Combining Classical, Genetic, and Process Strategies for Improved Precursor-Directed Production of 6-Deoxyerythronolide B Analogues

Biotechnology Progress

Volumn 20, Issue 1, 2004, Pages 38-43

  Desai, Ruchir P ^a   Leaf, Timothy ^a   Hu, Zhihao ^a   Hutchinson, C Richard ^a   Hong, Anderson ^b   Byng, Graham ^b   Galazzo, Jorge ^a   Licari, Peter ^a  

^a KOSAN BIOSCIENCES INC   (United States)

^b Fermentation Laboratories   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADSORPTION; DNA; DRUG PRODUCTS; FERMENTATION; GENETIC ENGINEERING; MUTAGENESIS; SOLUBILITY;

PLASMIDS; PRECURSORS;

BIOTECHNOLOGY;

6 DEOXYERYTHRONOLIDE B; 6-DEOXYERYTHRONOLIDE B; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; ERYTHROMYCIN;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; COMPARATIVE STUDY; CULTURE TECHNIQUE; EVALUATION; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETICS; METABOLISM; METHODOLOGY; MICROBIOLOGY; MUTAGENESIS; PHYSIOLOGY; PILOT STUDY; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; BIOREACTORS; CELL CULTURE TECHNIQUES; ERYTHROMYCIN; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENHANCEMENT; MUTAGENESIS; PILOT PROJECTS; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES COELICOLOR;

EID: 1142293830     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp034171u     Document Type: Article

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