Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

Neuroscience

Volumn 90, Issue 1, 1999, Pages 1-13

  Dawson, G R ^a   Seabrook, G R ^a   Zheng, H ^b   Smith, D W ^a   Graham, S ^a   O'Dowd, G ^a   Bowery, B J ^a   Boyce, S ^a   Trumbauer, M E ^b   Chen, H Y ^b   Van Der Ploeg, L H T ^b   Sirinathsinghji, D J S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

amyloid precursor protein; Cognition; Gene deletion; Long term potentiation; Mouse; Synaptic function

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ADOLESCENT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; COGNITION; CONTROLLED STUDY; GENE DELETION; IMMUNOHISTOCHEMISTRY; LEARNING TEST; LONG TERM POTENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AVOIDANCE LEARNING; BIOLOGICAL MARKERS; CEREBRAL CORTEX; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; RECEPTORS, PRESYNAPTIC; SYNAPSINS; SYNAPTOPHYSIN;

EID: 0033017690     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00410-2     Document Type: Article

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