-
1
-
-
4344630985
-
BACE1: The beta-secretase enzyme in Alzheimer's disease
-
10.1385/JMN:23:1-2:105. 15126696
-
BACE1: the beta-secretase enzyme in Alzheimer's disease. R Vassar, J Mol Neurosci 2004 23 105 114 10.1385/JMN:23:1-2:105 15126696
-
(2004)
J Mol Neurosci
, vol.23
, pp. 105-114
-
-
Vassar, R.1
-
2
-
-
38349107593
-
The Alzheimer's disease beta-secretase enzyme, BACE1
-
10.1186/1750-1326-2-22. 18005427
-
The Alzheimer's disease beta-secretase enzyme, BACE1. SL Cole R Vassar, Mol Neurodegener 2007 2 22 10.1186/1750-1326-2-22 18005427
-
(2007)
Mol Neurodegener
, vol.2
, pp. 22
-
-
Cole, S.L.1
Vassar, R.2
-
3
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
10.1126/science.1072994. 12130773
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. J Hardy DJ Selkoe, Science 2002 297 353 356 10.1126/science.1072994 12130773
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
4
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
10.1126/science.1074069. 12399581
-
Alzheimer's disease is a synaptic failure. DJ Selkoe, Science 2002 298 789 791 10.1126/science.1074069 12399581
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
5
-
-
30444440132
-
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
-
10.1523/JNEUROSCI.2766-05.2005. 16354928
-
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. FM Laird H Cai AV Savonenko MH Farah K He T Melnikova H Wen H-C Chiang G Xu VE Koliatsos,, et al. J Neurosci 2005 25 11693 11709 10.1523/JNEUROSCI.2766-05.2005 16354928
-
(2005)
J Neurosci
, vol.25
, pp. 11693-11709
-
-
Laird, F.M.1
Cai, H.2
Savonenko, A.V.3
Farah, M.H.4
He, K.5
Melnikova, T.6
Wen, H.7
Chiang, H.-C.8
Xu, G.9
Koliatsos, V.E.10
-
6
-
-
33750455150
-
Control of peripheral nerve myelination by the beta-secretase BACE1
-
10.1126/science.1132341. 16990514
-
Control of peripheral nerve myelination by the beta-secretase BACE1. M Willem AN Garratt B Novak M Citron S Kaufmann A Rittger B DeStrooper P Saftig C Birchmeier C Haass, Science 2006 314 664 666 10.1126/science.1132341 16990514
-
(2006)
Science
, vol.314
, pp. 664-666
-
-
Willem, M.1
Garratt, A.N.2
Novak, B.3
Citron, M.4
Kaufmann, S.5
Rittger, A.6
Destrooper, B.7
Saftig, P.8
Birchmeier, C.9
Haass, C.10
-
7
-
-
33845236399
-
Bace1 modulates myelination in the central and peripheral nervous system
-
10.1038/nn1797. 17099708
-
Bace1 modulates myelination in the central and peripheral nervous system. X Hu CW Hicks W He P Wong WB Macklin BD Trapp R Yan, Nat Neurosci 2006 9 1520 1525 10.1038/nn1797 17099708
-
(2006)
Nat Neurosci
, vol.9
, pp. 1520-1525
-
-
Hu, X.1
Hicks, C.W.2
He, W.3
Wong, P.4
MacKlin, W.B.5
Trapp, B.D.6
Yan, R.7
-
8
-
-
77954051527
-
Identification of beta-secretase (BACE1) substrates using quantitative proteomics
-
10.1371/journal.pone.0008477. 20041192
-
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. ML Hemming JE Elias SP Gygi DJ Selkoe, PLoS ONE 2009 4 8477 10.1371/journal.pone.0008477 20041192
-
(2009)
PLoS ONE
, vol.4
, pp. 58477
-
-
Hemming, M.L.1
Elias, J.E.2
Gygi, S.P.3
Selkoe, D.J.4
-
9
-
-
0037675876
-
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta secretase (BACE1)
-
10.1074/jbc.M206262200. 12473667
-
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta secretase (BACE1). S Kitazume Y Tachida R Oka N Kotani K Ogawa M Suzuki N Dohmae K Takio TC Saido Y Hashimoto, J Biol Chem 2003 278 14865 14871 10.1074/jbc.M206262200 12473667
-
(2003)
J Biol Chem
, vol.278
, pp. 14865-14871
-
-
Kitazume, S.1
Tachida, Y.2
Oka, R.3
Kotani, N.4
Ogawa, K.5
Suzuki, M.6
Dohmae, N.7
Takio, K.8
Saido, T.C.9
Hashimoto, Y.10
-
10
-
-
0842325530
-
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
-
10.1074/jbc.M303861200. 14507929
-
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. SF Lichtenthaler D-I Dominguez GG Westmeyer K Reiss C Haass P Saftig B De Strooper B Seed, J Biol Chem 2003 278 48713 48719 10.1074/jbc.M303861200 14507929
-
(2003)
J Biol Chem
, vol.278
, pp. 48713-48719
-
-
Lichtenthaler, S.F.1
Dominguez, D.-I.2
Westmeyer, G.G.3
Reiss, K.4
Haass, C.5
Saftig, P.6
De Strooper, B.7
Seed, B.8
-
11
-
-
20744458852
-
Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration
-
10.1074/jbc.M412938200. 15833746
-
Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. DY Kim LAM Ingano BW Carey WH Pettingell DM Kovacs, J Biol Chem 2005 280 23251 23261 10.1074/jbc.M412938200 15833746
-
(2005)
J Biol Chem
, vol.280
, pp. 23251-23261
-
-
Kim, D.Y.1
Ingano, L.A.M.2
Carey, B.W.3
Pettingell, W.H.4
Kovacs, D.M.5
-
12
-
-
20744454142
-
Beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase
-
10.1074/jbc.M414648200. 15824102
-
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. H-K Wong T Sakurai F Oyama K Kaneko K Wada H Miyazaki M Kurosawa B De Strooper P Saftig N Nukina, J Biol Chem 2005 280 23009 23017 10.1074/jbc.M414648200 15824102
-
(2005)
J Biol Chem
, vol.280
, pp. 23009-23017
-
-
Wong, H.-K.1
Sakurai, T.2
Oyama, F.3
Kaneko, K.4
Wada, K.5
Miyazaki, H.6
Kurosawa, M.7
De Strooper, B.8
Saftig, P.9
Nukina, N.10
-
13
-
-
0033694833
-
From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
-
10.1016/S0896-6273(00)81133-2. 10798388
-
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. WA Catterall, Neuron 2000 26 13 25 10.1016/S0896-6273(00)81133-2 10798388
-
(2000)
Neuron
, vol.26
, pp. 13-25
-
-
Catterall, W.A.1
-
14
-
-
0035139342
-
Sodium channel beta subunits: Anything but auxiliary
-
10.1177/107385840100700108. 11486343
-
Sodium channel beta subunits: anything but auxiliary. LL Isom, Neuroscientist 2001 7 42 54 10.1177/107385840100700108 11486343
-
(2001)
Neuroscientist
, vol.7
, pp. 42-54
-
-
Isom, L.L.1
-
15
-
-
0041419702
-
Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2
-
12930796
-
Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. FH Yu RE Westenbroek I Silos-Santiago KA McCormick D Lawson P Ge H Ferriera J Lilly PS DiStefano WA Catterall,, et al. J Neurosci 2003 23 7577 7585 12930796
-
(2003)
J Neurosci
, vol.23
, pp. 7577-7585
-
-
Yu, F.H.1
Westenbroek, R.E.2
Silos-Santiago, I.3
McCormick, K.A.4
Lawson, D.5
Ge, P.6
Ferriera, H.7
Lilly, J.8
Distefano, P.S.9
Catterall, W.A.10
-
16
-
-
0037168659
-
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits
-
10.1073/pnas.212638099. 12481039
-
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. C Chen V Bharucha Y Chen RE Westenbroek A Brown JD Malhotra D Jones C Avery PJ Gillespie KA Kazen-Gillespie,, et al. Proc Natl Acad Sci USA 2002 99 17072 17077 10.1073/pnas.212638099 12481039
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 17072-17077
-
-
Chen, C.1
Bharucha, V.2
Chen, Y.3
Westenbroek, R.E.4
Brown, A.5
Malhotra, J.D.6
Jones, D.7
Avery, C.8
Gillespie, P.J.9
Kazen-Gillespie, K.A.10
-
17
-
-
33747079860
-
Sodium channel β2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain
-
DOI 10.1523/JNEUROSCI.2211-06.2006
-
Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. LF Lopez-Santiago M Pertin X Morisod C Chen S Hong J Wiley I Decosterd LL Isom, J Neurosci 2006 26 79847994 10.1523/JNEUROSCI.2211-06.2006 (Pubitemid 44315167)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.30
, pp. 7984-7994
-
-
Lopez-Santiago, L.F.1
Pertin, M.2
Morisod, X.3
Chen, C.4
Hong, S.5
Wiley, J.6
Decosterd, I.7
Isom, L.L.8
-
18
-
-
0034646634
-
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact
-
10.1074/jbc.275.15.11383. 10753953
-
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. JD Malhotra K Kazen-Gillespie M Hortsch LL Isom, J Biol Chem 2000 275 11383 11388 10.1074/jbc.275.15.11383 10753953
-
(2000)
J Biol Chem
, vol.275
, pp. 11383-11388
-
-
Malhotra, J.D.1
Kazen-Gillespie, K.2
Hortsch, M.3
Isom, L.L.4
-
19
-
-
10944261324
-
Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons
-
10.1074/jbc.M410830200. 15452131
-
Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons. TH Davis C Chen LL Isom, J Biol Chem 2004 279 51424 51432 10.1074/jbc.M410830200 15452131
-
(2004)
J Biol Chem
, vol.279
, pp. 51424-51432
-
-
Davis, T.H.1
Chen, C.2
Isom, L.L.3
-
20
-
-
41149138794
-
Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo
-
10.1523/JNEUROSCI.5446-07.2008. 18354028
-
Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. WJ Brackenbury TH Davis C Chen EA Slat MJ Detrow TL Dickendesher B Ranscht LL Isom, J Neurosci 2008 28 3246 3256 10.1523/JNEUROSCI.5446-07.2008 18354028
-
(2008)
J Neurosci
, vol.28
, pp. 3246-3256
-
-
Brackenbury, W.J.1
Davis, T.H.2
Chen, C.3
Slat, E.A.4
Detrow, M.J.5
Dickendesher, T.L.6
Ranscht, B.7
Isom, L.L.8
-
21
-
-
34347394695
-
BACE1 regulates voltage-gated sodium channels and neuronal activity
-
10.1038/ncb1602. 17576410
-
BACE1 regulates voltage-gated sodium channels and neuronal activity. DY Kim BW Carey H Wang LAM Ingano AM Binshtok MH Wertz WH Pettingell P He VM-Y Lee CJ Woolf DM Kovacs, Nat Cell Biol 2007 9 755 764 10.1038/ncb1602 17576410
-
(2007)
Nat Cell Biol
, vol.9
, pp. 755-764
-
-
Kim, D.Y.1
Carey, B.W.2
Wang, H.3
Ingano, L.A.M.4
Binshtok, A.M.5
Wertz, M.H.6
Pettingell, W.H.7
He, P.8
Vm-Y, L.9
Woolf, C.J.10
Kovacs, D.M.11
-
22
-
-
78049403832
-
Alzheimer's secretases regulate voltage-gated sodium channels
-
10.1016/j.neulet.2010.08.048. 20817076
-
Alzheimer's secretases regulate voltage-gated sodium channels. DM Kovacs MT Gersbacher DY Kim, Neuroscience letters 2010 486 2 68 72 10.1016/j.neulet. 2010.08.048 20817076
-
(2010)
Neuroscience Letters
, vol.486
, Issue.2
, pp. 68-72
-
-
Kovacs, D.M.1
Gersbacher, M.T.2
Kim, D.Y.3
-
23
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
10.1038/990114. 10591214
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain. S Sinha JP Anderson R Barbour GS Basi R Caccavello D Davis M Doan HF Dovey N Frigon J Hong,, et al. Nature 1999 402 537 540 10.1038/990114 10591214
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
-
24
-
-
0035964269
-
Subsite specificity of memapsin 2 (beta-secretase): Implications for inhibitor design
-
10.1021/bi015546s. 11513577
-
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design. RT Turner G Koelsch L Hong P Castanheira J Ermolieff AK Ghosh J Tang P Castenheira A Ghosh, Biochemistry 2001 40 10001 10006 10.1021/bi015546s 11513577
-
(2001)
Biochemistry
, vol.40
, pp. 10001-10006
-
-
Turner, R.T.1
Koelsch, G.2
Hong, L.3
Castanheira, P.4
Ermolieff, J.5
Ghosh, A.K.6
Tang, J.7
Castenheira, P.8
Ghosh, A.9
-
25
-
-
0032741143
-
Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
-
10523497
-
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Schlondorff CP Blobel, J Cell Sci 1999 112 Pt 21 3603 3617 10523497
-
(1999)
J Cell Sci
, vol.112
, Issue.PART 21
, pp. 3603-3617
-
-
Schlondorff, J.1
Blobel, C.P.2
-
26
-
-
0036718272
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
10.1001/archneur.59.9.1381. 12223024
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. H Fukumoto BS Cheung BT Hyman MC Irizarry, Arch Neurol 2002 59 1381 1389 10.1001/archneur.59.9.1381 12223024
-
(2002)
Arch Neurol
, vol.59
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
27
-
-
0036434569
-
Alpha- and beta-secretase: Profound changes in Alzheimer's disease
-
10.1016/S0006-291X(02)02635-9. 12445809
-
alpha- and beta-secretase: profound changes in Alzheimer's disease. SJ Tyler D Dawbarn GK Wilcock SJ Allen, Biochem Biophys Res Commun 2002 299 373 376 10.1016/S0006-291X(02)02635-9 12445809
-
(2002)
Biochem Biophys Res Commun
, vol.299
, pp. 373-376
-
-
Tyler, S.J.1
Dawbarn, D.2
Wilcock, G.K.3
Allen, S.J.4
-
28
-
-
0037236622
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
-
10.1038/nm0103-3. 12514700
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. L-B Yang K Lindholm R Yan M Citron W Xia X-L Yang T Beach L Sue PC Wong D Price,, et al. Nat Med 2003 9 3 4 10.1038/nm0103-3 12514700
-
(2003)
Nat Med
, vol.9
, pp. 3-4
-
-
Yang, L.-B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.-L.6
Beach, T.7
Sue, L.8
Wong, P.C.9
Price, D.10
-
29
-
-
64149105502
-
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
-
10.1038/nm.1940. 19287391
-
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. DJ Loane A Pocivavsek CE-H Moussa R Thompson Y Matsuoka AI Faden GW Rebeck MP Burns, Nat Med 2009 15 377 379 10.1038/nm.1940 19287391
-
(2009)
Nat Med
, vol.15
, pp. 377-379
-
-
Loane, D.J.1
Pocivavsek, A.2
Ce-H, M.3
Thompson, R.4
Matsuoka, Y.5
Faden, A.I.6
Rebeck, G.W.7
Burns, M.P.8
-
30
-
-
2142815707
-
Increased beta-secretase activity and expression in rats following transient cerebral ischemia
-
10.1016/j.brainres.2003.09.086. 15120577
-
Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Y Wen O Onyewuchi S Yang R Liu JW Simpkins, Brain Res 2004 1009 1 8 10.1016/j.brainres.2003.09.086 15120577
-
(2004)
Brain Res
, vol.1009
, pp. 1-8
-
-
Wen, Y.1
Onyewuchi, O.2
Yang, S.3
Liu, R.4
Simpkins, J.W.5
-
31
-
-
58549119790
-
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: Role of oxidative stress and HIF1alpha
-
10.1111/j.1471-4159.2008.05858.x. 19196431
-
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. M Guglielmotto M Aragno R Autelli L Giliberto E Novo S Colombatto O Danni M Parola MA Smith G Perry,, et al. J Neurochem 2009 108 1045 1056 10.1111/j.1471-4159.2008.05858.x 19196431
-
(2009)
J Neurochem
, vol.108
, pp. 1045-1056
-
-
Guglielmotto, M.1
Aragno, M.2
Autelli, R.3
Giliberto, L.4
Novo, E.5
Colombatto, S.6
Danni, O.7
Parola, M.8
Smith, M.A.9
Perry, G.10
-
32
-
-
34249734831
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
-
10.1016/j.neuron.2007.05.012. 17553422
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. G Tesco YH Koh EL Kang AN Cameron S Das M Sena-Esteves M Hiltunen S-H Yang Z Zhong Y Shen,, et al. Neuron 2007 54 721 737 10.1016/j.neuron.2007.05.012 17553422
-
(2007)
Neuron
, vol.54
, pp. 721-737
-
-
Tesco, G.1
Koh, Y.H.2
Kang, E.L.3
Cameron, A.N.4
Das, S.5
Sena-Esteves, M.6
Hiltunen, M.7
Yang, S.-H.8
Zhong, Z.9
Shen, Y.10
|