-
1
-
-
26444607532
-
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
-
Andersen O.M., Reiche J., Schmidt V., Gotthardt M., Spoelgen R., Behlke J., von Arnim C.A., Breiderhoff T., Jansen P., Wu X., et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 2005, 102:13461-13466.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13461-13466
-
-
Andersen, O.M.1
Reiche, J.2
Schmidt, V.3
Gotthardt, M.4
Spoelgen, R.5
Behlke, J.6
von Arnim, C.A.7
Breiderhoff, T.8
Jansen, P.9
Wu, X.10
-
2
-
-
0036441486
-
A cell biological perspective on Alzheimer's disease
-
Annaert W., De Strooper B. A cell biological perspective on Alzheimer's disease. Annu. Rev. Cell Dev. Biol. 2002, 18:25-51.
-
(2002)
Annu. Rev. Cell Dev. Biol.
, vol.18
, pp. 25-51
-
-
Annaert, W.1
De Strooper, B.2
-
4
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio invitro and invivo
-
Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio invitro and invivo. Neuron 1996, 17:1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
-
5
-
-
84890894103
-
A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production
-
this issue
-
Buggia-Prévot V., Fernandez C.G., Udayar V., Vetrivel K.S., Elie A., Roseman J., Sasse V.A., Lefkow M., Meckler X., Bhattacharyya S., et al. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Rep. 2013, 5:1552-1563. this issue.
-
(2013)
Cell Rep.
, vol.5
, pp. 1552-1563
-
-
Buggia-Prévot, V.1
Fernandez, C.G.2
Udayar, V.3
Vetrivel, K.S.4
Elie, A.5
Roseman, J.6
Sasse, V.A.7
Lefkow, M.8
Meckler, X.9
Bhattacharyya, S.10
-
6
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
-
Cataldo A.M., Peterhoff C.M., Troncoso J.C., Gomez-Isla T., Hyman B.T., Nixon R.A. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am. J. Pathol. 2000, 157:277-286.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 277-286
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Troncoso, J.C.3
Gomez-Isla, T.4
Hyman, B.T.5
Nixon, R.A.6
-
7
-
-
0036083829
-
Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells
-
Choudhury A., Dominguez M., Puri V., Sharma D.K., Narita K., Wheatley C.L., Marks D.L., Pagano R.E. Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. J.Clin. Invest. 2002, 109:1541-1550.
-
(2002)
J.Clin. Invest.
, vol.109
, pp. 1541-1550
-
-
Choudhury, A.1
Dominguez, M.2
Puri, V.3
Sharma, D.K.4
Narita, K.5
Wheatley, C.L.6
Marks, D.L.7
Pagano, R.E.8
-
8
-
-
84864359816
-
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network
-
Choy R.W., Cheng Z., Schekman R. Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network. Proc. Natl. Acad. Sci. USA 2012, 109:E2077-E2082.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
-
-
Choy, R.W.1
Cheng, Z.2
Schekman, R.3
-
9
-
-
0345803941
-
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface
-
Chyung J.H., Selkoe D.J. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J.Biol. Chem. 2003, 278:51035-51043.
-
(2003)
J.Biol. Chem.
, vol.278
, pp. 51035-51043
-
-
Chyung, J.H.1
Selkoe, D.J.2
-
10
-
-
84881496428
-
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway
-
Das U., Scott D.A., Ganguly A., Koo E.H., Tang Y., Roy S. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 2013, 79:447-460.
-
(2013)
Neuron
, vol.79
, pp. 447-460
-
-
Das, U.1
Scott, D.A.2
Ganguly, A.3
Koo, E.H.4
Tang, Y.5
Roy, S.6
-
11
-
-
77951060145
-
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process
-
De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol. Rev. 2010, 90:465-494.
-
(2010)
Physiol. Rev.
, vol.90
, pp. 465-494
-
-
De Strooper, B.1
-
12
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 1996, 383:710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
-
13
-
-
0032787598
-
Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport
-
Dumanchin C., Czech C., Campion D., Cuif M.H., Poyot T., Martin C., Charbonnier F., Goud B., Pradier L., Frebourg T. Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum. Mol. Genet. 1999, 8:1263-1269.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1263-1269
-
-
Dumanchin, C.1
Czech, C.2
Campion, D.3
Cuif, M.H.4
Poyot, T.5
Martin, C.6
Charbonnier, F.7
Goud, B.8
Pradier, L.9
Frebourg, T.10
-
14
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
-
Ehehalt R., Keller P., Haass C., Thiele C., Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J.Cell Biol. 2003, 160:113-123.
-
(2003)
J.Cell Biol.
, vol.160
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
15
-
-
84856119703
-
Illuminating the functional and structural repertoire of human TBC/RABGAPs
-
Frasa M.A., Koessmeier K.T., Ahmadian M.R., Braga V.M. Illuminating the functional and structural repertoire of human TBC/RABGAPs. Nat. Rev. Mol. Cell Biol. 2012, 13:67-73.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 67-73
-
-
Frasa, M.A.1
Koessmeier, K.T.2
Ahmadian, M.R.3
Braga, V.M.4
-
16
-
-
79958805180
-
Revised criteria for Alzheimer's disease: what are the lessons for clinicians?
-
Frisoni G.B., Hampel H., O'Brien J.T., Ritchie K., Winblad B. Revised criteria for Alzheimer's disease: what are the lessons for clinicians?. Lancet Neurol. 2011, 10:598-601.
-
(2011)
Lancet Neurol.
, vol.10
, pp. 598-601
-
-
Frisoni, G.B.1
Hampel, H.2
O'Brien, J.T.3
Ritchie, K.4
Winblad, B.5
-
17
-
-
0033836520
-
The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components
-
Gagescu R., Demaurex N., Parton R.G., Hunziker W., Huber L.A., Gruenberg J. The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components. Mol. Biol. Cell 2000, 11:2775-2791.
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 2775-2791
-
-
Gagescu, R.1
Demaurex, N.2
Parton, R.G.3
Hunziker, W.4
Huber, L.A.5
Gruenberg, J.6
-
18
-
-
84871880234
-
SnapShot: mammalian Rab proteins in endocytic trafficking
-
Galvez T., Gilleron J., Zerial M., O'Sullivan G.A. SnapShot: mammalian Rab proteins in endocytic trafficking. Cell 2012, 151:234-234.e232.
-
(2012)
Cell
, vol.151
-
-
Galvez, T.1
Gilleron, J.2
Zerial, M.3
O'Sullivan, G.A.4
-
19
-
-
0026735070
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
-
Haass C., Koo E.H., Mellon A., Hung A.Y., Selkoe D.J. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 1992, 357:500-503.
-
(1992)
Nature
, vol.357
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
20
-
-
15744380393
-
GGA proteins mediate the recycling pathway of memapsin 2 (BACE)
-
He X., Li F., Chang W.P., Tang J. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J.Biol. Chem. 2005, 280:11696-11703.
-
(2005)
J.Biol. Chem.
, vol.280
, pp. 11696-11703
-
-
He, X.1
Li, F.2
Chang, W.P.3
Tang, J.4
-
21
-
-
77951183654
-
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C
-
Hsu C., Morohashi Y., Yoshimura S., Manrique-Hoyos N., Jung S., Lauterbach M.A., Bakhti M., Grønborg M., Möbius W., Rhee J., et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J.Cell Biol. 2010, 189:223-232.
-
(2010)
J.Cell Biol.
, vol.189
, pp. 223-232
-
-
Hsu, C.1
Morohashi, Y.2
Yoshimura, S.3
Manrique-Hoyos, N.4
Jung, S.5
Lauterbach, M.A.6
Bakhti, M.7
Grønborg, M.8
Möbius, W.9
Rhee, J.10
-
22
-
-
84863337843
-
Alzheimer mechanisms and therapeutic strategies
-
Huang Y., Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012, 148:1204-1222.
-
(2012)
Cell
, vol.148
, pp. 1204-1222
-
-
Huang, Y.1
Mucke, L.2
-
23
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T., Atwal J.K., Steinberg S., Snaedal J., Jonsson P.V., Bjornsson S., Stefansson H., Sulem P., Gudbjartsson D., Maloney J., et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012, 488:96-99.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
Snaedal, J.4
Jonsson, P.V.5
Bjornsson, S.6
Stefansson, H.7
Sulem, P.8
Gudbjartsson, D.9
Maloney, J.10
-
24
-
-
33644862462
-
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
-
Kaether C., Schmitt S., Willem M., Haass C. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 2006, 7:408-415.
-
(2006)
Traffic
, vol.7
, pp. 408-415
-
-
Kaether, C.1
Schmitt, S.2
Willem, M.3
Haass, C.4
-
25
-
-
27744501797
-
Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids invitro
-
Kalvodova L., Kahya N., Schwille P., Ehehalt R., Verkade P., Drechsel D., Simons K. Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids invitro. J.Biol. Chem. 2005, 280:36815-36823.
-
(2005)
J.Biol. Chem.
, vol.280
, pp. 36815-36823
-
-
Kalvodova, L.1
Kahya, N.2
Schwille, P.3
Ehehalt, R.4
Verkade, P.5
Drechsel, D.6
Simons, K.7
-
26
-
-
0344873113
-
Mutant presenilin (A260V) affects Rab8 in PC12D cell
-
Kametani F., Usami M., Tanaka K., Kume H., Mori H. Mutant presenilin (A260V) affects Rab8 in PC12D cell. Neurochem. Int. 2004, 44:313-320.
-
(2004)
Neurochem. Int.
, vol.44
, pp. 313-320
-
-
Kametani, F.1
Usami, M.2
Tanaka, K.3
Kume, H.4
Mori, H.5
-
27
-
-
0042887148
-
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
-
Kinoshita A., Fukumoto H., Shah T., Whelan C.M., Irizarry M.C., Hyman B.T. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J.Cell Sci. 2003, 116:3339-3346.
-
(2003)
J.Cell Sci.
, vol.116
, pp. 3339-3346
-
-
Kinoshita, A.1
Fukumoto, H.2
Shah, T.3
Whelan, C.M.4
Irizarry, M.C.5
Hyman, B.T.6
-
28
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo E.H., Squazzo S.L. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J.Biol. Chem. 1994, 269:17386-17389.
-
(1994)
J.Biol. Chem.
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
29
-
-
84865104488
-
Evi5 promotes collective cell migration through its Rab-GAP activity
-
Laflamme C., Assaker G., Ramel D., Dorn J.F., She D., Maddox P.S., Emery G. Evi5 promotes collective cell migration through its Rab-GAP activity. J.Cell Biol. 2012, 198:57-67.
-
(2012)
J.Cell Biol.
, vol.198
, pp. 57-67
-
-
Laflamme, C.1
Assaker, G.2
Ramel, D.3
Dorn, J.F.4
She, D.5
Maddox, P.S.6
Emery, G.7
-
30
-
-
78650166808
-
α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
-
Lichtenthaler S.F. α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential. J.Neurochem. 2011, 116:10-21.
-
(2011)
J.Neurochem.
, vol.116
, pp. 10-21
-
-
Lichtenthaler, S.F.1
-
31
-
-
0037178832
-
Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain
-
Lindsay A.J., McCaffrey M.W. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. J.Biol. Chem. 2002, 277:27193-27199.
-
(2002)
J.Biol. Chem.
, vol.277
, pp. 27193-27199
-
-
Lindsay, A.J.1
McCaffrey, M.W.2
-
32
-
-
84862611041
-
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
-
Longatti A., Lamb C.A., Razi M., Yoshimura S., Barr F.A., Tooze S.A. TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J.Cell Biol. 2012, 197:659-675.
-
(2012)
J.Cell Biol.
, vol.197
, pp. 659-675
-
-
Longatti, A.1
Lamb, C.A.2
Razi, M.3
Yoshimura, S.4
Barr, F.A.5
Tooze, S.A.6
-
33
-
-
0023506243
-
Endosome acidification and the pathways of receptor-mediated endocytosis
-
Maxfield F.R., Yamashiro D.J. Endosome acidification and the pathways of receptor-mediated endocytosis. Adv. Exp. Med. Biol. 1987, 225:189-198.
-
(1987)
Adv. Exp. Med. Biol.
, vol.225
, pp. 189-198
-
-
Maxfield, F.R.1
Yamashiro, D.J.2
-
34
-
-
84881324927
-
Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
-
Morel E., Chamoun Z., Lasiecka Z.M., Chan R.B., Williamson R.L., Vetanovetz C., Dall'Armi C., Simoes S., Point Du Jour K.S., McCabe B.D., et al. Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat. Commun. 2013, 4:2250.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2250
-
-
Morel, E.1
Chamoun, Z.2
Lasiecka, Z.M.3
Chan, R.B.4
Williamson, R.L.5
Vetanovetz, C.6
Dall'Armi, C.7
Simoes, S.8
Point Du Jour, K.S.9
McCabe, B.D.10
-
35
-
-
0027421610
-
Receptor-coupled amyloid precursor protein processing
-
Nitsch R.M., Slack B.E., Farber S.A., Borghesani P.R., Schulz J.G., Kim C., Felder C.C., Growdon J.H., Wurtman R.J. Receptor-coupled amyloid precursor protein processing. Ann. N Y Acad. Sci. 1993, 695:122-127.
-
(1993)
Ann. N Y Acad. Sci.
, vol.695
, pp. 122-127
-
-
Nitsch, R.M.1
Slack, B.E.2
Farber, S.A.3
Borghesani, P.R.4
Schulz, J.G.5
Kim, C.6
Felder, C.C.7
Growdon, J.H.8
Wurtman, R.J.9
-
36
-
-
84863749351
-
Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
-
Onodera Y., Nam J.M., Hashimoto A., Norman J.C., Shirato H., Hashimoto S., Sabe H. Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion. J.Cell Biol. 2012, 197:983-996.
-
(2012)
J.Cell Biol.
, vol.197
, pp. 983-996
-
-
Onodera, Y.1
Nam, J.M.2
Hashimoto, A.3
Norman, J.C.4
Shirato, H.5
Hashimoto, S.6
Sabe, H.7
-
37
-
-
79953136097
-
Rab27a and Rab27b control different steps of the exosome secretion pathway
-
Ostrowski M., Carmo N.B., Krumeich S., Fanget I., Raposo G., Savina A., Moita C.F., Schauer K., Hume A.N., Freitas R.P., et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 2010, 12:19-30.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 19-30
-
-
Ostrowski, M.1
Carmo, N.B.2
Krumeich, S.3
Fanget, I.4
Raposo, G.5
Savina, A.6
Moita, C.F.7
Schauer, K.8
Hume, A.N.9
Freitas, R.P.10
-
38
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
-
Perez R.G., Soriano S., Hayes J.D., Ostaszewski B., Xia W., Selkoe D.J., Chen X., Stokin G.B., Koo E.H. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J.Biol. Chem. 1999, 274:18851-18856.
-
(1999)
J.Biol. Chem.
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
Ostaszewski, B.4
Xia, W.5
Selkoe, D.J.6
Chen, X.7
Stokin, G.B.8
Koo, E.H.9
-
39
-
-
8444243363
-
Targeting Rab GTPases to distinct membrane compartments
-
Pfeffer S., Aivazian D. Targeting Rab GTPases to distinct membrane compartments. Nat. Rev. Mol. Cell Biol. 2004, 5:886-896.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 886-896
-
-
Pfeffer, S.1
Aivazian, D.2
-
40
-
-
84862549612
-
Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing
-
Prabhu Y., Burgos P.V., Schindler C., Farías G.G., Magadán J.G., Bonifacino J.S. Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing. Mol. Biol. Cell 2012, 23:2339-2351.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2339-2351
-
-
Prabhu, Y.1
Burgos, P.V.2
Schindler, C.3
Farías, G.G.4
Magadán, J.G.5
Bonifacino, J.S.6
-
41
-
-
84860919373
-
Membrane trafficking pathways in Alzheimer's disease
-
Rajendran L., Annaert W. Membrane trafficking pathways in Alzheimer's disease. Traffic 2012, 13:759-770.
-
(2012)
Traffic
, vol.13
, pp. 759-770
-
-
Rajendran, L.1
Annaert, W.2
-
42
-
-
33746593662
-
Alzheimer's disease beta-amyloid peptides are released in association with exosomes
-
Rajendran L., Honsho M., Zahn T.R., Keller P., Geiger K.D., Verkade P., Simons K. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. USA 2006, 103:11172-11177.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
Simons, K.7
-
43
-
-
42549148456
-
Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting
-
Rajendran L., Schneider A., Schlechtingen G., Weidlich S., Ries J., Braxmeier T., Schwille P., Schulz J.B., Schroeder C., Simons M., et al. Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting. Science 2008, 320:520-523.
-
(2008)
Science
, vol.320
, pp. 520-523
-
-
Rajendran, L.1
Schneider, A.2
Schlechtingen, G.3
Weidlich, S.4
Ries, J.5
Braxmeier, T.6
Schwille, P.7
Schulz, J.B.8
Schroeder, C.9
Simons, M.10
-
44
-
-
0032568657
-
Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes
-
Ren M., Xu G., Zeng J., De Lemos-Chiarandini C., Adesnik M., Sabatini D.D. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc. Natl. Acad. Sci. USA 1998, 95:6187-6192.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6187-6192
-
-
Ren, M.1
Xu, G.2
Zeng, J.3
De Lemos-Chiarandini, C.4
Adesnik, M.5
Sabatini, D.D.6
-
45
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva E., Meng Y., Lee J.H., Gu Y., Kawarai T., Zou F., Katayama T., Baldwin C.T., Cheng R., Hasegawa H., et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 2007, 39:168-177.
-
(2007)
Nat. Genet.
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
Gu, Y.4
Kawarai, T.5
Zou, F.6
Katayama, T.7
Baldwin, C.T.8
Cheng, R.9
Hasegawa, H.10
-
46
-
-
80052149544
-
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
-
Sannerud R., Declerck I., Peric A., Raemaekers T., Menendez G., Zhou L., Veerle B., Coen K., Munck S., De Strooper B., et al. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc. Natl. Acad. Sci. USA 2011, 108:E559-E568.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
-
-
Sannerud, R.1
Declerck, I.2
Peric, A.3
Raemaekers, T.4
Menendez, G.5
Zhou, L.6
Veerle, B.7
Coen, K.8
Munck, S.9
De Strooper, B.10
-
47
-
-
2942737775
-
A complete genetic analysis of neuronal Rab3 function
-
Schlüter O.M., Schmitz F., Jahn R., Rosenmund C., Südhof T.C. A complete genetic analysis of neuronal Rab3 function. J.Neurosci. 2004, 24:6629-6637.
-
(2004)
J.Neurosci.
, vol.24
, pp. 6629-6637
-
-
Schlüter, O.M.1
Schmitz, F.2
Jahn, R.3
Rosenmund, C.4
Südhof, T.C.5
-
48
-
-
34249819046
-
Recycling endosomes in neuronal membrane traffic
-
Schmidt M.R., Haucke V. Recycling endosomes in neuronal membrane traffic. Biol. Cell 2007, 99:333-342.
-
(2007)
Biol. Cell
, vol.99
, pp. 333-342
-
-
Schmidt, M.R.1
Haucke, V.2
-
49
-
-
40849097929
-
Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons
-
Schneider A., Rajendran L., Honsho M., Gralle M., Donnert G., Wouters F., Hell S.W., Simons M. Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J.Neurosci. 2008, 28:2874-2882.
-
(2008)
J.Neurosci.
, vol.28
, pp. 2874-2882
-
-
Schneider, A.1
Rajendran, L.2
Honsho, M.3
Gralle, M.4
Donnert, G.5
Wouters, F.6
Hell, S.W.7
Simons, M.8
-
50
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
Schuldiner M., Collins S.R., Thompson N.J., Denic V., Bhamidipati A., Punna T., Ihmels J., Andrews B., Boone C., Greenblatt J.F., et al. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 2005, 123:507-519.
-
(2005)
Cell
, vol.123
, pp. 507-519
-
-
Schuldiner, M.1
Collins, S.R.2
Thompson, N.J.3
Denic, V.4
Bhamidipati, A.5
Punna, T.6
Ihmels, J.7
Andrews, B.8
Boone, C.9
Greenblatt, J.F.10
-
51
-
-
0036137684
-
Rab GTPases, intracellular traffic and disease
-
Seabra M.C., Mules E.H., Hume A.N. Rab GTPases, intracellular traffic and disease. Trends Mol. Med. 2002, 8:23-30.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 23-30
-
-
Seabra, M.C.1
Mules, E.H.2
Hume, A.N.3
-
53
-
-
80052501210
-
Resolving controversies on the path to Alzheimer's therapeutics
-
Selkoe D.J. Resolving controversies on the path to Alzheimer's therapeutics. Nat. Med. 2011, 17:1060-1065.
-
(2011)
Nat. Med.
, vol.17
, pp. 1060-1065
-
-
Selkoe, D.J.1
-
54
-
-
35348860241
-
Presenilin: running with scissors in the membrane
-
Selkoe D.J., Wolfe M.S. Presenilin: running with scissors in the membrane. Cell 2007, 131:215-221.
-
(2007)
Cell
, vol.131
, pp. 215-221
-
-
Selkoe, D.J.1
Wolfe, M.S.2
-
55
-
-
33750365184
-
Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1
-
Shiba T., Koga H., Shin H.W., Kawasaki M., Kato R., Nakayama K., Wakatsuki S. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc. Natl. Acad. Sci. USA 2006, 103:15416-15421.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 15416-15421
-
-
Shiba, T.1
Koga, H.2
Shin, H.W.3
Kawasaki, M.4
Kato, R.5
Nakayama, K.6
Wakatsuki, S.7
-
57
-
-
33749042749
-
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis
-
Small S.A., Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 2006, 52:15-31.
-
(2006)
Neuron
, vol.52
, pp. 15-31
-
-
Small, S.A.1
Gandy, S.2
-
58
-
-
27744576858
-
Model-guided microarray implicates the retromer complex in Alzheimer's disease
-
Small S.A., Kent K., Pierce A., Leung C., Kang M.S., Okada H., Honig L., Vonsattel J.P., Kim T.W. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann. Neurol. 2005, 58:909-919.
-
(2005)
Ann. Neurol.
, vol.58
, pp. 909-919
-
-
Small, S.A.1
Kent, K.2
Pierce, A.3
Leung, C.4
Kang, M.S.5
Okada, H.6
Honig, L.7
Vonsattel, J.P.8
Kim, T.W.9
-
59
-
-
0242446165
-
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11
-
Sönnichsen B., De Renzis S., Nielsen E., Rietdorf J., Zerial M. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11. J.Cell Biol. 2000, 149:901-914.
-
(2000)
J.Cell Biol.
, vol.149
, pp. 901-914
-
-
Sönnichsen, B.1
De Renzis, S.2
Nielsen, E.3
Rietdorf, J.4
Zerial, M.5
-
60
-
-
40949159198
-
Building gamma-secretase: the bits and pieces
-
Spasic D., Annaert W. Building gamma-secretase: the bits and pieces. J.Cell Sci. 2008, 121:413-420.
-
(2008)
J.Cell Sci.
, vol.121
, pp. 413-420
-
-
Spasic, D.1
Annaert, W.2
-
62
-
-
70949085531
-
APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle
-
Szodorai A., Kuan Y.H., Hunzelmann S., Engel U., Sakane A., Sasaki T., Takai Y., Kirsch J., Müller U., Beyreuther K., et al. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J.Neurosci. 2009, 29:14534-14544.
-
(2009)
J.Neurosci.
, vol.29
, pp. 14534-14544
-
-
Szodorai, A.1
Kuan, Y.H.2
Hunzelmann, S.3
Engel, U.4
Sakane, A.5
Sasaki, T.6
Takai, Y.7
Kirsch, J.8
Müller, U.9
Beyreuther, K.10
-
63
-
-
34249734831
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
-
Tesco G., Koh Y.H., Kang E.L., Cameron A.N., Das S., Sena-Esteves M., Hiltunen M., Yang S.H., Zhong Z., Shen Y., et al. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 2007, 54:721-737.
-
(2007)
Neuron
, vol.54
, pp. 721-737
-
-
Tesco, G.1
Koh, Y.H.2
Kang, E.L.3
Cameron, A.N.4
Das, S.5
Sena-Esteves, M.6
Hiltunen, M.7
Yang, S.H.8
Zhong, Z.9
Shen, Y.10
-
64
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran G., Koo E.H. Amyloid precursor protein trafficking, processing, and function. J.Biol. Chem. 2008, 283:29615-29619.
-
(2008)
J.Biol. Chem.
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
65
-
-
0346732291
-
Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation
-
Tisdale E.J. Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. J.Biol. Chem. 2003, 278:52524-52530.
-
(2003)
J.Biol. Chem.
, vol.278
, pp. 52524-52530
-
-
Tisdale, E.J.1
-
66
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
-
67
-
-
70350455062
-
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential
-
Vassar R., Kovacs D.M., Yan R., Wong P.C. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J.Neurosci. 2009, 29:12787-12794.
-
(2009)
J.Neurosci.
, vol.29
, pp. 12787-12794
-
-
Vassar, R.1
Kovacs, D.M.2
Yan, R.3
Wong, P.C.4
-
68
-
-
33749176134
-
GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing
-
von Arnim C.A., Spoelgen R., Peltan I.D., Deng M., Courchesne S., Koker M., Matsui T., Kowa H., Lichtenthaler S.F., Irizarry M.C., Hyman B.T. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J.Neurosci. 2006, 26:9913-9922.
-
(2006)
J.Neurosci.
, vol.26
, pp. 9913-9922
-
-
von Arnim, C.A.1
Spoelgen, R.2
Peltan, I.D.3
Deng, M.4
Courchesne, S.5
Koker, M.6
Matsui, T.7
Kowa, H.8
Lichtenthaler, S.F.9
Irizarry, M.C.10
Hyman, B.T.11
-
69
-
-
70449523262
-
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains
-
Wakabayashi T., Craessaerts K., Bammens L., Bentahir M., Borgions F., Herdewijn P., Staes A., Timmerman E., Vandekerckhove J., Rubinstein E., et al. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat. Cell Biol. 2009, 11:1340-1346.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1340-1346
-
-
Wakabayashi, T.1
Craessaerts, K.2
Bammens, L.3
Bentahir, M.4
Borgions, F.5
Herdewijn, P.6
Staes, A.7
Timmerman, E.8
Vandekerckhove, J.9
Rubinstein, E.10
-
70
-
-
0034638828
-
Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network
-
Wilcke M., Johannes L., Galli T., Mayau V., Goud B., Salamero J. Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network. J.Cell Biol. 2000, 151:1207-1220.
-
(2000)
J.Cell Biol.
, vol.151
, pp. 1207-1220
-
-
Wilcke, M.1
Johannes, L.2
Galli, T.3
Mayau, V.4
Goud, B.5
Salamero, J.6
-
71
-
-
63949088562
-
Function, regulation and therapeutic properties of beta-secretase (BACE1)
-
Willem M., Lammich S., Haass C. Function, regulation and therapeutic properties of beta-secretase (BACE1). Semin. Cell Dev. Biol. 2009, 20:175-182.
-
(2009)
Semin. Cell Dev. Biol.
, vol.20
, pp. 175-182
-
-
Willem, M.1
Lammich, S.2
Haass, C.3
-
72
-
-
0037236622
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
-
Yang L.B., Lindholm K., Yan R., Citron M., Xia W., Yang X.L., Beach T., Sue L., Wong P., Price D., et al. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 2003, 9:3-4.
-
(2003)
Nat. Med.
, vol.9
, pp. 3-4
-
-
Yang, L.B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.L.6
Beach, T.7
Sue, L.8
Wong, P.9
Price, D.10
-
73
-
-
34547590810
-
Functional dissection of Rab GTPases involved in primary cilium formation
-
Yoshimura S., Egerer J., Fuchs E., Haas A.K., Barr F.A. Functional dissection of Rab GTPases involved in primary cilium formation. J.Cell Biol. 2007, 178:363-369.
-
(2007)
J.Cell Biol.
, vol.178
, pp. 363-369
-
-
Yoshimura, S.1
Egerer, J.2
Fuchs, E.3
Haas, A.K.4
Barr, F.A.5
|