Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae

Biotechnology and Bioengineering

Volumn 93, Issue 2, 2006, Pages 212-224

  DeJong, JingHong M ^a   Liu, Yule ^a,c   Bollon, Arthur P ^a,d   Long, Robert M ^b   Jennewein, Stefan ^b,e   Williams, David ^b   Croteau, Rodney B ^b  

^a eXegenics Inc   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c Inhibitex Inc   (United States)

^d HemoBiotech Inc   (United States)

^e DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Paclitaxel; Saccharomyces cerevisiae; Taxadiene synthase; Taxoid acyl transferase; Taxoid hydroxylase; Taxol; Taxus; Yeast; Yew

Indexed keywords

BIOSYNTHESIS; DRUG PRODUCTS; ENZYMES; GENETIC ENGINEERING; HYDROXYLATION; IMMUNOLOGY; MONOCLONAL ANTIBODIES; YEAST;

PACLITAXEL; SACCHAROMYCES CEREVISIAE; TAXADIENE SYNTHASE; TAXOID ACYL TRANSFERASE; TAXOID HYDROXYLASE; TAXOL; TAXUS; YEW;

GENES;

ANTINEOPLASTIC AGENT; BACCATIN III; EPITOPE; ISOPRENOID; MONOCLONAL ANTIBODY; PACLITAXEL; RECOMBINANT PROTEIN; TAXADIEN 5ALPHA ACETOXY 10BETA OL; TAXANE DITERPENOID; TAXOID; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; EPISOME; FUNGAL GENE; GENE CASSETTE; GENE EXPRESSION; GENE FUNCTION; GENETIC ENGINEERING; HYDROXYLATION; IMMUNOBLOTTING; METABOLITE; NONHUMAN; PLASMID; PROMOTER REGION; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE;

ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; COENZYME A-TRANSFERASES; CYTOCHROME P-450 ENZYME SYSTEM; FARNESYLTRANSTRANSFERASE; GENES, PLANT; GENETIC ENGINEERING; MIXED FUNCTION OXYGENASES; PACLITAXEL; SACCHAROMYCES CEREVISIAE; TAXOIDS; TAXUS;

SACCHAROMYCES CEREVISIAE; TAXUS;

EID: 33645573250     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20694     Document Type: Article

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