Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of β-secretase

Journal of Medicinal Chemistry

Volumn 50, Issue 6, 2007, Pages 1124-1132

  Congreve, Miles ^a   Aharony, David ^b   Albert, Jeffrey ^b   Callaghan, Owen ^a   Campbell, James ^b   Carr, Robin A E ^a   Chessari, Gianni ^a   Cowan, Suzanna ^a   Edwards, Philip D ^b   Frederickson, Martyn ^a   McMenamin, Rachel ^a   Murray, Christopher W ^a   Patel, Sahil ^a   Wallis, Nicola ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE DERIVATIVE; ASPARTIC PROTEINASE; BETA SECRETASE;

ARTICLE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HIGH THROUGHPUT SCREENING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINOQUINOLINES; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDOLES; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS;

EID: 33947636525     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061197u     Document Type: Article

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