Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

EMBO Journal

Volumn 31, Issue 14, 2012, Pages 3157-3168

  Kuhn, Peer Hendrik ^a,b   Koroniak, Katarzyna ^c   Hogl, Sebastian ^b   Colombo, Alessio ^a   Zeitschel, Ulrike ^d   Willem, Michael ^b   Volbracht, Christiane ^e   Schepers, Ute ^f   Imhof, Axel ^b   Hoffmeister, Albrecht ^d   Haass, Christian ^a,b   Roner, Steffen ^d   Bräse, Stefan ^c   Lichtenthaler, Stefan F ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e H LUNDBECK A S   (Denmark)

^f KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Alzheimer's disease; bioorthogonal chemistry; click chemistry; proteases; quantitative proteomics

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AXONIN 1; BETA SECRETASE 1; BETA TUBULIN; BIOLOGICAL MARKER; CELL PROTEIN; GLYCAN; MEMBRANE PROTEIN; NERVE CELL ADHESION MOLECULE; PROTEIN APLP1; PROTEIN APLP2; PROTEIN CHL1; PROTEIN L1; PROTEINASE; PROTEOME; SECRETOME PROTEIN; SEIZURE PROTEIN 6; SHEDDASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CELL COMMUNICATION; CELL SURFACE; CLICK CHEMISTRY; CONTROLLED STUDY; ENZYME SUBSTRATE; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; SECRETOME PROTEIN ENRICHMENT WITH CLICK SUGARS METHOD; STEM CELL; SYNAPTOGENESIS; VALIDATION PROCESS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURITES; SUBSTRATE SPECIFICITY; SYNAPSES;

MUS;

EID: 84864148410     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.173     Document Type: Article

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