Function, therapeutic potential and cell biology of BACE proteases: Current status and future prospects

Journal of Neurochemistry

Volumn 130, Issue 1, 2014, Pages 4-28

  Vassar, Robert ^a   Kuhn, Peer Hendrik ^b,c,d   Haass, Christian ^b,e,f   Kennedy, Matthew E ^g,h   Rajendran, Lawrence ^h   Wong, Philip C ⁱ   Lichtenthaler, Stefan F ^b,c,d,e  

^a NORTHWESTERN UNIVERSITY   (United States)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e Munich Cluster of Systems Neurology ^*  (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

^g MERCK RESEARCH LABORATORIES   (United States)

^h UNIVERSITY OF ZURICH   (Switzerland)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; BACE1; BACE2; protease; regulated intramembrane proteolysis; secretase

Indexed keywords

5,6 DIHYDRO 2 IMINO 3 METHYL 6 [4 [5 (1 PROPYNYL) 3 PYRIDINYL] 2 THIENYL] 4 PYRIMIDINONE; AMYLOID BETA PROTEIN; AVAGACESTAT; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE 2; BETA SECRETASE INHIBITOR; LY 2811376; LY 2886721; MYELIN; NEU DIFFERENTIATION FACTOR; SEMAGACESTAT; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; SECRETASE;

ALZHEIMER DISEASE; BINDING AFFINITY; BINDING SITE; CELL MIGRATION; CELLULAR DISTRIBUTION; CLINICAL EFFECTIVENESS; DISEASE ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SUBSTRATE; HUMAN; IC 50; IN VIVO STUDY; LIVER TOXICITY; MOLECULAR PATHOLOGY; MUSCLE SPINDLE; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; FORECASTING; INTRACELLULAR FLUID; PHYSIOLOGY; PROTEIN TRANSPORT;

MUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; FORECASTING; HUMANS; INTRACELLULAR FLUID; PROTEIN TRANSPORT;

EID: 84903190262     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12715     Document Type: Review

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