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Volumn 130, Issue 1, 2014, Pages 4-28

Function, therapeutic potential and cell biology of BACE proteases: Current status and future prospects

Author keywords

Alzheimer's disease; BACE1; BACE2; protease; regulated intramembrane proteolysis; secretase

Indexed keywords

5,6 DIHYDRO 2 IMINO 3 METHYL 6 [4 [5 (1 PROPYNYL) 3 PYRIDINYL] 2 THIENYL] 4 PYRIMIDINONE; AMYLOID BETA PROTEIN; AVAGACESTAT; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE 2; BETA SECRETASE INHIBITOR; LY 2811376; LY 2886721; MYELIN; NEU DIFFERENTIATION FACTOR; SEMAGACESTAT; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; SECRETASE;

EID: 84903190262     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12715     Document Type: Review
Times cited : (276)

References (213)
  • 1
    • 33644875891 scopus 로고    scopus 로고
    • Tmem27: A cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation
    • Akpinar P., Kuwajima S., Krutzfeldt J., and, Stoffel M., (2005) Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab. 2, 385-397.
    • (2005) Cell Metab. , vol.2 , pp. 385-397
    • Akpinar, P.1    Kuwajima, S.2    Krutzfeldt, J.3    Stoffel, M.4
  • 2
    • 79960040736 scopus 로고    scopus 로고
    • Progress in the development of beta-secretase inhibitors for Alzheimer's disease
    • Albert J. S., (2009) Progress in the development of beta-secretase inhibitors for Alzheimer's disease. Prog. Med. Chem. 48, 133-161.
    • (2009) Prog. Med. Chem. , vol.48 , pp. 133-161
    • Albert, J.S.1
  • 6
    • 79957452852 scopus 로고    scopus 로고
    • A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo
    • Atwal J. K., Chen Y., Chiu C., et al,. (2011) A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo. Sci. Transl. Med., 3, 84ra43.
    • (2011) Sci. Transl. Med. , vol.3
    • Atwal, J.K.1    Chen, Y.2    Chiu, C.3
  • 7
    • 84878020681 scopus 로고    scopus 로고
    • A matter of balance: Role of neurexin and neuroligin at the synapse
    • Bang M. L., and, Owczarek S., (2013) A matter of balance: role of neurexin and neuroligin at the synapse. Neurochem. Res. 38, 1174-1189.
    • (2013) Neurochem. Res. , vol.38 , pp. 1174-1189
    • Bang, M.L.1    Owczarek, S.2
  • 8
    • 0037815413 scopus 로고    scopus 로고
    • Back signaling by the Nrg-1 intracellular domain
    • DOI 10.1083/jcb.200212085
    • Bao J., Wolpowitz D., Role L. W., and, Talmage D. A., (2003) Back signaling by the Nrg-1 intracellular domain. J. Cell Biol. 161, 1133-1141. (Pubitemid 36870174)
    • (2003) Journal of Cell Biology , vol.161 , Issue.6 , pp. 1133-1141
    • Bao, J.1    Wolpowitz, D.2    Role, L.W.3    Talmage, D.A.4
  • 10
    • 0042858264 scopus 로고    scopus 로고
    • Antagonistic effects of β-site amyloid precursor protein-cleaving enzymes 1 and 2 β-amyloid peptide production in cells
    • DOI 10.1074/jbc.M300169200
    • Basi G., Frigon N., Barbour R., Doan T., Gordon G., McConlogue L., Sinha S., and, Zeller M., (2003) Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells. J. Biol. Chem. 278, 31512-31520. (Pubitemid 37048328)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.34 , pp. 31512-31520
    • Basi, G.1    Frigon, N.2    Barbour, R.3    Doan, T.4    Gordon, G.5    McConlogue, L.6    Sinha, S.7    Zeller, M.8
  • 11
    • 66749084437 scopus 로고    scopus 로고
    • A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system
    • Bateman R. J., Siemers E. R., Mawuenyega K. G., et al,. (2009) A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann. Neurol. 66, 48-54.
    • (2009) Ann. Neurol. , vol.66 , pp. 48-54
    • Bateman, R.J.1    Siemers, E.R.2    Mawuenyega, K.G.3
  • 12
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    • Bateman R. J., Xiong C., Benzinger T. L., et al,. (2012) Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367, 795-804.
    • (2012) N. Engl. J. Med. , vol.367 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3
  • 13
    • 84887031752 scopus 로고    scopus 로고
    • Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
    • van Bebber F., Hruscha A., Willem M., Schmid B., and, Haass C., (2013) Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. J. Neurochem. 127, 471-481.
    • (2013) J. Neurochem. , vol.127 , pp. 471-481
    • Van Bebber, F.1    Hruscha, A.2    Willem, M.3    Schmid, B.4    Haass, C.5
  • 18
    • 61549136754 scopus 로고    scopus 로고
    • Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation
    • Birchmeier C., and, Nave K. A., (2008) Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation. Glia 56, 1491-1497.
    • (2008) Glia , vol.56 , pp. 1491-1497
    • Birchmeier, C.1    Nave, K.A.2
  • 19
    • 78149330220 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer's disease drug development
    • Blennow K., (2010) Biomarkers in Alzheimer's disease drug development. Nat. Med. 16, 1218-1222.
    • (2010) Nat. Med. , vol.16 , pp. 1218-1222
    • Blennow, K.1
  • 21
    • 26944444692 scopus 로고    scopus 로고
    • A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to α- and β-neurexins
    • DOI 10.1016/j.neuron.2005.08.026, PII S0896627305007014
    • Boucard A. A., Chubykin A. A., Comoletti D., Taylor P., and, Sudhof T. C., (2005) A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron 48, 229-236. (Pubitemid 41476357)
    • (2005) Neuron , vol.48 , Issue.2 , pp. 229-236
    • Boucard, A.A.1    Chubykin, A.A.2    Comoletti, D.3    Taylor, P.4    Sudhof, T.C.5
  • 22
    • 84858597379 scopus 로고    scopus 로고
    • High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex
    • Boucard A. A., Ko J., and, Sudhof T. C., (2012) High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex. J. Biol. Chem. 287, 9399-9413.
    • (2012) J. Biol. Chem. , vol.287 , pp. 9399-9413
    • Boucard, A.A.1    Ko, J.2    Sudhof, T.C.3
  • 23
    • 77955499229 scopus 로고    scopus 로고
    • Peptidylgycine alpha-amidating monooxygenase and copper: A gene-nutrient interaction critical to nervous system function
    • Bousquet-Moore D., Mains R. E., and, Eipper B. A., (2010) Peptidylgycine alpha-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function. J. Neurosci. Res. 88, 2535-2545.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 2535-2545
    • Bousquet-Moore, D.1    Mains, R.E.2    Eipper, B.A.3
  • 24
    • 0024429540 scopus 로고
    • Tissue specific expression of rat peptidylglycine α-amidating monooxygenase activity and mRNA
    • Braas K. M., Stoffers D. A., Eipper B. A., and, May V., (1989) Tissue specific expression of rat peptidylglycine alpha-amidating monooxygenase activity and mRNA. Mol. Endocrinol. 3, 1387-1398. (Pubitemid 19241031)
    • (1989) Molecular Endocrinology , vol.3 , Issue.9 , pp. 1387-1398
    • Braas, K.M.1    Stoffers, D.A.2    Eipper, B.A.3    May, V.4
  • 25
  • 26
    • 84890894103 scopus 로고    scopus 로고
    • A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production
    • Buggia-Prevot V., Fernandez C. G., Udayar V., et al,. (2013) A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Rep. 5, 1552-1563.
    • (2013) Cell Rep. , vol.5 , pp. 1552-1563
    • Buggia-Prevot, V.1    Fernandez, C.G.2    Udayar, V.3
  • 28
    • 0035112647 scopus 로고    scopus 로고
    • BACE1 is the major β-secretase for generation of Aβ peptides by neurons
    • DOI 10.1038/85064
    • Cai H., Wang Y., McCarthy D., Wen H., Borchelt D. R., Price D. L., and, Wong P. C., (2001) BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4, 233-234. (Pubitemid 32194867)
    • (2001) Nature Neuroscience , vol.4 , Issue.3 , pp. 233-234
    • Cai, H.1    Wang, Y.2    McCarthy, D.3    Wen, H.4    Borchelt, D.R.5    Price, D.L.6    Wong, P.C.7
  • 29
    • 84865804437 scopus 로고    scopus 로고
    • Beta-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment
    • Cai J., Qi X., Kociok N., et al,. (2012) beta-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol. Med. 4, 980-991.
    • (2012) EMBO Mol. Med. , vol.4 , pp. 980-991
    • Cai, J.1    Qi, X.2    Kociok, N.3
  • 30
    • 84859746205 scopus 로고    scopus 로고
    • The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease
    • Cao L., Rickenbacher G. T., Rodriguez S., Moulia T. W., and, Albers M. W., (2012) The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease. Sci. Rep. 2, 231.
    • (2012) Sci. Rep. , vol.2 , pp. 231
    • Cao, L.1    Rickenbacher, G.T.2    Rodriguez, S.3    Moulia, T.W.4    Albers, M.W.5
  • 32
    • 84876210341 scopus 로고    scopus 로고
    • BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease
    • Chami L., and, Checler F., (2012) BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease. Mol. Neurodegener. 7, 52.
    • (2012) Mol. Neurodegener. , vol.7 , pp. 52
    • Chami, L.1    Checler, F.2
  • 34
    • 77954510804 scopus 로고    scopus 로고
    • Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons
    • Chen Y., Hancock M. L., Role L. W., and, Talmage D. A., (2010) Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons. J. Neurosci. 30, 9199-9208.
    • (2010) J. Neurosci. , vol.30 , pp. 9199-9208
    • Chen, Y.1    Hancock, M.L.2    Role, L.W.3    Talmage, D.A.4
  • 35
    • 84880326330 scopus 로고    scopus 로고
    • Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
    • Cheret C., Willem M., Fricker F. R., et al,. (2013) Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO J. 32, 2015-2028.
    • (2013) EMBO J. , vol.32 , pp. 2015-2028
    • Cheret, C.1    Willem, M.2    Fricker, F.R.3
  • 36
    • 0026745610 scopus 로고
    • Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
    • DOI 10.1038/360672a0
    • Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A. Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., and, Selkoe D. J., (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360, 672-674. (Pubitemid 23007680)
    • (1992) Nature , vol.360 , Issue.6405 , pp. 672-674
    • Citron, M.1    Oltersdorf, T.2    Haass, C.3    McConlogue, L.4    Hung, A.Y.5    Seubert, P.6    Vigo-Pelfrey, C.7    Lieberburg, I.8    Selkoe, D.J.9
  • 37
    • 33750132225 scopus 로고    scopus 로고
    • Acylguanidines as small-molecule beta-secretase inhibitors
    • Cole D. C., Manas E. S., Stock J. R., et al,. (2006) Acylguanidines as small-molecule beta-secretase inhibitors. J. Med. Chem. 49, 6158-6161.
    • (2006) J. Med. Chem. , vol.49 , pp. 6158-6161
    • Cole, D.C.1    Manas, E.S.2    Stock, J.R.3
  • 38
    • 84866525057 scopus 로고    scopus 로고
    • Constitutive alpha- and beta-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines
    • Colombo A., Wang H., Kuhn P. H., Page R., Kremmer E., Dempsey P. J., Crawford H. C., and, Lichtenthaler S. F., (2012) Constitutive alpha- and beta-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiol. Dis. 49C, 137-147.
    • (2012) Neurobiol. Dis. , vol.49 C , pp. 137-147
    • Colombo, A.1    Wang, H.2    Kuhn, P.H.3    Page, R.4    Kremmer, E.5    Dempsey, P.J.6    Crawford, H.C.7    Lichtenthaler, S.F.8
  • 40
    • 84868516038 scopus 로고    scopus 로고
    • Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease
    • Coric V., van Dyck C. H., Salloway S., et al,. (2012) Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease. Arch. Neurol. 69, 1430-1440.
    • (2012) Arch. Neurol. , vol.69 , pp. 1430-1440
    • Coric, V.1    Van Dyck, C.H.2    Salloway, S.3
  • 41
    • 84878276906 scopus 로고    scopus 로고
    • Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
    • 181-112
    • Couch J. A., Yu Y. J., and, Zhang Y., et al,. (2013) Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier. Sci. Transl. Med., 5, 183ra157, 181-112.
    • (2013) Sci. Transl. Med. , vol.5
    • Couch, J.A.1    Yu, Y.J.2    Zhang, Y.3
  • 42
    • 33748976828 scopus 로고    scopus 로고
    • Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice
    • Crusio W. E., and, Schwegler H., (2005) Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice. Behav. Brain Funct. 1, 3.
    • (2005) Behav. Brain Funct. , vol.1 , pp. 3
    • Crusio, W.E.1    Schwegler, H.2
  • 43
    • 84862777524 scopus 로고    scopus 로고
    • Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor
    • Cumming J. N., Smith E. M., Wang L., et al,. (2012) Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor. Bioorg. Med. Chem. Lett. 22, 2444-2449.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2444-2449
    • Cumming, J.N.1    Smith, E.M.2    Wang, L.3
  • 44
    • 27744573043 scopus 로고    scopus 로고
    • Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse
    • DOI 10.1016/j.ydbio.2005.09.001, PII S0012160605005920
    • Czyzyk T. A., Ning Y., Hsu M. S., Peng B., Mains R. E., Eipper B. A., and, Pintar J. E., (2005) Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev. Biol. 287, 301-313. (Pubitemid 41636766)
    • (2005) Developmental Biology , vol.287 , Issue.2 , pp. 301-313
    • Czyzyk, T.A.1    Ning, Y.2    Hsu, M.-S.3    Peng, B.4    Mains, R.E.5    Eipper, B.A.6    Pintar, J.E.7
  • 46
    • 0034656090 scopus 로고    scopus 로고
    • Batten's disease: Clues to neuronal protein catabolism in lysosomes
    • DOI 10.1002/(SICI)1097-4547(20000415)60:2<133::AID-JNR1>3.0.CO;2-3
    • Dawson G., and, Cho S., (2000) Batten's disease: clues to neuronal protein catabolism in lysosomes. J. Neurosci. Res. 60, 133-140. (Pubitemid 30198619)
    • (2000) Journal of Neuroscience Research , vol.60 , Issue.2 , pp. 133-140
    • Dawson, G.1    Cho, S.2
  • 48
    • 76849086405 scopus 로고    scopus 로고
    • The secretases: Enzymes with therapeutic potential in Alzheimer disease
    • De Strooper B., Vassar R., and, Golde T., (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99-107.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 99-107
    • De Strooper, B.1    Vassar, R.2    Golde, T.3
  • 50
    • 84886892404 scopus 로고    scopus 로고
    • Increased expression of reticulon 3 in neurons leads to reduced axonal transport of beta site amyloid precursor protein-cleaving enzyme 1
    • Deng M., He W., Tan Y., Han H., Hu X., Xia K., Zhang Z., and, Yan R., (2013) Increased expression of reticulon 3 in neurons leads to reduced axonal transport of beta site amyloid precursor protein-cleaving enzyme 1. J. Biol. Chem. 288, 30236-30245.
    • (2013) J. Biol. Chem. , vol.288 , pp. 30236-30245
    • Deng, M.1    He, W.2    Tan, Y.3    Han, H.4    Hu, X.5    Xia, K.6    Zhang, Z.7    Yan, R.8
  • 51
    • 62449330486 scopus 로고    scopus 로고
    • A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis
    • Di Fede G., Catania M., Morbin M., et al,. (2009) A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 323, 1473-1477.
    • (2009) Science , vol.323 , pp. 1473-1477
    • Di Fede, G.1    Catania, M.2    Morbin, M.3
  • 52
    • 84866291339 scopus 로고    scopus 로고
    • The membrane-bound aspartyl protease BACE1: Molecular and functional properties in Alzheimer's disease and beyond
    • Dislich B., and, Lichtenthaler S. F., (2012) The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond. Front. Physiol. 3, 8.
    • (2012) Front. Physiol. , vol.3 , pp. 8
    • Dislich, B.1    Lichtenthaler, S.F.2
  • 54
    • 84880712325 scopus 로고    scopus 로고
    • A phase 3 trial of semagacestat for treatment of Alzheimer's disease
    • Doody R. S., Raman R., Farlow M., et al,. (2013) A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N. Engl. J. Med. 369, 341-350.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 341-350
    • Doody, R.S.1    Raman, R.2    Farlow, M.3
  • 55
    • 0037421206 scopus 로고    scopus 로고
    • Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
    • DOI 10.1083/jcb.200207113
    • Ehehalt R., Keller P., Haass C., Thiele C., and, Simons K., (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J. Cell Biol. 160, 113-123. (Pubitemid 36091721)
    • (2003) Journal of Cell Biology , vol.160 , Issue.1 , pp. 113-123
    • Ehehalt, R.1    Keller, P.2    Haass, C.3    Thiele, C.4    Simons, K.5
  • 56
    • 80052723784 scopus 로고    scopus 로고
    • Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
    • Esterhazy D., Stutzer I., Wang H., et al,. (2011) Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 14, 365-377.
    • (2011) Cell Metab. , vol.14 , pp. 365-377
    • Esterhazy, D.1    Stutzer, I.2    Wang, H.3
  • 57
    • 70449686185 scopus 로고    scopus 로고
    • Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
    • Etherton M. R., Blaiss C. A., Powell C. M., and, Sudhof T. C., (2009) Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc. Natl Acad. Sci. USA 106, 17998-18003.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 17998-18003
    • Etherton, M.R.1    Blaiss, C.A.2    Powell, C.M.3    Sudhof, T.C.4
  • 58
    • 3042668916 scopus 로고    scopus 로고
    • Neuregulins and the neuromuscular system: 10 Years of answers and questions
    • DOI 10.1023/B:NEUR.0000020614.83883.be
    • Falls D. L., (2003) Neuregulins and the neuromuscular system: 10 years of answers and questions. J. Neurocytol. 32, 619-647. (Pubitemid 39011250)
    • (2003) Journal of Neurocytology , vol.32 , Issue.5-8 , pp. 619-647
    • Falls, D.L.1
  • 59
    • 79955751702 scopus 로고    scopus 로고
    • Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system
    • Farah M. H., Pan B. H., Hoffman P. N., et al,. (2011) Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. J. Neurosci. 31, 5744-5754.
    • (2011) J. Neurosci. , vol.31 , pp. 5744-5754
    • Farah, M.H.1    Pan, B.H.2    Hoffman, P.N.3
  • 62
    • 84877125044 scopus 로고    scopus 로고
    • Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling
    • Fleck D., van Bebber F., Colombo A., et al,. (2013) Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. J. Neurosci. 33, 7856-7869.
    • (2013) J. Neurosci. , vol.33 , pp. 7856-7869
    • Fleck, D.1    Van Bebber, F.2    Colombo, A.3
  • 64
    • 0034610999 scopus 로고    scopus 로고
    • A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool
    • Garratt A. N., Voiculescu O., Topilko P., Charnay P., and, Birchmeier C., (2000) A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J. Cell Biol. 148, 1035-1046.
    • (2000) J. Cell Biol. , vol.148 , pp. 1035-1046
    • Garratt, A.N.1    Voiculescu, O.2    Topilko, P.3    Charnay, P.4    Birchmeier, C.5
  • 65
    • 78650342675 scopus 로고    scopus 로고
    • Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
    • Gersbacher M. T., Kim D. Y., Bhattacharyya R., and, Kovacs D. M., (2010) Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit. Mol. Neurodegener. 5, 61.
    • (2010) Mol. Neurodegener. , vol.5 , pp. 61
    • Gersbacher, M.T.1    Kim, D.Y.2    Bhattacharyya, R.3    Kovacs, D.M.4
  • 67
    • 84655162702 scopus 로고    scopus 로고
    • Developing beta-secretase inhibitors for treatment of Alzheimer's disease
    • Ghosh A. K., Brindisi M., and, Tang J., (2012) Developing beta-secretase inhibitors for treatment of Alzheimer's disease. J. Neurochem. 120 (Suppl 1), 71-83.
    • (2012) J. Neurochem. , vol.120 , Issue.SUPPL. 1 , pp. 71-83
    • Ghosh, A.K.1    Brindisi, M.2    Tang, J.3
  • 69
    • 84879522237 scopus 로고    scopus 로고
    • Altered social behaviours in neurexin 1alpha knockout mice resemble core symptoms in neurodevelopmental disorders
    • Grayton H. M., Missler M., Collier D. A., and, Fernandes C., (2013) Altered social behaviours in neurexin 1alpha knockout mice resemble core symptoms in neurodevelopmental disorders. PLoS ONE 8, e67114.
    • (2013) PLoS ONE , vol.8
    • Grayton, H.M.1    Missler, M.2    Collier, D.A.3    Fernandes, C.4
  • 71
    • 1442264828 scopus 로고    scopus 로고
    • Take five - BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
    • DOI 10.1038/sj.emboj.7600061
    • Haass C., (2004) Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 23, 483-488. (Pubitemid 38282380)
    • (2004) EMBO Journal , vol.23 , Issue.3 , pp. 483-488
    • Haass, C.1
  • 72
    • 0028866435 scopus 로고
    • The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
    • Haass C., Lemere C. A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., and, Selkoe D. J., (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat. Med. 1, 1291-1296.
    • (1995) Nat. Med. , vol.1 , pp. 1291-1296
    • Haass, C.1    Lemere, C.A.2    Capell, A.3    Citron, M.4    Seubert, P.5    Schenk, D.6    Lannfelt, L.7    Selkoe, D.J.8
  • 74
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J., and, Selkoe D. J., (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 76
    • 15744380393 scopus 로고    scopus 로고
    • GGA proteins mediate the recycling pathway of memapsin 2 (BACE)
    • DOI 10.1074/jbc.M411296200
    • He X., Li F., Chang W. P., and, Tang J., (2005) GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J. Biol. Chem. 280, 11696-11703. (Pubitemid 40418483)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.12 , pp. 11696-11703
    • He, X.1    Li, F.2    Chang, W.-P.3    Tang, J.4
  • 77
    • 11144314304 scopus 로고    scopus 로고
    • Biogenesis of pigment granules: A sensitive way to regulate melanocyte function
    • DOI 10.1016/j.jdermsci.2004.08.014, PII S0923181104002038
    • Hearing V. J., (2005) Biogenesis of pigment granules: a sensitive way to regulate melanocyte function. J. Dermatol. Sci. 37, 3-14. (Pubitemid 40037573)
    • (2005) Journal of Dermatological Science , vol.37 , Issue.1 , pp. 3-14
    • Hearing, V.J.1
  • 78
    • 0034329291 scopus 로고    scopus 로고
    • Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members
    • Heber S., Herms J., Gajic V., et al,. (2000) Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J. Neurosci. 20, 7951-7963.
    • (2000) J. Neurosci. , vol.20 , pp. 7951-7963
    • Heber, S.1    Herms, J.2    Gajic, V.3
  • 79
    • 77954051527 scopus 로고    scopus 로고
    • Identification of beta-secretase (BACE1) substrates using quantitative proteomics
    • Hemming M. L., Elias J. E., Gygi S. P., and, Selkoe D. J., (2009) Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS ONE 4, e8477.
    • (2009) PLoS ONE , vol.4
    • Hemming, M.L.1    Elias, J.E.2    Gygi, S.P.3    Selkoe, D.J.4
  • 80
    • 8144230876 scopus 로고    scopus 로고
    • Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
    • DOI 10.1038/sj.emboj.7600390
    • Herms J., Anliker B., Heber S., Ring S., Fuhrmann M., Kretzschmar H., Sisodia S., and, Muller U., (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 23, 4106-4115. (Pubitemid 39472431)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4106-4115
    • Herms, J.1    Anliker, B.2    Heber, S.3    Ring, S.4    Fuhrmann, M.5    Kretzschmar, H.6    Sisodia, S.7    Muller, U.8
  • 81
    • 47249085516 scopus 로고    scopus 로고
    • Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule
    • Heyden A., Angenstein F., Sallaz M., Seidenbecher C., and, Montag D., (2008) Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule. Neuroscience 155, 221-233.
    • (2008) Neuroscience , vol.155 , pp. 221-233
    • Heyden, A.1    Angenstein, F.2    Sallaz, M.3    Seidenbecher, C.4    Montag, D.5
  • 82
    • 0037137688 scopus 로고    scopus 로고
    • A role for Neuregulin1 signaling in muscle spindle differentiation
    • DOI 10.1016/S0896-6273(02)01101-7
    • Hippenmeyer S., Shneider N. A., Birchmeier C., Burden S. J., Jessell T. M., and, Arber S., (2002) A role for neuregulin1 signaling in muscle spindle differentiation. Neuron 36, 1035-1049. (Pubitemid 36044506)
    • (2002) Neuron , vol.36 , Issue.6 , pp. 1035-1049
    • Hippenmeyer, S.1    Shneider, N.A.2    Birchmeier, C.3    Burden, S.J.4    Jessell, T.M.5    Arber, S.6
  • 83
    • 77955792343 scopus 로고    scopus 로고
    • BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
    • Hitt B. D., Jaramillo T. C., Chetkovich D. M., and, Vassar R., (2010) BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol. Neurodegener. 5, 31.
    • (2010) Mol. Neurodegener. , vol.5 , pp. 31
    • Hitt, B.D.1    Jaramillo, T.C.2    Chetkovich, D.M.3    Vassar, R.4
  • 84
    • 84869070324 scopus 로고    scopus 로고
    • Beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects
    • Hitt B., Riordan S., Kukreja L., Eimer W., Rajapaksha T., and, Vassar R., (2012) beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J. Biol. Chem. 287, 38408-38425.
    • (2012) J. Biol. Chem. , vol.287 , pp. 38408-38425
    • Hitt, B.1    Riordan, S.2    Kukreja, L.3    Eimer, W.4    Rajapaksha, T.5    Vassar, R.6
  • 85
    • 0034613320 scopus 로고    scopus 로고
    • Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
    • Hong L., Koelsch G., Lin X., Wu S., Terzyan S., Ghosh A. K., Zhang X. C., and, Tang J., (2000) Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 290, 150-153.
    • (2000) Science , vol.290 , pp. 150-153
    • Hong, L.1    Koelsch, G.2    Lin, X.3    Wu, S.4    Terzyan, S.5    Ghosh, A.K.6    Zhang, X.C.7    Tang, J.8
  • 86
    • 33845236399 scopus 로고    scopus 로고
    • Bace1 modulates myelination in the central and peripheral nervous system
    • DOI 10.1038/nn1797, PII NN1797
    • Hu X., Hicks C. W., He W., Wong P., Macklin W. B., Trapp B. D., and, Yan R., (2006) Bace1 modulates myelination in the central and peripheral nervous system. Nat. Neurosci. 9, 1520-1525. (Pubitemid 44862660)
    • (2006) Nature Neuroscience , vol.9 , Issue.12 , pp. 1520-1525
    • Hu, X.1    Hicks, C.W.2    He, W.3    Wong, P.4    MacKlin, W.B.5    Trapp, B.D.6    Yan, R.7
  • 87
    • 48749111028 scopus 로고    scopus 로고
    • Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves
    • Hu X., He W., Diaconu C., Tang X., Kidd G. J., Macklin W. B., Trapp B. D., and, Yan R., (2008) Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J. 22, 2970-2980.
    • (2008) FASEB J. , vol.22 , pp. 2970-2980
    • Hu, X.1    He, W.2    Diaconu, C.3    Tang, X.4    Kidd, G.J.5    Macklin, W.B.6    Trapp, B.D.7    Yan, R.8
  • 88
    • 77954394162 scopus 로고    scopus 로고
    • BACE1 deficiency causes altered neuronal activity and neurodegeneration
    • Hu X., Zhou X., He W., Yang J., Xiong W., Wong P., Wilson C. G., and, Yan R., (2010) BACE1 deficiency causes altered neuronal activity and neurodegeneration. J. Neurosci. 30, 8819-8829.
    • (2010) J. Neurosci. , vol.30 , pp. 8819-8829
    • Hu, X.1    Zhou, X.2    He, W.3    Yang, J.4    Xiong, W.5    Wong, P.6    Wilson, C.G.7    Yan, R.8
  • 89
    • 84892436283 scopus 로고    scopus 로고
    • BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway
    • Hu X., He W., Luo X., Tsubota K. E., and, Yan R., (2013) BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway. Cell Rep. 4, 40-49.
    • (2013) Cell Rep. , vol.4 , pp. 40-49
    • Hu, X.1    He, W.2    Luo, X.3    Tsubota, K.E.4    Yan, R.5
  • 92
    • 0035139342 scopus 로고    scopus 로고
    • Sodium channel β subunits: Anything but auxiliary
    • Isom L. L., (2001) Sodium channel beta subunits: anything but auxiliary. Neuroscientist 7, 42-54. (Pubitemid 32098822)
    • (2001) Neuroscientist , vol.7 , Issue.1 , pp. 42-54
    • Isom, L.L.1
  • 93
    • 84863800101 scopus 로고    scopus 로고
    • Shapes of the trajectories of 5 major biomarkers of Alzheimer disease
    • Jack C. R., Jr, Vemuri P., Wiste H. J., et al,. (2012) Shapes of the trajectories of 5 major biomarkers of Alzheimer disease. Arch. Neurol. 69, 856-867.
    • (2012) Arch. Neurol. , vol.69 , pp. 856-867
    • Jack, Jr.C.R.1    Vemuri, P.2    Wiste, H.J.3
  • 95
    • 42949109643 scopus 로고    scopus 로고
    • Aliskiren: The first renin inhibitor for clinical treatment
    • DOI 10.1038/nrd2550, PII NRD2550
    • Jensen C., Herold P., and, Brunner H. R., (2008) Aliskiren: the first renin inhibitor for clinical treatment. Nat. Rev. Drug Discovery 7, 399-410. (Pubitemid 351619112)
    • (2008) Nature Reviews Drug Discovery , vol.7 , Issue.5 , pp. 399-410
    • Jensen, C.1    Herold, P.2    Brunner, H.R.3
  • 96
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T., Atwal J. K., Steinberg S., et al,. (2012) A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99.
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3
  • 97
    • 77950613181 scopus 로고    scopus 로고
    • The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
    • Jorissen E., Prox J., Bernreuther C., et al,. (2010) The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J. Neurosci. 30, 4833-4844.
    • (2010) J. Neurosci. , vol.30 , pp. 4833-4844
    • Jorissen, E.1    Prox, J.2    Bernreuther, C.3
  • 98
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • DOI 10.1038/nature05482, PII NATURE05482
    • Kahn S. E., Hull R. L., and, Utzschneider K. M., (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846. (Pubitemid 46024990)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 99
    • 27744501797 scopus 로고    scopus 로고
    • Lipids as modulators of proteolytic activity of BACE: Involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
    • DOI 10.1074/jbc.M504484200
    • Kalvodova L., Kahya N., Schwille P., Ehehalt R., Verkade P., Drechsel D., and, Simons K., (2005) Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J. Biol. Chem. 280, 36815-36823. (Pubitemid 41587762)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.44 , pp. 36815-36823
    • Kalvodova, L.1    Kahya, N.2    Schwille, P.3    Ehehalt, R.4    Verkade, P.5    Drechsel, D.6    Simons, K.7
  • 100
    • 84883462681 scopus 로고    scopus 로고
    • The Alzheimer's beta-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
    • Kandalepas P. C., Sadleir K. R., Eimer W. A., Zhao J., Nicholson D. A., and, Vassar R., (2013) The Alzheimer's beta-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 126, 329-352.
    • (2013) Acta Neuropathol. , vol.126 , pp. 329-352
    • Kandalepas, P.C.1    Sadleir, K.R.2    Eimer, W.A.3    Zhao, J.4    Nicholson, D.A.5    Vassar, R.6
  • 101
  • 102
    • 84871147381 scopus 로고    scopus 로고
    • BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus
    • Kang E. L., Biscaro B., Piazza F., and, Tesco G., (2012) BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus. J. Biol. Chem. 287, 42867-42880.
    • (2012) J. Biol. Chem. , vol.287 , pp. 42867-42880
    • Kang, E.L.1    Biscaro, B.2    Piazza, F.3    Tesco, G.4
  • 105
    • 48249156612 scopus 로고    scopus 로고
    • Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals
    • Kim J., Jung S. Y., Lee Y. K., et al,. (2008) Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. Proc. Natl Acad. Sci. USA 105, 9087-9092.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9087-9092
    • Kim, J.1    Jung, S.Y.2    Lee, Y.K.3
  • 106
    • 79953129279 scopus 로고    scopus 로고
    • Reduced sodium channel Na(v)1.1 levels in BACE1-null mice
    • Kim D. Y., Gersbacher M. T., Inquimbert P., and, Kovacs D. M., (2011) Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J. Biol. Chem. 286, 8106-8116.
    • (2011) J. Biol. Chem. , vol.286 , pp. 8106-8116
    • Kim, D.Y.1    Gersbacher, M.T.2    Inquimbert, P.3    Kovacs, D.M.4
  • 107
    • 0042887148 scopus 로고    scopus 로고
    • Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
    • DOI 10.1242/jcs.00643
    • Kinoshita A., Fukumoto H., Shah T., Whelan C. M., Irizarry M. C., and, Hyman B. T., (2003) Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J. Cell Sci. 116, 3339-3346. (Pubitemid 37038982)
    • (2003) Journal of Cell Science , vol.116 , Issue.16 , pp. 3339-3346
    • Kinoshita, A.1    Fukumoto, H.2    Shah, T.3    Whelan, C.M.4    Irizarry, M.C.5    Hyman, B.T.6
  • 108
    • 59049092157 scopus 로고    scopus 로고
    • Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels
    • Ko M. H., and, Puglielli L., (2009) Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J. Biol. Chem. 284, 2482-2492.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2482-2492
    • Ko, M.H.1    Puglielli, L.2
  • 112
  • 113
    • 84864148410 scopus 로고    scopus 로고
    • Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
    • Kuhn P. H., Koroniak K., Hogl S., et al,. (2012) Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J. 31, 3157-3168.
    • (2012) EMBO J. , vol.31 , pp. 3157-3168
    • Kuhn, P.H.1    Koroniak, K.2    Hogl, S.3
  • 114
    • 79959665249 scopus 로고    scopus 로고
    • TACE (ADAM17) inhibits Schwann cell myelination
    • La Marca R., Cerri F., Horiuchi K., et al,. (2011) TACE (ADAM17) inhibits Schwann cell myelination. Nat. Neurosci. 14, 857-865.
    • (2011) Nat. Neurosci. , vol.14 , pp. 857-865
    • La Marca, R.1    Cerri, F.2    Horiuchi, K.3
  • 116
    • 33644764063 scopus 로고    scopus 로고
    • Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
    • DOI 10.1016/j.cell.2005.12.038, PII S0092867406001231
    • Lakadamyali M., Rust M. J., and, Zhuang X., (2006) Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124, 997-1009. (Pubitemid 43344239)
    • (2006) Cell , vol.124 , Issue.5 , pp. 997-1009
    • Lakadamyali, M.1    Rust, M.J.2    Zhuang, X.3
  • 117
    • 0037938677 scopus 로고    scopus 로고
    • Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development
    • DOI 10.1242/dev.00447
    • Leu M., Bellmunt E., Schwander M., Farinas I., Brenner H. R., and, Muller U., (2003) Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development. Development 130, 2291-2301. (Pubitemid 36722382)
    • (2003) Development , vol.130 , Issue.11 , pp. 2291-2301
    • Leu, M.1    Bellmunt, E.2    Schwander, M.3    Farinas, I.4    Brenner, H.R.5    Muller, U.6
  • 118
    • 0029954239 scopus 로고    scopus 로고
    • Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells
    • DOI 10.1073/pnas.93.12.6158
    • Li Z. W., Stark G., Gotz J., Rulicke T., Gschwind M., Huber G., Muller U., and, Weissmann C., (1996) Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proc. Natl Acad. Sci. USA 93, 6158-6162. (Pubitemid 26190820)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.12 , pp. 6158-6162
    • Li, Z.-W.1    Stark, G.2    Gotz, J.3    Rulicke, T.4    Muller, U.5    Weissmann, C.6
  • 119
    • 78049267204 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    • Li H., Wang B., Wang Z., Guo Q., Tabuchi K., Hammer R. E., Sudhof T. C., and, Zheng H., (2010) Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc. Natl Acad. Sci. USA 107, 17362-17367.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 17362-17367
    • Li, H.1    Wang, B.2    Wang, Z.3    Guo, Q.4    Tabuchi, K.5    Hammer, R.E.6    Sudhof, T.C.7    Zheng, H.8
  • 123
    • 0042334543 scopus 로고    scopus 로고
    • BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time
    • DOI 10.1016/S0969-9961(03)00104-9
    • Luo Y., Bolon B., Damore M. A., Fitzpatrick D., Liu H., Zhang J., Yan Q., Vassar R., and, Citron M., (2003) BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol. Dis. 14, 81-88. (Pubitemid 37103182)
    • (2003) Neurobiology of Disease , vol.14 , Issue.1 , pp. 81-88
    • Luo, Y.1    Bolon, B.2    Damore, M.A.3    Fitzpatrick, D.4    Liu, H.5    Zhang, J.6    Yan, Q.7    Vassar, R.8    Citron, M.9
  • 124
    • 79959895698 scopus 로고    scopus 로고
    • Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination
    • Luo X., Prior M., He W., et al,. (2011) Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. J. Biol. Chem. 286, 23967-23974.
    • (2011) J. Biol. Chem. , vol.286 , pp. 23967-23974
    • Luo, X.1    Prior, M.2    He, W.3
  • 127
    • 81255143061 scopus 로고    scopus 로고
    • Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor
    • May P. C., Dean R. A., Lowe S. L., et al,. (2011) Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J. Neurosci. 31, 16507-16516.
    • (2011) J. Neurosci. , vol.31 , pp. 16507-16516
    • May, P.C.1    Dean, R.A.2    Lowe, S.L.3
  • 129
    • 84055223593 scopus 로고    scopus 로고
    • Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
    • Meakin P. J., Harper A. J., Hamilton D. L., et al,. (2012) Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochem. J. 441, 285-296.
    • (2012) Biochem. J. , vol.441 , pp. 285-296
    • Meakin, P.J.1    Harper, A.J.2    Hamilton, D.L.3
  • 131
    • 77954389124 scopus 로고    scopus 로고
    • Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms
    • Mitterreiter S., Page R. M., Kamp F., et al,. (2010) Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. J. Neurosci. 30, 8974-8983.
    • (2010) J. Neurosci. , vol.30 , pp. 8974-8983
    • Mitterreiter, S.1    Page, R.M.2    Kamp, F.3
  • 133
    • 0036841466 scopus 로고    scopus 로고
    • Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1
    • DOI 10.1128/MCB.22.22.7967-7981.2002
    • Montag-Sallaz M., Schachner M., and, Montag D., (2002) Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol. Cell. Biol. 22, 7967-7981. (Pubitemid 35217305)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.22 , pp. 7967-7981
    • Montag-Sallaz, M.1    Schachner, M.2    Montag, D.3
  • 134
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M., Crawford F., Houlden H., Axelman K., Lilius L., Winblad B., and, Lannfelt L., (1992a) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat. Genet. 1, 345-347.
    • (1992) Nat. Genet. , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Houlden, H.3    Axelman, K.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 136
    • 1942533555 scopus 로고    scopus 로고
    • Ectodomain Shedding of the Neural Recognition Molecule CHL1 by the Metalloprotease-disintegrin ADAM8 Promotes Neurite Outgrowth and Suppresses Neuronal Cell Death
    • DOI 10.1074/jbc.M400560200
    • Naus S., Richter M., Wildeboer D., Moss M., Schachner M., and, Bartsch J. W., (2004) Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J. Biol. Chem. 279, 16083-16090. (Pubitemid 38509299)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.16 , pp. 16083-16090
    • Naus, S.1    Richter, M.2    Wildeboer, D.3    Moss, M.4    Schachner, M.5    Bartsch, J.W.6
  • 137
    • 0346055155 scopus 로고    scopus 로고
    • BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease
    • DOI 10.1016/S0896-6273(03)00810-9
    • Ohno M., Sametsky E. A., Younkin L. H., Oakley H., Younkin S. G., Citron M., Vassar R., and, Disterhoft J. F., (2004) BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 41, 27-33. (Pubitemid 38071826)
    • (2004) Neuron , vol.41 , Issue.1 , pp. 27-33
    • Ohno, M.1    Sametsky, E.A.2    Younkin, L.H.3    Oakley, H.4    Younkin, S.G.5    Citron, M.6    Vassar, R.7    Disterhoft, J.F.8
  • 139
    • 33947247360 scopus 로고    scopus 로고
    • BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
    • DOI 10.1016/j.nbd.2006.12.008, PII S0969996106003172
    • Ohno M., Cole S. L., Yasvoina M., Zhao J., Citron M., Berry R., Disterhoft J. F., and, Vassar R., (2007) BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiol. Dis. 26, 134-145. (Pubitemid 46436493)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 134-145
    • Ohno, M.1    Cole, S.L.2    Yasvoina, M.3    Zhao, J.4    Citron, M.5    Berry, R.6    Disterhoft, J.F.7    Vassar, R.8
  • 140
    • 0036200884 scopus 로고    scopus 로고
    • The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total Aβ
    • DOI 10.1006/mcne.2001.1065
    • Pastorino L., Ikin A. F., Nairn A. C., Pursnani A., and, Buxbaum J. D., (2002) The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol. Cell. Neurosci. 19, 175-185. (Pubitemid 34211898)
    • (2002) Molecular and Cellular Neuroscience , vol.19 , Issue.2 , pp. 175-185
    • Pastorino, L.1    Ikin, A.F.2    Nairn, A.C.3    Pursnani, A.4    Buxbaum, J.D.5
  • 141
    • 0033516554 scopus 로고    scopus 로고
    • Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
    • Perez R. G., Soriano S., Hayes J. D., Ostaszewski B., Xia W., Selkoe D. J., Chen X., Stokin G. B., and, Koo E. H., (1999) Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J. Biol. Chem. 274, 18851-18856.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18851-18856
    • Perez, R.G.1    Soriano, S.2    Hayes, J.D.3    Ostaszewski, B.4    Xia, W.5    Selkoe, D.J.6    Chen, X.7    Stokin, G.B.8    Koo, E.H.9
  • 142
    • 0032926449 scopus 로고    scopus 로고
    • No hippocampal neuron or synaptic bouton loss in learning-impaired aged β-amyloid precursor protein-null mice
    • DOI 10.1016/S0306-4522(98)00645-9, PII S0306452298006459
    • Phinney A. L., Calhoun M. E., Wolfer D. P., Lipp H. P., Zheng H., and, Jucker M., (1999) No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience 90, 1207-1216. (Pubitemid 29170139)
    • (1999) Neuroscience , vol.90 , Issue.4 , pp. 1207-1216
    • Phinney, A.L.1    Calhoun, M.E.2    Wolfer, D.P.3    Lipp, H.-P.4    Zheng, H.5    Jucker, M.6
  • 145
    • 84886237088 scopus 로고    scopus 로고
    • Semagacestat for treatment of Alzheimer's disease
    • Pomara N., (2013) Semagacestat for treatment of Alzheimer's disease. N. Engl. J. Med. 369, 1661.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1661
    • Pomara, N.1
  • 146
    • 84862549612 scopus 로고    scopus 로고
    • Adaptor protein 2-mediated endocytosis of the beta-secretase BACE1 is dispensable for amyloid precursor protein processing
    • Prabhu Y., Burgos P. V., Schindler C., Farias G. G., Magadan J. G., and, Bonifacino J. S., (2012) Adaptor protein 2-mediated endocytosis of the beta-secretase BACE1 is dispensable for amyloid precursor protein processing. Mol. Biol. Cell 23, 2339-2351.
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2339-2351
    • Prabhu, Y.1    Burgos, P.V.2    Schindler, C.3    Farias, G.G.4    Magadan, J.G.5    Bonifacino, J.S.6
  • 147
    • 78049411203 scopus 로고    scopus 로고
    • Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme
    • Rajagopal C., Stone K. L., Mains R. E., and, Eipper B. A., (2010) Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme. J. Biol. Chem. 285, 34632-34642.
    • (2010) J. Biol. Chem. , vol.285 , pp. 34632-34642
    • Rajagopal, C.1    Stone, K.L.2    Mains, R.E.3    Eipper, B.A.4
  • 148
    • 84455162426 scopus 로고    scopus 로고
    • The Alzheimer's beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
    • Rajapaksha T. W., Eimer W. A., Bozza T. C., and, Vassar R., (2011) The Alzheimer's beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb. Mol. Neurodegener. 6, 88.
    • (2011) Mol. Neurodegener. , vol.6 , pp. 88
    • Rajapaksha, T.W.1    Eimer, W.A.2    Bozza, T.C.3    Vassar, R.4
  • 152
    • 34648828526 scopus 로고    scopus 로고
    • Melanosomes - Dark organelles enlighten endosomal membrane transport
    • DOI 10.1038/nrm2258, PII NRM2258
    • Raposo G., and, Marks M. S., (2007) Melanosomes-dark organelles enlighten endosomal membrane transport. Nat. Rev. Mol. Cell Biol. 8, 786-797. (Pubitemid 47462136)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 786-797
    • Raposo, G.1    Marks, M.S.2
  • 156
    • 84879544231 scopus 로고    scopus 로고
    • BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
    • Rochin L., Hurbain I., Serneels L., et al,. (2013) BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc. Natl Acad Sci. USA 110, 10658-10663.
    • (2013) Proc. Natl Acad Sci. USA , vol.110 , pp. 10658-10663
    • Rochin, L.1    Hurbain, I.2    Serneels, L.3
  • 158
    • 33747347875 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of BACE1 expression-Implications for Alzheimer's disease
    • DOI 10.1016/j.pneurobio.2006.06.001, PII S0301008206000566
    • Rossner S., Sastre M., Bourne K., and, Lichtenthaler S. F., (2006) Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease. Prog. Neurobiol. 79, 95-111. (Pubitemid 44247281)
    • (2006) Progress in Neurobiology , vol.79 , Issue.2 , pp. 95-111
    • Rossner, S.1    Sastre, M.2    Bourne, K.3    Lichtenthaler, S.F.4
  • 159
    • 0029083689 scopus 로고
    • Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
    • Saftig P., Hetman M., Schmahl W., et al,. (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J. 14, 3599-3608.
    • (1995) EMBO J. , vol.14 , pp. 3599-3608
    • Saftig, P.1    Hetman, M.2    Schmahl, W.3
  • 160
    • 77955933540 scopus 로고    scopus 로고
    • Neural map formation in the mouse olfactory system
    • Sakano H., (2010) Neural map formation in the mouse olfactory system. Neuron 67, 530-542.
    • (2010) Neuron , vol.67 , pp. 530-542
    • Sakano, H.1
  • 162
    • 59149083352 scopus 로고    scopus 로고
    • First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates
    • Sankaranarayanan S., Holahan M. A., Colussi D., et al,. (2009) First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. J. Pharmacol. Exp. Ther. 328, 131-140.
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 131-140
    • Sankaranarayanan, S.1    Holahan, M.A.2    Colussi, D.3
  • 163
    • 80052149544 scopus 로고    scopus 로고
    • ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
    • Sannerud R., Declerck I., Peric A., et al,. (2011) ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc. Natl Acad. Sci. USA 108, E559-E568.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108
    • Sannerud, R.1    Declerck, I.2    Peric, A.3
  • 166
    • 40849097929 scopus 로고    scopus 로고
    • Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons
    • DOI 10.1523/JNEUROSCI.5345-07.2008
    • Schneider A., Rajendran L., Honsho M., Gralle M., Donnert G., Wouters F., Hell S. W., and, Simons M., (2008) Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J. Neurosci. 28, 2874-2882. (Pubitemid 351398889)
    • (2008) Journal of Neuroscience , vol.28 , Issue.11 , pp. 2874-2882
    • Schneider, A.1    Rajendran, L.2    Honsho, M.3    Gralle, M.4    Donnert, G.5    Wouters, F.6    Hell, S.W.7    Simons, M.8
  • 168
    • 33847215777 scopus 로고    scopus 로고
    • Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
    • Shacka J. J., Klocke B. J., Young C., Shibata M., Olney J. W., Uchiyama Y., Saftig P., and, Roth K. A., (2007) Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J. Neurosci. 27, 2081-2090.
    • (2007) J. Neurosci. , vol.27 , pp. 2081-2090
    • Shacka, J.J.1    Klocke, B.J.2    Young, C.3    Shibata, M.4    Olney, J.W.5    Uchiyama, Y.6    Saftig, P.7    Roth, K.A.8
  • 169
    • 0035512077 scopus 로고    scopus 로고
    • Loss of HNF-1α Function in Mice Leads to Abnormal Expression of Genes Involved in Pancreatic Islet Development and Metabolism
    • Shih D. Q., Screenan S., Munoz K. N., Philipson L., Pontoglio M., Yaniv M., Polonsky K. S., and, Stoffel M., (2001) Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes 50, 2472-2480. (Pubitemid 33642764)
    • (2001) Diabetes , vol.50 , Issue.7-12 , pp. 2472-2480
    • Shih, D.Q.1    Screenan, S.2    Munoz, K.N.3    Philipson, L.4    Pontoglio, M.5    Yaniv, M.6    Polonsky, K.S.7    Stoffel, M.8
  • 171
    • 33745079623 scopus 로고    scopus 로고
    • Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis
    • DOI 10.1093/brain/awl107
    • Siintola E., Partanen S., Stromme P., Haapanen A., Haltia M., Maehlen J., Lehesjoki A. E., and, Tyynela J., (2006) Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. Brain 129, 1438-1445. (Pubitemid 43999376)
    • (2006) Brain , vol.129 , Issue.6 , pp. 1438-1445
    • Siintola, E.1    Partanen, S.2    Stromme, P.3    Haapanen, A.4    Haltia, M.5    Maehlen, J.6    Lehesjoki, A.-E.7    Tyynela, J.8
  • 172
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein beta-secretase from human brain
    • Sinha S., Anderson J. P., Barbour R., et al,. (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540.
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3
  • 173
    • 0036548070 scopus 로고    scopus 로고
    • γ-secretase, Notch, Aβ and Alzheimer's disease: Where do the presenilins fit in?
    • DOI 10.1038/nrn785
    • Sisodia S. S., and, St George-Hyslop P. H., (2002) gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat. Rev. Neurosci. 3, 281-290. (Pubitemid 135706607)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.4 , pp. 281-290
    • Sisodia, S.S.1    St George-Hyslop, P.H.2
  • 174
    • 33749042749 scopus 로고    scopus 로고
    • Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
    • DOI 10.1016/j.neuron.2006.09.001, PII S0896627306006763
    • Small S. A., and, Gandy S., (2006) Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 52, 15-31. (Pubitemid 44466354)
    • (2006) Neuron , vol.52 , Issue.1 , pp. 15-31
    • Small, S.A.1    Gandy, S.2
  • 175
    • 84878886764 scopus 로고    scopus 로고
    • Inhibitors of BACE for treating Alzheimer's disease: A fragment-based drug discovery story
    • Stamford A., and, Strickland C., (2013) Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story. Curr. Opin. Chem. Biol. 17, 320-328.
    • (2013) Curr. Opin. Chem. Biol. , vol.17 , pp. 320-328
    • Stamford, A.1    Strickland, C.2
  • 176
    • 84868540195 scopus 로고    scopus 로고
    • Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS abeta reduction
    • Stamford A. W., Scott J. D., Li S. W., et al,. (2012) Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS abeta reduction. ACS Med. Chem. Lett. 3, 897-902.
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 897-902
    • Stamford, A.W.1    Scott, J.D.2    Li, S.W.3
  • 178
    • 84876263985 scopus 로고    scopus 로고
    • Systematic proteomic analysis identifies beta-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic beta-cells
    • Stutzer I., Selevsek N., Esterhazy D., Schmidt A., Aebersold R., and, Stoffel M., (2013) Systematic proteomic analysis identifies beta-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic beta-cells. J. Biol. Chem. 288, 10536-10547.
    • (2013) J. Biol. Chem. , vol.288 , pp. 10536-10547
    • Stutzer, I.1    Selevsek, N.2    Esterhazy, D.3    Schmidt, A.4    Aebersold, R.5    Stoffel, M.6
  • 179
    • 84885704987 scopus 로고    scopus 로고
    • ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function
    • Suh J., Choi S. H., Romano D. M., Gannon M. A., Lesinski A. N., Kim D. Y., and, Tanzi R. E., (2013) ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function. Neuron 80, 385-401.
    • (2013) Neuron , vol.80 , pp. 385-401
    • Suh, J.1    Choi, S.H.2    Romano, D.M.3    Gannon, M.A.4    Lesinski, A.N.5    Kim, D.Y.6    Tanzi, R.E.7
  • 180
    • 84867722362 scopus 로고    scopus 로고
    • Activity-dependent proteolytic cleavage of neuroligin-1
    • Suzuki K., Hayashi Y., Nakahara S., et al,. (2012) Activity-dependent proteolytic cleavage of neuroligin-1. Neuron 76, 410-422.
    • (2012) Neuron , vol.76 , pp. 410-422
    • Suzuki, K.1    Hayashi, Y.2    Nakahara, S.3
  • 186
    • 84863343191 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral gamma-secretase inhibitor BMS-708163 (Avagacestat): Tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers
    • Tong G., Wang J. S., Sverdlov O., et al,. (2012) Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral gamma-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers. Clin. Ther. 34, 654-667.
    • (2012) Clin. Ther. , vol.34 , pp. 654-667
    • Tong, G.1    Wang, J.S.2    Sverdlov, O.3
  • 188
    • 84890919877 scopus 로고    scopus 로고
    • A Paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production
    • Udayar V., Buggia-Prevot V., Guerreiro R. L., et al,. (2013) A Paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production. Cell Rep. 5, 1536-1551.
    • (2013) Cell Rep. , vol.5 , pp. 1536-1551
    • Udayar, V.1    Buggia-Prevot, V.2    Guerreiro, R.L.3
  • 190
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar R., Bennett B. D., Babu-Khan S., et al,. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 191
    • 70350455062 scopus 로고    scopus 로고
    • The beta-secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential
    • Vassar R., Kovacs D. M., Yan R., and, Wong P. C., (2009) The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J. Neurosci. 29, 12787-12794.
    • (2009) J. Neurosci. , vol.29 , pp. 12787-12794
    • Vassar, R.1    Kovacs, D.M.2    Yan, R.3    Wong, P.C.4
  • 192
    • 62149091579 scopus 로고    scopus 로고
    • Alzheimer disease Abeta production in the absence of S-palmitoylation- dependent targeting of BACE1 to lipid rafts
    • Vetrivel K. S., Meckler X., Chen Y., et al,. (2009) Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J. Biol. Chem. 284, 3793-3803.
    • (2009) J. Biol. Chem. , vol.284 , pp. 3793-3803
    • Vetrivel, K.S.1    Meckler, X.2    Chen, Y.3
  • 193
    • 84897365237 scopus 로고    scopus 로고
    • Molecular mechanisms of cognitive dysfunction following traumatic brain injury
    • Walker K. R., and, Tesco G., (2013) Molecular mechanisms of cognitive dysfunction following traumatic brain injury. Front. Aging Neurosci. 5, 29.
    • (2013) Front. Aging Neurosci. , vol.5 , pp. 29
    • Walker, K.R.1    Tesco, G.2
  • 194
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers - A decade of discovery
    • Walsh D. M., and, Selkoe D. J., (2007) A beta oligomers-a decade of discovery. J. Neurochem. 101, 1172-1184.
    • (2007) J. Neurochem. , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 195
    • 77953422164 scopus 로고    scopus 로고
    • Translational medicine lessons from flurizan's failure in Alzheimer's disease (AD) trial: Implication for future drug discovery and development for AD
    • Wan H. I., Jacobsen J. S., Rutkowski J. L., and, Feuerstein G. Z., (2009) Translational medicine lessons from flurizan's failure in Alzheimer's disease (AD) trial: implication for future drug discovery and development for AD. Clin. Transl. Sci. 2, 242-247.
    • (2009) Clin. Transl. Sci. , vol.2 , pp. 242-247
    • Wan, H.I.1    Jacobsen, J.S.2    Rutkowski, J.L.3    Feuerstein, G.Z.4
  • 197
    • 77249094569 scopus 로고    scopus 로고
    • Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
    • Wang Y. S., Strickland C., Voigt J. H., et al,. (2010) Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors. J. Med. Chem. 53, 942-950.
    • (2010) J. Med. Chem. , vol.53 , pp. 942-950
    • Wang, Y.S.1    Strickland, C.2    Voigt, J.H.3
  • 198
    • 72149111129 scopus 로고    scopus 로고
    • N-terminal domains elicit formation of functional Pmel17 amyloid fibrils
    • Watt B., van Niel G., Fowler D. M., et al,. (2009) N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. J. Biol. Chem. 284, 35543-35555.
    • (2009) J. Biol. Chem. , vol.284 , pp. 35543-35555
    • Watt, B.1    Van Niel, G.2    Fowler, D.M.3
  • 199
    • 79957909084 scopus 로고    scopus 로고
    • APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
    • Weyer S. W., Klevanski M., Delekate A., et al,. (2011) APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J. 30, 2266-2280.
    • (2011) EMBO J. , vol.30 , pp. 2266-2280
    • Weyer, S.W.1    Klevanski, M.2    Delekate, A.3
  • 201
    • 63949088562 scopus 로고    scopus 로고
    • Function, regulation and therapeutic properties of beta-secretase (BACE1)
    • Willem M., Lammich S., and, Haass C., (2009) Function, regulation and therapeutic properties of beta-secretase (BACE1). Semin. Cell Dev. Biol. 20, 175-182.
    • (2009) Semin. Cell Dev. Biol. , vol.20 , pp. 175-182
    • Willem, M.1    Lammich, S.2    Haass, C.3
  • 203
    • 84879714373 scopus 로고    scopus 로고
    • A review on the current neuroligin mouse models
    • Xu J. Y., Xia Q. Q., and, Xia J., (2012) A review on the current neuroligin mouse models. Sheng Li Xue Bao 64, 550-562.
    • (2012) Sheng Li Xue Bao , vol.64 , pp. 550-562
    • Xu, J.Y.1    Xia, Q.Q.2    Xia, J.3
  • 204
    • 0033518264 scopus 로고    scopus 로고
    • Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    • Yan R., Bienkowski M. J., Shuck M. E., et al,. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537.
    • (1999) Nature , vol.402 , pp. 533-537
    • Yan, R.1    Bienkowski, M.J.2    Shuck, M.E.3
  • 205
    • 0035823610 scopus 로고    scopus 로고
    • BACE2 functions as an alternative alpha-secretase in cells
    • Yan R., Munzner J. B., Shuck M. E., and, Bienkowski M. J., (2001) BACE2 functions as an alternative alpha-secretase in cells. J. Biol. Chem. 276, 34019-34027.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34019-34027
    • Yan, R.1    Munzner, J.B.2    Shuck, M.E.3    Bienkowski, M.J.4
  • 207
    • 72449130946 scopus 로고    scopus 로고
    • Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity
    • Yang L., Wang Z., Wang B., Justice N. J., and, Zheng H., (2009a) Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. J. Neurosci. 29, 15660-15668.
    • (2009) J. Neurosci. , vol.29 , pp. 15660-15668
    • Yang, L.1    Wang, Z.2    Wang, B.3    Justice, N.J.4    Zheng, H.5
  • 208
    • 66349101292 scopus 로고    scopus 로고
    • Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering
    • Yang W., Fucini R. V., Fahr B. T., et al,. (2009b) Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering. Biochemistry 48, 4488-4496.
    • (2009) Biochemistry , vol.48 , pp. 4488-4496
    • Yang, W.1    Fucini, R.V.2    Fahr, B.T.3
  • 209
    • 79957439772 scopus 로고    scopus 로고
    • Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
    • Yu Y. J., Zhang Y., and, Kenrick M., et al,. (2011) Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci. Transl. Med. 3, 84ra44.
    • (2011) Sci. Transl. Med. , vol.3
    • Yu, Y.J.1    Zhang, Y.2    Kenrick, M.3
  • 210
    • 0035907347 scopus 로고    scopus 로고
    • Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys
    • Zhang H., Wada J., Hida K., et al,. (2001) Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J. Biol. Chem. 276, 17132-17139.
    • (2001) J. Biol. Chem. , vol.276 , pp. 17132-17139
    • Zhang, H.1    Wada, J.2    Hida, K.3
  • 211
    • 0028988801 scopus 로고
    • Beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
    • Zheng H., Jiang M., Trumbauer M. E., et al,. (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81, 525-531.
    • (1995) Cell , vol.81 , pp. 525-531
    • Zheng, H.1    Jiang, M.2    Trumbauer, M.E.3
  • 212
    • 84864389673 scopus 로고    scopus 로고
    • The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo
    • Zhou L., Barao S., Laga M., et al,. (2012) The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. J. Biol. Chem. 287, 25927-25940.
    • (2012) J. Biol. Chem. , vol.287 , pp. 25927-25940
    • Zhou, L.1    Barao, S.2    Laga, M.3
  • 213
    • 77249100811 scopus 로고    scopus 로고
    • Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I-inhibitor design and validation
    • Zhu Z., Sun Z. Y., Ye Y., et al,. (2010) Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: part I-inhibitor design and validation. J. Med. Chem. 53, 951-965.
    • (2010) J. Med. Chem. , vol.53 , pp. 951-965
    • Zhu, Z.1    Sun, Z.Y.2    Ye, Y.3


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