Generation of polyketide libraries via combinatorial biosynthesis

Trends in Biotechnology

Volumn 14, Issue 9, 1996, Pages 335-341

  Khosla, Chaitan ^a   Zawada, Robert J X ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CHEMICAL MODIFICATION; COENZYMES; CONDENSATION; MONOMERS; REDUCTION;

COMBINATORIAL BIOSYNTHESIS; NATURAL PRODUCTS; POLYKETIDE; POLYKETIDE SYNTHASES;

ENZYMES;

POLYKETIDE;

ARTICLE; BIOSYNTHESIS; BIOTECHNOLOGY; GENE LIBRARY; GENETIC ENGINEERING; PRIORITY JOURNAL;

EID: 0030249160     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-7799(96)10046-9     Document Type: Article

References (33)

1. 1 O'Hagan, D. (1991) The Polyketide Metabolites, Ellis Horwood
2. 2 Katz, L. and Donadio, S. (1993) Annu. Rev. Microbiol. 47, 875-912
3. 3 Hutchinson, C. R. and Fujii, I. (1995) Annu. Rev. Microbiol. 49, 201-238
4. 4 Cortes, J., Haydock, S. F., Roberts, G. A., Bevitt, D. J. and Leadlay, P. F. (1990) Nature 348, 176-178
5. 5 Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J. and Katz, L. (1991) Science 252, 675-679
6. 6 MacNeil, D. J. et al. (1992) Gene 115, 119-125
7. 7 Schweke, T. et al. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7839-7843
8. 8 Fernández-Moreno, M. A., Martínez, E., Boto, L., Hopwood, D. A. and Malpartida, F. (1992) J. Biol Chem. 267, 19278-19290
9. 9 Sherman, D. H. et al. (1989) EMBO J. 8, 2717-2725
10. 10 Bibb, M. J., Biró, S., Motamedi, H., Collins, J. F. and Hutchinson, C. R. (1989) EMBO J. 8, 2727-2736
11. 11 Beck, J., Ripka, S., Siegner, A., Schlitz, E. and Schweizer, E. (1990) Em. J. Biochem. 192, 487-498
12. 12 Hopwood, D. A. et al. (1985) Nature 314, 642-644
13. 13 Epp, J. K. et al. (1989) Gene 95, 293-301
14. 14 Bartel, P. L. et al. (1990) J. Bacteriol. 172, 4816-4826
15. 15 Donadio, S., McAlpine, J. B., Sheldon, P. J., Jackson, M. and Katz, L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 7119-7123
16. 16 McDaniel, R., Ebert-Khosla, S., Hopwood, D. A. and Khosla, C. (1993) Science 262, 1546-1550
17. 17 Kao, C. M., Katz, L. and Khosla, C. (1994) Science 265, 509-512
18. 18 Bedford, D. J., Schweizer, E., Hopwood, D. A. and Khosla, C. (1995) J. Bacteriol. 177, 4544-4548
19. 19 McDaniel, R., Ebert-Khosla, S., Hopwood, D. A. and Khosla, C. (1994) J. Am. Chem. Soc. 116, 10855-10859
20. 20 McDaniel, R., Hutchinson, C. R. and Khosla, C. (1995) J. Am. Chem. Soc. 117, 6805-6810
21. 21 Shen, B., Summers, R. G., Wendt-Pienkowski, E. and Hutchinson, C. R. (1995) J. Am. Chem. Soc. 117, 6811-6821
22. 22 Fu, H., McDaniel, R., Hopwood, D. A. and Khosla, C. (1994) Biochemistry 33, 9321-9326
23. 23 McDaniel, R., Ebert-Khosla, S., Hopwood, D. A. and Khosla, C. (1995) Nature 375, 549-554
24. 24 Tsoi, C. J. and Khosla, C. (1995) Chem. Biol. 2, 355-362
25. 25 Kao, C. M., Luo, G., Katz, L., Cane, D. E. and Khosla, C. (1994) J. Am. Chem. Soc. 116, 11612-11613
26. 26 Kao, C. M., Luo, G., Katz, L., Cane, D. E. and Khosla, C. (1995) J. Am. Chem. Soc. 117, 9105-9106
27. 27 Cortes, J. et al. (1995) Science 268, 1487-1489
28. 28 Shen, B. and Hutchinson, C. R. (1993) Science 262, 1535-1540
29. 29 Pieper, R., Luo, G., Cane, D. E. and Khosla, C. (1995) Nature 378, 263-266
30. 30 Pieper, R., Luo, G., Cane, D. E. and Khosla, C. (1995) J. Am. Chem. Soc. 117, 11373-11374
31. 31 Wiesmann, K. E. H. et al. (1995) Chem. Biol. 2, 583-589
32. 32 Luo, G., Pieper, R., Khosla, C. and Cane, D. E. Bioorg. Med. Chem. 4, 995-999
33. 33 Carreras, C. W., Pieper, R. and Khosla, C. J. Am. Chem. Soc. (in press)