Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

Neurobiology of Aging

Volumn 18, Issue 6, 1997, Pages 661-669

  Von Koch, C S ^a   Zheng, H ^b   Chen, H ^b   Trumbauer, M ^b   Thinakaran, G ^a   Van Der Ploeg, L H T ^b   Price, D L ^a   Sisodia, S S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amyloid precursor protein; Amyloid precursor like protein; Axonal outgrowth; Epithelium; Gene targeting; Olfactory

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE TARGETING; IMMUNOHISTOCHEMISTRY; LETHALITY; MATING; MOUSE; MULTIGENE FAMILY; NONHUMAN; OLFACTORY EPITHELIUM; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; SENILE PLAQUE; SENSORY NERVE CELL;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; ATAXIA; BEHAVIOR, ANIMAL; BLASTOCYST; BRAIN; GENE TARGETING; IMMUNOHISTOCHEMISTRY; LIFE EXPECTANCY; MICE; MICE, KNOCKOUT; MUSCULOSKELETAL EQUILIBRIUM; NERVE REGENERATION; OLFACTORY BULB; SEXUAL BEHAVIOR, ANIMAL;

EID: 0031470093     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(97)00151-6     Document Type: Article

References (42)

1. Bradley, A. Teratocarcinomas and Embryonic Stem Cells. A Practical Approach. E.J. Robertson, ed.; Oxford: IRL Press; 1987:113-151.
2. Breen K. C., Bruce M., Anderton B. H. Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion. J. Neurosci. Res. 28:1991;90-100.
3. Brittis P., Canning D., Silver J. Chondroitin sulfate as a regulator of neuronal patterning in the retina. Science. 255:1992;733-736.
4. Chen M., Yankner B. A. An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci. Lett. 125:1991;223-226.
5. Clarris H. J., Key B., Beyreuther K., Masters C. L., Small D. H. Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system. Dev. Brain Res. 88:1995;87-95.
6. Furukawa K., Barger S. W., Blalock E. M., Mattson M. P. Activation of K+ channels and suppression of neuronal activity by secreted β-amyloid precursor protein. Nature. 379:1996;74-78.
7. Glenner G. G., Wong C. W. Alzheimer's disease Initial report of the purification and characterization of a novel cerebrovascular amyloid protein . Biochem. Biophys. Res. Commun. 120:1984;885-890.
8. Hanes J., von der Kammer H., Kristjansson G. I., Scheit K. H. The complete cDNA coding sequence for the mouse CDEI binding protein. Biochim. Biophys. Acta. 1216:1993;154-156.
9. Jackson R., Busch S., Cardin A. Glycosaminoglycans. Molecular properties, protein interactions, and role in physiological processes. Physiol. Rev. 71:1991;481-539.
10. Klier F. G., Cole G., Stallcup W., Schubert D. Amyloid β-protein precursor is associated with extracellular matrix. Brain Res. 515:1990;336-342.
11. Lee M. K., Tuttle J. B., Rebhun L. I., Cleveland D. W., Frankfurter A. The expression and posttranslational modification of a neuron-specific β-tubulin isotype during chick embryogenesis. Cell Motility and the Cytoskeleton. 17:1990;118-132.
12. Lorent K., Overbergh L., Moechars D., deStrooper B., van Leuven F., van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the α-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, α-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 65:1995;1009-1025.
13. Mansour S. L., Thomas K. R., Capecchi M. R. Distribution of the proto-oncogene int-2 in mouse embryo-derived stem cells A general strategy for targeting mutations to non-selectable genes . Nature. 336:1988;348-352.
14. Mattson M., Cheng B., Culwell A., Esch F., Lieberburg I., Rydel R. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron. 10:1993;243-254.
15. Milev P., Friedlander D., Sakurai T., Karthikeyan L., Flad M., Margolis R., Grunet M., Margolis R. Interactions of the chondroitin sulfate porteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. J. Cell. Biol. 127:1994;1703-1715.
16. Milward E. A., Papadopulous R., Fuller S. J., Moir R. D., Small D., Beyreuther K., Masters C. L. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron. 9:1992;129-137.
17. Namba T., Nakamura T., Grob D. Staining for nerve fibers and cholinesterase activity in fresh frozen sections. Am. J. Clin. Pathol. 47:1967;74-77.
18. Oltersdorf T., Fritz L. C., Schenk D. B., Lieberburg I., Johnson-Wood K. L., Beattie E. C., Ward P. J., Blacher R. W., Dovey H. F., Sinha S. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II. Nature. 341:1989;144-147.
19. Pangalos M. N., Shioi J., Robakis N. K. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. J. Neurochem. 65:1995;762-769.
20. Qiu W. Q., Ferreira A., Miller C., Koo E. H., Selkoe D. J. Cell-surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J. Neurosci. 15:1995;2157-2167.
21. Ramirez-Solis R., Rivera-Perez J., Wallace J. D., Wims M., Zheng H., Bradley A. Genomic DNA microextraction. A method to screen numerous samples. Anal. Biochem. 201:1992;331-335.
22. Ramirez-Solis R., Zheng H., Whiting J., Krumlauf R., Bradley A. Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell. 73:1993;279-294.
23. Saitoh T., Sundsmo M., Roch J. M., Kimura N., Cole G., Schubert D., Oltersdorf T., Schenk D. B. Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell. 58:1989;615-622.
24. Sandbrink R., Masters C. L., Beyreuther K. Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH) Two amino acids length difference to human and murine homologues . Biochim. Biophys. Acta. 1219:1994;167-170.
25. Sandbrink R., Masters C. L., Beyreuther K. Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins. J. Biol. Chem. 269:1994;14227-14234.
26. Sandbrink R., Masters C. L., Beyreuther K. APP gene family Unique age-associated changes in splicing of Alzheimer's βA4-amyloid protein precursor . Neurobiol. Dis. 1:1994;13-24.
27. Schubert D., Jin L. W., Saitoh T., Cole G. The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion. Neuron. 3:1989;689-694.
28. Sinha S., Dovey H. F., Seubert P., Ward P. J., Blacher R. W., Blaber M., Bradshaw R. A., Arici M., Mobley W. C., Lieberburg I. The protease inhibitory properties of the Alzheimer's β-amyloid precursor protein. J. Biol. Chem. 265:1990;8983-8985.
29. Sisodia S. S., Koo E. H., Hoffman P. N., Perry G., Price D. L. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13:1993;3136-3142.
30. Slunt H. H., Thinakaran G., von Koch C., Lo A. C. Y., Tanzi R. E., Sisodia S. S. Expression of a ubiquitous, cross-reactive homolog of the mouse β-amyloid precursor protein (APP). J. Biol. Chem. 269:1994;2637-2644.
31. Soriano P., Montgomery C., Geske R., Bradly A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 64:1991;693-702.
32. Sprecher C. A., Grant F. J., Grimm G., O'Hara P. J., Norris F., Norris K., Foster D. C. Molecular cloning of the cDNA for a human amyloid precursor protein homolog Evidence for a multigene family . Biochemistry. 32:1993;4481-4486.
33. Thinakaran G., Sisodia S. S. Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site. J. Biol. Chem. 269:1994;22099-22104.
34. Thinakaran G., Slunt H. H., Sisodia S. S. Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homolog, APLP2. J. Biol. Chem. 270:1995;16522-16525.
35. Thinakaran G., Slunt H. H., Spitzer L., Lee M. K., Sisodia S. S. Tissue distribution and developmental expression of the amyloid precursor protein homolog, APLP1. Soc. Neurosci. Abstr. 21:1995;205.
36. Thinakaran G., Kitt C. A., Roskams A. J. I., Slunt H. H., Masliah E., von Koch C., Ginsberg S. D., Ronnett G. V., Reed R. R., Price D. L., Sisodia S. S. Distribution of an APP homolog, APLP2, in the mouse olfactory system A potential role for APLP2 in axogenesis . J. Neurosci. 15:(10):1995;6314-6326.
37. van Nostrand W. E., Wagner S. L., Suzuki M., Choi B. H., Farrow J. S., Geddes J. W., Cotman C. W., Cunningham D. D. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid β-protein precursor. Nature. 341:1989;546-549.
38. von Koch C. S., Lahiri D. K., Mammen A. L., Copeland N. G., Gilbert D. J., Jenkins N. A., Sisodia S. S. The mouse APLP2 gene Chromosomal localization and promoter characterization . J. Biol. Chem. 270:1995;25475-25480.
39. Wasco W., Bupp K., Magendantz M., Gusella J. F., Tanzi R. E., Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid β protein precursor. Proc. Natl. Acad. Sci. USA. 89:1992;10758-10762.
40. Wasco W., Gurubhagavatula S., Paradis M. D., Romano D. M., Sisodia S. S., Hyman B. T., Neve R. L., Tanzi R. E. Isolation and characterization of APLP2 encoding a homolog of the Alzheimer's associated amyloid β protein precursor. Nature Genetics. 5:1993;95-99.
41. Weidemann A., Koenig G., Bunke D., Fischer P., Salbaum J. M., Masters C. L., Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell. 57:1989;115-126.
42. Zheng H., Jiang M., Trumbauer M. E., Sirinathsinghji D. J. S., Hopkins R., Smith D. W., Heavens R. P., Dawson G. R., Boyce S., Conner M. W., Stevens K. A., Slunt H. H., Sisodia S. S., Chen H. Y., van der Ploeg L. H. T. β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell. 81:1995;525-531.