-
1
-
-
33847724188
-
The amyloid precursor protein: Beyond amyloid
-
Zheng H, Koo EH (2006) The amyloid precursor protein: Beyond amyloid. Mol Neurodegener 1:5.
-
(2006)
Mol Neurodegener
, vol.1
, pp. 5
-
-
Zheng, H.1
Koo, E.H.2
-
2
-
-
0042634362
-
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
-
Turner PR, O'Connor K, Tate WP, Abraham WC (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1-32.
-
(2003)
Prog Neurobiol
, vol.70
, pp. 1-32
-
-
Turner, P.R.1
O'Connor, K.2
Tate, W.P.3
Abraham, W.C.4
-
3
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DDM, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-989.
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'Leary, D.D.M.3
Tessier-Lavigne, M.4
-
4
-
-
0035816661
-
A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Südhof TC (2001) A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293:115-120.
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Südhof, T.C.2
-
5
-
-
2642582435
-
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
-
Cao X, Südhof TC (2004) Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem 279:24601-24611.
-
(2004)
J Biol Chem
, vol.279
, pp. 24601-24611
-
-
Cao, X.1
Südhof, T.C.2
-
6
-
-
0037067655
-
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein
-
Baek SH, et al. (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110:55-67.
-
(2002)
Cell
, vol.110
, pp. 55-67
-
-
Baek, S.H.1
-
7
-
-
33845324145
-
C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression
-
Kim HS, et al. (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J 17:1951-1953.
-
(2003)
FASEB J
, vol.17
, pp. 1951-1953
-
-
Kim, H.S.1
-
8
-
-
20444398562
-
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP
-
Pardossi-Piquard R, et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46:541-554.
-
(2005)
Neuron
, vol.46
, pp. 541-554
-
-
Pardossi-Piquard, R.1
-
9
-
-
34547539177
-
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
-
Zhang YW, et al. (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci USA 104:10613-10618.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10613-10618
-
-
Zhang, Y.W.1
-
10
-
-
34748897213
-
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
-
Liu Q, et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56:66-78.
-
(2007)
Neuron
, vol.56
, pp. 66-78
-
-
Liu, Q.1
-
11
-
-
5444275067
-
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
-
von Rotz RC, et al. (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci 117:4435-4448.
-
(2004)
J Cell Sci
, vol.117
, pp. 4435-4448
-
-
Von Rotz, R.C.1
-
12
-
-
33645218231
-
A dominant role for FE65 (APBB1) in nuclear signaling
-
Yang Z, Cool BH, Martin GM, Hu Q (2006) A dominant role for FE65 (APBB1) in nuclear signaling. J Biol Chem 281:4207-4214.
-
(2006)
J Biol Chem
, vol.281
, pp. 4207-4214
-
-
Yang, Z.1
Cool, B.H.2
Martin, G.M.3
Hu, Q.4
-
13
-
-
33745584643
-
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
-
Hebert SS, et al. (2006) Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep 7:739-745.
-
(2006)
EMBO Rep
, vol.7
, pp. 739-745
-
-
Hebert, S.S.1
-
14
-
-
33846807664
-
Response to: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP." Neuron 46:541-554
-
Chen AC, Selkoe DJ (2007) Response to: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP." Neuron 46:541-554. Neuron 53:479-483.
-
(2007)
Neuron
, vol.53
, pp. 479-483
-
-
Chen, A.C.1
Selkoe, D.J.2
-
15
-
-
35748940970
-
Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway
-
Repetto E, Yoon IS, Zheng H, Kang DE (2007) Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem 282:31504-31516.
-
(2007)
J Biol Chem
, vol.282
, pp. 31504-31516
-
-
Repetto, E.1
Yoon, I.S.2
Zheng, H.3
Kang, D.E.4
-
16
-
-
58149345003
-
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis
-
Tamboli IY, et al. (2008) Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci 28:12097-12106.
-
(2008)
J Neurosci
, vol.28
, pp. 12097-12106
-
-
Tamboli, I.Y.1
-
17
-
-
52049112089
-
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role
-
Giliberto L, et al. (2008) Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Mol Neurodegener 3:12.
-
(2008)
Mol Neurodegener
, vol.3
, pp. 12
-
-
Giliberto, L.1
-
18
-
-
0028988801
-
Beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, et al. (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-531.
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
-
19
-
-
0033017690
-
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein
-
Dawson GR, et al. (1999) Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience 90:1-13.
-
(1999)
Neuroscience
, vol.90
, pp. 1-13
-
-
Dawson, G.R.1
-
20
-
-
0031470093
-
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice
-
von Koch CS, et al. (1997) Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging 18:661-669.
-
(1997)
Neurobiol Aging
, vol.18
, pp. 661-669
-
-
Von Koch, C.S.1
-
21
-
-
13944274830
-
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2
-
DOI 10.1523/JNEUROSCI.4660-04.2005
-
Wang P, et al. (2005) Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci 25:1219-1225. (Pubitemid 40268964)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.5
, pp. 1219-1225
-
-
Wang, P.1
Yang, G.2
Mosier, D.R.3
Chang, P.4
Zaidi, T.5
Gong, Y.-D.6
Zhao, N.-M.7
Dominguez, B.8
Lee, K.-F.9
Gan, W.-B.10
Zheng, H.11
-
22
-
-
0345743462
-
Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?
-
King GD, Scott Turner R (2004) Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? Exp Neurol 185:208-219.
-
(2004)
Exp Neurol
, vol.185
, pp. 208-219
-
-
King, G.D.1
Scott Turner, R.2
-
23
-
-
34447640166
-
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
Ring S, et al. (2007) The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817-7826.
-
(2007)
J Neurosci
, vol.27
, pp. 7817-7826
-
-
Ring, S.1
-
24
-
-
33846923049
-
APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability
-
Hornsten A, et al. (2007) APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. Proc Natl Acad Sci USA 104:1971-1976.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1971-1976
-
-
Hornsten, A.1
-
25
-
-
0029950149
-
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
-
Koo EH, Squazzo SL, Selkoe DJ, Koo CH (1996) Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci 109:991-998.
-
(1996)
J Cell Sci
, vol.109
, pp. 991-998
-
-
Koo, E.H.1
Squazzo, S.L.2
Selkoe, D.J.3
Koo, C.H.4
-
26
-
-
69749115919
-
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
-
Wang Z, et al. (2009) Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci 29:10788-10801.
-
(2009)
J Neurosci
, vol.29
, pp. 10788-10801
-
-
Wang, Z.1
-
27
-
-
34548301693
-
Beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment
-
Back S, et al. (2007) beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res 85:2580-2590.
-
(2007)
J Neurosci Res
, vol.85
, pp. 2580-2590
-
-
Back, S.1
-
28
-
-
0036759157
-
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways
-
Stein TD, Johnson JA (2002) Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J Neurosci 22:7380-7388.
-
(2002)
J Neurosci
, vol.22
, pp. 7380-7388
-
-
Stein, T.D.1
Johnson, J.A.2
-
29
-
-
31844453586
-
Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease
-
Wu ZL, et al. (2006) Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease. Neurobiol Aging 27:377-386.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 377-386
-
-
Wu, Z.L.1
-
30
-
-
33746042956
-
Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency
-
Liao L, et al. (2006) Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology 147:3877-3888.
-
(2006)
Endocrinology
, vol.147
, pp. 3877-3888
-
-
Liao, L.1
-
31
-
-
8144230876
-
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
-
Herms J, et al. (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J 23:4106-4115.
-
(2004)
EMBO J
, vol.23
, pp. 4106-4115
-
-
Herms, J.1
-
32
-
-
77957254613
-
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
-
10.1074/jbc.M110.137729
-
Li H, et al. (2010) Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem, 10.1074/jbc.M110.137729.
-
(2010)
J Biol Chem
-
-
Li, H.1
-
33
-
-
0036468435
-
Biomedicine. A cargo receptor mystery APParently solved?
-
Sisodia SS (2002) Biomedicine. A cargo receptor mystery APParently solved? Science 295:805-807.
-
(2002)
Science
, vol.295
, pp. 805-807
-
-
Sisodia, S.S.1
-
34
-
-
0029128232
-
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation
-
Kounnas MZ, et al. (1995) LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82:331-340.
-
(1995)
Cell
, vol.82
, pp. 331-340
-
-
Kounnas, M.Z.1
-
35
-
-
0035903204
-
Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor
-
Santiago-García J, Mas-Oliva J, Innerarity TL, Pitas RE (2001) Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor. J Biol Chem 276:30655-30661.
-
(2001)
J Biol Chem
, vol.276
, pp. 30655-30661
-
-
Santiago-García, J.1
Mas-Oliva, J.2
Innerarity, T.L.3
Pitas, R.E.4
-
36
-
-
2542519087
-
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
-
Caille I, et al. (2004) Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131:2173-2181.
-
(2004)
Development
, vol.131
, pp. 2173-2181
-
-
Caille, I.1
-
37
-
-
46149126877
-
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
-
Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ (2008) Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Develop 3:15.
-
(2008)
Neural Develop
, vol.3
, pp. 15
-
-
Young-Pearse, T.L.1
Chen, A.C.2
Chang, R.3
Marquez, C.4
Selkoe, D.J.5
-
38
-
-
67349109401
-
Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production
-
Lourenço FC, et al. (2009) Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell Death Differ 16:655-663.
-
(2009)
Cell Death Differ
, vol.16
, pp. 655-663
-
-
Lourenço, F.C.1
-
39
-
-
67049167155
-
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth
-
Hoe HS, et al. (2009) Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci 29:7459-7473.
-
(2009)
J Neurosci
, vol.29
, pp. 7459-7473
-
-
Hoe, H.S.1
-
40
-
-
0027999030
-
Transthyretin sequesters amyloid beta protein and prevents amyloid formation
-
Schwarzman AL, et al. (1994) Transthyretin sequesters amyloid beta protein and prevents amyloid formation. Proc Natl Acad Sci USA 91:8368-8372.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8368-8372
-
-
Schwarzman, A.L.1
-
41
-
-
34347364708
-
Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin)
-
Choi SH, et al. (2007) Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci 27:7006-7010.
-
(2007)
J Neurosci
, vol.27
, pp. 7006-7010
-
-
Choi, S.H.1
-
42
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51.
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-o, M.1
-
43
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H, et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309:1829-1833.
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
-
44
-
-
34250803923
-
Alpha-Klotho as a regulator of calcium homeostasis
-
Imura A, et al. (2007) alpha-Klotho as a regulator of calcium homeostasis. Science 316:1615-1618.
-
(2007)
Science
, vol.316
, pp. 1615-1618
-
-
Imura, A.1
-
45
-
-
40649096849
-
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity
-
Buxbaum JN, et al. (2008) Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity. Proc Natl Acad Sci USA 105:2681-2686.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2681-2686
-
-
Buxbaum, J.N.1
-
47
-
-
18844466386
-
Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: Relation with the senile plaques and cytoskeleton biochemistry
-
Merched A, et al. (1998) Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: Relation with the senile plaques and cytoskeleton biochemistry. FEBS Lett 425:225-228.
-
(1998)
FEBS Lett
, vol.425
, pp. 225-228
-
-
Merched, A.1
-
48
-
-
0025302430
-
Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: Alterations in normal aging and in Alzheimer's disease
-
Palmert MR, et al. (1990) Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: Alterations in normal aging and in Alzheimer's disease. Neurology 40:1028-1034.
-
(1990)
Neurology
, vol.40
, pp. 1028-1034
-
-
Palmert, M.R.1
-
49
-
-
35348889638
-
Amyloid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
-
Wang B, Yang L, Wang Z, Zheng H (2007) Amyloid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc Natl Acad Sci USA 104:14140-14145.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14140-14145
-
-
Wang, B.1
Yang, L.2
Wang, Z.3
Zheng, H.4
-
50
-
-
0032842478
-
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
-
Tronche F, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103.
-
(1999)
Nat Genet
, vol.23
, pp. 99-103
-
-
Tronche, F.1
|