Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 12, 1996, Pages 6158-6162

  Li, Zhi Wei ^a   Stark, Gerlinde ^a   Götz, Jürgen ^a   Rülicke, Thomas ^b   Müller, Ulrike ^a   Weissmann, Charles ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Cre recombination; embryonic stem cells; homologous recombination

Indexed keywords

AMYLOID PRECURSOR PROTEIN; RECOMBINASE;

ALLELE; ANIMAL CELL; ARTICLE; CELL CLONE; CHIMERA; EXPRESSION VECTOR; GENE ACTIVATION; GENE DELETION; GENETIC RECOMBINATION; GERM LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BASE SEQUENCE; DNA NUCLEOTIDYLTRANSFERASES; DNA PRIMERS; EMBRYO; GENE DELETION; INTEGRASES; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC; STEM CELLS; VIRAL PROTEINS;

EID: 0029954239     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.12.6158     Document Type: Article

References (30)

1. Brandon, E. P., Idzerda, R. L. & McKnight, G. S. (1995) Curr. Biol. 5, 873-881.
2. Capecchi, M. R. (1989) Trends Genet. 5, 70-76.
3. Li, E., Bestor, T. H. & Jaenisch, R. (1992) Cell 69, 915-926.
4. Müller, U., Cristina, N., Li, Z.-W., Wolfer, D. P., Lipp, H.-P., Rülicke, T., Brandner, S., Aguzzi, A. & Weissmann, C. (1994) Cell 79, 755-765.
5. Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A. & Breitman, M. L. (1994) Genes Dev. 8, 1897-1909.
6. Sternberg, N. & Hamilton, D. (1981) J. Mol. Biol. 150, 467-486.
7. Hoess, R. H. & Abremski, K. (1984) Proc. Natl. Acad. Sci. USA 81, 1026-1029.
8. Sauer, B. (1987) Mol. Cell. Biol. 7, 2087-2096.
9. Sauer, B. & Henderson, N. (1989) Nucleic Acids Res. 17, 147-161
10. Kühn, R., Schwenk, F., Aguet, M. & Rajewsky, K. (1995) Science 269, 1427-1429.
11. Qin, M., Bayley, C., Stockton, T. & Ow, D. W. (1994) Proc. Natl. Acad. Sci. USA 91, 1706-1710.
12. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. (1991) Cell 64, 693-702.
13. Heard, J. M., Herbomel, P., Ott, M. O., Mottura, R. A., Weiss, M. & Yaniv, M. (1987) Mol. Cell. Biol. 7, 2425-2434.
14. Mansour, S. L., Thomas, K. R. & Capecchi, M. R. (1988) Nature (London) 336, 348-352.
15. Palmiter, R. D., Behringer, R. R., Quaife, C. J., Maxwell, F., Maxwell, I. H. & Brinster, R. L. (1987) Cell 50, 435-443.
16. Kühn, R., Rajewsky, K. & Muller, W. (1991) Science 254, 707-710.
17. Stewart, C. L., Schuetze, S., Vanek, M. & Wagner, E. F. (1987) EMBO J. 6, 383-388.
18. Ruffner, H., Reis, L. F. L., Näf, D. & Weissmann, C. (1993) Proc Natl. Acad. Sci. USA 90, 11503-11507.
19. Huttner, K. M., Pudney, J., Milstone, D. S., Ladd, D. & Seidman, J. G. (1993) Biol. Reprod. 49, 251-261.
20. Braun, R. E., Lo, D., Pinkert, C. A., Widera, G., Flavell, R. A., Palmiter, R. D. & Brinster, R. L. (1990) Biol. Reprod. 43, 684-693.
21. Sauer, B. & Henderson, N. (1990) New Biol. 2, 441-449.
22. Hogan, B., Beddington, R., Costantini, F. & Lacy, E. (1994) Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
23. Reis, L. F. L., Ruffner, H., Stark, G., Aguet, M. & Weissmann, C. (1994) EMBO J. 13, 4798-4806.
24. Yang, Y.-L., Reis, L. F. L., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B. R. G., Aguet, M. & Weissmann, C. (1995) EMBO J. 14, 6095-6106.
25. Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. G., Pearson, P. L., Price, D. L. & Gearhart, J. D. (1993) Nat. Genet. 5, 22-30.
26. Zheng, H., Jiang, M., Trumbauer, M. E., Sirinathsinghji, D. J., Hopkins, R., Smith, D. W., Heavens, R. P., Dawson, G. R., Boyce, S., Conner, M. W., Stevens, K. A., Slunt, H. H., Sisodia, S. S., Chen, H. Y. & van der Ploeg, L. H. T. (1995) Cell 81, 525-531.
27. Lazar, M. A., Hodin, R. A., Darling, D. S. & Chin, W. W. (1989) Mol. Cell. Biol. 9, 1128-1136.
28. Levinson, B., Kenwrick, S., Lakich, D., Hammonds, G., Jr., & Gitschier, J. (1990) Genomics 7, 1-11.
29. Ohno, H., Goto, S., Taki, S., Shirasawa, T., Nakano, H., Miyatake, S., Aoe, T., Ishida, Y., Maeda, H., Shirai, T., Rajewsky, K. & Saito, T. (1994) EMBO J. 13, 1157-1165.
30. Ramirez-Solis, R., Liu, P. & Bradley, A. (1995) Nature (London) 378, 720-724.