635293 scopus 로고    scopus 로고
    • Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
    • Carreau A., et al. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J. Cell. Mol. Med. 2011, 15:1239-1253.
    • (2011) J. Cell. Mol. Med. , vol.15 , pp. 1239-1253
    • Carreau, A.1
  • 2
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J., et al. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441:437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1
  • 3
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang G.L., et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:5510-5514.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 5510-5514
    • Wang, G.L.1
  • 4
    • 0037031808 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus
    • Makino Y., et al. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J. Biol. Chem. 2002, 277:32405-32408.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32405-32408
    • Makino, Y.1
  • 5
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    • Holmquist-Mengelbier L., et al. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 2006, 10:413-423.
    • (2006) Cancer Cell , vol.10 , pp. 413-423
    • Holmquist-Mengelbier, L.1
  • 6
    • 79957440998 scopus 로고    scopus 로고
    • The hypoxia-associated factor switches cells from HIF-1{alpha}- to HIF-2{alpha}-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
    • Koh M.Y., et al. The hypoxia-associated factor switches cells from HIF-1{alpha}- to HIF-2{alpha}-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 2011, 71:4015-4027.
    • (2011) Cancer Res. , vol.71 , pp. 4015-4027
    • Koh, M.Y.1
  • 7
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001, 292:468-472.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 8
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M., et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2000, 2:423-427.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1
  • 9
    • 0035370253 scopus 로고    scopus 로고
    • Activation of the HIF pathway in cancer
    • Maxwell P.H., et al. Activation of the HIF pathway in cancer. Curr. Opin. Genet. Dev. 2001, 11:293-299.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 293-299
    • Maxwell, P.H.1
  • 10
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon P.C., et al. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001, 15:2675-2686.
    • (2001) Genes Dev. , vol.15 , pp. 2675-2686
    • Mahon, P.C.1
  • 11
    • 1642315195 scopus 로고    scopus 로고
    • Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
    • Koivunen P., et al. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J. Biol. Chem. 2004, 279:9899-9904.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9899-9904
    • Koivunen, P.1
  • 12
    • 34047215555 scopus 로고    scopus 로고
    • RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization
    • Liu Y.V., Semenza G.L. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle 2007, 6:656-659.
    • (2007) Cell Cycle , vol.6 , pp. 656-659
    • Liu, Y.V.1    Semenza, G.L.2
  • 13
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    • Ravi R., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 2000, 14:34-44.
    • (2000) Genes Dev. , vol.14 , pp. 34-44
    • Ravi, R.1
  • 14
    • 57349136768 scopus 로고    scopus 로고
    • Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation
    • Koh M.Y., et al. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol. Cell. Biol. 2008, 28:7081-7095.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 7081-7095
    • Koh, M.Y.1
  • 15
    • 77950473770 scopus 로고    scopus 로고
    • Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but not HIF-2alpha
    • Luo W., et al. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but not HIF-2alpha. J. Biol. Chem. 2010, 285:3651-3663.
    • (2010) J. Biol. Chem. , vol.285 , pp. 3651-3663
    • Luo, W.1
  • 16
    • 78649753203 scopus 로고    scopus 로고
    • The chaperone-dependent ubiquitin ligase CHIP targets HIF-1alpha for degradation in the presence of methylglyoxal
    • Bento C.F., et al. The chaperone-dependent ubiquitin ligase CHIP targets HIF-1alpha for degradation in the presence of methylglyoxal. PLoS ONE 2010, 5:e15062.
    • (2010) PLoS ONE , vol.5
    • Bento, C.F.1
  • 17
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H., et al. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997, 11:72-82.
    • (1997) Genes Dev. , vol.11 , pp. 72-82
    • Tian, H.1
  • 18
    • 0037315337 scopus 로고    scopus 로고
    • Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs
    • Wiesener M.S., et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 2003, 17:271-273.
    • (2003) FASEB J. , vol.17 , pp. 271-273
    • Wiesener, M.S.1
  • 19
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval R.R., et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 2005, 25:5675-5686.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5675-5686
    • Raval, R.R.1
  • 20
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole D.R., et al. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J. Biol. Chem. 2009, 284:16767-16775.
    • (2009) J. Biol. Chem. , vol.284 , pp. 16767-16775
    • Mole, D.R.1
  • 21
    • 77958177671 scopus 로고    scopus 로고
    • Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
    • Kapitsinou P.P., et al. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 2010, 116:3039-3048.
    • (2010) Blood , vol.116 , pp. 3039-3048
    • Kapitsinou, P.P.1
  • 22
    • 9444283176 scopus 로고    scopus 로고
    • Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
    • Warnecke C., et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J. 2004, 18:1462-1464.
    • (2004) FASEB J. , vol.18 , pp. 1462-1464
    • Warnecke, C.1
  • 23
    • 17044378251 scopus 로고    scopus 로고
    • HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner
    • Scortegagna M., et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 2005, 105:3133-3140.
    • (2005) Blood , vol.105 , pp. 3133-3140
    • Scortegagna, M.1
  • 24
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
    • Keith B., et al. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2012, 12:9-22.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1
  • 25
    • 34247847903 scopus 로고    scopus 로고
    • Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas
    • Fujiwara S., et al. Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int. J. Oncol. 2007, 30:793-802.
    • (2007) Int. J. Oncol. , vol.30 , pp. 793-802
    • Fujiwara, S.1
  • 26
    • 4644318828 scopus 로고    scopus 로고
    • Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    • Appelhoff R.J., et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 2004, 279:38458-38465.
    • (2004) J. Biol. Chem. , vol.279 , pp. 38458-38465
    • Appelhoff, R.J.1
  • 27
    • 2442544693 scopus 로고    scopus 로고
    • Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha
    • Uchida T., et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J. Biol. Chem. 2004, 279:14871-14878.
    • (2004) J. Biol. Chem. , vol.279 , pp. 14871-14878
    • Uchida, T.1
  • 28
    • 34247628002 scopus 로고    scopus 로고
    • Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
    • Sanchez M., et al. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat. Struct. Mol. Biol. 2007, 14:420-426.
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 420-426
    • Sanchez, M.1
  • 29
    • 35848938945 scopus 로고    scopus 로고
    • The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha
    • Hu C.J., et al. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007, 18:4528-4542.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 4528-4542
    • Hu, C.J.1
  • 30
    • 77954837195 scopus 로고    scopus 로고
    • Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy
    • Pringle K.G., et al. Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy. Hum. Reprod. Update 2010, 16:415-431.
    • (2010) Hum. Reprod. Update , vol.16 , pp. 415-431
    • Pringle, K.G.1
  • 31
    • 1842346472 scopus 로고    scopus 로고
    • Molecular mechanisms of vasculogenesis and embryonic angiogenesis
    • Flamme I., et al. Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J. Cell Physiol. 1997, 173:206-210.
    • (1997) J. Cell Physiol. , vol.173 , pp. 206-210
    • Flamme, I.1
  • 32
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin H.G., et al. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat. Rev. Mol. Cell Biol. 2009, 10:165-177.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 165-177
    • Augustin, H.G.1
  • 33
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams R.H., Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 2007, 8:464-478.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 34
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G.H., et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1
  • 35
    • 80052015794 scopus 로고    scopus 로고
    • VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting
    • Oladipupo S., et al. VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:13264-13269.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 13264-13269
    • Oladipupo, S.1
  • 36
    • 0032921704 scopus 로고    scopus 로고
    • ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3
    • Oda N., et al. ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3. J. Cell Physiol. 1999, 178:121-132.
    • (1999) J. Cell Physiol. , vol.178 , pp. 121-132
    • Oda, N.1
  • 37
    • 33745274488 scopus 로고    scopus 로고
    • Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
    • Aprelikova O., et al. Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res. 2006, 66:5641-5647.
    • (2006) Cancer Res. , vol.66 , pp. 5641-5647
    • Aprelikova, O.1
  • 38
    • 3343013829 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1
    • Takeda N., et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ. Res. 2004, 95:146-153.
    • (2004) Circ. Res. , vol.95 , pp. 146-153
    • Takeda, N.1
  • 39
    • 0037470245 scopus 로고    scopus 로고
    • Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)
    • Elvert G., et al. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J. Biol. Chem. 2003, 278:7520-7530.
    • (2003) J. Biol. Chem. , vol.278 , pp. 7520-7530
    • Elvert, G.1
  • 40
    • 36349033527 scopus 로고    scopus 로고
    • HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites
    • Le Bras A., et al. HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites. Oncogene 2007, 26:7480-7489.
    • (2007) Oncogene , vol.26 , pp. 7480-7489
    • Le Bras, A.1
  • 41
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer N.V., et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998, 12:149-162.
    • (1998) Genes Dev. , vol.12 , pp. 149-162
    • Iyer, N.V.1
  • 42
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • Kotch L.E., et al. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 1999, 209:254-267.
    • (1999) Dev. Biol. , vol.209 , pp. 254-267
    • Kotch, L.E.1
  • 43
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan H.E., et al. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998, 17:3005-3015.
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.E.1
  • 44
    • 33748742457 scopus 로고    scopus 로고
    • Hypoxia-inducible Factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development
    • Yoon D., et al. Hypoxia-inducible Factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J. Biol. Chem. 2006, 281:25703-25711.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25703-25711
    • Yoon, D.1
  • 45
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
    • Peng J., et al. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:8386-8391.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 8386-8391
    • Peng, J.1
  • 46
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H., et al. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 1998, 12:3320-3324.
    • (1998) Genes Dev. , vol.12 , pp. 3320-3324
    • Tian, H.1
  • 47
    • 0035983324 scopus 로고    scopus 로고
    • Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    • Compernolle V., et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 2002, 8:702-710.
    • (2002) Nat. Med. , vol.8 , pp. 702-710
    • Compernolle, V.1
  • 48
    • 0344826529 scopus 로고    scopus 로고
    • Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice
    • Scortegagna M., et al. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat. Genet. 2003, 35:331-340.
    • (2003) Nat. Genet. , vol.35 , pp. 331-340
    • Scortegagna, M.1
  • 49
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang N., et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004, 6:485-495.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1
  • 50
    • 67651098992 scopus 로고    scopus 로고
    • Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
    • Skuli N., et al. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 2009, 114:469-477.
    • (2009) Blood , vol.114 , pp. 469-477
    • Skuli, N.1
  • 51
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 52
    • 79957510410 scopus 로고    scopus 로고
    • A central role for hypoxic signaling in cartilage, bone, and hematopoiesis
    • Rankin E.B., et al. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr. Osteoporos. Rep. 2011, 9:46-52.
    • (2011) Curr. Osteoporos. Rep. , vol.9 , pp. 46-52
    • Rankin, E.B.1
  • 53
    • 77953208836 scopus 로고    scopus 로고
    • Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development
    • Saito T., et al. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat. Med. 2010, 16:678-686.
    • (2010) Nat. Med. , vol.16 , pp. 678-686
    • Saito, T.1
  • 54
    • 70349758284 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes
    • Duval E., et al. Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes. Arthritis Rheum. 2009, 60:3038-3048.
    • (2009) Arthritis Rheum. , vol.60 , pp. 3038-3048
    • Duval, E.1
  • 55
    • 34248532510 scopus 로고    scopus 로고
    • HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway
    • Bohensky J., et al. HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway. Autophagy 2007, 3:207-214.
    • (2007) Autophagy , vol.3 , pp. 207-214
    • Bohensky, J.1
  • 56
    • 66049155861 scopus 로고    scopus 로고
    • Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy
    • Bohensky J., et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009, 60:1406-1415.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1406-1415
    • Bohensky, J.1
  • 57
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S., et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat. Med. 2010, 16:687-693.
    • (2010) Nat. Med. , vol.16 , pp. 687-693
    • Yang, S.1
  • 58
    • 73849108257 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development
    • Shomento S.H., et al. Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. J. Cell Biochem. 2010, 109:196-204.
    • (2010) J. Cell Biochem. , vol.109 , pp. 196-204
    • Shomento, S.H.1
  • 59
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel P., Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007, 26:225-239.
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 60
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson W.R., Hay M.P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 2011, 11:393-410.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 61
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999, 59:5830-5835.
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1
  • 62
    • 75849160216 scopus 로고    scopus 로고
    • Human cancers converge at the HIF-2alpha oncogenic axis
    • Franovic A., et al. Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:21306-21311.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 21306-21311
    • Franovic, A.1
  • 63
    • 17044452288 scopus 로고    scopus 로고
    • HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron
    • Mandriota S.J., et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 2002, 1:459-468.
    • (2002) Cancer Cell , vol.1 , pp. 459-468
    • Mandriota, S.J.1
  • 64
    • 80054771537 scopus 로고    scopus 로고
    • Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene
    • Shen C., et al. Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. Cancer Discov. 2011, 1:222-235.
    • (2011) Cancer Discov. , vol.1 , pp. 222-235
    • Shen, C.1
  • 65
    • 56849096837 scopus 로고    scopus 로고
    • HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
    • Gordan J.D., et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008, 14:435-446.
    • (2008) Cancer Cell , vol.14 , pp. 435-446
    • Gordan, J.D.1
  • 66
    • 1542328965 scopus 로고    scopus 로고
    • Plasticity of adult stem cells
    • Wagers A.J., Weissman I.L. Plasticity of adult stem cells. Cell 2004, 116:639-648.
    • (2004) Cell , vol.116 , pp. 639-648
    • Wagers, A.J.1    Weissman, I.L.2
  • 67
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 2008, 8:755-768.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 68
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler C.E., Rich J.N. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J. Clin. Oncol. 2008, 26:2839-2845.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 69
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden D.T. The stem-cell niche as an entity of action. Nature 2006, 441:1075-1079.
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 70
    • 0037076385 scopus 로고    scopus 로고
    • Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
    • Jögi A., et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:7021-7026.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 7021-7026
    • Jögi, A.1
  • 71
    • 79957933050 scopus 로고    scopus 로고
    • Interaction between Notch and Hif-α in development and survival of Drosophila blood cells
    • Mukherjee T., et al. Interaction between Notch and Hif-α in development and survival of Drosophila blood cells. Science 2011, 332:1210-1213.
    • (2011) Science , vol.332 , pp. 1210-1213
    • Mukherjee, T.1
  • 72
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu C.J., et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23:9361-9374.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9361-9374
    • Hu, C.J.1
  • 73
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z., et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009, 15:501-513.
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1
  • 74
    • 70449687092 scopus 로고    scopus 로고
    • Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1[alpha]
    • Soeda A., et al. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1[alpha]. Oncogene 2009, 28:3949-3959.
    • (2009) Oncogene , vol.28 , pp. 3949-3959
    • Soeda, A.1
  • 75
    • 78349283042 scopus 로고    scopus 로고
    • The HIF-2alpha-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization
    • Pietras A., et al. The HIF-2alpha-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization. Curr. Top. Microbiol. Immunol. 2010, 345:1-20.
    • (2010) Curr. Top. Microbiol. Immunol. , vol.345 , pp. 1-20
    • Pietras, A.1
  • 76
    • 79953870540 scopus 로고    scopus 로고
    • Targeting HIF1α eliminates cancer stem cells in hematological malignancies
    • Wang Y., et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 2011, 8:399-411.
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1
  • 77
    • 50849102656 scopus 로고    scopus 로고
    • A specialized vascular niche for adult neural stem cells
    • Tavazoie M., et al. A specialized vascular niche for adult neural stem cells. Cell Stem Cell 2008, 3:279-288.
    • (2008) Cell Stem Cell , vol.3 , pp. 279-288
    • Tavazoie, M.1
  • 78
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: glioblastoma stem cells and the vascular niche
    • Gilbertson R.J., Rich J.N. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat. Rev. Cancer 2007, 7:733-736.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 79
    • 70349753257 scopus 로고    scopus 로고
    • HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
    • Pietras A., et al. HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:16805-16810.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 16805-16810
    • Pietras, A.1
  • 80
    • 77955499804 scopus 로고    scopus 로고
    • Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α
    • Lim J.-H., et al. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α. Mol. Cell 2010, 38:864-878.
    • (2010) Mol. Cell , vol.38 , pp. 864-878
    • Lim, J.-H.1
  • 81
    • 79954609893 scopus 로고    scopus 로고
    • Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
    • Chen R., et al. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J. Biol. Chem. 2011, 286:13869-13878.
    • (2011) J. Biol. Chem. , vol.286 , pp. 13869-13878
    • Chen, R.1
  • 82
    • 84859113488 scopus 로고    scopus 로고
    • Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1alpha protein under hypoxic conditions
    • Laemmle A., et al. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1alpha protein under hypoxic conditions. PLoS ONE 2012, 7:e33433.
    • (2012) PLoS ONE , vol.7
    • Laemmle, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.