-
1
-
-
0022720457
-
What to call the AIDS virus?
-
Coffin, J.; Haase, A.; Levy, J.A.; Montagnier, L.; Oroszlan, S.; Teich, N.; Temin, H.; Toyoshima, K.; Varmus, H.; Vogt, P.; Weiss, R.A. What to call the AIDS virus? Nature, 1986, 321, 10.
-
(1986)
Nature
, vol.321
, pp. 10
-
-
Coffin, J.1
Haase, A.2
Levy, J.A.3
Montagnier, L.4
Oroszlan, S.5
Teich, N.6
Temin, H.7
Toyoshima, K.8
Varmus, H.9
Vogt, P.10
Weiss, R.A.11
-
2
-
-
84871324199
-
-
AIDS epedimic update, UNAIDS
-
AIDS epedimic update, UNAIDS, 2009.
-
(2009)
-
-
-
3
-
-
2642709177
-
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
-
HIV outpatient study investigators
-
Palella, F.J.Jr; Delaney, K.M; Moorman, A.C.; Loveless, M.O.; Fuhrer, J.; Satten, G.A.; Aschman, D.J.; Holmberg, S.D. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. N. Engl. J. Med., 1998, 338, 853-60.
-
(1998)
N. Engl. J. Med
, vol.338
, pp. 853-860
-
-
Palella Jr., F.J.1
Delaney, K.M.2
Moorman, A.C.3
Loveless, M.O.4
Fuhrer, J.5
Satten, G.A.6
Aschman, D.J.7
Holmberg, S.D.8
-
4
-
-
0025953621
-
Indeterminate human immuno deficiency virus type 1 western blot, seroconversion risk, specificity of supplemental tests and an algorithm for evaluation
-
Celum, C.L.; Coombs, R.W.; Lafferty, W.; Inui, T.S.; Louie, P.H.; Gates, C.A.; McCreedy, B.J.; Egan, R.; Grove, T.; Alexander, S., et al. Indeterminate human immuno deficiency virus type 1 western blot, seroconversion risk, specificity of supplemental tests and an algorithm for evaluation. J. Infect. Dis., 1991, 164, 656-64.
-
(1991)
J. Infect. Dis
, vol.164
, pp. 656-664
-
-
Celum, C.L.1
Coombs, R.W.2
Lafferty, W.3
Inui, T.S.4
Louie, P.H.5
Gates, C.A.6
McCreedy, B.J.7
Egan, R.8
Grove, T.9
Alexander, S.10
-
5
-
-
84921537578
-
Revised guidelines for HIV counseling testing and referral MMWR
-
Centers for disease control and prevention
-
Centers for disease control and prevention. Revised guidelines for HIV counseling testing and referral MMWR. Recomn Rep 50 (RR- 19), 2001, 1-57.
-
(2001)
Recomn Rep
, vol.50
, Issue.19
, pp. 1-57
-
-
-
6
-
-
0033576816
-
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults
-
Study 006 team
-
Staszewski, S.; Morales-Ramirez, J.; Tashima, K.T. Rachlis, A.; Skiest, D.; Stanford, J.; Stryker, R.; Johnson, P.; Labriola, D.F.; Farina, D.; Manjon, D.J.; Ruiz, N.M. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 team. N. Engl. J. Med., 1999, 341, 1865-73.
-
(1999)
N. Engl. J. Med
, vol.341
, pp. 1865-1873
-
-
Staszewski, S.1
Morales-Ramirez, J.2
Tashima, K.T.3
Rachlis, A.4
Skiest, D.5
Stanford, J.6
Stryker, R.7
Johnson, P.8
Labriola, D.F.9
Farina, D.10
Manjon, D.J.11
Ruiz, N.M.12
-
7
-
-
0043069555
-
Toxicity of antiretroviral therapy and implications for drug development
-
Carr, A. Toxicity of antiretroviral therapy and implications for drug development. Nat. Rev. Drug Discov., 2003, 2, 624-34.
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, pp. 624-634
-
-
Carr, A.1
-
8
-
-
0034685037
-
Antiretroviral therapy in adults: Updated recommendations of the international AIDS society-USA panel
-
Carpenter, C.C.; Cooper, D.A.; Fischl, M.A.; Gatell, J.M.; Gazzard, B.G.; Hammer, S.M.; Hirsch, M.S.; Jacobsen, D.M.; Katzenstein, D.A.; Montaner, J.S.; Richman, D.D.; Saag, M.S.; Schechter, M.; Schooley, R.T.; Thompson, M.A.; Vella S.; Yeni, P.G.; Volberding, P.A., et al. Antiretroviral therapy in adults: updated recommendations of the international AIDS society-USA panel. JAMA, 2000, 283, 381-90.
-
(2000)
JAMA
, vol.283
, pp. 381-390
-
-
Carpenter, C.C.1
Cooper, D.A.2
Fischl, M.A.3
Gatell, J.M.4
Gazzard, B.G.5
Hammer, S.M.6
Hirsch, M.S.7
Jacobsen, D.M.8
Katzenstein, D.A.9
Montaner, J.S.10
Richman, D.D.11
Saag, M.S.12
Schechter, M.13
Schooley, R.T.14
Thampson, M.A.15
Vella, S.16
Yeni, P.G.17
Volberding, P.A.18
-
9
-
-
0345012053
-
Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection
-
Robbins, G.K.; De Gruttola, V.; Shafer, R.W.; Smeaton, L.M.; Snyder, S.W.; Pettinelli, C.; Dubé, M.P.; Fischl, M.A.; Pollard, R.B.; Delapenha, R.; Gedeon, L.; Van der Horst, C.; Murphy, R.L.; Becker, M.I.; D'Aquila, R.T.; Vella, S.; Merigan, T.C.; Hirsch, M.S., et al. Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection. N. Engl. J. Med., 2003, 349, 2293-303.
-
(2003)
N. Engl. J. Med
, vol.349
, pp. 2293-2303
-
-
Robbins, G.K.1
de Gruttola, V.2
Shafer, R.W.3
Smeaton, L.M.4
Snyder, S.W.5
Pettinelli, C.6
Dubé, M.P.7
Fischl, M.A.8
Pollard, R.B.9
Delapenha, R.10
Gedeon, L.11
van der Horst, C.12
Murphy, R.L.13
Becker, M.I.14
D'Aquila, R.T.15
Vella, S.16
Merigan, T.C.17
Hirsch, M.S.18
-
10
-
-
0344149561
-
Comparison of four-drug regimens and pairs of sequential threedrug regimens as initial therapy for HIV-1 infection
-
Shafer, R.W.; Smeaton, L.M.; Robbins, G.K.; Gruttola, V.D.; Snyder, S.W.; D'Aquila, R.T.; Johnson, V.A.; Morse, G.D.; Nokta, M.A.; Martinez, A.I.; Gripshover, B.M.; Kaul, P.; Haubrich, R.; Swingle, M.; McCarty, S.D.; Vella, S.; Hirsch, M.S.; Merigan, T.C. Comparison of four-drug regimens and pairs of sequential threedrug regimens as initial therapy for HIV-1 infection. N. Engl. J. Med., 2003, 349, 2304-15.
-
(2003)
N. Engl. J. Med
, vol.349
, pp. 2304-2315
-
-
Shafer, R.W.1
Smeaton, L.M.2
Robbins, G.K.3
Gruttola, V.D.4
Snyder, S.W.5
D'Aquila, R.T.6
Johnson, V.A.7
Morse, G.D.8
Nokta, M.A.9
Martinez, A.I.10
Gripshover, B.M.11
Kaul, P.12
Haubrich, R.13
Swingle, M.14
McCarty, S.D.15
Vella, S.16
Hirsch, M.S.17
Merigan, T.C.18
-
11
-
-
0022996630
-
Phosphorylation of 3'-azido-3'- deoxythymidine & selective interaction of the 3'-triphosphate with human immunodeficiency virus reverse transcriptase
-
Furman, P.A.; Fyfe, J.A.; St Clair, M.H.; Weinhold, K.; Rideout, J.L.; Freeman, G.A.; Nusinoff-Lehrman, S.; Bolognesi, D.P.; Broder, S.; Mitsuya, H. Phosphorylation of 3'-azido-3'- deoxythymidine & selective interaction of the 3'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA, 1986, 83, 8333-7.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 8333-8337
-
-
Furman, P.A.1
Fyfe, J.A.2
St. Clair, M.H.3
Weinhold, K.4
Rideout, J.L.5
Freeman, G.A.6
Nusinoff-Lehrman, S.7
Bolognesi, D.P.8
Broder, S.9
Mitsuya, H.10
-
12
-
-
0001707601
-
3'-Azido-3'-deoxythymidine (BWA 509U): An antiviral agent that inhibits the inefectivity & cytopathic effect of human Tlymphotropic virus type III/ lymphadenopathy-associated virus in vitro
-
Mitsuya, H.; Weinhold, K.J.; Furman, P.A.; St. Clair, M.H.; Lehrman, N.S.; Gallo, R.C.; Bloguesi, D.; Barry, D.W.; Broder, S. 3'-Azido-3'-deoxythymidine (BWA 509U): an antiviral agent that inhibits the inefectivity & cytopathic effect of human Tlymphotropic virus type III/ lymphadenopathy-associated virus in vitro. Proc. Natl. Acad. Sci. USA, 1985, 82, 7096-100.
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 7096-7100
-
-
Mitsuya, H.1
Weinhold, K.J.2
Furman, P.A.3
St. Clair, M.H.4
Lehrman, N.S.5
Gallo, R.C.6
Bloguesi, D.7
Barry, D.W.8
Broder, S.9
-
13
-
-
0025912292
-
Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo
-
Goody, R.S.; Muller, B.; Restle, T. Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo. FEBS Lett., 1991, 291, 1-5.
-
(1991)
FEBS Lett
, vol.291
, pp. 1-5
-
-
Goody, R.S.1
Muller, B.2
Restle, T.3
-
14
-
-
84871319403
-
Improved synthesis of zidovudine
-
Jiang, Y.Q.; Hao, E.J.; Li, W.; Yu, G.; Wang, W.; Chinere, J. Improved synthesis of zidovudine. Chin. J. Pharm., 2005, 36, 323.
-
(2005)
Chin. J. Pharm
, vol.36
, pp. 323
-
-
Jiang, Y.Q.1
Hao, E.J.2
Li, W.3
Yu, G.4
Wang, W.5
Chinere, J.6
-
15
-
-
0023268502
-
The efficacy of azidothimidine (AZT) in the treatment of patients with AIDS and AIDS related complex. A double blind placebo-controlled trial
-
Fischl, M.A.; Richman, D.D.; Grieco, M.H.; Gottlieb, M.S.; Volberding, P.A.; Laskin, O.L.; Leedom, J.M.; Groopman, J.E.; Mildvan, D.; Hirsch, M.S., et al. The efficacy of azidothimidine (AZT) in the treatment of patients with AIDS and AIDS related complex. A double blind placebo-controlled trial. N. Engl. J. Med., 1987, 317, 185-91.
-
(1987)
N. Engl. J. Med
, vol.317
, pp. 185-191
-
-
Fischl, M.A.1
Richman, D.D.2
Grieco, M.H.3
Gottlieb, M.S.4
Volberding, P.A.5
Laskin, O.L.6
Leedom, J.M.7
Groopman, J.E.8
Mildvan, D.9
Hirsch, M.S.10
-
16
-
-
0028003766
-
Reduction of maternal infant transmission of human immunodeficiency virus type-I with ziduvudine treatment
-
Pediatric AIDS clinical trials group protocol 076 study group
-
Connor, E.; Sperling, R.; Gelber, R.; Kiselev, P.; Scott, G.; O'Sullivan, M.J.; VanDyke, R.; Bey, M.; Shearer, W.; Jacobson, R.L.; Jimenez, E.; O'Neill, E.; Bazin, B.; Delfraissy, J.F.; Culnane, M.; Coombs, R.; Elkins, M.; Moye, J.; Stratton, P.; Balsley, J., et al. Reduction of maternal infant transmission of human immunodeficiency virus type-I with ziduvudine treatment. Pediatric AIDS clinical trials group protocol 076 study group. N. Engl. J. Med., 1994, 331, 1173-80.
-
(1994)
N. Engl. J. Med
, vol.331
, pp. 1173-1180
-
-
Connor, E.1
Sperling, R.2
Gelber, R.3
Kiselev, P.4
Scott, G.5
O'Sullivan, M.J.6
Vandyke, R.7
Bey, M.8
Shearer, W.9
Jacobson, R.L.10
Jimenez, E.11
O'Neill, E.12
Bazin, B.13
Delfraissy, J.F.14
Culnane, M.15
Coombs, R.16
Elkins, M.17
Moye, J.18
Stratton, P.19
Balsley, J.20
more..
-
17
-
-
0022996630
-
Phosphorylation of 3'-azido-3-deoxythimidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
-
Ferman, P.; Fyfe, J.; St Clair, M.; Winhold, K.; Freeman, G.A.; Lehrman, S.N.; Bolognesi, D.P.; Broder, S.; Mitsuya H., et al. Phosphorylation of 3'-azido-3-deoxythimidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA, 1986, 83, 8333-7.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 8333-8337
-
-
Ferman, P.1
Fyfe, J.2
St. Clair, M.3
Winhold, K.4
Freeman, G.A.5
Lehrman, S.N.6
Bolognesi, D.P.7
Broder, S.8
Mitsuya, H.9
-
19
-
-
0024349612
-
In vivo activity against HIV and favourable toxicity profile of 2', 3'- dideoxyinosine
-
Yarchoan, R.; Mitsura, H.; Thomas, R.V.; Pluda, J.M.; Hartman, N.R.; Perno, C.F.; Marczyk, K.S.; Allain, J.P.; DG Johns, D.G.; Broder, S. In vivo activity against HIV and favourable toxicity profile of 2', 3'- dideoxyinosine. Science, 1989, 245, 412-5.
-
(1989)
Science
, vol.245
, pp. 412-415
-
-
Yarchoan, R.1
Mitsura, H.2
Thomas, R.V.3
Pluda, J.M.4
Hartman, N.R.5
Perno, C.F.6
Marczyk, K.S.7
Allain, J.P.8
Johns, D.G.9
Broder, S.10
-
20
-
-
0027192916
-
Zalcitabine
-
Shelton, M.J.; O' Donnell, A.M.; Morse, G.D., Zalcitabine. Ann. Pharmacother., 1993, 27, 480-9.
-
(1993)
Ann. Pharmacother
, vol.27
, pp. 480-489
-
-
Shelton, M.J.1
O'Donnell, A.M.2
Morse, G.D.3
-
21
-
-
0025186450
-
Molecular targets for AIDS therapy
-
Mitsuya H.; Yarchaon, R.; Broder, S. Molecular targets for AIDS therapy. Science, 1990, 249, 1533-44.
-
(1990)
Science
, vol.249
, pp. 1533-1544
-
-
Mitsuya, H.1
Yarchaon, R.2
Broder, S.3
-
22
-
-
0029774808
-
Use of viral resistance patterns to antiretroviral drugs in optimizing selection of drug combination and sequences
-
Moyle, G.J. Use of viral resistance patterns to antiretroviral drugs in optimizing selection of drug combination and sequences. Drugs, 1996, 52, 168-85.
-
(1996)
Drugs
, vol.52
, pp. 168-185
-
-
Moyle, G.J.1
-
23
-
-
0013869085
-
Nucleside IX. The formation of 2', 3'-unsaturated pyrimidine nucleoside via a novel beta elimination reaction
-
Horwitz, J.P. Nucleside IX. The formation of 2', 3'-unsaturated pyrimidine nucleoside via a novel beta elimination reaction. J. Org. Chem., 1996, 31, 205-11.
-
(1996)
J. Org. Chem
, vol.31
, pp. 205-211
-
-
Horwitz, J.P.1
-
24
-
-
84871268116
-
Synthesis of Stavudine
-
Liu, S.L.; Ye, F.; Chen, Y.; Shen, X.X. Synthesis of Stavudine. Chinese J. Pharma., 2006, 37, 510-2.
-
(2006)
Chinese J. Pharma
, vol.37
, pp. 510-512
-
-
Liu, S.L.1
Ye, F.2
Chen, Y.3
Shen, X.X.4
-
25
-
-
0032784006
-
Stavudine: A update of its use in the treatment of HIV infection
-
Hurst, M.; Noble, S. Stavudine: a update of its use in the treatment of HIV infection. Drugs, 1999, 58, 919-49.
-
(1999)
Drugs
, vol.58
, pp. 919-949
-
-
Hurst, M.1
Noble, S.2
-
26
-
-
0028928910
-
Biological effects and safety of stavudine: Overview of phase I clinical trials
-
Skowron, G. Biological effects and safety of stavudine: overview of phase I clinical trials. J. Infec. Dis., 1995, 171, S113-7.
-
(1995)
J. Infec. Dis
, vol.171
-
-
Skowron, G.1
-
27
-
-
27644482372
-
Practical enantioselective synthesis of lamivudine (3TC) via a dynamic kinetic resolution
-
Goodyear, M.D.; Hill, M.L.; West, J.P.; Whitehead, A.J. Practical enantioselective synthesis of lamivudine (3TC) via a dynamic kinetic resolution. Tet. Lett., 2005, 46, 8535-8.
-
(2005)
Tet. Lett
, vol.46
, pp. 8535-8538
-
-
Goodyear, M.D.1
Hill, M.L.2
West, J.P.3
Whitehead, A.J.4
-
28
-
-
0037001153
-
CH-126443: Anti-HBV anti-HIV
-
Sorbera, L.A.; Castaner, J.; Bayes, M. A.CH-126443: Anti-HBV anti-HIV. Drugs Future, 2002, 27, 1131-40.
-
(2002)
Drugs Future
, vol.27
, pp. 1131-1140
-
-
Sorbera, L.A.1
Castaner, J.2
Bayes, M.A.3
-
29
-
-
84871341398
-
-
Pat. Application no. 1570/MUM/2005. Published 07/13/2007
-
Gharpure, M.M.; Bhaal, B.M.; Rane, D.R.; Barde, A.R.; Zope, U.R.; Mehta, S.R. Industrial process for the manufacture of lamivudine. Pat. Application no. 1570/MUM/2005. Published 07/13/2007.
-
Industrial Process For the Manufacture of Lamivudine
-
-
Gharpure, M.M.1
Bhaal, B.M.2
Rane, D.R.3
Barde, A.R.4
Zope, U.R.5
Mehta, S.R.6
-
30
-
-
55949099628
-
Rapid re-emergence of YMDD mutation of HBV with hepatic decompensation after lamivudine re-treatment
-
Kwon, S.Y.; Choe, W.H.; Lee, C.H.; Yeon, J.E.; Byun, K.S.; Rapid re-emergence of YMDD mutation of HBV with hepatic decompensation after lamivudine re-treatment. World J. Gastroenterol, 2008, 14, 4416-9.
-
(2008)
World J. Gastroenterol
, vol.14
, pp. 4416-4419
-
-
Kwon, S.Y.1
Choe, W.H.2
Lee, C.H.3
Yeon, J.E.4
Byun, K.S.5
-
31
-
-
0032416060
-
Abacavir sulfate
-
Graul, A.; Leeson, P.A.; Castaner, J. Abacavir sulfate. Drugs Future, 1998, 23, 1155-67.
-
(1998)
Drugs Future
, vol.23
, pp. 1155-1167
-
-
Graul, A.1
Leeson, P.A.2
Castaner, J.3
-
33
-
-
0043124520
-
Tenofovir Disoproxil Fumarate: AIDS drug profile
-
Chapman, T.M.; McGavin, J.K.; Noble, S. Tenofovir Disoproxil Fumarate: AIDS drug profile. Drugs, 2003, 6, 1597-608.
-
(2003)
Drugs
, vol.6
, pp. 1597-1608
-
-
Chapman, T.M.1
McGavin, J.K.2
Noble, S.3
-
34
-
-
0030782524
-
Synthesis, In vitroevaluatio, and oral bioavailability of 9-[2- (phosphonomethoxy)propyladenine(PMPA) prodrugs
-
Arimilli, M.; Kim, C.; Bischofberger, N. Synthesis, In vitroevaluatio, and oral bioavailability of 9-[2- (phosphonomethoxy)propyladenine(PMPA) prodrugs. Antimicrob. Agents Chemother., 1997, 8, 557-64.
-
(1997)
Antimicrob. Agents Chemother
, vol.8
, pp. 557-564
-
-
Arimilli, M.1
Kim, C.2
Bischofberger, N.3
-
35
-
-
0031710248
-
Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy) propyladenine, a novel anti-human immunodeficiency virus(HIV) therapy, in HIV infected adults
-
Deeks, S.G.; Barditch- Crovo, P.; Lietman, P.S.; Hwang, F.; Cundy, K.C.; Rooney, J.F.; Hellmann, N.S.; Safrin, S. Kahn, J.O. Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy) propyladenine, a novel anti-human immunodeficiency virus(HIV) therapy, in HIV infected adults. Antimicrob. Agents Chemother., 1998, 42, 2380-4.
-
(1998)
Antimicrob. Agents Chemother
, vol.42
, pp. 2380-2384
-
-
Deeks, S.G.1
Barditch-Crovo, P.2
Lietman, P.S.3
Hwang, F.4
Cundy, K.C.5
Rooney, J.F.6
Hellmann, N.S.7
Safrin, S.8
Kahn, J.O.9
-
36
-
-
18244398917
-
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor Tenofovir leads to a preferential distribution and accumulation in lymphatic tissue
-
Lee, W.A.; He, G.X.; Eisenberg, E.; Cihlar, T.; Swaminathan, S.; Mulato, A.; Cundy, K.C. Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor Tenofovir leads to a preferential distribution and accumulation in lymphatic tissue. Antimicrob. Agents Chemother., 2005, 49, 1898-906.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 1898-1906
-
-
Lee, W.A.1
He, G.X.2
Eisenberg, E.3
Cihlar, T.4
Swaminathan, S.5
Mulato, A.6
Cundy, K.C.7
-
37
-
-
0023741036
-
Phosphonyl methoxymethyl purine derivatives, a new class of ti- human immunodeficiency virus agent
-
Pauwels, R.; Balzarini, J.; Schols, D.; Baba, M.; Desmyter, J.; Rosenberg, I.; Holy, A.; Clercq, E.D. Phosphonyl methoxymethyl purine derivatives, a new class of ti- human immunodeficiency virus agent. Antimicrob. Agents Chemother., 1988, 32, 1025-30.
-
(1988)
Antimicrob. Agents Chemother
, vol.32
, pp. 1025-1030
-
-
Pauwels, R.1
Balzarini, J.2
Schols, D.3
Baba, M.4
Desmyter, J.5
Rosenberg, I.6
Holy, A.7
Clercq, E.D.8
-
38
-
-
84871306014
-
Synthesis of emtricitabine
-
Meng, J.F.; Wu, X.S.; Cen, J.D. Synthesis of emtricitabine. Chinese J. Pharma., 2005, 36, 589-90.
-
(2005)
Chinese J. Pharma
, vol.36
, pp. 589-590
-
-
Meng, J.F.1
Wu, X.S.2
Cen, J.D.3
-
39
-
-
33845275093
-
In vitro human imunodeficieny virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine
-
Margot, N.A.; Waters, J.M.; Miller, M.D. In vitro human imunodeficieny virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine. Antimicrob. Agents Chemothe., 2006, 50, 4087-95.
-
(2006)
Antimicrob. Agents Chemothe
, vol.50
, pp. 4087-4095
-
-
Margot, N.A.1
Waters, J.M.2
Miller, M.D.3
-
41
-
-
4544265135
-
Conformational changes in HIV-1 reverse transcriptase induced by non-nucleoside reverse transcriptase inhibitor binding
-
Sluis-Cremer, N.; Temiz, N.A.; Bahar, I. Conformational changes in HIV-1 reverse transcriptase induced by non-nucleoside reverse transcriptase inhibitor binding. Curr. HIV Res., 2004, 2, 323-32.
-
(2004)
Curr. HIV Res
, vol.2
, pp. 323-332
-
-
Sluis-Cremer, N.1
Temiz, N.A.2
Bahar, I.3
-
42
-
-
34248162966
-
Liver toxicity induced by NNRTIs
-
Rivero, A.; Mira, J.A.; Pineda, J.A. Liver toxicity induced by NNRTIs. J. Antimicrob. Chemother., 2007, 59, 342-6.
-
(2007)
J. Antimicrob. Chemother
, vol.59
, pp. 342-346
-
-
Rivero, A.1
Mira, J.A.2
Pineda, J.A.3
-
43
-
-
0034100184
-
Non nucleoside reverse transcriptase inhibitors
-
Hajos, G.; Riedle, Z.; Molnar J.; Szabo, D. Non nucleoside reverse transcriptase inhibitors. Drug Future, 2000, 25, 47-62.
-
(2000)
Drug Future
, vol.25
, pp. 47-62
-
-
Hajos, G.1
Riedle, Z.2
Molnar, J.3
Szabo, D.4
-
44
-
-
0032565098
-
A randomized double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV infected patients. The INCAS trial
-
Montaner, J.S.G.; Reiss, P.; Cooper, D.; Vella, S.; Harris, M.; Conway, B.; Wainberg, M.A.; Smith, D.; Robinson, P.; Hall, D.; Myers, M.; Lange, J.M.A. A randomized double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV infected patients. The INCAS trial. JAMA, 1998, 279, 930-7.
-
(1998)
JAMA
, vol.279
, pp. 930-937
-
-
Montaner, J.S.G.1
Reiss, P.2
Cooper, D.3
Vella, S.4
Harris, M.5
Conway, B.6
Wainberg, M.A.7
Smith, D.8
Robinson, P.9
Hall, D.10
Myers, M.11
Lange, J.M.A.12
-
45
-
-
0037195081
-
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors
-
Ren, J.; Bird, L.E.; Chamberlain, P.P.; Stewart-Jones, G.B.; Stuart, D. I.; Stammers, D.K. Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors. Proc. Natl. Acad. Sci. USA, 2002, 99, 14410-5.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14410-14415
-
-
Ren, J.1
Bird, L.E.2
Chamberlain, P.P.3
Stewart-Jones, G.B.4
Stuart, D.I.5
Stammers, D.K.6
-
46
-
-
0033523454
-
Intrapartum and neonatal single dose nevirapine compared with zidovudine for prevention of mother to chile transmission of HIV-1 in Kampala, Uganda: HIV NET 012 randomized trial
-
Guay, L.A.; Musoke, P.; Flening, T.; Bagenda, D.; Allen, M.; Nakabiito, C.; Sherman, J.; Bakaki, P.; Ducar, C.; Deseyve, M.; Emel, L.; Mirochnick, M.; Fowler, M.G.; Mofenson, L.; Miotti, P.; Dransfield, K.; Bray, D.; Mmiro, F.; Jackson, J.B. Intrapartum and neonatal single dose nevirapine compared with zidovudine for prevention of mother to chile transmission of HIV-1 in Kampala, Uganda: HIV NET 012 randomized trial. Lancet, 1999, 354, 795-802.
-
(1999)
Lancet
, vol.354
, pp. 795-802
-
-
Guay, L.A.1
Musoke, P.2
Flening, T.3
Bagenda, D.4
Allen, M.5
Nakabiito, C.6
Sherman, J.7
Bakaki, P.8
Ducar, C.9
Deseyve, M.10
Emel, L.11
Mirochnick, M.12
Fowler, M.G.13
Mofenson, L.14
Miotti, P.15
Dransfield, K.16
Bray, D.17
Mmiro, F.18
Jackson, J.B.19
-
47
-
-
20844451906
-
Resistance HIV-1 after intrapartum administration of single dose nevirapine is substantially under estimated
-
Johnson, J.A.; Li, J.F.; Morris, L.; Martinson, N.; Gray, G.; McIntyre, J.; Heneine, W. Resistance HIV-1 after intrapartum administration of single dose nevirapine is substantially under estimated. J. Infect. Dis., 2005, 192, 16-23.
-
(2005)
J. Infect. Dis
, vol.192
, pp. 16-23
-
-
Johnson, J.A.1
Li, J.F.2
Morris, L.3
Martinson, N.4
Gray, G.5
McIntyre, J.6
Heneine, W.7
-
48
-
-
84871273826
-
-
San Franc.Calif. Jan 30- Feb 2
-
Eron, J.; McKinley, G.; Lecrerq, P.; Nieto, L.; Wathen, L.; Pietrantoni, C.; Greenwald, C.; Conklin, M.; Paxton, L.; Freimuth, W. Potent anti viral activity using delavirdine and reduced-dose indinavir combination therapies: a 48 week analysis. Conference on retroviruses and opportunistic infections. San Franc.Calif. Jan 30- Feb 2, 2000.
-
(2000)
Potent Anti Viral Activity Using Delavirdine and Reduced-dose Indinavir Combination Therapies: A 48 Week Analysis. Conference On Retroviruses and Opportunistic Infections
-
-
Eron, J.1
McKinley, G.2
Lecrerq, P.3
Nieto, L.4
Wathen, L.5
Pietrantoni, C.6
Greenwald, C.7
Conklin, M.8
Paxton, L.9
Freimuth, W.10
-
49
-
-
0031944616
-
Efavirenz
-
Graul, A.; Rabasseda, X.; Castaner, J. Efavirenz. Drugs Future, 1998, 23, 133-41.
-
(1998)
Drugs Future
, vol.23
, pp. 133-141
-
-
Graul, A.1
Rabasseda, X.2
Castaner, J.3
-
50
-
-
0034633611
-
Efavirez is a potent nonnucleoside reverse transcriptase inhibitor of HIV type I. Replication in microglia in vitro
-
Albrigh, A.V.; Erickson -Vitanen, S.; O'Connov, M.; Frank, I.; Rayner, M.M.; Gonzalez-Scarano. Efavirez is a potent nonnucleoside reverse transcriptase inhibitor of HIV type I. Replication in microglia in vitro. AIDS Res. Hum. Retroviruses, 2000, 16, 1527-37.
-
(2000)
AIDS Res. Hum. Retroviruses
, vol.16
, pp. 1527-1537
-
-
Albrigh, A.V.1
Erickson-Vitanen, S.2
O'Connov, M.3
Frank, I.4
Rayner, M.M.5
Gonzalez-Scarano6
-
51
-
-
33749426630
-
Neuropsychiatry complications of antiretroviral therapy
-
Cespedes, H.S.; Aberg, J.A. Neuropsychiatry complications of antiretroviral therapy. Drug Safety, 2006, 29, 865-74.
-
(2006)
Drug Safety
, vol.29
, pp. 865-874
-
-
Cespedes, H.S.1
Aberg, J.A.2
-
52
-
-
0037271311
-
Long-term assessment of neuropsychiatry adverse reactions associated with efavirenz
-
Lochet, P.; Peyriere, H.; Lotthe, A.; Mauboussiz, J.M.; Dclmas, B.; Reynes, J. Long-term assessment of neuropsychiatry adverse reactions associated with efavirenz. HIV Med., 2003, 4, 62-6.
-
(2003)
HIV Med
, vol.4
, pp. 62-66
-
-
Lochet, P.1
Peyriere, H.2
Lotthe, A.3
Mauboussiz, J.M.4
Dclmas, B.5
Reynes, J.6
-
53
-
-
0035879609
-
Manic syndrome associated with Efavirenz overdose
-
Blanch, J.; Corbella, B.; Garcia, F.; Parellada, E.; Gatell, J.M. Manic syndrome associated with Efavirenz overdose. Clin. Infect. Dis., 2001, 33, 270-1.
-
(2001)
Clin. Infect. Dis
, vol.33
, pp. 270-271
-
-
Blanch, J.1
Corbella, B.2
Garcia, F.3
Parellada, E.4
Gatell, J.M.5
-
54
-
-
22244491993
-
Etravirine
-
Davies, S.; L. Castaner, J.; Silvestres, J.S.; Bayes, M. Etravirine. Drugs Future, 2005, 30, 462-8.
-
(2005)
Drugs Future
, vol.30
, pp. 462-468
-
-
Davies, S.1
Castaner, L.2
Silvestres, J.S.3
Bayes, M.4
-
55
-
-
33750562171
-
-
Etravirine, R165335, TMC 125
-
Etravirine: R165335, TMC 125. Drugs R D., 2006, 7, 367-73.
-
(2006)
Drugs R D
, vol.7
, pp. 367-373
-
-
-
56
-
-
2342620790
-
-
Das, K.; Clark, A.D.; Jr. Lewi, P.J.; Heeres, J.; De Jonge, M.R.; Koymans, L.M.; Vinkers, H.M.; Daeyaert, F.; Ludovici, D.W.; Kukla, M.J.; De Corte, B.; Kavash, R.W.; Ho, C.Y.; Ye, H.; Lichtenstein, M.A.; Andries, K.; Pauwels, R.; De Béthune, M.P.; Boyer, P.L.; Clark, P.; Hughes, S.H.; Janssen, P.A.; Arnold, E. Roles of conformational and positional adaptability in structurebased design of TMC 125-R165335 (etravirine) and related nonnucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug resistant HIV-1 variants. J. Med. Chem., 2004, 47, 2550-60.
-
(2004)
Roles of Conformational and Positional Adaptability In Structurebased Design of TMC 125-R165335 (etravirine) and Related Nonnucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective Against Wild-type and Drug Resistant HIV-1 Variants. J. Med. Chem
, vol.47
, pp. 2550-2560
-
-
Das, K.1
Clark, A.D.2
Lewi Jr., P.J.3
Heeres, J.4
de Jonge, M.R.5
Koymans, L.M.6
Vinkers, H.M.7
Daeyaert, F.8
Ludovici, D.W.9
Kukla, M.J.10
de Corte, B.11
Kavash, R.W.12
Ho, C.Y.13
Ye, H.14
Lichtenstein, M.A.15
Andries, K.16
Pauwels, R.17
de Béthune, M.P.18
Boyer, P.L.19
Clark, P.20
Hughes, S.H.21
Janssen, P.A.22
Arnold, E.23
more..
-
57
-
-
35548957272
-
Antiviral drugs in the treatment of AIDS: What is in the pipe line
-
Stelbrink, H.J. Antiviral drugs in the treatment of AIDS: what is in the pipe line. Eur. J. Med. Res., 2007, 12, 483-95.
-
(2007)
Eur. J. Med. Res
, vol.12
, pp. 483-495
-
-
Stelbrink, H.J.1
-
58
-
-
44449115313
-
Development of non-nucleoside reverse transcriptase inhibitors for anti-HIV therapy
-
Sahlberg, C.; Zhou, X.X. Development of non-nucleoside reverse transcriptase inhibitors for anti-HIV therapy. Anti-Infective Agents Med. Chem., 2008, 7, 101-17.
-
(2008)
Anti-Infective Agents Med. Chem
, vol.7
, pp. 101-117
-
-
Sahlberg, C.1
Zhou, X.X.2
-
59
-
-
2342620790
-
Roles of conformational and positional adaptability in structurebased design of TMC125-R165335 (Etravirine) and related nonnucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
-
Das, K.; Clark, A.D. Jr.; Lewi, P.J.; Heeres, J.; De Jonge, M.R.; Koymans, L.M.; Vinkers, H.M.; Daeyaert, F.; Ludovici, D.W.; Kukla, M.J.; De Corte, B.; Kavash, R.W.; Ho, C.Y.; Ye, H.; Lichtenstein, M.A.; Andries, K.; Pauwels, R.; De Béthune, M.P.; Boyer, P.L.; Clark, P.; Hughes, S.H.; Janssen, P.A.; Arnold, E. Roles of conformational and positional adaptability in structurebased design of TMC125-R165335 (Etravirine) and related nonnucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. J. Med. Chem., 2004, 47, 2550-60.
-
(2004)
J. Med. Chem
, vol.47
, pp. 2550-2560
-
-
Das, K.1
Clark Jr., A.D.2
Lewi, P.J.3
Heeres, J.4
de Jonge, M.R.5
Koymans, L.M.6
Vinkers, H.M.7
Daeyaert, F.8
Ludovici, D.W.9
Kukla, M.J.10
de Corte, B.11
Kavash, R.W.12
Ho, C.Y.13
Ye, H.14
Lichtenstein, M.A.15
Andries, K.16
Pauwels, R.17
de Béthune, M.P.18
Boyer, P.L.19
Clark, P.20
Hughes, S.H.21
Janssen, P.A.22
Arnold, E.23
more..
-
60
-
-
0026592957
-
The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptasef
-
Dueweke, T.J.; Kezdy, F.J.; Waszak, G.A.; Deibel, M.R. Jr.; Tarpley, W.G. The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase J. Biol. Chem., 1992, 267, 27-30.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 27-30
-
-
Dueweke, T.J.1
Kezdy, F.J.2
Waszak, G.A.3
Deibel Jr., M.R.4
Tarpley, W.G.5
-
61
-
-
0027278282
-
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl) carbony l]-4-[3-[(1 methylethyl) amino] pyridinyl] piperazine monomethane sulfonate (U-90152S), a second-generation clinical candidate
-
Romero, D. L.; Morge, R. A.; Genin, M. J.; Biles, C.; Busso, M.; Resnick, L.; Althaus, I. W.; Reusser, F.; Thomas, R. C.; Tarpley, W. G. Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl) carbony l]-4-[3-[(1 methylethyl) amino] pyridinyl] piperazine monomethane sulfonate (U-90152S), a second-generation clinical candidate J. Med. Chem., 1993, 36, 1505-8.
-
(1993)
J. Med. Chem
, vol.36
, pp. 1505-1508
-
-
Romero, D.L.1
Morge, R.A.2
Genin, M.J.3
Biles, C.4
Busso, M.5
Resnick, L.6
Althaus, I.W.7
Reusser, F.8
Thomas, R.C.9
Tarpley, W.G.10
-
62
-
-
0027178052
-
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
-
Dueweke, T.J.; Poppe, S.M.; Romero, D.L., et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agent. Chemother., 1993, 37, 1127-31
-
(1993)
Antimicrob. Agent. Chemother
, vol.37
, pp. 1127-1131
-
-
Dueweke, T.J.1
Poppe, S.M.2
Romero, D.L.3
-
63
-
-
5544231319
-
Synthesis and bioactivity of novel bis (heteroaryl) piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs
-
Genin, M. J.; Poel, T. J.; Yagi, Y.; Biles, C.; Althaus, I.; Keiser, B.J.; Kopta, L.A.; Friis, J.M.; Reusser, F.; Adams, W.J.; Olmsted, R.A.; Voorman, R.L.; Thomas, R.C.; Romero, D.L. Synthesis and bioactivity of novel bis (heteroaryl) piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs. J. Med. Chem., 1996, 39, 5267-75
-
(1996)
J. Med. Chem
, vol.39
, pp. 5267-5275
-
-
Genin, M.J.1
Poel, T.J.2
Yagi, Y.3
Biles, C.4
Althaus, I.5
Keiser, B.J.6
Kopta, L.A.7
Friis, J.M.8
Reusser, F.9
Adams, W.J.10
Olmsted, R.A.11
Voorman, R.L.12
Thomas, R.C.13
Romero, D.L.14
-
64
-
-
9544229686
-
Targeting delaverdine/atevirdine resistant HIV-1: Identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors
-
Romero, D. L.; Olmsted, R.L.; Poel, T.J.; Morge, R.A.; Biles, C.; Keiser, B.J.; Kopta, L.A.; Friis, J.M.; Hosley, J.D.; Stefanski, K.J.; Wishka, D.G.; Evans, D.B.; Morris, J.; Stehle, R.G.; Sharma, S.K.; Yagi, Y.; Voorman, R.L.; Adams, W.J.; Tarpley, W.G.; Thomas, R.C. Targeting delaverdine/atevirdine resistant HIV-1: Identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors. J. Med. Chem., 1996, 39, 3769-89.
-
(1996)
J. Med. Chem
, vol.39
, pp. 3769-3789
-
-
Romero, D.L.1
Olmsted, R.L.2
Poel, T.J.3
Morge, R.A.4
Biles, C.5
Keiser, B.J.6
Kopta, L.A.7
Friis, J.M.8
Hosley, J.D.9
Stefanski, K.J.10
Wishka, D.G.11
Evans, D.B.12
Morris, J.13
Stehle, R.G.14
Sharma, S.K.15
Yagi, Y.16
Voorman, R.L.17
Adams, W.J.18
Tarpley, W.G.19
Thomas, R.C.20
more..
-
65
-
-
0028273009
-
Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors
-
Romero, D.L.; Morge, R.A.; Biles, C.; Berrios-Pena, N.; May, P.D.; Palmer, J.R.; Johnson, P.D.; Smith, H.W.; Busso, M., et al. Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors. J. Med. Chem., 1994, 37, 999-1014.
-
(1994)
J. Med. Chem
, vol.37
, pp. 999-1014
-
-
Romero, D.L.1
Morge, R.A.2
Biles, C.3
Berrios-Pena, N.4
May, P.D.5
Palmer, J.R.6
Johnson, P.D.7
Smith, H.W.8
Busso, M.9
-
66
-
-
0025740266
-
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. tricyclic pyridobenzo- and dipyridodiazepinones
-
Karl D. Hargrave; John R. Proudfoot; Karl G. Grozinger; Ernest Cullen, Suresh R. Kapadia; Usha R. Patel; Victor U. Fuchs; Scott C. Mauldin; Jana Vitous. Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. tricyclic pyridobenzo- and dipyridodiazepinones. J. Med. Chem., 1991, 34, 2231-41.
-
(1991)
J. Med. Chem
, vol.34
, pp. 2231-2241
-
-
Hargrave, K.D.1
Proudfoot, J.R.2
Grozinger, K.G.3
Cullen, E.4
Kapadia, S.R.5
Patel, U.R.6
Fuchs, V.U.7
Mauldin, S.C.8
Vitous, J.9
-
67
-
-
0028823979
-
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes
-
Proudfoot, J. R.; Hargrave, K. D.; Kapadia, S. R.; Patel, U. R.; Grozinger, K.G.; McNeil, D. W.; Cullen, E.; Cardozo, M; Tong, L. Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes. J. Med. Chem., 1995, 38, 4830-8.
-
(1995)
J. Med. Chem
, vol.38
, pp. 4830-4838
-
-
Proudfoot, J.R.1
Hargrave, K.D.2
Kapadia, S.R.3
Patel, U.R.4
Grozinger, K.G.5
McNeil, D.W.6
Cullen, E.7
Cardozo, M.8
Tong, L.9
-
68
-
-
0033571566
-
Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA)
-
Patel, M.; McHugh, R.; Cordova, B.; Klabe, R.; Erickson- Vitanen, S.; Trainor, G.; Ko, S. Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA) Bioorg Med Chem. Lett., 1999, 9, 3221-4.
-
(1999)
Bioorg Med Chem. Lett
, vol.9
, pp. 3221-3224
-
-
Patel, M.1
McHugh, R.2
Cordova, B.3
Klabe, R.4
Erickson-Vitanen, S.5
Trainor, G.6
Ko, S.7
-
69
-
-
0033523619
-
Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors
-
Patel, M.; Ko, S.; McHugh, R.; Markwalder, J.; Srivastava, A.; Cordova, B.C.; Klabe, R.M.; Erickson-Viitanen, S.; Trainor, G.L.; Seitz, S.P. Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett., 1999, 9, 2805-10.
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, pp. 2805-2810
-
-
Patel, M.1
Ko, S.2
McHugh, R.3
Markwalder, J.4
Srivastava, A.5
Cordova, B.C.6
Klabe, R.M.7
Erickson-Viitanen, S.8
Trainor, G.L.9
Seitz, S.P.10
-
70
-
-
0038184354
-
HIV-1 protease: Mechanism and drug discovery
-
Brik, A.; Wong, C.H. HIV-1 protease: mechanism and drug discovery. Org. Biomol. Chem., 2003, 1, 5-14.
-
(2003)
Org. Biomol. Chem
, vol.1
, pp. 5-14
-
-
Brik, A.1
Wong, C.H.2
-
71
-
-
0032580479
-
HIV protease inhibitors
-
Flexner, C. HIV protease inhibitors. New. Eng. J. Med., 1998, 338, 1281-93.
-
(1998)
New. Eng. J. Med
, vol.338
, pp. 1281-1293
-
-
Flexner, C.1
-
72
-
-
0032551258
-
Pathogenesis of HIV-1 protease inhibitor-associated peripheral lipodystrophy, hyper lipedaemia and insulin resistance
-
Carr, A.; Samaras, K.; Chisholm, D.J.; Coper, D.A. Pathogenesis of HIV-1 protease inhibitor-associated peripheral lipodystrophy, hyper lipedaemia and insulin resistance. Lancet, 1998, 351, 1881-3.
-
(1998)
Lancet
, vol.351
, pp. 1881-1883
-
-
Carr, A.1
Samaras, K.2
Chisholm, D.J.3
Coper, D.A.4
-
73
-
-
17144463863
-
Severe premature coronary artery disease with protease inhibitors
-
Henry, K., et al. Severe premature coronary artery disease with protease inhibitors. Lancet 1998, 351, 1328.
-
(1998)
Lancet
, vol.351
, pp. 1328
-
-
Henry, K.1
-
74
-
-
0037316788
-
HIV protease inhibitors and atherosclerosis
-
David, Y.H. HIV protease inhibitors and atherosclerosis.J. Clin. Invest., 2003, 111, 317-8.
-
(2003)
J. Clin. Invest
, vol.111
, pp. 317-318
-
-
David, Y.H.1
-
75
-
-
0031765907
-
Role of Pglycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
-
Wacher, V.J.; Silverman, J.A.; Zhang, Y.; Benet, L.Z. Role of Pglycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J. Pharm. Sci., 1998, 87, 1322-30.
-
(1998)
J. Pharm. Sci
, vol.87
, pp. 1322-1330
-
-
Wacher, V.J.1
Silverman, J.A.2
Zhang, Y.3
Benet, L.Z.4
-
76
-
-
0027992464
-
Studies towards the large scale synthesis of the HIV proteinase inhibitors RO-31-8959
-
Parkes, KEB., et al. Studies towards the large scale synthesis of the HIV proteinase inhibitors RO-31-8959. J. Org. Chem., 1994, 59, 3656-64.
-
(1994)
J. Org. Chem
, vol.59
, pp. 3656-3664
-
-
Parkes, K.E.B.1
-
77
-
-
33644640442
-
An improved synthetic method of saquinavir
-
Yang, O.G.; He, X.C.; Lei, L.J.; Zhou, O.T.; Bai, D.I. An improved synthetic method of saquinavir. Chemical Res. Chinese Universities, 2006, 22, 51-5.
-
(2006)
Chemical Res. Chinese Universities
, vol.22
, pp. 51-55
-
-
Yang, O.G.1
He, X.C.2
Lei, L.J.3
Zhou, O.T.4
Bai, D.I.5
-
78
-
-
0141612910
-
Randomized trial to evaluate indinavir (ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type-I infected patients. The Max Cunin 1 Trial
-
Dragsted, U.B.; Gerstoft, J.; Pedersen, C., et al. Randomized trial to evaluate indinavir (ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type-I infected patients. The Max Cunin 1 Trial. J. Infect Dis., 2003, 188, 635-42.
-
(2003)
J. Infect Dis
, vol.188
, pp. 635-642
-
-
Dragsted, U.B.1
Gerstoft, J.2
Pedersen, C.3
-
79
-
-
84871292469
-
-
Inventor, US patent 6407252 dated June 18, 2002 Pat. No. WO/2001/02/603, dt. 29.03.2001
-
Inventor: Bellani, P.; Frigerio, M.; Castoldi, P. Process for the synthesis of ritonavir. US patent 6407252 dated June 18, 2002 Pat. No. WO/2001/02/603, dt. 29.03.2001.
-
Process For the Synthesis of Ritonavir
-
-
Bellani, P.1
Frigerio, M.2
Castoldi, P.3
-
80
-
-
0346025675
-
Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIVinfected patients
-
Zeldin, R.K.; Petrusche, R.A. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIVinfected patients. J. Antimicrob. Chemother., 2004, 53, 4-9.
-
(2004)
J. Antimicrob. Chemother
, vol.53
, pp. 4-9
-
-
Zeldin, R.K.1
Petrusche, R.A.2
-
81
-
-
0031035968
-
Pharmacokinetic enhancement of the human imunodeficiency virus & protease by co-administration with retonavir
-
Kempf, D.J.; Marsh, K.C.; Kumar, G., et al. Pharmacokinetic enhancement of the human imunodeficiency virus & protease by co-administration with retonavir. Antimicrob.Agents Chemother., 1997, 41, 654-60.
-
(1997)
Antimicrob.Agents Chemother
, vol.41
, pp. 654-660
-
-
Kempf, D.J.1
Marsh, K.C.2
Kumar, G.3
-
82
-
-
0031054507
-
Saquinavir, pharmacokinetics alone and in combination with ritonavir in HIV-infected patients [FAST TRACK]
-
Merry, C.; Barry, M.G.; Mulcahy, F.; Ryan, M.; Heavey, J.; Tija, J.F.; Gibbons, S.E.; Breckenridge, A.M.; Back, D.J. Saquinavir, pharmacokinetics alone and in combination with ritonavir in HIV-infected patients [FAST TRACK] AIDS, 1997, 11, 29-33.
-
(1997)
AIDS
, vol.11
, pp. 29-33
-
-
Merry, C.1
Barry, M.G.2
Mulcahy, F.3
Ryan, M.4
Heavey, J.5
Tija, J.F.6
Gibbons, S.E.7
Breckenridge, A.M.8
Back, D.J.9
-
83
-
-
41949102996
-
Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia
-
Sharma, B.; Singh, N.; Singh, M.; Jaggi, A.S. Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia. Pharmaco. Biochem Behav., 2008, 89, 535-45.
-
(2008)
Pharmaco. Biochem Behav
, vol.89
, pp. 535-545
-
-
Sharma, B.1
Singh, N.2
Singh, M.3
Jaggi, A.S.4
-
84
-
-
0038780072
-
The synthesis of indinavir and other clinically useful HIV-I protease inhibitors
-
Askin, D. The synthesis of indinavir and other clinically useful HIV-I protease inhibitors. Curr. Opin. Drug Disc. Dev., 1998, 1, 338-48.
-
(1998)
Curr. Opin. Drug Disc. Dev
, vol.1
, pp. 338-348
-
-
Askin, D.1
-
85
-
-
0034268096
-
Solid Phase Synthesis of Indinavir and Its Analogues
-
Cheng, Y.; Zhijian, Lu; Chapman, K. T.; Tata, J. R. Solid Phase Synthesis of Indinavir and Its Analogues. J. Comb. Chem., 2000, 2, 445-6.
-
(2000)
J. Comb. Chem
, vol.2
, pp. 445-446
-
-
Cheng, Y.1
Zhijian, L.2
Chapman, K.T.3
Tata, J.R.4
-
86
-
-
17944365215
-
A synthesis of the HIV-protease inhibitor nelfinavir from D-tartaric acid
-
Albizati, K.F.; Babu, S.; Birchper, A.; Busse, J. K.; Fugett, M.; Grubbs, A.; Haddach, A.; Pagan, M.; Potts, B.; Remarchuk, T.; Rieger, D.; Rodriguez, R.; Shanley, J.; Szendroi, R.; Tibbetts, T.; Whitten, K.; Borer, B.C.; et al. A synthesis of the HIV-protease inhibitor nelfinavir from D-tartaric acid. Tet. Lett., 2001, 42, 6481-5.
-
(2001)
Tet. Lett
, vol.42
, pp. 6481-6485
-
-
Albizati, K.F.1
Babu, S.2
Birchper, A.3
Busse, J.K.4
Fugett, M.5
Grubbs, A.6
Haddach, A.7
Pagan, M.8
Potts, B.9
Remarchuk, T.10
Rieger, D.11
Rodriguez, R.12
Shanley, J.13
Szendroi, R.14
Tibbetts, T.15
Whitten, K.16
Borer, B.C.17
-
87
-
-
14444281534
-
Viracept (nefinavir mesylate, AG 1343): A potent orally bioavailable inhibitor of HIV-1 protease
-
Kaldor, S.W.; Kalish, V.J.; Davies2nd, J.F.; Shetty, B.V.; Fritz, J.E.; Appelt, K.; Burgess, J.A.; Campanale, K.M.; Chirgadze, N.Y.; Clawson, D.K.; Dressman, B.A.; Hatch, S.D.; Khalil, D.A.; Kosa, M.B.; Lubbehusen, P.P.; Muesing, M.A.; Patick, A.K.; Reich, S.H.; Su, K.S.; Tatlock, J.H. Viracept (nefinavir mesylate, AG 1343): A potent orally bioavailable inhibitor of HIV-1 protease. J. Med Chem., 1997, 40, 3979-85.
-
(1997)
J. Med Chem
, vol.40
, pp. 3979-3985
-
-
Kaldor, S.W.1
Kalish, V.J.2
Davies II, J.F.3
Shetty, B.V.4
Fritz, J.E.5
Appelt, K.6
Burgess, J.A.7
Campanale, K.M.8
Chirgadze, N.Y.9
Clawson, D.K.10
Dressman, B.A.11
Hatch, S.D.12
Khalil, D.A.13
Kosa, M.B.14
Lubbehusen, P.P.15
Muesing, M.A.16
Patick, A.K.17
Reich, S.H.18
Su, K.S.19
Tatlock, J.H.20
more..
-
88
-
-
38049040718
-
Synthesis, anti HIV & anti tubercular activities of nelfinavir diester derivative Kaletra (lopinavir/ ritonavir)
-
Sriram, D.; Yogeeswari, P.; Dinakaran, M.; Sowmya, M. Synthesis, anti HIV & anti tubercular activities of nelfinavir diester derivative Kaletra (lopinavir/ ritonavir). Biomedicine & Pharmacotherapy, 2008, 62, 1-5.
-
(2008)
Biomedicine & Pharmacotherapy
, vol.62
, pp. 1-5
-
-
Sriram, D.1
Yogeeswari, P.2
Dinakaran, M.3
Sowmya, M.4
-
89
-
-
3843132927
-
-
Honda, Y.; Katayama, M.; Kajima, M.; Suzuki, T.; Kishibata, N.; Izawa, K. Org. Biol. Chem., 2004, 2, 2061-70.
-
(2004)
Org. Biol. Chem
, vol.2
, pp. 2061-2070
-
-
Honda, Y.1
Katayama, M.2
Kajima, M.3
Suzuki, T.4
Kishibata, N.5
Izawa, K.6
-
90
-
-
0034374764
-
Synthesis of HIV protease inhibitor ABT-378 (Lopinavir)
-
Stoner, E.J.; Cooper, A.J.; Dickman, D.A.; Kolaczkowski, L.; Lallaman, J.E.; Liu, J.H.; Oliver-Shaffer, P.A.; Patel, K.M.; Paterson, J.B.; Plata, D.J.; Riley, D.A.; Sham, H.L.; Stengel, P.J.; Tien, J.H. Synthesis of HIV protease inhibitor ABT-378 (Lopinavir). Org. Proc. Res. Dev., 2000, 4, 264-9.
-
(2000)
Org. Proc. Res. Dev
, vol.4
, pp. 264-269
-
-
Stoner, E.J.1
Cooper, A.J.2
Dickman, D.A.3
Kolaczkowski, L.4
Lallaman, J.E.5
Liu, J.H.6
Oliver-Shaffer, P.A.7
Patel, K.M.8
Paterson, J.B.9
Plata, D.J.10
Riley, D.A.11
Sham, H.L.12
Stengel, P.J.13
Tien, J.H.14
-
91
-
-
0032527418
-
The conformation of hepatitis C virus NS3 protinase with and without NS4A: A structural basis for the activation of the enzyme by its cofactor
-
Love, R.A.; Parge, H.E.; Wickersham, J.A., et al. The conformation of hepatitis C virus NS3 protinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor. Clin. Diagn. Virol., 1998, 10, 151-6.
-
(1998)
Clin. Diagn. Virol
, vol.10
, pp. 151-156
-
-
Love, R.A.1
Parge, H.E.2
Wickersham, J.A.3
-
92
-
-
54849427710
-
Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase
-
Hong-Brown, L.Q.; Bron, R.; Huber, D.; Lany, C.H. Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase. J. Cellular. Biochem., 2008, 105, 814-23.
-
(2008)
J. Cellular. Biochem
, vol.105
, pp. 814-823
-
-
Hong-Brown, L.Q.1
Bron, R.2
Huber, D.3
Lany, C.H.4
-
93
-
-
0035160110
-
Lopinavir-Ritonavir: A new protease inhibitor
-
Magnum, E.M.; Graham, K.K. Lopinavir-Ritonavir: a new protease inhibitor. Pharmacotherapy, 2001, 21, 1352-63.
-
(2001)
Pharmacotherapy
, vol.21
, pp. 1352-1363
-
-
Magnum, E.M.1
Graham, K.K.2
-
94
-
-
0036020162
-
Kaletra (lopinavir/ritonavir)
-
Corbett, A.H.; Lim, M.L.; Kashuba, A.D. Kaletra (lopinavir/ritonavir). Ann. Pharmacothe., 2002, 36, 1193-203.
-
(2002)
Ann. Pharmacothe
, vol.36
, pp. 1193-1203
-
-
Corbett, A.H.1
Lim, M.L.2
Kashuba, A.D.3
-
95
-
-
0037103110
-
Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome
-
Kikuchi, Y.; Genka, I.; Ishizaki, A.; Sunagawa, K.; Yasuoka, A.; Oka, S. Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome. Clin. Infect. Dis., 2002, 35, 488-90.
-
(2002)
Clin. Infect. Dis
, vol.35
, pp. 488-490
-
-
Kikuchi, Y.1
Genka, I.2
Ishizaki, A.3
Sunagawa, K.4
Yasuoka, A.5
Oka, S.6
-
96
-
-
33746706779
-
The KLEAN Study of fosamprenavir-ritonavir versus lopinavirritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infections are 48 weeks: A randomized noninferiority trial
-
Eron, J. Jr.; Yeni, P.; Gathe, J. Jr. DeJesus, E.; Staszewski, S.; Lackey, P.; Katlama, C.; Young, B.; Yau, L.; Sutherland-Phillips, D.; Wannamaker, P.; Vavro, C.; Patel, L.; Yeo, J.; Shaefer, M. The KLEAN Study of fosamprenavir-ritonavir versus lopinavirritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infections are 48 weeks: a randomized noninferiority trial. Lanct, 2006, 368, 476-82.
-
(2006)
Lanct
, vol.368
, pp. 476-482
-
-
Eron Jr., J.1
Yeni, P.2
Gathe Jr., J.3
Dejesus, E.4
Staszewski, S.5
Lackey, P.6
Katlama, C.7
Young, B.8
Yau, L.9
Sutherland-Phillips, D.10
Wannamaker, P.11
Vavro, C.12
Patel, L.13
Yeo, J.14
Shaefer, M.15
-
97
-
-
3843151487
-
SOLO:48 week efficacy and safety comparison of once daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naïve HIV-1 infected patients
-
Gathe, J.C Jr.; Ive, P.; Wood, R.; Schurmann, D.; Bellos, N.C.; De Jesus, E.; Gladysz, A.; Garris, C.; Yeo, J. SOLO:48 week efficacy and safety comparison of once daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naïve HIV-1 infected patients. AIDS, 2004, 18, 1529-37.
-
(2004)
AIDS
, vol.18
, pp. 1529-1537
-
-
Gathe Jr., J.C.1
Ive, P.2
Wood, R.3
Schurmann, D.4
Bellos, N.C.5
de Jesus, E.6
Gladysz, A.7
Garris, C.8
Yeo, J.9
-
98
-
-
0035065299
-
BMS-232632 Novartis/Bristol-Myers Squibb
-
Witherell, G. BMS-232632 Novartis/Bristol-Myers Squibb. Curr. Opin. Invest. Drugs, 2001, 2, 340-7.
-
(2001)
Curr. Opin. Invest. Drugs
, vol.2
, pp. 340-347
-
-
Witherell, G.1
-
99
-
-
36348961452
-
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
-
Pyrteo, P. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res., 2007, 67, 10920-8.
-
(2007)
Cancer Res
, vol.67
, pp. 10920-10928
-
-
Pyrteo, P.1
-
100
-
-
12944322516
-
Tipranavir (PNU-140690). A potent, orally bioavailable, nonpeptidic HIV protease inhibitor of the 5, 6- dihydro-4-hydroxy -2-pyrone sulfonamide class
-
Turner, S.R.; Strohbach, J.W.; Tommasi, R.A.; Aristoff, P.A.; Johnson, P.D.; Skulnick, H.I.; Dolak, L.A.; Seest, E.P.; Tomich, P.K.; Bohanon, M.J.; Horng, M.M.; Lynn, J.C.; Chong, K.T.; Hinshaw, R.R.; Watenpaugh, K.D.; Janakiraman, M.N.; Thaisrivongs, S., et al. Tipranavir (PNU-140690). A potent, orally bioavailable, nonpeptidic HIV protease inhibitor of the 5, 6- dihydro-4-hydroxy -2-pyrone sulfonamide class. J. Med. Chem., 1998, 41, 3467-76.
-
(1998)
J. Med. Chem
, vol.41
, pp. 3467-3476
-
-
Turner, S.R.1
Strohbach, J.W.2
Tommasi, R.A.3
Aristoff, P.A.4
Johnson, P.D.5
Skulnick, H.I.6
Dolak, L.A.7
Seest, E.P.8
Tomich, P.K.9
Bohanon, M.J.10
Horng, M.M.11
Lynn, J.C.12
Chong, K.T.13
Hinshaw, R.R.14
Watenpaugh, K.D.15
Janakiraman, M.N.16
Thaisrivongs, S.17
-
102
-
-
1542409142
-
A 14 day dose response study of the efficacy, safety and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naïve-HIV-1infected patients
-
McCallister, S.; Valdez, H.; Curry, K.; MacGregor, T.; Borin, M.; Freimuth, W.; Wang, Y.Y.; Mayers, D.L. A 14 day dose response study of the efficacy, safety and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naïve-HIV-1infected patients - JAIDS, 2004, 35, 376-82.
-
(2004)
JAIDS
, vol.35
, pp. 376-382
-
-
McCallister, S.1
Valdez, H.2
Curry, K.3
Macgregor, T.4
Borin, M.5
Freimuth, W.6
Wang, Y.Y.7
Mayers, D.L.8
-
103
-
-
38349173832
-
Significant effects of tipranavir on platelet aggregation and thromboxane B2 formation in vitro and in vivo
-
Graff, J.; Von Hentig, N.; Kuczka, K.; Angiom, C.; Gute, P.; Klauke, S.; Babacan, E.; Harder, S. Significant effects of tipranavir on platelet aggregation and thromboxane B2 formation in vitro and in vivo. J. Antimicrob. Chemother., 2008, 61, 394-9.
-
(2008)
J. Antimicrob. Chemother
, vol.61
, pp. 394-399
-
-
Graff, J.1
von Hentig, N.2
Kuczka, K.3
Angiom, C.4
Gute, P.5
Klauke, S.6
Babacan, E.7
Harder, S.8
-
104
-
-
35348829315
-
Darunavir, a conceptually new HIV-1 protease inhibitor for the reatment of drug-resistant HIV
-
Ghosh, A.K.; Dawson, Z.L.; Mitsua, H. Darunavir, a conceptually new HIV-1 protease inhibitor for the reatment of drug-resistant HIV. Bioorg. Med. Chem., 2007, 15, 7576-80.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 7576-7580
-
-
Ghosh, A.K.1
Dawson, Z.L.2
Mitsua, H.3
-
105
-
-
34047207229
-
Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER-1 and 2: A pooled subgroup analysis of data from two randomized trials
-
Clotet, B.; Bellos, N.; Molina, J-M. Cooper, D.; Goffard, J.C.; Lazzarin, A.; Wöhrmann, A.; Katlama, C.; Wilkin, T.; Haubrich, R.; Cohen, C.; Farthing, C.; Jayaweera, D.; Markowitz, M.; Ruane, P.; Spinosa-Guzman, S.; Lefebvre, E. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER-1 and 2: a pooled subgroup analysis of data from two randomized trials. Lancet, 2007, 369, 1169-78.
-
(2007)
Lancet
, vol.369
, pp. 1169-1178
-
-
Clotet, B.1
Bellos, N.2
Molina, J.-M.3
Cooper, D.4
Goffard, J.C.5
Lazzarin, A.6
Wöhrmann, A.7
Katlama, C.8
Wilkin, T.9
Haubrich, R.10
Cohen, C.11
Farthing, C.12
Jayaweera, D.13
Markowitz, M.14
Ruane, P.15
Spinosa-Guzman, S.16
Lefebvre, E.17
-
106
-
-
0038066624
-
J.R. Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus
-
Lu, Z.; Ragharan, S.; Bohn, J. Charest, M.; Mark W., Stahlhut, M.W.; Rutkowski, C.A.; Simcoe, A.L.; Olsen, D.B.; Schleif, W.A.; Carella, A.; Gabryelski, L.; Jin, L.; Lin, J.H.; Emini, E.; Chapman K.; R. Tata, J.R. Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus. Bioorg. Med. Chem. Lett., 2003, 13, 1821-4.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1821-1824
-
-
Lu, Z.1
Ragharan, S.2
Bohn, J.3
Charest, M.4
Mark, W.5
Stahlhut, M.W.6
Rutkowski, C.A.7
Simcoe, A.L.8
Olsen, D.B.9
Schleif, W.A.10
Carella, A.11
Gabryelski, L.12
Jin, L.13
Lin, J.H.14
Emini, E.15
Chapman, K.16
Tata, R.17
-
107
-
-
10744228836
-
Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease
-
Nagaranjan, S.R.; Crescenzo, G.A.; German, D. P.; Lu, H.F.; Sikorski, J.A.; Walker, J.L.; Mcdonald, J.J.; Houseman K.A.; Kocan, G.P.; Kishore, N.; Mehta, P.P.; Funkes-shippy, C.L.; Blystone, L. Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease. Bioorg. Med. Chem., 2003, 11, 4769-77.
-
(2003)
Bioorg. Med. Chem
, vol.11
, pp. 4769-4777
-
-
Nagaranjan, S.R.1
Crescenzo, G.A.2
German, D.P.3
Lu, H.F.4
Sikorski, J.A.5
Walker, J.L.6
McDonald, J.J.7
Houseman, K.A.8
Kocan, G.P.9
Kishore, N.10
Mehta, P.P.11
Funkes-Shippy, C.L.12
Blystone, L.13
-
108
-
-
33846173647
-
Non-peptide protease inhibitors as novel anti HIV agents
-
Bhat, M.A.; Siddiqui, N.; Khan, S.A.; Ahmad, M.; Non-peptide protease inhibitors as novel anti HIV agents. IJPS, 2006, 68, 549-55.
-
(2006)
IJPS
, vol.68
, pp. 549-555
-
-
Bhat, M.A.1
Siddiqui, N.2
Khan, S.A.3
Ahmad, M.4
-
109
-
-
0037667047
-
Large scale manufacture of peptide therapeutics by chemical synthesis
-
Bray, B.L. Large scale manufacture of peptide therapeutics by chemical synthesis. Nature Rev. Drug Disc., 2003, 2, 587-93.
-
(2003)
Nature Rev. Drug Disc
, vol.2
, pp. 587-593
-
-
Bray, B.L.1
-
110
-
-
0025095635
-
Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein
-
Earl, P.L.; Doms, R.W.; Moss, B. Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein. Proc. Natl. Acad. Sci., USA, 1990, 87, 648-52.
-
(1990)
Proc. Natl. Acad. Sci., USA
, vol.87
, pp. 648-652
-
-
Earl, P.L.1
Doms, R.W.2
Moss, B.3
-
111
-
-
0023651341
-
Delineation of a region of the human immunodeficiency virus type-I gp 120 glycoprotein critical for interaction with the CD4 receptor
-
Lasky, L.A.; Nakamura, G.; Smith, D.H., et al. Delineation of a region of the human immunodeficiency virus type-I gp 120 glycoprotein critical for interaction with the CD4 receptor. Cell, 1987, 50, 975-85.
-
(1987)
Cell
, vol.50
, pp. 975-985
-
-
Lasky, L.A.1
Nakamura, G.2
Smith, D.H.3
-
112
-
-
0035846960
-
Mode of action of an antiviral peptide from HIV-1. Inhibition at a post- lipid mixing stage
-
Kliger, Y.; Gallo, Sa.; Peisajovich, S.G., et al. Mode of action of an antiviral peptide from HIV-1. Inhibition at a post- lipid mixing stage. J. Biological. Chem., 2001, 276, 1391-7.
-
(2001)
J. Biological. Chem
, vol.276
, pp. 1391-1397
-
-
Kliger, Y.1
Gallo, S.A.2
Peisajovich, S.G.3
-
113
-
-
0037471311
-
A phase-II clinical study of the long term safety and antiviral activity of enfuvirtidebased antiretroviral therapy
-
Lalezari, J.P.; Eron, J.J.; Carlson, M., et al. A phase-II clinical study of the long term safety and antiviral activity of enfuvirtidebased antiretroviral therapy. AIDS, 2003, II, 641-8.
-
(2003)
AIDS
, vol.2
, pp. 641-648
-
-
Lalezari, J.P.1
Eron, J.J.2
Carlson, M.3
-
114
-
-
0031729823
-
Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp 41-mediated virus entry
-
Kilby, J.M.; Hopkins, S.; Venetta, T.M.; DiMassimo, B.; Cloud, G.A.; Lee, J.Y.; Alldredge, L.; Hunter, E.; Lambert, D.; Bolognesi, D.; Matthews, T.; Johnson, M.R.; Nowak, M.A.; Shaw, G.M.; Saag, M.S. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp 41-mediated virus entry. Nat. Med., 1998, 4, 1302-7.
-
(1998)
Nat. Med
, vol.4
, pp. 1302-1307
-
-
Kilby, J.M.1
Hopkins, S.2
Venetta, T.M.3
Dimassimo, B.4
Cloud, G.A.5
Lee, J.Y.6
Alldredge, L.7
Hunter, E.8
Lambert, D.9
Bolognesi, D.10
Matthews, T.11
Johnson, M.R.12
Nowak, M.A.13
Shaw, G.M.14
Saag, M.S.15
-
115
-
-
0038576281
-
Enfuvirtide, an HIV-1 fusion inhibitor, for drug - resistant HIV infection in North and South America
-
Lalezaris, J.P., et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug - resistant HIV infection in North and South America. New Eng. J. Med., 2003, 348, 2175-85.
-
(2003)
New Eng. J. Med
, vol.348
, pp. 2175-2185
-
-
Lalezaris, J.P.1
-
116
-
-
4444375658
-
Review: Resistance to enfuvirtide, the first HIV fusion inhibitor
-
Greenberg, M.L; Cammack, N. Review: Resistance to enfuvirtide, the first HIV fusion inhibitor. J. Antimicrob. Chemother., 2004, 54, 333-40.
-
(2004)
J. Antimicrob. Chemother
, vol.54
, pp. 333-340
-
-
Greenberg, M.L.1
Cammack, N.2
-
117
-
-
37749011180
-
Maraviroc
-
Kuritzkeys, D.; Kar, S.; Kirkpatrik, P. Maraviroc. Nat. Rev. Drug Discov., 2008, 7, 15-6.
-
(2008)
Nat. Rev. Drug Discov
, vol.7
, pp. 15-16
-
-
Kuritzkeys, D.1
Kar, S.2
Kirkpatrik, P.3
-
118
-
-
33745077340
-
A pharmacokinetic - pharmacodynamic model to optimize the phase II, a development programme of maraviroc
-
Rosario, M.C.; Poland, B.; Sullivan J.; Westby, M.; VanduRyst, E. A pharmacokinetic - pharmacodynamic model to optimize the phase II, a development programme of maraviroc. JAIDS, 2006, 42, 183-91.
-
(2006)
JAIDS
, vol.42
, pp. 183-191
-
-
Rosario, M.C.1
Poland, B.2
Sullivan, J.3
Westby, M.4
Vanduryst, E.5
-
119
-
-
27644510382
-
Maraviroc (UK-427, 857), a potent, orally bioavailable, and selective small molecule inhibitor of chemokine receptor CCR5 with broad - spectrum anti-human immunodeficiency virus type 1 activity
-
Dorr, P.; Westby, M.; Dobbs, S.; Griffin, P.; Pvine, B.; Macartney, M.; Mori, J.; Rickett G.; Smity - Burchnell, C.; Napier, C.; Webster, R.; Amour, D.; Price, D.; Stammen, B.; Wood, A.; Perros, M. Maraviroc (UK-427, 857), a potent, orally bioavailable, and selective small molecule inhibitor of chemokine receptor CCR5 with broad - spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob. Agents Chemother., 2005, 49, 4721-32.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
Griffin, P.4
Pvine, B.5
Macartney, M.6
Mori, J.7
Rickett, G.8
Smity-Burchnell, C.9
Napier, C.10
Webster, R.11
Amour, D.12
Price, D.13
Stammen, B.14
Wood, A.15
Perros, M.16
-
120
-
-
30744447460
-
Efficiency of short-term monotherapy with marviroc, a new CCR5 antagonist, in patients infected with HIV-1
-
Fatkenhener, G.; Pozniak, A.L.; Johnson, M.A.; Plettenber, A.; Sfazzewski, S.; Hoepelman, A.L.; Saag, M.S.; Goebel, F.D.; Rockstroh, J.K.; Dezube, B.J.; Jenkins, T.M.; Medhurst, C.; Sullivan, J.F.; Ridgway, C.; Abel, S.; James, I.T.; Youle, M.; VandorRyst, E. Efficiency of short-term monotherapy with marviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat. Med., 2005, 11, 1170-2.
-
(2005)
Nat. Med
, vol.11
, pp. 1170-1172
-
-
Fatkenhener, G.1
Pozniak, A.L.2
Johnson, M.A.3
Plettenber, A.4
Sfazzewski, S.5
Hoepelman, A.L.6
Saag, M.S.7
Goebel, F.D.8
Rockstroh, J.K.9
Dezube, B.J.10
Jenkins, T.M.11
Medhurst, C.12
Sullivan, J.F.13
Ridgway, C.14
Abel, S.15
James, I.T.16
Youle, M.17
Vandorryst, E.18
-
121
-
-
27744548649
-
The discovery of the CCR5 receptor antagonist, UK-427, 857, a new agent for the treatment of HIV infection and AIDS
-
Wood, A.; Armour, D. The discovery of the CCR5 receptor antagonist, UK-427, 857, a new agent for the treatment of HIV infection and AIDS. Prog. Med. Chem., 2005, 43, 239-71.
-
(2005)
Prog. Med. Chem
, vol.43
, pp. 239-271
-
-
Wood, A.1
Armour, D.2
-
122
-
-
15344350690
-
Species differences in the disposition of the CCR5 antagonist, UK-427, 857, a new potential treatment for UK- 427, 857, a new potential treatment for HIV
-
Walker, D.K.; Abel, S.; Comby, P.; Muirhead, G.J.; Nedderman, A.N.; Smith, D.A. Species differences in the disposition of the CCR5 antagonist, UK-427, 857, a new potential treatment for UK- 427, 857, a new potential treatment for HIV. Drug Metabolism and Disposition: The Biological Fate of Chemical, 2005, 33, 587-95.
-
(2005)
Drug Metabolism and Disposition: The Biological Fate of Chemical
, vol.33
, pp. 587-595
-
-
Walker, D.K.1
Abel, S.2
Comby, P.3
Muirhead, G.J.4
Nedderman, A.N.5
Smith, D.A.6
-
123
-
-
20544475634
-
Stinchuri Initial synthesis of UK-427, 857 (Maraviroc)
-
Price, D.A.; Gayton, S.; Selby, M.D.; Ahman, J.; Haycock- Lewandowski, S.; Stammen, B.L; Warren, A.; Stinchuri Initial synthesis of UK-427, 857 (Maraviroc). Tet. Lett., 2005, 46, 5005-7.
-
(2005)
Tet. Lett
, vol.46
, pp. 5005-5007
-
-
Price, D.A.1
Gayton, S.2
Selby, M.D.3
Ahman, J.4
Haycock- Lewandowski, S.5
Stammen, B.L.6
Warren, A.7
-
124
-
-
33845204239
-
A historical sketch of the discovery and development of HIV-1 integrase inhibitors
-
Savarimo, A. A historical sketch of the discovery and development of HIV-1 integrase inhibitors. Expert. Opin. Investig. Drugs, 2006, 15, 1507-1.
-
(2006)
Expert. Opin. Investig. Drugs
, vol.15
, pp. 1507-1601
-
-
Savarimo, A.1
-
125
-
-
12944270496
-
HIV-1 integrase inhibitors that compete with target DNA substrate define a unique strand transfer conformation for integrase
-
Espeseth, A.S.; Felock, P.; Wolfe, A., et al. HIV-1 integrase inhibitors that compete with target DNA substrate define a unique strand transfer conformation for integrase. Proc. Natl. Acad. Sci. USA, 2000, 97, 11244-9.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11244-11249
-
-
Espeseth, A.S.1
Felock, P.2
Wolfe, A.3
-
126
-
-
47949120697
-
Raltegravir with Optimized Background Therapy for resistant HIV- 1 infection
-
Steigbigel, R.T.; Cooper, D.A.; Kumar, P.N.; Eron, J.E., et al. Raltegravir with Optimized Background Therapy for resistant HIV- 1 infection. N. Engl. J. Med., 2008, 359, 339-54.
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 339-354
-
-
Steigbigel, R.T.1
Cooper, D.A.2
Kumar, P.N.3
Eron, J.E.4
-
127
-
-
34548065793
-
Metabolism and disposition in humans of raltegravir (MK - 0518), and anti-AIDS drug targeting the Human Immunodeficiency Virus-1 integrase enzyme
-
DOI:10.1124/dmd.10T.016196. DMD (2007) # 16196 1
-
Kassahun, K.; Mc Intosh, I.; Cui, D., et al. Metabolism and disposition in humans of raltegravir (MK - 0518), and anti-AIDS drug targeting the Human Immunodeficiency Virus-1 integrase enzyme. Drug Metabolism and Disposition Fast Forward, 2007, DOI:10.1124/dmd.10T.016196. DMD (2007) # 16196 1.
-
(2007)
Drug Metabolism and Disposition Fast Forward
-
-
Kassahun, K.1
McIntosh, I.2
Cui, D.3
-
128
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazula, D.J.; Felock, P.; Witmer, M., et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science, 2000, 287, 646-50.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazula, D.J.1
Felock, P.2
Witmer, M.3
-
129
-
-
3242769788
-
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
-
Hazuda, D.J.; Young, S.D.; Guare, J.P. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science, 2004, 305, 528-32.
-
(2004)
Science
, vol.305
, pp. 528-532
-
-
Hazuda, D.J.1
Young, S.D.2
Guare, J.P.3
-
130
-
-
33845366857
-
Antiretroviral activity, pharmacokinetics, and tolerability of MK-o518, a novel inhibitor of HIV-1 integrase, dosed as mono therapy for 10 days in treatment - naïve HIV-1 infected individuals
-
Markowitz, M.; Morals-Ramirez, J.O.; Nguyen, B.Y. Antiretroviral activity, pharmacokinetics, and tolerability of MK-o518, a novel inhibitor of HIV-1 integrase, dosed as mono therapy for 10 days in treatment - naïve HIV-1 infected individuals. JAIDS, 2006, 43, 509-15.
-
(2006)
JAIDS
, vol.43
, pp. 509-515
-
-
Markowitz, M.1
Morals-Ramirez, J.O.2
Nguyen, B.Y.3
|