Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2444-2449

  Cumming, Jared N ^a   Smith, Elizabeth M ^a   Wang, Lingyan ^a   Misiaszek, Jeffrey ^a   Durkin, James ^a   Pan, Jianping ^a   Iserloh, Ulrich ^a   Wu, Yusheng ^a   Zhu, Zhaoning ^a   Strickland, Corey ^a   Voigt, Johannes ^a   Chen, Xia ^a   Kennedy, Matthew E ^a   Kuvelkar, Reshma ^a   Hyde, Lynn A ^a   Cox, Kathleen ^a   Favreau, Leonard ^a   Czarniecki, Michael F ^a   Greenlee, William J ^a   McKittrick, Brian A ^a   Parker, Eric M ^a   Stamford, Andrew W ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Secretase; Alzheimer s disease; BACE; Iminohydantoin; In vivo

Indexed keywords

ASPARTIC PROTEINASE INHIBITOR; BETA SECRETASE 1; HYDANTOIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTICONVULSANTS; ASPARTIC ACID ENDOPEPTIDASES; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDANTOINS; MODELS, MOLECULAR; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84862777524     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.013     Document Type: Article

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