Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

Journal of Cell Science

Volumn 116, Issue 16, 2003, Pages 3339-3346

  Kinoshita, Ayae ^a   Fukumoto, Hiroaki ^a   Shah, Tejal ^a   Whelan, Christa M ^a   Irizarry, Michael C ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Amyloid peptide; BACE; Co localization; Endocytosis; Fluorescence resonance energy transfer

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; MUTANT PROTEIN;

CELL SURFACE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; GENETIC TRANSFECTION; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; LYSOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; WILD TYPE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; CELLS, CULTURED; ENDOCYTOSIS; ENDOSOMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LYSOSOMES;

EID: 0042887148     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00643     Document Type: Review

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