-
1
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007, 70:461-477.
-
(2007)
J Nat Prod
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
2
-
-
0020480512
-
Recognition of protein coding regions in DNA sequences
-
Fickett J.W. Recognition of protein coding regions in DNA sequences. Nucleic Acids Res 1982, 10:5303-5318.
-
(1982)
Nucleic Acids Res
, vol.10
, pp. 5303-5318
-
-
Fickett, J.W.1
-
3
-
-
0000241874
-
GENMARK: parallel gene recognition for both DNA strands
-
Borodovsky M., McIninch J. GENMARK: parallel gene recognition for both DNA strands. Compu Chem 1993, 17:123-133.
-
(1993)
Compu Chem
, vol.17
, pp. 123-133
-
-
Borodovsky, M.1
McIninch, J.2
-
4
-
-
0032519353
-
GeneMark.hmm: new solutions for gene finding
-
Lukashin A.V., Borodovsky M. GeneMark.hmm: new solutions for gene finding. Nucleic Acids Res 1998, 26:1107-1115.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 1107-1115
-
-
Lukashin, A.V.1
Borodovsky, M.2
-
5
-
-
0035875343
-
GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions
-
Besemer J., Lomsadze A., Borodovsky M. GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions. Nucleic Acids Res 2001, 29:2607-2618.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2607-2618
-
-
Besemer, J.1
Lomsadze, A.2
Borodovsky, M.3
-
6
-
-
23144452801
-
GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses
-
Besemer J., Borodovsky M. GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses. Nucleic Acids Res 2005, 33:W451-454.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Besemer, J.1
Borodovsky, M.2
-
7
-
-
57149099395
-
Gene prediction in novel fungal genomes using an ab initio algorithm with unsupervised training
-
Ter-Hovhannisyan V., Lomsadze A., Chernoff Y.O., Borodovsky M. Gene prediction in novel fungal genomes using an ab initio algorithm with unsupervised training. Genome Res 2008, 18:1979-1990.
-
(2008)
Genome Res
, vol.18
, pp. 1979-1990
-
-
Ter-Hovhannisyan, V.1
Lomsadze, A.2
Chernoff, Y.O.3
Borodovsky, M.4
-
8
-
-
0033485517
-
Improved microbial gene identification with GLIMMER
-
Delcher A.L., Harmon D., Kasif S., White O., Salzberg S.L. Improved microbial gene identification with GLIMMER. Nucleic Acids Res 1999, 27:4636-4641.
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 4636-4641
-
-
Delcher, A.L.1
Harmon, D.2
Kasif, S.3
White, O.4
Salzberg, S.L.5
-
9
-
-
0032518163
-
Microbial gene identification using interpolated Markov models
-
Salzberg S.L., Delcher A.L., Kasif S., White O. Microbial gene identification using interpolated Markov models. Nucleic Acids Res 1998, 26:544-548.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 544-548
-
-
Salzberg, S.L.1
Delcher, A.L.2
Kasif, S.3
White, O.4
-
10
-
-
8844252293
-
TigrScan and GlimmerHMM: two open source ab initio eukaryotic gene-finders
-
Majoros W.H., Pertea M., Salzberg S.L. TigrScan and GlimmerHMM: two open source ab initio eukaryotic gene-finders. Bioinformatics 2004, 20:2878-2879.
-
(2004)
Bioinformatics
, vol.20
, pp. 2878-2879
-
-
Majoros, W.H.1
Pertea, M.2
Salzberg, S.L.3
-
11
-
-
0033166634
-
Interpolated Markov models for eukaryotic gene finding
-
Salzberg S.L., Pertea M., Delcher A.L., Gardner M.J., Tettelin H. Interpolated Markov models for eukaryotic gene finding. Genomics 1999, 59:24-31.
-
(1999)
Genomics
, vol.59
, pp. 24-31
-
-
Salzberg, S.L.1
Pertea, M.2
Delcher, A.L.3
Gardner, M.J.4
Tettelin, H.5
-
12
-
-
34147132825
-
Identifying bacterial genes and endosymbiont DNA with Glimmer
-
Delcher A.L., Bratke K.A., Powers E.C., Salzberg S.L. Identifying bacterial genes and endosymbiont DNA with Glimmer. Bioinformatics 2007, 23:673-679.
-
(2007)
Bioinformatics
, vol.23
, pp. 673-679
-
-
Delcher, A.L.1
Bratke, K.A.2
Powers, E.C.3
Salzberg, S.L.4
-
13
-
-
84855258501
-
Gene prediction with Glimmer for metagenomic sequences augmented by classification and clustering
-
40:e9
-
Kelley D.R., Liu B., Delcher A.L., Pop M., Salzberg S.L. Gene prediction with Glimmer for metagenomic sequences augmented by classification and clustering. Nucleic Acids Res 2012, 40:e9.
-
(2012)
Nucleic Acids Res
-
-
Kelley, D.R.1
Liu, B.2
Delcher, A.L.3
Pop, M.4
Salzberg, S.L.5
-
14
-
-
0013889249
-
An improved method of testing for evolutionary homology
-
Fitch W.M. An improved method of testing for evolutionary homology. J Mol Biol 1966, 16:9-16.
-
(1966)
J Mol Biol
, vol.16
, pp. 9-16
-
-
Fitch, W.M.1
-
15
-
-
0000821965
-
On the theory and computation of evolutionary distances
-
Sellers P.H. On the theory and computation of evolutionary distances. SIAM J Appl Math 1974, 26:787-793.
-
(1974)
SIAM J Appl Math
, vol.26
, pp. 787-793
-
-
Sellers, P.H.1
-
16
-
-
0020484488
-
An improved algorithm for matching biological sequences
-
Gotoh O. An improved algorithm for matching biological sequences. J Mol Biol 1982, 162:705-708.
-
(1982)
J Mol Biol
, vol.162
, pp. 705-708
-
-
Gotoh, O.1
-
17
-
-
0021919480
-
Rapid and sensitive protein similarity searches
-
Lipman D.J., Pearson W.R. Rapid and sensitive protein similarity searches. Science 1985, 227:1435-1441.
-
(1985)
Science
, vol.227
, pp. 1435-1441
-
-
Lipman, D.J.1
Pearson, W.R.2
-
18
-
-
0028186046
-
Using the FASTA program to search protein and DNA sequence databases
-
Pearson W.R. Using the FASTA program to search protein and DNA sequence databases. Methods Mol Biol 1994, 24:307-331.
-
(1994)
Methods Mol Biol
, vol.24
, pp. 307-331
-
-
Pearson, W.R.1
-
19
-
-
0023989064
-
Improved tools for biological sequence comparison
-
Pearson W.R., Lipman D.J. Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 1988, 85:2444-2448.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 2444-2448
-
-
Pearson, W.R.1
Lipman, D.J.2
-
21
-
-
0027968068
-
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994, 22:4673-4680.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
22
-
-
0032438987
-
Hidden Markov models for detecting remote protein homologies
-
Karplus K., Barrett C., Hughey R. Hidden Markov models for detecting remote protein homologies. Bioinformatics 1998, 14:846-856.
-
(1998)
Bioinformatics
, vol.14
, pp. 846-856
-
-
Karplus, K.1
Barrett, C.2
Hughey, R.3
-
23
-
-
0031743421
-
Profile hidden Markov models
-
Eddy S.R. Profile hidden Markov models. Bioinformatics 1998, 14:755-763.
-
(1998)
Bioinformatics
, vol.14
, pp. 755-763
-
-
Eddy, S.R.1
-
24
-
-
0025183708
-
Basic local alignment search tool
-
Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J Mol Biol 1990, 215:403-410.
-
(1990)
J Mol Biol
, vol.215
, pp. 403-410
-
-
Altschul, S.F.1
Gish, W.2
Miller, W.3
Myers, E.W.4
Lipman, D.J.5
-
25
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
-
Altschul S.F., Madden T.L., Schaffer A.A., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25:3389-3402.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
-
26
-
-
58149203237
-
CDD: specific functional annotation with the Conserved Domain Database
-
Marchler-Bauer A., Anderson J.B., Chitsaz F., et al. CDD: specific functional annotation with the Conserved Domain Database. Nucleic Acids Res 2009, 37:D205-210.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Marchler-Bauer, A.1
Anderson, J.B.2
Chitsaz, F.3
-
28
-
-
84862221167
-
SMART 7: recent updates to the protein domain annotation resource
-
Letunic I., Doerks T., Bork P. SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res 2012, 40:D302-D305.
-
(2012)
Nucleic Acids Res
, vol.40
-
-
Letunic, I.1
Doerks, T.2
Bork, P.3
-
29
-
-
79959936663
-
GCView: the genomic context viewer for protein homology searches
-
Grin I., Linke D. GCView: the genomic context viewer for protein homology searches. Nucleic Acids Res 2011, 39:W353-356.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Grin, I.1
Linke, D.2
-
30
-
-
66349108229
-
IsoRankN: spectral methods for global alignment of multiple protein networks
-
Liao C.S., Lu K., Baym M., Singh R., Berger B. IsoRankN: spectral methods for global alignment of multiple protein networks. Bioinformatics 2009, 25:i253-258.
-
(2009)
Bioinformatics
, vol.25
-
-
Liao, C.S.1
Lu, K.2
Baym, M.3
Singh, R.4
Berger, B.5
-
31
-
-
79951736762
-
High-quality annotation of promoter regions for 913 bacterial genomes
-
Rangannan V., Bansal M. High-quality annotation of promoter regions for 913 bacterial genomes. Bioinformatics 2010, 26:3043-3050.
-
(2010)
Bioinformatics
, vol.26
, pp. 3043-3050
-
-
Rangannan, V.1
Bansal, M.2
-
32
-
-
79959934449
-
ConTra v2: a tool to identify transcription factor binding sites across species, update 2011
-
Broos S., Hulpiau P., Galle J., Hooghe B., Van Roy F., De Bleser P. ConTra v2: a tool to identify transcription factor binding sites across species, update 2011. Nucleic Acids Res 2011, 39:W74-78.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Broos, S.1
Hulpiau, P.2
Galle, J.3
Hooghe, B.4
Van Roy, F.5
De Bleser, P.6
-
34
-
-
0039194307
-
Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene
-
de Crécy-Lagard V., Saurin W., Thibaut D., et al. Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene. Antimicrob Agents Chemother 1997, 41:1904-1909.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 1904-1909
-
-
de Crécy-Lagard, V.1
Saurin, W.2
Thibaut, D.3
-
35
-
-
0033179468
-
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
-
Stachelhaus T., Mootz H.D., Marahiel M.A. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol 1999, 6:493-505.
-
(1999)
Chem Biol
, vol.6
, pp. 493-505
-
-
Stachelhaus, T.1
Mootz, H.D.2
Marahiel, M.A.3
-
36
-
-
0034013269
-
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
-
Challis G.L., Ravel J., Townsend C.A. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 2000, 7:211-224.
-
(2000)
Chem Biol
, vol.7
, pp. 211-224
-
-
Challis, G.L.1
Ravel, J.2
Townsend, C.A.3
-
37
-
-
26944502019
-
Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)
-
Rausch C., Weber T., Kohlbacher O., Wohlleben W., Huson D.H. Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs). Nucleic Acids Res 2005, 33:5799-5808.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 5799-5808
-
-
Rausch, C.1
Weber, T.2
Kohlbacher, O.3
Wohlleben, W.4
Huson, D.H.5
-
38
-
-
79959936207
-
NRPSpredictor2 - a web server for predicting NRPS adenylation domain specificity
-
Rottig M., Medema M.H., Blin K., Weber T., Rausch C., Kohlbacher O. NRPSpredictor2 - a web server for predicting NRPS adenylation domain specificity. Nucleic Acids Res 2011, 39:W362-367.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Rottig, M.1
Medema, M.H.2
Blin, K.3
Weber, T.4
Rausch, C.5
Kohlbacher, O.6
-
39
-
-
38549094609
-
NORINE: a database of nonribosomal peptides
-
Caboche S., Pupin M., Leclere V., Fontaine A., Jacques P., Kucherov G. NORINE: a database of nonribosomal peptides. Nucleic Acids Res 2008, 36:D326-331.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Caboche, S.1
Pupin, M.2
Leclere, V.3
Fontaine, A.4
Jacques, P.5
Kucherov, G.6
-
40
-
-
0037466331
-
Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases
-
Yadav G., Gokhale R.S., Mohanty D. Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases. J Mol Biol 2003, 328:335-363.
-
(2003)
J Mol Biol
, vol.328
, pp. 335-363
-
-
Yadav, G.1
Gokhale, R.S.2
Mohanty, D.3
-
41
-
-
0041620248
-
SEARCHPKS: a program for detection and analysis of polyketide synthase domains
-
Yadav G., Gokhale R.S., Mohanty D. SEARCHPKS: a program for detection and analysis of polyketide synthase domains. Nucleic Acids Res 2003, 31:3654-3658.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3654-3658
-
-
Yadav, G.1
Gokhale, R.S.2
Mohanty, D.3
-
42
-
-
0036404537
-
A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase
-
Udwary D.W., Merski M., Townsend C.A. A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. J Mol Biol 2002, 323:585-598.
-
(2002)
J Mol Biol
, vol.323
, pp. 585-598
-
-
Udwary, D.W.1
Merski, M.2
Townsend, C.A.3
-
43
-
-
35248844459
-
ASMPKS: an analysis system for modular polyketide synthases
-
Tae H., Kong E.B., Park K. ASMPKS: an analysis system for modular polyketide synthases. BMC Bioinformatics 2007, 8:327.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 327
-
-
Tae, H.1
Kong, E.B.2
Park, K.3
-
44
-
-
79959983606
-
Kernel based machine learning algorithm for the efficient prediction of type III polyketide synthase family of proteins
-
Mallika V., Sivakumar K.C., Jaichand S., Soniya E.V. Kernel based machine learning algorithm for the efficient prediction of type III polyketide synthase family of proteins. J Integr Bioinform 2010, 7:143.
-
(2010)
J Integr Bioinform
, vol.7
, pp. 143
-
-
Mallika, V.1
Sivakumar, K.C.2
Jaichand, S.3
Soniya, E.V.4
-
45
-
-
77954265333
-
SBSPKS: structure based sequence analysis of polyketide synthases
-
Anand S., Prasad M.V., Yadav G., et al. SBSPKS: structure based sequence analysis of polyketide synthases. Nucleic Acids Res 2010, 38:W487-496.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Anand, S.1
Prasad, M.V.2
Yadav, G.3
-
46
-
-
3442896886
-
NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases
-
Ansari M.Z., Yadav G., Gokhale R.S., Mohanty D. NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Nucleic Acids Res 2004, 32:W405-413.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Ansari, M.Z.1
Yadav, G.2
Gokhale, R.S.3
Mohanty, D.4
-
47
-
-
57149112966
-
ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
-
Starcevic A., Zucko J., Simunkovic J., Long P.F., Cullum J., Hranueli D. ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures. Nucleic Acids Res 2008, 36:6882-6892.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 6882-6892
-
-
Starcevic, A.1
Zucko, J.2
Simunkovic, J.3
Long, P.F.4
Cullum, J.5
Hranueli, D.6
-
48
-
-
61649111711
-
CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters
-
Weber T., Rausch C., Lopez P., et al. CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters. J Biotechnol 2009, 140:13-17.
-
(2009)
J Biotechnol
, vol.140
, pp. 13-17
-
-
Weber, T.1
Rausch, C.2
Lopez, P.3
-
49
-
-
67650898253
-
Automated genome mining for natural products
-
Li M.H., Ung P.M., Zajkowski J., Garneau-Tsodikova S., Sherman D.H. Automated genome mining for natural products. BMC Bioinformatics 2009, 10:185.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 185
-
-
Li, M.H.1
Ung, P.M.2
Zajkowski, J.3
Garneau-Tsodikova, S.4
Sherman, D.H.5
-
50
-
-
64249084052
-
Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
-
Bachmann B.O., Ravel J. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods Enzymol 2009, 458:181-217.
-
(2009)
Methods Enzymol
, vol.458
, pp. 181-217
-
-
Bachmann, B.O.1
Ravel, J.2
-
52
-
-
77955274600
-
SMURF: genomic mapping of fungal secondary metabolite clusters
-
Khaldi N., Seifuddin F.T., Turner G., et al. SMURF: genomic mapping of fungal secondary metabolite clusters. Fungal Genet Biol 2010, 47:736-741.
-
(2010)
Fungal Genet Biol
, vol.47
, pp. 736-741
-
-
Khaldi, N.1
Seifuddin, F.T.2
Turner, G.3
-
53
-
-
79959920872
-
AntiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
-
Medema M.H., Blin K., Cimermancic P., et al. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 2011, 39:W339-346.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Medema, M.H.1
Blin, K.2
Cimermancic, P.3
-
54
-
-
0642343749
-
In silico metabolic pathway analysis and design: succinic acid production by metabolically engineered Escherichia coli as an example
-
Lee S.Y., Hong S.H., Moon S.Y. In silico metabolic pathway analysis and design: succinic acid production by metabolically engineered Escherichia coli as an example. Genome Inform 2002, 13:214-223.
-
(2002)
Genome Inform
, vol.13
, pp. 214-223
-
-
Lee, S.Y.1
Hong, S.H.2
Moon, S.Y.3
-
55
-
-
0242487787
-
Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
-
Burgard A.P., Pharkya P., Maranas C.D. Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol Bioeng 2003, 84:647-657.
-
(2003)
Biotechnol Bioeng
, vol.84
, pp. 647-657
-
-
Burgard, A.P.1
Pharkya, P.2
Maranas, C.D.3
-
56
-
-
8744224466
-
OptStrain: a computational framework for redesign of microbial production systems
-
Pharkya P., Burgard A.P., Maranas C.D. OptStrain: a computational framework for redesign of microbial production systems. Genome Res 2004, 14:2367-2376.
-
(2004)
Genome Res
, vol.14
, pp. 2367-2376
-
-
Pharkya, P.1
Burgard, A.P.2
Maranas, C.D.3
-
57
-
-
29544436058
-
An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems
-
Pharkya P., Maranas C.D. An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems. Metab Eng 2006, 8:1-13.
-
(2006)
Metab Eng
, vol.8
, pp. 1-13
-
-
Pharkya, P.1
Maranas, C.D.2
-
58
-
-
77954590959
-
OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions
-
Ranganathan S., Suthers P.F., Maranas C.D. OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions. PLoS Comput Biol 2010, 6:e1000744.
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Ranganathan, S.1
Suthers, P.F.2
Maranas, C.D.3
-
59
-
-
77952585143
-
CASOP: a computational approach for strain optimization aiming at high productivity
-
Hadicke O., Klamt S. CASOP: a computational approach for strain optimization aiming at high productivity. J Biotechnol 2010, 147:88-101.
-
(2010)
J Biotechnol
, vol.147
, pp. 88-101
-
-
Hadicke, O.1
Klamt, S.2
-
60
-
-
77951552860
-
OptORF: optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains
-
Kim J., Reed J.L. OptORF: optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains. BMC Syst Biol 2010, 4:53.
-
(2010)
BMC Syst Biol
, vol.4
, pp. 53
-
-
Kim, J.1
Reed, J.L.2
-
61
-
-
77950960250
-
OptFlux: an open-source software platform for in silico metabolic engineering
-
Rocha I., Maia P., Evangelista P., et al. OptFlux: an open-source software platform for in silico metabolic engineering. BMC Syst Biol 2010, 4:45.
-
(2010)
BMC Syst Biol
, vol.4
, pp. 45
-
-
Rocha, I.1
Maia, P.2
Evangelista, P.3
-
62
-
-
70349964350
-
Automated design of synthetic ribosome binding sites to control protein expression
-
Salis H.M., Mirsky E.A., Voigt C.A. Automated design of synthetic ribosome binding sites to control protein expression. Nat Biotechnol 2009, 27:946-950.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 946-950
-
-
Salis, H.M.1
Mirsky, E.A.2
Voigt, C.A.3
-
63
-
-
79957518680
-
Designing genes for successful protein expression
-
Welch M., Villalobos A., Gustafsson C., Minshull J. Designing genes for successful protein expression. Methods Enzymol 2011, 498:43-66.
-
(2011)
Methods Enzymol
, vol.498
, pp. 43-66
-
-
Welch, M.1
Villalobos, A.2
Gustafsson, C.3
Minshull, J.4
-
64
-
-
22144436255
-
Theoretical considerations and computational analysis of the complexity in polyketide synthesis pathways
-
Gonzalez-Lergier J., Broadbelt L.J., Hatzimanikatis V. Theoretical considerations and computational analysis of the complexity in polyketide synthesis pathways. J Am Chem Soc 2005, 127:9930-9938.
-
(2005)
J Am Chem Soc
, vol.127
, pp. 9930-9938
-
-
Gonzalez-Lergier, J.1
Broadbelt, L.J.2
Hatzimanikatis, V.3
-
65
-
-
54949140438
-
DESHARKY: automatic design of metabolic pathways for optimal cell growth
-
Rodrigo G., Carrera J., Prather K.J., Jaramillo A. DESHARKY: automatic design of metabolic pathways for optimal cell growth. Bioinformatics 2008, 24:2554-2556.
-
(2008)
Bioinformatics
, vol.24
, pp. 2554-2556
-
-
Rodrigo, G.1
Carrera, J.2
Prather, K.J.3
Jaramillo, A.4
-
66
-
-
71849105327
-
Engineering a new business
-
May M. Engineering a new business. Nat Biotechnol 2009, 27:1112-1120.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 1112-1120
-
-
May, M.1
-
67
-
-
0028784138
-
Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides
-
Stemmer W.P., Crameri A., Ha K.D., Brennan T.M., Heyneker H.L. Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Gene 1995, 164:49-53.
-
(1995)
Gene
, vol.164
, pp. 49-53
-
-
Stemmer, W.P.1
Crameri, A.2
Ha, K.D.3
Brennan, T.M.4
Heyneker, H.L.5
-
68
-
-
0347364647
-
Generating a synthetic genome by whole genome assembly: phiX174 bacteriophage from synthetic oligonucleotides
-
Smith H.O., Hutchison C.A., Pfannkoch C., Venter J.C. Generating a synthetic genome by whole genome assembly: phiX174 bacteriophage from synthetic oligonucleotides. Proc Natl Acad Sci USA 2003, 100:15440-15445.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15440-15445
-
-
Smith, H.O.1
Hutchison, C.A.2
Pfannkoch, C.3
Venter, J.C.4
-
69
-
-
56649114274
-
A one pot, one step, precision cloning method with high throughput capability
-
Engler C., Kandzia R., Marillonnet S. A one pot, one step, precision cloning method with high throughput capability. PLoS One 2008, 3:e3647.
-
(2008)
PLoS One
, vol.3
-
-
Engler, C.1
Kandzia, R.2
Marillonnet, S.3
-
70
-
-
67349270900
-
Enzymatic assembly of DNA molecules up to several hundred kilobases
-
Gibson D.G., Young L., Chuang R.Y., Venter J.C., Hutchison C.A., Smith H.O. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods 2009, 6:343-345.
-
(2009)
Nat Methods
, vol.6
, pp. 343-345
-
-
Gibson, D.G.1
Young, L.2
Chuang, R.Y.3
Venter, J.C.4
Hutchison, C.A.5
Smith, H.O.6
-
71
-
-
33847608289
-
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC
-
Li M.Z., Elledge S.J. Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods 2007, 4:251-256.
-
(2007)
Nat Methods
, vol.4
, pp. 251-256
-
-
Li, M.Z.1
Elledge, S.J.2
-
72
-
-
68149136937
-
Circular polymerase extension cloning of complex gene libraries and pathways
-
Quan J., Tian J. Circular polymerase extension cloning of complex gene libraries and pathways. PLoS One 2009, 4:e6441.
-
(2009)
PLoS One
, vol.4
-
-
Quan, J.1
Tian, J.2
-
73
-
-
34548812553
-
Total synthesis of multi-kilobase DNA sequences from oligonucleotides
-
Reisinger S.J., Patel K.G., Santi D.V. Total synthesis of multi-kilobase DNA sequences from oligonucleotides. Nat Protoc 2006, 1:2596-2603.
-
(2006)
Nat Protoc
, vol.1
, pp. 2596-2603
-
-
Reisinger, S.J.1
Patel, K.G.2
Santi, D.V.3
-
74
-
-
59649108349
-
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
-
Shao Z., Zhao H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res 2009, 37:e16.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Shao, Z.1
Zhao, H.2
-
75
-
-
39449112551
-
Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome
-
Gibson D.G., Benders G.A., Andrews-Pfannkoch C., et al. Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome. Science 2008, 319:1215-1220.
-
(2008)
Science
, vol.319
, pp. 1215-1220
-
-
Gibson, D.G.1
Benders, G.A.2
Andrews-Pfannkoch, C.3
-
76
-
-
28544451327
-
Foundations for engineering biology
-
Endy D. Foundations for engineering biology. Nature 2005, 438:449-453.
-
(2005)
Nature
, vol.438
, pp. 449-453
-
-
Endy, D.1
-
77
-
-
34548857194
-
Idempotent vector design for standard assembly of biobricks. MIT Synthetic Biology Working Group Technical Reports;
-
Knight T. Idempotent vector design for standard assembly of biobricks. MIT Synthetic Biology Working Group Technical Reports; 2003.
-
(2003)
-
-
Knight, T.1
-
78
-
-
80053064386
-
Reiterative recombination for the in vivo assembly of libraries of multigene pathways
-
Wingler L.M., Cornish V.W. Reiterative recombination for the in vivo assembly of libraries of multigene pathways. Proc Natl Acad Sci USA 2011, 108:15135-15140.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 15135-15140
-
-
Wingler, L.M.1
Cornish, V.W.2
-
79
-
-
79952642503
-
Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler
-
Shao Z., Luo Y., Zhao H. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Mol Biosyst 2011, 7:1056-1059.
-
(2011)
Mol Biosyst
, vol.7
, pp. 1056-1059
-
-
Shao, Z.1
Luo, Y.2
Zhao, H.3
-
80
-
-
66249088017
-
The second wave of synthetic biology: from modules to systems
-
Purnick P.E., Weiss R. The second wave of synthetic biology: from modules to systems. Nat Rev Mol Cell Biol 2009, 10:410-422.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 410-422
-
-
Purnick, P.E.1
Weiss, R.2
-
82
-
-
0031662188
-
Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity
-
Hugenholtz P., Goebel B.M., Pace N.R. Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity. J Bacteriol 1998, 180:4765-4774.
-
(1998)
J Bacteriol
, vol.180
, pp. 4765-4774
-
-
Hugenholtz, P.1
Goebel, B.M.2
Pace, N.R.3
-
83
-
-
0032192790
-
Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products
-
Handelsman J., Rondon M.R., Brady S.F., Clardy J., Goodman R.M. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem Biol 1998, 5:R245-249.
-
(1998)
Chem Biol
, vol.5
-
-
Handelsman, J.1
Rondon, M.R.2
Brady, S.F.3
Clardy, J.4
Goodman, R.M.5
-
84
-
-
77957774503
-
Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules
-
Banik J.J., Brady S.F. Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules. Curr Opin Microbiol 2010, 13:603-609.
-
(2010)
Curr Opin Microbiol
, vol.13
, pp. 603-609
-
-
Banik, J.J.1
Brady, S.F.2
-
85
-
-
27744453364
-
Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA
-
Brady S.F., Clardy J. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew Chem Int Ed Engl 2005, 44:7063-7065.
-
(2005)
Angew Chem Int Ed Engl
, vol.44
, pp. 7063-7065
-
-
Brady, S.F.1
Clardy, J.2
-
86
-
-
0034722959
-
Long-chain N-acyl amino acid antibiotics isolated from heterologously expressed environmental DNA
-
Brady S.F., Clardy J. Long-chain N-acyl amino acid antibiotics isolated from heterologously expressed environmental DNA. J Am Chem Soc 2000, 122:12903-12904.
-
(2000)
J Am Chem Soc
, vol.122
, pp. 12903-12904
-
-
Brady, S.F.1
Clardy, J.2
-
87
-
-
29144519503
-
Characterization of a forest soil metagenome clone that confers indirubin and indigo production on Escherichia coli
-
Lim H.K., Chung E.J., Kim J.C., et al. Characterization of a forest soil metagenome clone that confers indirubin and indigo production on Escherichia coli. Appl Environ Microbiol 2005, 71:7768-7777.
-
(2005)
Appl Environ Microbiol
, vol.71
, pp. 7768-7777
-
-
Lim, H.K.1
Chung, E.J.2
Kim, J.C.3
-
89
-
-
0036727242
-
Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA
-
Gillespie D.E., Brady S.F., Bettermann A.D., et al. Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA. Appl Environ Microb 2002, 68:4301-4306.
-
(2002)
Appl Environ Microb
, vol.68
, pp. 4301-4306
-
-
Gillespie, D.E.1
Brady, S.F.2
Bettermann, A.D.3
-
90
-
-
0035963668
-
Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA
-
Brady S.F., Chao C.J., Handelsman J., Clardy J. Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Org Lett 2001, 3:1981-1984.
-
(2001)
Org Lett
, vol.3
, pp. 1981-1984
-
-
Brady, S.F.1
Chao, C.J.2
Handelsman, J.3
Clardy, J.4
-
91
-
-
0035079979
-
Expression and isolation of antimicrobial small molecules from soil DNA libraries
-
MacNeil I.A., Tiong C.L., Minor C., et al. Expression and isolation of antimicrobial small molecules from soil DNA libraries. J Mol Microb Biotech 2001, 3:301-308.
-
(2001)
J Mol Microb Biotech
, vol.3
, pp. 301-308
-
-
MacNeil, I.A.1
Tiong, C.L.2
Minor, C.3
-
92
-
-
0034632413
-
Novel natural products from soil DNA libraries in a streptomycete host
-
Wang G.Y.S., Graziani E., Waters B., et al. Novel natural products from soil DNA libraries in a streptomycete host. Org Lett 2000, 2:2401-2404.
-
(2000)
Org Lett
, vol.2
, pp. 2401-2404
-
-
Wang, G.Y.S.1
Graziani, E.2
Waters, B.3
-
93
-
-
0014015635
-
Cytotoxicity of pederin and some of its derivatives on cultured mammalian cells
-
Soldati M., Fioretti A., Ghione M. Cytotoxicity of pederin and some of its derivatives on cultured mammalian cells. Experientia 1966, 22:176-178.
-
(1966)
Experientia
, vol.22
, pp. 176-178
-
-
Soldati, M.1
Fioretti, A.2
Ghione, M.3
-
94
-
-
0037195174
-
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
-
Piel J. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. Proc Natl Acad Sci USA 2002, 99:14002-14007.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14002-14007
-
-
Piel, J.1
-
95
-
-
56249128990
-
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary
-
Banik J.J., Brady S.F. Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proc Natl Acad Sci USA 2008, 105:17273-17277.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17273-17277
-
-
Banik, J.J.1
Brady, S.F.2
-
96
-
-
9244230571
-
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
-
Piel J., Hui D., Wen G., et al. Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei. Proc Natl Acad Sci USA 2004, 101:16222-16227.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 16222-16227
-
-
Piel, J.1
Hui, D.2
Wen, G.3
-
97
-
-
67650281479
-
Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting
-
Fisch K.M., Gurgui C., Heycke N., et al. Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting. Nat Chem Biol 2009, 5:494-501.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 494-501
-
-
Fisch, K.M.1
Gurgui, C.2
Heycke, N.3
-
98
-
-
67749122311
-
Pederin-type pathways of uncultivated bacterial symbionts: analysis of O-methyltransferases and generation of a biosynthetic hybrid
-
Zimmermann K., Engeser M., Blunt J.W., Munro M.H., Piel J. Pederin-type pathways of uncultivated bacterial symbionts: analysis of O-methyltransferases and generation of a biosynthetic hybrid. J Am Chem Soc 2009, 131:2780-2781.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 2780-2781
-
-
Zimmermann, K.1
Engeser, M.2
Blunt, J.W.3
Munro, M.H.4
Piel, J.5
-
99
-
-
18844410256
-
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella
-
Schmidt E.W., Nelson J.T., Rasko D.A., et al. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci USA 2005, 102:7315-7320.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7315-7320
-
-
Schmidt, E.W.1
Nelson, J.T.2
Rasko, D.A.3
-
100
-
-
33751096434
-
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
-
Donia M.S., Hathaway B.J., Sudek S., et al. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nat Chem Biol 2006, 2:729-735.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 729-735
-
-
Donia, M.S.1
Hathaway, B.J.2
Sudek, S.3
-
101
-
-
64249133292
-
Cyanobactin ribosomally synthesized peptides - a case of deep metagenome mining
-
Schmidt E.W., Donia M.S. Cyanobactin ribosomally synthesized peptides - a case of deep metagenome mining. Methods Enzymol 2009, 458:575-596.
-
(2009)
Methods Enzymol
, vol.458
, pp. 575-596
-
-
Schmidt, E.W.1
Donia, M.S.2
-
103
-
-
0141736926
-
Strategies for combinatorial biosynthesis with modular polyketide synthases
-
Donadio S., Sosio M. Strategies for combinatorial biosynthesis with modular polyketide synthases. Comb Chem High Throughput Screen 2003, 6:489-500.
-
(2003)
Comb Chem High Throughput Screen
, vol.6
, pp. 489-500
-
-
Donadio, S.1
Sosio, M.2
-
104
-
-
0021238139
-
Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host
-
Malpartida F., Hopwood D.A. Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. Nature 1984, 309:462-464.
-
(1984)
Nature
, vol.309
, pp. 462-464
-
-
Malpartida, F.1
Hopwood, D.A.2
-
105
-
-
77950127253
-
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
-
Olano C., Mendez C., Salas J.A. Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep 2010, 27:571-616.
-
(2010)
Nat Prod Rep
, vol.27
, pp. 571-616
-
-
Olano, C.1
Mendez, C.2
Salas, J.A.3
-
106
-
-
0036774667
-
Modification of post-PKS tailoring steps through combinatorial biosynthesis
-
Rix U., Fischer C., Remsing L.L., Rohr J. Modification of post-PKS tailoring steps through combinatorial biosynthesis. Nat Prod Rep 2002, 19:542-580.
-
(2002)
Nat Prod Rep
, vol.19
, pp. 542-580
-
-
Rix, U.1
Fischer, C.2
Remsing, L.L.3
Rohr, J.4
-
107
-
-
13744249199
-
Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters
-
Shen B., Chen M., Cheng Y., et al. Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters. Ernst Schering Res Found Workshop 2005, 107-126.
-
(2005)
Ernst Schering Res Found Workshop
, pp. 107-126
-
-
Shen, B.1
Chen, M.2
Cheng, Y.3
-
108
-
-
30544434619
-
Combinatorial biosynthesis of reduced polyketides
-
Weissman K.J., Leadlay P.F. Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol 2005, 3:925-936.
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 925-936
-
-
Weissman, K.J.1
Leadlay, P.F.2
-
109
-
-
0029894467
-
Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase
-
Fu H., Alvarez M.A., Khosla C., Bailey J.E. Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase. Biochemistry 1996, 35:6527-6532.
-
(1996)
Biochemistry
, vol.35
, pp. 6527-6532
-
-
Fu, H.1
Alvarez, M.A.2
Khosla, C.3
Bailey, J.E.4
-
110
-
-
0028674981
-
Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor
-
Fu H., Hopwood D.A., Khosla C. Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor. Chem Biol 1994, 1:205-210.
-
(1994)
Chem Biol
, vol.1
, pp. 205-210
-
-
Fu, H.1
Hopwood, D.A.2
Khosla, C.3
-
111
-
-
0027970295
-
Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase
-
McDaniel R., Ebert-Khosla S., Fu H., Hopwood D.A., Khosla C. Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase. Proc Natl Acad Sci USA 1994, 91:11542-11546.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 11542-11546
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Fu, H.3
Hopwood, D.A.4
Khosla, C.5
-
112
-
-
0027964653
-
Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase
-
Fu H., McDaniel R., Hopwood D.A., Khosla C. Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase. Biochemistry 1994, 33:9321-9326.
-
(1994)
Biochemistry
, vol.33
, pp. 9321-9326
-
-
Fu, H.1
McDaniel, R.2
Hopwood, D.A.3
Khosla, C.4
-
113
-
-
0027908014
-
Engineered biosynthesis of novel polyketides
-
McDaniel R., Ebert-Khosla S., Hopwood D.A., Khosla C. Engineered biosynthesis of novel polyketides. Science 1993, 262:1546-1550.
-
(1993)
Science
, vol.262
, pp. 1546-1550
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
114
-
-
0029064652
-
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits
-
McDaniel R., Ebert-Khosla S., Hopwood D.A., Khosla C. Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature 1995, 375:549-554.
-
(1995)
Nature
, vol.375
, pp. 549-554
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
115
-
-
0030249160
-
Generation of polyketide libraries via combinatorial biosynthesis
-
Khosla C., Zawada R.J. Generation of polyketide libraries via combinatorial biosynthesis. Trends Biotechnol 1996, 14:335-341.
-
(1996)
Trends Biotechnol
, vol.14
, pp. 335-341
-
-
Khosla, C.1
Zawada, R.J.2
-
116
-
-
0039708954
-
Tetracenomycin M, a novel genetically engineered tetracenomycin resulting from a combination of mithramycin and tetracenomycin biosynthetic genes
-
Kunzel E., Wohlert S.E., Beninga C., et al. Tetracenomycin M, a novel genetically engineered tetracenomycin resulting from a combination of mithramycin and tetracenomycin biosynthetic genes. Chem-Eur J 1997, 3:1675-1678.
-
(1997)
Chem-Eur J
, vol.3
, pp. 1675-1678
-
-
Kunzel, E.1
Wohlert, S.E.2
Beninga, C.3
-
117
-
-
0030957895
-
Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits
-
Zawada R.J.X., Khosla C. Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits. J Biol Chem 1997, 272:16184-16188.
-
(1997)
J Biol Chem
, vol.272
, pp. 16184-16188
-
-
Zawada, R.J.X.1
Khosla, C.2
-
118
-
-
0027234764
-
An erythromycin analog produced by reprogramming of polyketide synthesis
-
Donadio S., McAlpine J.B., Sheldon P.J., Jackson M., Katz L. An erythromycin analog produced by reprogramming of polyketide synthesis. Proc Natl Acad Sci USA 1993, 90:7119-7123.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7119-7123
-
-
Donadio, S.1
McAlpine, J.B.2
Sheldon, P.J.3
Jackson, M.4
Katz, L.5
-
119
-
-
0033515090
-
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel 'unnatural' natural products
-
McDaniel R., Thamchaipenet A., Gustafsson C., et al. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel 'unnatural' natural products. Proc Natl Acad Sci USA 1999, 96:1846-1851.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1846-1851
-
-
McDaniel, R.1
Thamchaipenet, A.2
Gustafsson, C.3
-
120
-
-
0002901362
-
The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis
-
Carreras C.W., Pieper R., Khosla C. The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis. Top Curr Chem 1997, 188:85-126.
-
(1997)
Top Curr Chem
, vol.188
, pp. 85-126
-
-
Carreras, C.W.1
Pieper, R.2
Khosla, C.3
-
121
-
-
0030902054
-
Gain-of-function mutagenesis of a modular polyketide synthase
-
McDaniel R., Kao C.M., Fu H., et al. Gain-of-function mutagenesis of a modular polyketide synthase. J Am Chem Soc 1997, 119:4309-4310.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 4309-4310
-
-
McDaniel, R.1
Kao, C.M.2
Fu, H.3
-
122
-
-
0030723673
-
Gain of function mutagenesis of the erythromycin polyketide synthase. 2. Engineered biosynthesis of eight-membered ring tetraketide lactone
-
Kao C.M., McPherson M., McDaniel R.N., Fu H., Cane D.E., Khosla C. Gain of function mutagenesis of the erythromycin polyketide synthase. 2. Engineered biosynthesis of eight-membered ring tetraketide lactone. J Am Chem Soc 1997, 119:11339-11340.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 11339-11340
-
-
Kao, C.M.1
McPherson, M.2
McDaniel, R.N.3
Fu, H.4
Cane, D.E.5
Khosla, C.6
-
123
-
-
0030266007
-
A hybrid modular polyketide synthase obtained by domain swapping
-
Oliynyk M., Brown M.J.B., Cortes J., Staunton J., Leadlay P.F. A hybrid modular polyketide synthase obtained by domain swapping. Chem Biol 1996, 3:833-839.
-
(1996)
Chem Biol
, vol.3
, pp. 833-839
-
-
Oliynyk, M.1
Brown, M.J.B.2
Cortes, J.3
Staunton, J.4
Leadlay, P.F.5
-
124
-
-
0030722980
-
Biosynthesis of 2-nor-6-deoxyerythronolide B by rationally designed domain substitution
-
Liu L., Thamchaipenet A., Fu H., Betlach M., Ashley G. Biosynthesis of 2-nor-6-deoxyerythronolide B by rationally designed domain substitution. J Am Chem Soc 1997, 119:10553-10554.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 10553-10554
-
-
Liu, L.1
Thamchaipenet, A.2
Fu, H.3
Betlach, M.4
Ashley, G.5
-
125
-
-
0030763125
-
Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives
-
Ruan X., Pereda A., Stassi D.L., et al. Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives. J Bacteriol 1997, 179:6416-6425.
-
(1997)
J Bacteriol
, vol.179
, pp. 6416-6425
-
-
Ruan, X.1
Pereda, A.2
Stassi, D.L.3
-
126
-
-
0030445331
-
Production of a novel polyketide through the construction of a hybrid polyketide synthase
-
Kuhstoss S., Huber M., Turner J.R., Paschal J.W., Rao R.N. Production of a novel polyketide through the construction of a hybrid polyketide synthase. Gene 1996, 183:231-236.
-
(1996)
Gene
, vol.183
, pp. 231-236
-
-
Kuhstoss, S.1
Huber, M.2
Turner, J.R.3
Paschal, J.W.4
Rao, R.N.5
-
127
-
-
0032498205
-
Engineering broader specificity into an antibiotic-producing polyketide synthase
-
Marsden A.F.A., Wilkinson B., Cortes J., Dunster N.J., Staunton J., Leadlay P.F. Engineering broader specificity into an antibiotic-producing polyketide synthase. Science 1998, 279:199-202.
-
(1998)
Science
, vol.279
, pp. 199-202
-
-
Marsden, A.F.A.1
Wilkinson, B.2
Cortes, J.3
Dunster, N.J.4
Staunton, J.5
Leadlay, P.F.6
-
128
-
-
0025981514
-
Novel avermectins produced by mutational biosynthesis
-
Dutton C.J., Gibson S.P., Goudie A.C., et al. Novel avermectins produced by mutational biosynthesis. J Antibiot 1991, 44:357-365.
-
(1991)
J Antibiot
, vol.44
, pp. 357-365
-
-
Dutton, C.J.1
Gibson, S.P.2
Goudie, A.C.3
-
129
-
-
0023098840
-
Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin
-
Cane D.E., Yang C.C. Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin. J Am Chem Soc 1987, 109:1255-1257.
-
(1987)
J Am Chem Soc
, vol.109
, pp. 1255-1257
-
-
Cane, D.E.1
Yang, C.C.2
-
130
-
-
0023122255
-
Macrolide biosynthesis - tylactone formation involves the processive addition of 3 carbon units
-
Yue S., Duncan J.S., Yamamoto Y., Hutchinson C.R. Macrolide biosynthesis - tylactone formation involves the processive addition of 3 carbon units. J Am Chem Soc 1987, 109:1253-1255.
-
(1987)
J Am Chem Soc
, vol.109
, pp. 1253-1255
-
-
Yue, S.1
Duncan, J.S.2
Yamamoto, Y.3
Hutchinson, C.R.4
-
131
-
-
0030875774
-
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
-
Jacobsen J.R., Hutchinson C.R., Cane D.E., Khosla C. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science 1997, 277:367-369.
-
(1997)
Science
, vol.277
, pp. 367-369
-
-
Jacobsen, J.R.1
Hutchinson, C.R.2
Cane, D.E.3
Khosla, C.4
-
132
-
-
0031259679
-
Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase
-
Chuck J.A., McPherson M., Huang H., Jacobsen J.R., Khosla C., Cane D.E. Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. Chem Biol 1997, 4:757-766.
-
(1997)
Chem Biol
, vol.4
, pp. 757-766
-
-
Chuck, J.A.1
McPherson, M.2
Huang, H.3
Jacobsen, J.R.4
Khosla, C.5
Cane, D.E.6
-
133
-
-
0031239838
-
Engineered intermodular and intramodular polyketide synthase fusions
-
McDaniel R., Kao C.M., Hwang S.J., Khosla C. Engineered intermodular and intramodular polyketide synthase fusions. Chem Biol 1997, 4:667-674.
-
(1997)
Chem Biol
, vol.4
, pp. 667-674
-
-
McDaniel, R.1
Kao, C.M.2
Hwang, S.J.3
Khosla, C.4
-
134
-
-
0346080764
-
Biosynthesis of penicillins; new crystalline biosynthetic penicillins
-
Behrens O.K., Corse J. Biosynthesis of penicillins; new crystalline biosynthetic penicillins. J Biol Chem 1948, 175:793-809.
-
(1948)
J Biol Chem
, vol.175
, pp. 793-809
-
-
Behrens, O.K.1
Corse, J.2
-
135
-
-
0018338526
-
Mutational biosynthesis of new antibiotics
-
Daum S.J., Lemke J.R. Mutational biosynthesis of new antibiotics. Annu Rev Microbiol 1979, 33:241-265.
-
(1979)
Annu Rev Microbiol
, vol.33
, pp. 241-265
-
-
Daum, S.J.1
Lemke, J.R.2
-
136
-
-
2642591970
-
Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase
-
Khaw L.E., Bohm G.A., Metcalfe S., Staunton J., Leadlay P.F. Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. J Bacteriol 1998, 180:809-814.
-
(1998)
J Bacteriol
, vol.180
, pp. 809-814
-
-
Khaw, L.E.1
Bohm, G.A.2
Metcalfe, S.3
Staunton, J.4
Leadlay, P.F.5
-
137
-
-
0027998112
-
Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria
-
Liu H.W., Thorson J.S. Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria. Annu Rev Microbiol 1994, 48:223-256.
-
(1994)
Annu Rev Microbiol
, vol.48
, pp. 223-256
-
-
Liu, H.W.1
Thorson, J.S.2
-
138
-
-
33748224623
-
Novel genetically-engineered tetracenomycins
-
Decker H., Haag S., Udvarnoki G., Rohr J. Novel genetically-engineered tetracenomycins. Angew Chem Int Edit Engl 1995, 34:1107-1110.
-
(1995)
Angew Chem Int Edit Engl
, vol.34
, pp. 1107-1110
-
-
Decker, H.1
Haag, S.2
Udvarnoki, G.3
Rohr, J.4
-
139
-
-
0031105304
-
Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis
-
Solenberg P.J., Matsushima P., Stack D.R., Wilkie S.C., Thompson R.C., Baltz R.H. Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis. Chem Biol 1997, 4:195-202.
-
(1997)
Chem Biol
, vol.4
, pp. 195-202
-
-
Solenberg, P.J.1
Matsushima, P.2
Stack, D.R.3
Wilkie, S.C.4
Thompson, R.C.5
Baltz, R.H.6
-
140
-
-
0031974553
-
Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
-
Madduri K., Kennedy J., Rivola G., et al. Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius. Nat Biotechnol 1998, 16:69-74.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 69-74
-
-
Madduri, K.1
Kennedy, J.2
Rivola, G.3
-
142
-
-
34848911303
-
Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
-
Donadio S., Monciardini P., Sosio M. Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics. Nat Prod Rep 2007, 24:1073-1109.
-
(2007)
Nat Prod Rep
, vol.24
, pp. 1073-1109
-
-
Donadio, S.1
Monciardini, P.2
Sosio, M.3
-
143
-
-
0037046560
-
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
-
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 2002, 417:141-147.
-
(2002)
Nature
, vol.417
, pp. 141-147
-
-
Bentley, S.D.1
Chater, K.F.2
Cerdeno-Tarraga, A.M.3
-
144
-
-
42949136443
-
Genome mining for novel natural product discovery
-
Challis G.L. Genome mining for novel natural product discovery. J Med Chem 2008, 51:2618-2628.
-
(2008)
J Med Chem
, vol.51
, pp. 2618-2628
-
-
Challis, G.L.1
-
145
-
-
33947308882
-
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
-
Bergmann S., Schumann J., Scherlach K., Lange C., Brakhage A.A., Hertweck C. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 2007, 3:213-217.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 213-217
-
-
Bergmann, S.1
Schumann, J.2
Scherlach, K.3
Lange, C.4
Brakhage, A.A.5
Hertweck, C.6
-
146
-
-
34249907531
-
Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects
-
Gross H. Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects. Appl Microbiol Biotechnol 2007, 75:267-277.
-
(2007)
Appl Microbiol Biotechnol
, vol.75
, pp. 267-277
-
-
Gross, H.1
-
147
-
-
34447302758
-
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
-
Udwary D.W., Zeigler L., Asolkar R.N., et al. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci USA 2007, 104:10376-10381.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10376-10381
-
-
Udwary, D.W.1
Zeigler, L.2
Asolkar, R.N.3
-
148
-
-
33846294440
-
The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters
-
Gross H., Stockwell V.O., Henkels M.D., Nowak-Thompson B., Loper J.E., Gerwick W.H. The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chem Biol 2007, 14:53-63.
-
(2007)
Chem Biol
, vol.14
, pp. 53-63
-
-
Gross, H.1
Stockwell, V.O.2
Henkels, M.D.3
Nowak-Thompson, B.4
Loper, J.E.5
Gerwick, W.H.6
-
149
-
-
33646512641
-
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase
-
Lin X., Hopson R., Cane D.E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J Am Chem Soc 2006, 128:6022-6023.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 6022-6023
-
-
Lin, X.1
Hopson, R.2
Cane, D.E.3
-
150
-
-
33845212858
-
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining
-
Song L., Barona-Gomez F., Corre C., et al. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc 2006, 128:14754-14755.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 14754-14755
-
-
Song, L.1
Barona-Gomez, F.2
Corre, C.3
-
151
-
-
34250818263
-
A genomic screening approach to the structure-guided identification of drug candidates from natural sources
-
Hornung A., Bertazzo M., Dziarnowski A., et al. A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem 2007, 8:757-766.
-
(2007)
Chembiochem
, vol.8
, pp. 757-766
-
-
Hornung, A.1
Bertazzo, M.2
Dziarnowski, A.3
-
152
-
-
34748829074
-
Histone deacetylase activity regulates chemical diversity in Aspergillus
-
Shwab E.K., Bok J.W., Tribus M., Galehr J., Graessle S., Keller N.P. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot Cell 2007, 6:1656-1664.
-
(2007)
Eukaryot Cell
, vol.6
, pp. 1656-1664
-
-
Shwab, E.K.1
Bok, J.W.2
Tribus, M.3
Galehr, J.4
Graessle, S.5
Keller, N.P.6
-
153
-
-
67650321573
-
Chromatin-level regulation of biosynthetic gene clusters
-
Bok J.W., Chiang Y.M., Szewczyk E., et al. Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol 2009, 5:462-464.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 462-464
-
-
Bok, J.W.1
Chiang, Y.M.2
Szewczyk, E.3
-
154
-
-
77951368996
-
Clinical study of a new antibiotic; erythromycin
-
Vannucchi V. Clinical study of a new antibiotic; erythromycin. Riv Crit Clin Med 1952, 52:128-136.
-
(1952)
Riv Crit Clin Med
, vol.52
, pp. 128-136
-
-
Vannucchi, V.1
-
155
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
-
Cortes J., Haydock S.F., Roberts G.A., Bevitt D.J., Leadlay P.F. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 1990, 348:176-178.
-
(1990)
Nature
, vol.348
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.F.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
156
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio S., Staver M.J., Mcalpine J.B., Swanson S.J., Katz L. Modular organization of genes required for complex polyketide biosynthesis. Science 1991, 252:675-679.
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
Mcalpine, J.B.3
Swanson, S.J.4
Katz, L.5
-
157
-
-
0026697224
-
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea
-
Caffrey P., Bevitt D.J., Staunton J., Leadlay P.F. Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. Febs Lett 1992, 304:225-228.
-
(1992)
Febs Lett
, vol.304
, pp. 225-228
-
-
Caffrey, P.1
Bevitt, D.J.2
Staunton, J.3
Leadlay, P.F.4
-
158
-
-
0027932534
-
Engineered biosynthesis of a complete macrolactone in a heterologous host
-
Kao C.M., Katz L., Khosla C. Engineered biosynthesis of a complete macrolactone in a heterologous host. Science 1994, 265:509-512.
-
(1994)
Science
, vol.265
, pp. 509-512
-
-
Kao, C.M.1
Katz, L.2
Khosla, C.3
-
159
-
-
0035793858
-
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
-
Pfeifer B.A., Admiraal S.J., Gramajo H., Cane D.E., Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 2001, 291:1790-1792.
-
(2001)
Science
, vol.291
, pp. 1790-1792
-
-
Pfeifer, B.A.1
Admiraal, S.J.2
Gramajo, H.3
Cane, D.E.4
Khosla, C.5
-
160
-
-
0036223415
-
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase
-
Long P.F., Wilkinson C.J., Bisang C.P., et al. Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol 2002, 43:1215-1225.
-
(2002)
Mol Microbiol
, vol.43
, pp. 1215-1225
-
-
Long, P.F.1
Wilkinson, C.J.2
Bisang, C.P.3
-
161
-
-
0037435553
-
Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases
-
Liou G.F., Lau J., Cane D.E., Khosla C. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. Biochemistry 2003, 42:200-207.
-
(2003)
Biochemistry
, vol.42
, pp. 200-207
-
-
Liou, G.F.1
Lau, J.2
Cane, D.E.3
Khosla, C.4
-
162
-
-
0141656418
-
Precursor-directed polyketide biosynthesis in Escherichia coli
-
Kinoshita K., Pfeifer B.A., Khosla C., Cane D.E. Precursor-directed polyketide biosynthesis in Escherichia coli. Bioorg Med Chem Lett 2003, 13:3701-3704.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 3701-3704
-
-
Kinoshita, K.1
Pfeifer, B.A.2
Khosla, C.3
Cane, D.E.4
-
163
-
-
0036008126
-
Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides
-
Cane D.E., Kudo F., Kinoshita K., Khosla C. Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. Chem Biol 2002, 9:131-142.
-
(2002)
Chem Biol
, vol.9
, pp. 131-142
-
-
Cane, D.E.1
Kudo, F.2
Kinoshita, K.3
Khosla, C.4
-
164
-
-
1142269603
-
Precursor-directed biosynthesis of novel triketide lactones
-
Regentin R., Kennedy J., Wu N., et al. Precursor-directed biosynthesis of novel triketide lactones. Biotechnol Progr 2004, 20:122-127.
-
(2004)
Biotechnol Progr
, vol.20
, pp. 122-127
-
-
Regentin, R.1
Kennedy, J.2
Wu, N.3
-
165
-
-
33845621530
-
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase
-
Ward S.L., Desai R.P., Hu Z.H., Gramajo H., Katz L. Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. J Ind Microbiol Biot 2007, 34:9-15.
-
(2007)
J Ind Microbiol Biot
, vol.34
, pp. 9-15
-
-
Ward, S.L.1
Desai, R.P.2
Hu, Z.H.3
Gramajo, H.4
Katz, L.5
-
166
-
-
0037617464
-
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules
-
Hans M., Hornung A., Dziarnowski A., Cane D.E., Khosla C. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. J Am Chem Soc 2003, 125:5366-5374.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 5366-5374
-
-
Hans, M.1
Hornung, A.2
Dziarnowski, A.3
Cane, D.E.4
Khosla, C.5
-
167
-
-
13144249211
-
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
-
Stassi D.L., Kakavas S.J., Reynolds K.A., et al. Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. Proc Natl Acad Sci USA 1998, 95:7305-7309.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7305-7309
-
-
Stassi, D.L.1
Kakavas, S.J.2
Reynolds, K.A.3
-
168
-
-
0037094002
-
Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B
-
Kato Y., Bai L.Q., Xue Q., Revill W.P., Yu T.W., Floss H.G. Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. J Am Chem Soc 2002, 124:5268-5269.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 5268-5269
-
-
Kato, Y.1
Bai, L.Q.2
Xue, Q.3
Revill, W.P.4
Yu, T.W.5
Floss, H.G.6
-
169
-
-
18444395871
-
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli
-
Peiru S., Menzella H.G., Rodriguez E., Carney J., Gramajo H. Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. Appl Environ Microb 2005, 71:2539-2547.
-
(2005)
Appl Environ Microb
, vol.71
, pp. 2539-2547
-
-
Peiru, S.1
Menzella, H.G.2
Rodriguez, E.3
Carney, J.4
Gramajo, H.5
-
170
-
-
27144509740
-
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
-
Menzella H.G., Reid R., Carney J.R., et al. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol 2005, 23:1171-1176.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1171-1176
-
-
Menzella, H.G.1
Reid, R.2
Carney, J.R.3
-
171
-
-
1142293830
-
Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues
-
Desai R.P., Leaf T., Hu Z.H., et al. Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. Biotechnol Progr 2004, 20:38-43.
-
(2004)
Biotechnol Progr
, vol.20
, pp. 38-43
-
-
Desai, R.P.1
Leaf, T.2
Hu, Z.H.3
-
172
-
-
0037161282
-
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli
-
Dayem L.C., Carney J.R., Santi D.V., Pfeifer B.A., Khosla C., Kealey J.T. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry 2002, 41:5193-5201.
-
(2002)
Biochemistry
, vol.41
, pp. 5193-5201
-
-
Dayem, L.C.1
Carney, J.R.2
Santi, D.V.3
Pfeifer, B.A.4
Khosla, C.5
Kealey, J.T.6
-
173
-
-
0042100690
-
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
-
Murli S., Kennedy J., Dayem L.C., Carney J.R., Kealey J.T. Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. J Ind Microbiol Biotechnol 2003, 30:500-509.
-
(2003)
J Ind Microbiol Biotechnol
, vol.30
, pp. 500-509
-
-
Murli, S.1
Kennedy, J.2
Dayem, L.C.3
Carney, J.R.4
Kealey, J.T.5
-
174
-
-
84856576230
-
Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering
-
Zhang H., Skalina K., Jiang M., Pfeifer B.A. Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering. Biotechnol Prog 2011, 28:292-296.
-
(2011)
Biotechnol Prog
, vol.28
, pp. 292-296
-
-
Zhang, H.1
Skalina, K.2
Jiang, M.3
Pfeifer, B.A.4
-
175
-
-
84882656051
-
-
World Health Organization.World Malaria Report 2010;
-
World Health Organization.World Malaria Report 2010; 2010.
-
(2010)
-
-
-
176
-
-
0034664686
-
Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L
-
Mercke P., Bengtsson M., Bouwmeester H.J., Posthumus M.A., Brodelius P.E. Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. Arch Biochem Biophys 2000, 381:173-180.
-
(2000)
Arch Biochem Biophys
, vol.381
, pp. 173-180
-
-
Mercke, P.1
Bengtsson, M.2
Bouwmeester, H.J.3
Posthumus, M.A.4
Brodelius, P.E.5
-
177
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
Martin V.J., Pitera D.J., Withers S.T., Newman J.D., Keasling J.D. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 2003, 21:796-802.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 796-802
-
-
Martin, V.J.1
Pitera, D.J.2
Withers, S.T.3
Newman, J.D.4
Keasling, J.D.5
-
178
-
-
55549116661
-
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
-
Anthony J.R., Anthony L.C., Nowroozi F., Kwon G., Newman J.D., Keasling J.D. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. Metab Eng 2009, 11:13-19.
-
(2009)
Metab Eng
, vol.11
, pp. 13-19
-
-
Anthony, J.R.1
Anthony, L.C.2
Nowroozi, F.3
Kwon, G.4
Newman, J.D.5
Keasling, J.D.6
-
179
-
-
33847309176
-
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
-
Pitera D.J., Paddon C.J., Newman J.D., Keasling J.D. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng 2007, 9:193-207.
-
(2007)
Metab Eng
, vol.9
, pp. 193-207
-
-
Pitera, D.J.1
Paddon, C.J.2
Newman, J.D.3
Keasling, J.D.4
-
180
-
-
84879142653
-
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli
-
Tsuruta H., Paddon C.J., Eng D., et al. High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PLoS One 2009, 4:e4489.
-
(2009)
PLoS One
, vol.4
-
-
Tsuruta, H.1
Paddon, C.J.2
Eng, D.3
-
181
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro D.K., Paradise E.M., Ouellet M., et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006, 440:940-943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
-
182
-
-
84856389651
-
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
-
Westfall P.J., Pitera D.J., Lenihan J.R., et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Natl Acad Sci USA 2012, 109:E111-E118.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Westfall, P.J.1
Pitera, D.J.2
Lenihan, J.R.3
-
183
-
-
34247182988
-
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
-
Chang M.C.Y., Eachus R.A., Trieu W., Ro D.K., Keasling J.D. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol 2007, 3:274-277.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 274-277
-
-
Chang, M.C.Y.1
Eachus, R.A.2
Trieu, W.3
Ro, D.K.4
Keasling, J.D.5
-
184
-
-
15944383707
-
Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis
-
Jennewein S., Park H., DeJong J.M., Long R.M., Bollon A.P., Croteau R.B. Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis. Biotechnol Bioeng 2005, 89:588-598.
-
(2005)
Biotechnol Bioeng
, vol.89
, pp. 588-598
-
-
Jennewein, S.1
Park, H.2
DeJong, J.M.3
Long, R.M.4
Bollon, A.P.5
Croteau, R.B.6
-
185
-
-
33645573250
-
Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae
-
Dejong J.M., Liu Y., Bollon A.P., et al. Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae. Biotechnol Bioeng 2006, 93:212-224.
-
(2006)
Biotechnol Bioeng
, vol.93
, pp. 212-224
-
-
Dejong, J.M.1
Liu, Y.2
Bollon, A.P.3
-
186
-
-
44749083814
-
Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
-
Engels B., Dahm P., Jennewein S. Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab Eng 2008, 10:201-206.
-
(2008)
Metab Eng
, vol.10
, pp. 201-206
-
-
Engels, B.1
Dahm, P.2
Jennewein, S.3
-
187
-
-
0034838359
-
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
-
Huang Q., Roessner C.A., Croteau R., Scott A.I. Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol. Bioorg Med Chem 2001, 9:2237-2242.
-
(2001)
Bioorg Med Chem
, vol.9
, pp. 2237-2242
-
-
Huang, Q.1
Roessner, C.A.2
Croteau, R.3
Scott, A.I.4
-
188
-
-
77957329119
-
Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli
-
Ajikumar P.K., Xiao W.H., Tyo K.E.J., et al. Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli. Science 2010, 330:70-74.
-
(2010)
Science
, vol.330
, pp. 70-74
-
-
Ajikumar, P.K.1
Xiao, W.H.2
Tyo, K.E.J.3
|