Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 3, 2012, Pages

  Westfall, Patrick J ^a   Pitera, Douglas J ^a   Lenihan, Jacob R ^a   Eng, Diana ^a   Woolard, Frank X ^a   Regentin, Rika ^a   Horning, Tizita ^a   Tsuruta, Hiroko ^a   Melis, David J ^a   Owens, Andrew ^a   Fickes, Scott ^a   Diola, Don ^a   Benjamin, Kirsten R ^a   Keasling, Jay D ^b,c,d,e   Leavell, Michael D ^a   McPhee, Derek J ^a   Renninger, Neil S ^a   Newman, Jack D ^a   Paddon, Chris J ^a  

^a Amyris Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California at Berkeley   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e JOINT BIOENERGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMORPHA 4,11 DIENE; ANTIMALARIAL AGENT; ARTEMISINIC ACID; ARTEMISININ; DIHYDROARTEMISINIC ACID; MEVALONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CODON USAGE; FERMENTATION; GENE DELETION; MALARIA; NONHUMAN; PARTIAL DRUG SYNTHESIS; PLASMODIUM; PRECURSOR; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE;

ANTIMALARIALS; ARTEMISININS; BATCH CELL CULTURE TECHNIQUES; CODON; ETHANOL; FERMENTATION; GALACTOSE; GENES, FUNGAL; GENOTYPE; GLUCOSE; SACCHAROMYCES CEREVISIAE; SESQUITERPENES;

AMORPHA; ARTEMISIA ANNUA; SACCHAROMYCES CEREVISIAE;

EID: 84856389651     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110740109     Document Type: Article

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