Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome p450 oxygenases involved in taxol biosynthesis

Biotechnology and Bioengineering

Volumn 89, Issue 5, 2005, Pages 588-598

  Jennewein, Stefan ^a,c   Park, Hangil ^b,d   DeJong, JingHong M ^b   Long, Robert M ^a   Bollon, Arthur P ^b   Croteau, Rodney B ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b eXegenics Inc   (United States)

^c DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^d MacroGenics Inc   (United States)

Author keywords

Cytochrome P450 reductase; Cytochrome P450 taxoid 10 hydroxylase; Cytochrome P450 taxoid 13 hydroxylase; Paclitaxel; Saccharomyces cerevisiae; Taxol; Taxus; Yeast; Yew

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; DNA; DRUG DOSAGE; GENES; HYDROXYLATION; PROTEINS; TUMORS;

HYDROXYLASE ACTIVITY; RECOMBINANT CYTOCHROMES; REDOX COUPLING; TRANSGENIC COUPLING;

YEAST;

CYTOCHROME P450 OXYGENASE; CYTOCHROME P450 REDUCTASE; OXYGENASE; PACLITAXEL; TAXOID 10BETA HYDROXYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FUNGAL GENE; GENE EXPRESSION; GYMNOSPERM; INSECT CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; TAXUS; TAXUS CUSPIDATA; TRANSGENE;

CYTOCHROME P-450 ENZYME SYSTEM; PACLITAXEL; SACCHAROMYCES CEREVISIAE; TAXUS;

CUSPIDATA; GYMNOSPERMAE; INSECTA; MAGNOLIOPHYTA; SACCHAROMYCES CEREVISIAE; TAXUS; TAXUS CUSPIDATA;

EID: 15944383707     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20390     Document Type: Article

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