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Volumn 10, Issue 2, 2010, Pages 147-161

Drugs for aids

Author keywords

Aids; Anti hiv; Fusion inhibitor; Integrase inhibitor; Protease inhibitor; Reverse transcriptase inhibitor

Indexed keywords

ABACAVIR; AMPRENAVIR; ATAZANAVIR; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ENFUVIRTIDE; ETRAVIRINE; FOSAMPRENAVIR; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; INDINAVIR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; MARAVIROC; NELFINAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RALTEGRAVIR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; TIPRANAVIR; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTEGRASE INHIBITOR;

EID: 77954705120     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955710791185145     Document Type: Article
Times cited : (19)

References (131)
  • 2
    • 84871324199 scopus 로고    scopus 로고
    • AIDS epedimic update, UNAIDS
    • AIDS epedimic update, UNAIDS, 2009.
    • (2009)
  • 3
  • 4
    • 0025953621 scopus 로고
    • Indeterminate human immuno deficiency virus type 1 western blot, seroconversion risk, specificity of supplemental tests and an algorithm for evaluation
    • Celum, C.L.; Coombs, R.W.; Lafferty, W.; Inui, T.S.; Louie, P.H.; Gates, C.A.; McCreedy, B.J.; Egan, R.; Grove, T.; Alexander, S., et al. Indeterminate human immuno deficiency virus type 1 western blot, seroconversion risk, specificity of supplemental tests and an algorithm for evaluation. J. Infect. Dis., 1991, 164, 656-64.
    • (1991) J. Infect. Dis , vol.164 , pp. 656-664
    • Celum, C.L.1    Coombs, R.W.2    Lafferty, W.3    Inui, T.S.4    Louie, P.H.5    Gates, C.A.6    McCreedy, B.J.7    Egan, R.8    Grove, T.9    Alexander, S.10
  • 5
    • 84921537578 scopus 로고    scopus 로고
    • Revised guidelines for HIV counseling testing and referral MMWR
    • Centers for disease control and prevention
    • Centers for disease control and prevention. Revised guidelines for HIV counseling testing and referral MMWR. Recomn Rep 50 (RR- 19), 2001, 1-57.
    • (2001) Recomn Rep , vol.50 , Issue.19 , pp. 1-57
  • 7
    • 0043069555 scopus 로고    scopus 로고
    • Toxicity of antiretroviral therapy and implications for drug development
    • Carr, A. Toxicity of antiretroviral therapy and implications for drug development. Nat. Rev. Drug Discov., 2003, 2, 624-34.
    • (2003) Nat. Rev. Drug Discov , vol.2 , pp. 624-634
    • Carr, A.1
  • 12
    • 0001707601 scopus 로고
    • 3'-Azido-3'-deoxythymidine (BWA 509U): An antiviral agent that inhibits the inefectivity & cytopathic effect of human Tlymphotropic virus type III/ lymphadenopathy-associated virus in vitro
    • Mitsuya, H.; Weinhold, K.J.; Furman, P.A.; St. Clair, M.H.; Lehrman, N.S.; Gallo, R.C.; Bloguesi, D.; Barry, D.W.; Broder, S. 3'-Azido-3'-deoxythymidine (BWA 509U): an antiviral agent that inhibits the inefectivity & cytopathic effect of human Tlymphotropic virus type III/ lymphadenopathy-associated virus in vitro. Proc. Natl. Acad. Sci. USA, 1985, 82, 7096-100.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3    St. Clair, M.H.4    Lehrman, N.S.5    Gallo, R.C.6    Bloguesi, D.7    Barry, D.W.8    Broder, S.9
  • 13
    • 0025912292 scopus 로고
    • Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo
    • Goody, R.S.; Muller, B.; Restle, T. Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo. FEBS Lett., 1991, 291, 1-5.
    • (1991) FEBS Lett , vol.291 , pp. 1-5
    • Goody, R.S.1    Muller, B.2    Restle, T.3
  • 17
    • 0022996630 scopus 로고
    • Phosphorylation of 3'-azido-3-deoxythimidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
    • Ferman, P.; Fyfe, J.; St Clair, M.; Winhold, K.; Freeman, G.A.; Lehrman, S.N.; Bolognesi, D.P.; Broder, S.; Mitsuya H., et al. Phosphorylation of 3'-azido-3-deoxythimidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA, 1986, 83, 8333-7.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8333-8337
    • Ferman, P.1    Fyfe, J.2    St. Clair, M.3    Winhold, K.4    Freeman, G.A.5    Lehrman, S.N.6    Bolognesi, D.P.7    Broder, S.8    Mitsuya, H.9
  • 21
    • 0025186450 scopus 로고
    • Molecular targets for AIDS therapy
    • Mitsuya H.; Yarchaon, R.; Broder, S. Molecular targets for AIDS therapy. Science, 1990, 249, 1533-44.
    • (1990) Science , vol.249 , pp. 1533-1544
    • Mitsuya, H.1    Yarchaon, R.2    Broder, S.3
  • 22
    • 0029774808 scopus 로고    scopus 로고
    • Use of viral resistance patterns to antiretroviral drugs in optimizing selection of drug combination and sequences
    • Moyle, G.J. Use of viral resistance patterns to antiretroviral drugs in optimizing selection of drug combination and sequences. Drugs, 1996, 52, 168-85.
    • (1996) Drugs , vol.52 , pp. 168-185
    • Moyle, G.J.1
  • 23
    • 0013869085 scopus 로고    scopus 로고
    • Nucleside IX. The formation of 2', 3'-unsaturated pyrimidine nucleoside via a novel beta elimination reaction
    • Horwitz, J.P. Nucleside IX. The formation of 2', 3'-unsaturated pyrimidine nucleoside via a novel beta elimination reaction. J. Org. Chem., 1996, 31, 205-11.
    • (1996) J. Org. Chem , vol.31 , pp. 205-211
    • Horwitz, J.P.1
  • 25
    • 0032784006 scopus 로고    scopus 로고
    • Stavudine: A update of its use in the treatment of HIV infection
    • Hurst, M.; Noble, S. Stavudine: a update of its use in the treatment of HIV infection. Drugs, 1999, 58, 919-49.
    • (1999) Drugs , vol.58 , pp. 919-949
    • Hurst, M.1    Noble, S.2
  • 26
    • 0028928910 scopus 로고
    • Biological effects and safety of stavudine: Overview of phase I clinical trials
    • Skowron, G. Biological effects and safety of stavudine: overview of phase I clinical trials. J. Infec. Dis., 1995, 171, S113-7.
    • (1995) J. Infec. Dis , vol.171
    • Skowron, G.1
  • 27
    • 27644482372 scopus 로고    scopus 로고
    • Practical enantioselective synthesis of lamivudine (3TC) via a dynamic kinetic resolution
    • Goodyear, M.D.; Hill, M.L.; West, J.P.; Whitehead, A.J. Practical enantioselective synthesis of lamivudine (3TC) via a dynamic kinetic resolution. Tet. Lett., 2005, 46, 8535-8.
    • (2005) Tet. Lett , vol.46 , pp. 8535-8538
    • Goodyear, M.D.1    Hill, M.L.2    West, J.P.3    Whitehead, A.J.4
  • 30
    • 55949099628 scopus 로고    scopus 로고
    • Rapid re-emergence of YMDD mutation of HBV with hepatic decompensation after lamivudine re-treatment
    • Kwon, S.Y.; Choe, W.H.; Lee, C.H.; Yeon, J.E.; Byun, K.S.; Rapid re-emergence of YMDD mutation of HBV with hepatic decompensation after lamivudine re-treatment. World J. Gastroenterol, 2008, 14, 4416-9.
    • (2008) World J. Gastroenterol , vol.14 , pp. 4416-4419
    • Kwon, S.Y.1    Choe, W.H.2    Lee, C.H.3    Yeon, J.E.4    Byun, K.S.5
  • 33
    • 0043124520 scopus 로고    scopus 로고
    • Tenofovir Disoproxil Fumarate: AIDS drug profile
    • Chapman, T.M.; McGavin, J.K.; Noble, S. Tenofovir Disoproxil Fumarate: AIDS drug profile. Drugs, 2003, 6, 1597-608.
    • (2003) Drugs , vol.6 , pp. 1597-1608
    • Chapman, T.M.1    McGavin, J.K.2    Noble, S.3
  • 34
    • 0030782524 scopus 로고    scopus 로고
    • Synthesis, In vitroevaluatio, and oral bioavailability of 9-[2- (phosphonomethoxy)propyladenine(PMPA) prodrugs
    • Arimilli, M.; Kim, C.; Bischofberger, N. Synthesis, In vitroevaluatio, and oral bioavailability of 9-[2- (phosphonomethoxy)propyladenine(PMPA) prodrugs. Antimicrob. Agents Chemother., 1997, 8, 557-64.
    • (1997) Antimicrob. Agents Chemother , vol.8 , pp. 557-564
    • Arimilli, M.1    Kim, C.2    Bischofberger, N.3
  • 35
    • 0031710248 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy) propyladenine, a novel anti-human immunodeficiency virus(HIV) therapy, in HIV infected adults
    • Deeks, S.G.; Barditch- Crovo, P.; Lietman, P.S.; Hwang, F.; Cundy, K.C.; Rooney, J.F.; Hellmann, N.S.; Safrin, S. Kahn, J.O. Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy) propyladenine, a novel anti-human immunodeficiency virus(HIV) therapy, in HIV infected adults. Antimicrob. Agents Chemother., 1998, 42, 2380-4.
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 2380-2384
    • Deeks, S.G.1    Barditch-Crovo, P.2    Lietman, P.S.3    Hwang, F.4    Cundy, K.C.5    Rooney, J.F.6    Hellmann, N.S.7    Safrin, S.8    Kahn, J.O.9
  • 36
    • 18244398917 scopus 로고    scopus 로고
    • Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor Tenofovir leads to a preferential distribution and accumulation in lymphatic tissue
    • Lee, W.A.; He, G.X.; Eisenberg, E.; Cihlar, T.; Swaminathan, S.; Mulato, A.; Cundy, K.C. Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor Tenofovir leads to a preferential distribution and accumulation in lymphatic tissue. Antimicrob. Agents Chemother., 2005, 49, 1898-906.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 1898-1906
    • Lee, W.A.1    He, G.X.2    Eisenberg, E.3    Cihlar, T.4    Swaminathan, S.5    Mulato, A.6    Cundy, K.C.7
  • 39
    • 33845275093 scopus 로고    scopus 로고
    • In vitro human imunodeficieny virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine
    • Margot, N.A.; Waters, J.M.; Miller, M.D. In vitro human imunodeficieny virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine. Antimicrob. Agents Chemothe., 2006, 50, 4087-95.
    • (2006) Antimicrob. Agents Chemothe , vol.50 , pp. 4087-4095
    • Margot, N.A.1    Waters, J.M.2    Miller, M.D.3
  • 40
    • 84871301534 scopus 로고    scopus 로고
    • The current status of HIV chemotherapy
    • Mehellou, Y.; De Clercq, E. The current status of HIV chemotherapy. IB Scientific J. Sci., 2007, 2, 44-56.
    • (2007) IB Scientific J. Sci , vol.2 , pp. 44-56
    • Mehellou, Y.1    de Clercq, E.2
  • 41
    • 4544265135 scopus 로고    scopus 로고
    • Conformational changes in HIV-1 reverse transcriptase induced by non-nucleoside reverse transcriptase inhibitor binding
    • Sluis-Cremer, N.; Temiz, N.A.; Bahar, I. Conformational changes in HIV-1 reverse transcriptase induced by non-nucleoside reverse transcriptase inhibitor binding. Curr. HIV Res., 2004, 2, 323-32.
    • (2004) Curr. HIV Res , vol.2 , pp. 323-332
    • Sluis-Cremer, N.1    Temiz, N.A.2    Bahar, I.3
  • 43
    • 0034100184 scopus 로고    scopus 로고
    • Non nucleoside reverse transcriptase inhibitors
    • Hajos, G.; Riedle, Z.; Molnar J.; Szabo, D. Non nucleoside reverse transcriptase inhibitors. Drug Future, 2000, 25, 47-62.
    • (2000) Drug Future , vol.25 , pp. 47-62
    • Hajos, G.1    Riedle, Z.2    Molnar, J.3    Szabo, D.4
  • 45
    • 0037195081 scopus 로고    scopus 로고
    • Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors
    • Ren, J.; Bird, L.E.; Chamberlain, P.P.; Stewart-Jones, G.B.; Stuart, D. I.; Stammers, D.K. Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors. Proc. Natl. Acad. Sci. USA, 2002, 99, 14410-5.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14410-14415
    • Ren, J.1    Bird, L.E.2    Chamberlain, P.P.3    Stewart-Jones, G.B.4    Stuart, D.I.5    Stammers, D.K.6
  • 47
    • 20844451906 scopus 로고    scopus 로고
    • Resistance HIV-1 after intrapartum administration of single dose nevirapine is substantially under estimated
    • Johnson, J.A.; Li, J.F.; Morris, L.; Martinson, N.; Gray, G.; McIntyre, J.; Heneine, W. Resistance HIV-1 after intrapartum administration of single dose nevirapine is substantially under estimated. J. Infect. Dis., 2005, 192, 16-23.
    • (2005) J. Infect. Dis , vol.192 , pp. 16-23
    • Johnson, J.A.1    Li, J.F.2    Morris, L.3    Martinson, N.4    Gray, G.5    McIntyre, J.6    Heneine, W.7
  • 51
    • 33749426630 scopus 로고    scopus 로고
    • Neuropsychiatry complications of antiretroviral therapy
    • Cespedes, H.S.; Aberg, J.A. Neuropsychiatry complications of antiretroviral therapy. Drug Safety, 2006, 29, 865-74.
    • (2006) Drug Safety , vol.29 , pp. 865-874
    • Cespedes, H.S.1    Aberg, J.A.2
  • 52
    • 0037271311 scopus 로고    scopus 로고
    • Long-term assessment of neuropsychiatry adverse reactions associated with efavirenz
    • Lochet, P.; Peyriere, H.; Lotthe, A.; Mauboussiz, J.M.; Dclmas, B.; Reynes, J. Long-term assessment of neuropsychiatry adverse reactions associated with efavirenz. HIV Med., 2003, 4, 62-6.
    • (2003) HIV Med , vol.4 , pp. 62-66
    • Lochet, P.1    Peyriere, H.2    Lotthe, A.3    Mauboussiz, J.M.4    Dclmas, B.5    Reynes, J.6
  • 55
    • 33750562171 scopus 로고    scopus 로고
    • Etravirine, R165335, TMC 125
    • Etravirine: R165335, TMC 125. Drugs R D., 2006, 7, 367-73.
    • (2006) Drugs R D , vol.7 , pp. 367-373
  • 57
    • 35548957272 scopus 로고    scopus 로고
    • Antiviral drugs in the treatment of AIDS: What is in the pipe line
    • Stelbrink, H.J. Antiviral drugs in the treatment of AIDS: what is in the pipe line. Eur. J. Med. Res., 2007, 12, 483-95.
    • (2007) Eur. J. Med. Res , vol.12 , pp. 483-495
    • Stelbrink, H.J.1
  • 58
    • 44449115313 scopus 로고    scopus 로고
    • Development of non-nucleoside reverse transcriptase inhibitors for anti-HIV therapy
    • Sahlberg, C.; Zhou, X.X. Development of non-nucleoside reverse transcriptase inhibitors for anti-HIV therapy. Anti-Infective Agents Med. Chem., 2008, 7, 101-17.
    • (2008) Anti-Infective Agents Med. Chem , vol.7 , pp. 101-117
    • Sahlberg, C.1    Zhou, X.X.2
  • 60
    • 0026592957 scopus 로고
    • The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptasef
    • Dueweke, T.J.; Kezdy, F.J.; Waszak, G.A.; Deibel, M.R. Jr.; Tarpley, W.G. The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase J. Biol. Chem., 1992, 267, 27-30.
    • (1992) J. Biol. Chem , vol.267 , pp. 27-30
    • Dueweke, T.J.1    Kezdy, F.J.2    Waszak, G.A.3    Deibel Jr., M.R.4    Tarpley, W.G.5
  • 61
    • 0027278282 scopus 로고
    • Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl) carbony l]-4-[3-[(1 methylethyl) amino] pyridinyl] piperazine monomethane sulfonate (U-90152S), a second-generation clinical candidate
    • Romero, D. L.; Morge, R. A.; Genin, M. J.; Biles, C.; Busso, M.; Resnick, L.; Althaus, I. W.; Reusser, F.; Thomas, R. C.; Tarpley, W. G. Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl) carbony l]-4-[3-[(1 methylethyl) amino] pyridinyl] piperazine monomethane sulfonate (U-90152S), a second-generation clinical candidate J. Med. Chem., 1993, 36, 1505-8.
    • (1993) J. Med. Chem , vol.36 , pp. 1505-1508
    • Romero, D.L.1    Morge, R.A.2    Genin, M.J.3    Biles, C.4    Busso, M.5    Resnick, L.6    Althaus, I.W.7    Reusser, F.8    Thomas, R.C.9    Tarpley, W.G.10
  • 62
    • 0027178052 scopus 로고
    • U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
    • Dueweke, T.J.; Poppe, S.M.; Romero, D.L., et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agent. Chemother., 1993, 37, 1127-31
    • (1993) Antimicrob. Agent. Chemother , vol.37 , pp. 1127-1131
    • Dueweke, T.J.1    Poppe, S.M.2    Romero, D.L.3
  • 63
    • 5544231319 scopus 로고    scopus 로고
    • Synthesis and bioactivity of novel bis (heteroaryl) piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs
    • Genin, M. J.; Poel, T. J.; Yagi, Y.; Biles, C.; Althaus, I.; Keiser, B.J.; Kopta, L.A.; Friis, J.M.; Reusser, F.; Adams, W.J.; Olmsted, R.A.; Voorman, R.L.; Thomas, R.C.; Romero, D.L. Synthesis and bioactivity of novel bis (heteroaryl) piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs. J. Med. Chem., 1996, 39, 5267-75
    • (1996) J. Med. Chem , vol.39 , pp. 5267-5275
    • Genin, M.J.1    Poel, T.J.2    Yagi, Y.3    Biles, C.4    Althaus, I.5    Keiser, B.J.6    Kopta, L.A.7    Friis, J.M.8    Reusser, F.9    Adams, W.J.10    Olmsted, R.A.11    Voorman, R.L.12    Thomas, R.C.13    Romero, D.L.14
  • 65
    • 0028273009 scopus 로고
    • Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors
    • Romero, D.L.; Morge, R.A.; Biles, C.; Berrios-Pena, N.; May, P.D.; Palmer, J.R.; Johnson, P.D.; Smith, H.W.; Busso, M., et al. Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors. J. Med. Chem., 1994, 37, 999-1014.
    • (1994) J. Med. Chem , vol.37 , pp. 999-1014
    • Romero, D.L.1    Morge, R.A.2    Biles, C.3    Berrios-Pena, N.4    May, P.D.5    Palmer, J.R.6    Johnson, P.D.7    Smith, H.W.8    Busso, M.9
  • 67
    • 0028823979 scopus 로고
    • Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes
    • Proudfoot, J. R.; Hargrave, K. D.; Kapadia, S. R.; Patel, U. R.; Grozinger, K.G.; McNeil, D. W.; Cullen, E.; Cardozo, M; Tong, L. Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes. J. Med. Chem., 1995, 38, 4830-8.
    • (1995) J. Med. Chem , vol.38 , pp. 4830-4838
    • Proudfoot, J.R.1    Hargrave, K.D.2    Kapadia, S.R.3    Patel, U.R.4    Grozinger, K.G.5    McNeil, D.W.6    Cullen, E.7    Cardozo, M.8    Tong, L.9
  • 68
    • 0033571566 scopus 로고    scopus 로고
    • Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA)
    • Patel, M.; McHugh, R.; Cordova, B.; Klabe, R.; Erickson- Vitanen, S.; Trainor, G.; Ko, S. Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA) Bioorg Med Chem. Lett., 1999, 9, 3221-4.
    • (1999) Bioorg Med Chem. Lett , vol.9 , pp. 3221-3224
    • Patel, M.1    McHugh, R.2    Cordova, B.3    Klabe, R.4    Erickson-Vitanen, S.5    Trainor, G.6    Ko, S.7
  • 70
    • 0038184354 scopus 로고    scopus 로고
    • HIV-1 protease: Mechanism and drug discovery
    • Brik, A.; Wong, C.H. HIV-1 protease: mechanism and drug discovery. Org. Biomol. Chem., 2003, 1, 5-14.
    • (2003) Org. Biomol. Chem , vol.1 , pp. 5-14
    • Brik, A.1    Wong, C.H.2
  • 71
    • 0032580479 scopus 로고    scopus 로고
    • HIV protease inhibitors
    • Flexner, C. HIV protease inhibitors. New. Eng. J. Med., 1998, 338, 1281-93.
    • (1998) New. Eng. J. Med , vol.338 , pp. 1281-1293
    • Flexner, C.1
  • 72
    • 0032551258 scopus 로고    scopus 로고
    • Pathogenesis of HIV-1 protease inhibitor-associated peripheral lipodystrophy, hyper lipedaemia and insulin resistance
    • Carr, A.; Samaras, K.; Chisholm, D.J.; Coper, D.A. Pathogenesis of HIV-1 protease inhibitor-associated peripheral lipodystrophy, hyper lipedaemia and insulin resistance. Lancet, 1998, 351, 1881-3.
    • (1998) Lancet , vol.351 , pp. 1881-1883
    • Carr, A.1    Samaras, K.2    Chisholm, D.J.3    Coper, D.A.4
  • 73
    • 17144463863 scopus 로고    scopus 로고
    • Severe premature coronary artery disease with protease inhibitors
    • Henry, K., et al. Severe premature coronary artery disease with protease inhibitors. Lancet 1998, 351, 1328.
    • (1998) Lancet , vol.351 , pp. 1328
    • Henry, K.1
  • 74
    • 0037316788 scopus 로고    scopus 로고
    • HIV protease inhibitors and atherosclerosis
    • David, Y.H. HIV protease inhibitors and atherosclerosis.J. Clin. Invest., 2003, 111, 317-8.
    • (2003) J. Clin. Invest , vol.111 , pp. 317-318
    • David, Y.H.1
  • 75
    • 0031765907 scopus 로고    scopus 로고
    • Role of Pglycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher, V.J.; Silverman, J.A.; Zhang, Y.; Benet, L.Z. Role of Pglycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J. Pharm. Sci., 1998, 87, 1322-30.
    • (1998) J. Pharm. Sci , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 76
    • 0027992464 scopus 로고
    • Studies towards the large scale synthesis of the HIV proteinase inhibitors RO-31-8959
    • Parkes, KEB., et al. Studies towards the large scale synthesis of the HIV proteinase inhibitors RO-31-8959. J. Org. Chem., 1994, 59, 3656-64.
    • (1994) J. Org. Chem , vol.59 , pp. 3656-3664
    • Parkes, K.E.B.1
  • 78
    • 0141612910 scopus 로고    scopus 로고
    • Randomized trial to evaluate indinavir (ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type-I infected patients. The Max Cunin 1 Trial
    • Dragsted, U.B.; Gerstoft, J.; Pedersen, C., et al. Randomized trial to evaluate indinavir (ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type-I infected patients. The Max Cunin 1 Trial. J. Infect Dis., 2003, 188, 635-42.
    • (2003) J. Infect Dis , vol.188 , pp. 635-642
    • Dragsted, U.B.1    Gerstoft, J.2    Pedersen, C.3
  • 80
    • 0346025675 scopus 로고    scopus 로고
    • Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIVinfected patients
    • Zeldin, R.K.; Petrusche, R.A. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIVinfected patients. J. Antimicrob. Chemother., 2004, 53, 4-9.
    • (2004) J. Antimicrob. Chemother , vol.53 , pp. 4-9
    • Zeldin, R.K.1    Petrusche, R.A.2
  • 81
    • 0031035968 scopus 로고    scopus 로고
    • Pharmacokinetic enhancement of the human imunodeficiency virus & protease by co-administration with retonavir
    • Kempf, D.J.; Marsh, K.C.; Kumar, G., et al. Pharmacokinetic enhancement of the human imunodeficiency virus & protease by co-administration with retonavir. Antimicrob.Agents Chemother., 1997, 41, 654-60.
    • (1997) Antimicrob.Agents Chemother , vol.41 , pp. 654-660
    • Kempf, D.J.1    Marsh, K.C.2    Kumar, G.3
  • 83
    • 41949102996 scopus 로고    scopus 로고
    • Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia
    • Sharma, B.; Singh, N.; Singh, M.; Jaggi, A.S. Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia. Pharmaco. Biochem Behav., 2008, 89, 535-45.
    • (2008) Pharmaco. Biochem Behav , vol.89 , pp. 535-545
    • Sharma, B.1    Singh, N.2    Singh, M.3    Jaggi, A.S.4
  • 84
    • 0038780072 scopus 로고    scopus 로고
    • The synthesis of indinavir and other clinically useful HIV-I protease inhibitors
    • Askin, D. The synthesis of indinavir and other clinically useful HIV-I protease inhibitors. Curr. Opin. Drug Disc. Dev., 1998, 1, 338-48.
    • (1998) Curr. Opin. Drug Disc. Dev , vol.1 , pp. 338-348
    • Askin, D.1
  • 85
    • 0034268096 scopus 로고    scopus 로고
    • Solid Phase Synthesis of Indinavir and Its Analogues
    • Cheng, Y.; Zhijian, Lu; Chapman, K. T.; Tata, J. R. Solid Phase Synthesis of Indinavir and Its Analogues. J. Comb. Chem., 2000, 2, 445-6.
    • (2000) J. Comb. Chem , vol.2 , pp. 445-446
    • Cheng, Y.1    Zhijian, L.2    Chapman, K.T.3    Tata, J.R.4
  • 88
    • 38049040718 scopus 로고    scopus 로고
    • Synthesis, anti HIV & anti tubercular activities of nelfinavir diester derivative Kaletra (lopinavir/ ritonavir)
    • Sriram, D.; Yogeeswari, P.; Dinakaran, M.; Sowmya, M. Synthesis, anti HIV & anti tubercular activities of nelfinavir diester derivative Kaletra (lopinavir/ ritonavir). Biomedicine & Pharmacotherapy, 2008, 62, 1-5.
    • (2008) Biomedicine & Pharmacotherapy , vol.62 , pp. 1-5
    • Sriram, D.1    Yogeeswari, P.2    Dinakaran, M.3    Sowmya, M.4
  • 91
    • 0032527418 scopus 로고    scopus 로고
    • The conformation of hepatitis C virus NS3 protinase with and without NS4A: A structural basis for the activation of the enzyme by its cofactor
    • Love, R.A.; Parge, H.E.; Wickersham, J.A., et al. The conformation of hepatitis C virus NS3 protinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor. Clin. Diagn. Virol., 1998, 10, 151-6.
    • (1998) Clin. Diagn. Virol , vol.10 , pp. 151-156
    • Love, R.A.1    Parge, H.E.2    Wickersham, J.A.3
  • 92
    • 54849427710 scopus 로고    scopus 로고
    • Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase
    • Hong-Brown, L.Q.; Bron, R.; Huber, D.; Lany, C.H. Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase. J. Cellular. Biochem., 2008, 105, 814-23.
    • (2008) J. Cellular. Biochem , vol.105 , pp. 814-823
    • Hong-Brown, L.Q.1    Bron, R.2    Huber, D.3    Lany, C.H.4
  • 93
    • 0035160110 scopus 로고    scopus 로고
    • Lopinavir-Ritonavir: A new protease inhibitor
    • Magnum, E.M.; Graham, K.K. Lopinavir-Ritonavir: a new protease inhibitor. Pharmacotherapy, 2001, 21, 1352-63.
    • (2001) Pharmacotherapy , vol.21 , pp. 1352-1363
    • Magnum, E.M.1    Graham, K.K.2
  • 95
    • 0037103110 scopus 로고    scopus 로고
    • Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome
    • Kikuchi, Y.; Genka, I.; Ishizaki, A.; Sunagawa, K.; Yasuoka, A.; Oka, S. Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome. Clin. Infect. Dis., 2002, 35, 488-90.
    • (2002) Clin. Infect. Dis , vol.35 , pp. 488-490
    • Kikuchi, Y.1    Genka, I.2    Ishizaki, A.3    Sunagawa, K.4    Yasuoka, A.5    Oka, S.6
  • 97
    • 3843151487 scopus 로고    scopus 로고
    • SOLO:48 week efficacy and safety comparison of once daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naïve HIV-1 infected patients
    • Gathe, J.C Jr.; Ive, P.; Wood, R.; Schurmann, D.; Bellos, N.C.; De Jesus, E.; Gladysz, A.; Garris, C.; Yeo, J. SOLO:48 week efficacy and safety comparison of once daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naïve HIV-1 infected patients. AIDS, 2004, 18, 1529-37.
    • (2004) AIDS , vol.18 , pp. 1529-1537
    • Gathe Jr., J.C.1    Ive, P.2    Wood, R.3    Schurmann, D.4    Bellos, N.C.5    de Jesus, E.6    Gladysz, A.7    Garris, C.8    Yeo, J.9
  • 98
    • 0035065299 scopus 로고    scopus 로고
    • BMS-232632 Novartis/Bristol-Myers Squibb
    • Witherell, G. BMS-232632 Novartis/Bristol-Myers Squibb. Curr. Opin. Invest. Drugs, 2001, 2, 340-7.
    • (2001) Curr. Opin. Invest. Drugs , vol.2 , pp. 340-347
    • Witherell, G.1
  • 99
    • 36348961452 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
    • Pyrteo, P. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res., 2007, 67, 10920-8.
    • (2007) Cancer Res , vol.67 , pp. 10920-10928
    • Pyrteo, P.1
  • 102
    • 1542409142 scopus 로고    scopus 로고
    • A 14 day dose response study of the efficacy, safety and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naïve-HIV-1infected patients
    • McCallister, S.; Valdez, H.; Curry, K.; MacGregor, T.; Borin, M.; Freimuth, W.; Wang, Y.Y.; Mayers, D.L. A 14 day dose response study of the efficacy, safety and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naïve-HIV-1infected patients - JAIDS, 2004, 35, 376-82.
    • (2004) JAIDS , vol.35 , pp. 376-382
    • McCallister, S.1    Valdez, H.2    Curry, K.3    Macgregor, T.4    Borin, M.5    Freimuth, W.6    Wang, Y.Y.7    Mayers, D.L.8
  • 104
    • 35348829315 scopus 로고    scopus 로고
    • Darunavir, a conceptually new HIV-1 protease inhibitor for the reatment of drug-resistant HIV
    • Ghosh, A.K.; Dawson, Z.L.; Mitsua, H. Darunavir, a conceptually new HIV-1 protease inhibitor for the reatment of drug-resistant HIV. Bioorg. Med. Chem., 2007, 15, 7576-80.
    • (2007) Bioorg. Med. Chem , vol.15 , pp. 7576-7580
    • Ghosh, A.K.1    Dawson, Z.L.2    Mitsua, H.3
  • 108
    • 33846173647 scopus 로고    scopus 로고
    • Non-peptide protease inhibitors as novel anti HIV agents
    • Bhat, M.A.; Siddiqui, N.; Khan, S.A.; Ahmad, M.; Non-peptide protease inhibitors as novel anti HIV agents. IJPS, 2006, 68, 549-55.
    • (2006) IJPS , vol.68 , pp. 549-555
    • Bhat, M.A.1    Siddiqui, N.2    Khan, S.A.3    Ahmad, M.4
  • 109
    • 0037667047 scopus 로고    scopus 로고
    • Large scale manufacture of peptide therapeutics by chemical synthesis
    • Bray, B.L. Large scale manufacture of peptide therapeutics by chemical synthesis. Nature Rev. Drug Disc., 2003, 2, 587-93.
    • (2003) Nature Rev. Drug Disc , vol.2 , pp. 587-593
    • Bray, B.L.1
  • 110
    • 0025095635 scopus 로고
    • Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein
    • Earl, P.L.; Doms, R.W.; Moss, B. Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein. Proc. Natl. Acad. Sci., USA, 1990, 87, 648-52.
    • (1990) Proc. Natl. Acad. Sci., USA , vol.87 , pp. 648-652
    • Earl, P.L.1    Doms, R.W.2    Moss, B.3
  • 111
    • 0023651341 scopus 로고
    • Delineation of a region of the human immunodeficiency virus type-I gp 120 glycoprotein critical for interaction with the CD4 receptor
    • Lasky, L.A.; Nakamura, G.; Smith, D.H., et al. Delineation of a region of the human immunodeficiency virus type-I gp 120 glycoprotein critical for interaction with the CD4 receptor. Cell, 1987, 50, 975-85.
    • (1987) Cell , vol.50 , pp. 975-985
    • Lasky, L.A.1    Nakamura, G.2    Smith, D.H.3
  • 112
    • 0035846960 scopus 로고    scopus 로고
    • Mode of action of an antiviral peptide from HIV-1. Inhibition at a post- lipid mixing stage
    • Kliger, Y.; Gallo, Sa.; Peisajovich, S.G., et al. Mode of action of an antiviral peptide from HIV-1. Inhibition at a post- lipid mixing stage. J. Biological. Chem., 2001, 276, 1391-7.
    • (2001) J. Biological. Chem , vol.276 , pp. 1391-1397
    • Kliger, Y.1    Gallo, S.A.2    Peisajovich, S.G.3
  • 113
    • 0037471311 scopus 로고    scopus 로고
    • A phase-II clinical study of the long term safety and antiviral activity of enfuvirtidebased antiretroviral therapy
    • Lalezari, J.P.; Eron, J.J.; Carlson, M., et al. A phase-II clinical study of the long term safety and antiviral activity of enfuvirtidebased antiretroviral therapy. AIDS, 2003, II, 641-8.
    • (2003) AIDS , vol.2 , pp. 641-648
    • Lalezari, J.P.1    Eron, J.J.2    Carlson, M.3
  • 115
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug - resistant HIV infection in North and South America
    • Lalezaris, J.P., et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug - resistant HIV infection in North and South America. New Eng. J. Med., 2003, 348, 2175-85.
    • (2003) New Eng. J. Med , vol.348 , pp. 2175-2185
    • Lalezaris, J.P.1
  • 116
    • 4444375658 scopus 로고    scopus 로고
    • Review: Resistance to enfuvirtide, the first HIV fusion inhibitor
    • Greenberg, M.L; Cammack, N. Review: Resistance to enfuvirtide, the first HIV fusion inhibitor. J. Antimicrob. Chemother., 2004, 54, 333-40.
    • (2004) J. Antimicrob. Chemother , vol.54 , pp. 333-340
    • Greenberg, M.L.1    Cammack, N.2
  • 118
    • 33745077340 scopus 로고    scopus 로고
    • A pharmacokinetic - pharmacodynamic model to optimize the phase II, a development programme of maraviroc
    • Rosario, M.C.; Poland, B.; Sullivan J.; Westby, M.; VanduRyst, E. A pharmacokinetic - pharmacodynamic model to optimize the phase II, a development programme of maraviroc. JAIDS, 2006, 42, 183-91.
    • (2006) JAIDS , vol.42 , pp. 183-191
    • Rosario, M.C.1    Poland, B.2    Sullivan, J.3    Westby, M.4    Vanduryst, E.5
  • 121
    • 27744548649 scopus 로고    scopus 로고
    • The discovery of the CCR5 receptor antagonist, UK-427, 857, a new agent for the treatment of HIV infection and AIDS
    • Wood, A.; Armour, D. The discovery of the CCR5 receptor antagonist, UK-427, 857, a new agent for the treatment of HIV infection and AIDS. Prog. Med. Chem., 2005, 43, 239-71.
    • (2005) Prog. Med. Chem , vol.43 , pp. 239-271
    • Wood, A.1    Armour, D.2
  • 124
    • 33845204239 scopus 로고    scopus 로고
    • A historical sketch of the discovery and development of HIV-1 integrase inhibitors
    • Savarimo, A. A historical sketch of the discovery and development of HIV-1 integrase inhibitors. Expert. Opin. Investig. Drugs, 2006, 15, 1507-1.
    • (2006) Expert. Opin. Investig. Drugs , vol.15 , pp. 1507-1601
    • Savarimo, A.1
  • 125
    • 12944270496 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitors that compete with target DNA substrate define a unique strand transfer conformation for integrase
    • Espeseth, A.S.; Felock, P.; Wolfe, A., et al. HIV-1 integrase inhibitors that compete with target DNA substrate define a unique strand transfer conformation for integrase. Proc. Natl. Acad. Sci. USA, 2000, 97, 11244-9.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11244-11249
    • Espeseth, A.S.1    Felock, P.2    Wolfe, A.3
  • 126
    • 47949120697 scopus 로고    scopus 로고
    • Raltegravir with Optimized Background Therapy for resistant HIV- 1 infection
    • Steigbigel, R.T.; Cooper, D.A.; Kumar, P.N.; Eron, J.E., et al. Raltegravir with Optimized Background Therapy for resistant HIV- 1 infection. N. Engl. J. Med., 2008, 359, 339-54.
    • (2008) N. Engl. J. Med , vol.359 , pp. 339-354
    • Steigbigel, R.T.1    Cooper, D.A.2    Kumar, P.N.3    Eron, J.E.4
  • 127
    • 34548065793 scopus 로고    scopus 로고
    • Metabolism and disposition in humans of raltegravir (MK - 0518), and anti-AIDS drug targeting the Human Immunodeficiency Virus-1 integrase enzyme
    • DOI:10.1124/dmd.10T.016196. DMD (2007) # 16196 1
    • Kassahun, K.; Mc Intosh, I.; Cui, D., et al. Metabolism and disposition in humans of raltegravir (MK - 0518), and anti-AIDS drug targeting the Human Immunodeficiency Virus-1 integrase enzyme. Drug Metabolism and Disposition Fast Forward, 2007, DOI:10.1124/dmd.10T.016196. DMD (2007) # 16196 1.
    • (2007) Drug Metabolism and Disposition Fast Forward
    • Kassahun, K.1    McIntosh, I.2    Cui, D.3
  • 128
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    • Hazula, D.J.; Felock, P.; Witmer, M., et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science, 2000, 287, 646-50.
    • (2000) Science , vol.287 , pp. 646-650
    • Hazula, D.J.1    Felock, P.2    Witmer, M.3
  • 129
    • 3242769788 scopus 로고    scopus 로고
    • Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
    • Hazuda, D.J.; Young, S.D.; Guare, J.P. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science, 2004, 305, 528-32.
    • (2004) Science , vol.305 , pp. 528-532
    • Hazuda, D.J.1    Young, S.D.2    Guare, J.P.3
  • 130
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-o518, a novel inhibitor of HIV-1 integrase, dosed as mono therapy for 10 days in treatment - naïve HIV-1 infected individuals
    • Markowitz, M.; Morals-Ramirez, J.O.; Nguyen, B.Y. Antiretroviral activity, pharmacokinetics, and tolerability of MK-o518, a novel inhibitor of HIV-1 integrase, dosed as mono therapy for 10 days in treatment - naïve HIV-1 infected individuals. JAIDS, 2006, 43, 509-15.
    • (2006) JAIDS , vol.43 , pp. 509-515
    • Markowitz, M.1    Morals-Ramirez, J.O.2    Nguyen, B.Y.3


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