Natural products as sources of new drugs over the last 25 years

Journal of Natural Products

Volumn 70, Issue 3, 2007, Pages 461-477

  Newman, David J ^a   Cragg, Gordon M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; APALCILLIN; ASPOXICILLIN; AZITHROMYCIN; AZTREONAM; BIAPENEM; CARUMONAM; CEFCAPENE PIVOXIL; CEFDINIR; CEFDITOREN PIVOXIL; CEFEPIME; CEFETAMET PIVOXIL; CEFIXIME; CEFMENOXIME; CEFMINOX; DAPTOMYCIN; FORTIMICIN; FOSFOMYCIN TROMETAMOL; HABEKACIN; ISEPAMICIN; L 162313; MICRONOMICIN; MIOKAMYCIN; NATURAL PRODUCT; PSEUDOMONIC ACID; SORAFENIB; TEICOPLANIN; UNCLASSIFIED DRUG; ZALIG;

CANCER; CANCER RESEARCH; CANCER THERAPY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMBINATORIAL CHEMISTRY; DRUG CONTROL; DRUG RESEARCH; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; MONOTHERAPY; REVIEW; TREATMENT INDICATION; TREATMENT PLANNING;

BIOLOGICAL PRODUCTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG APPROVAL; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; MOLECULAR STRUCTURE; PHARMACOLOGY; RESEARCH;

EID: 34247109045     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np068054v     Document Type: Review

References (97)

1. Cragg, G. M.; Newman, D. J.; Snader, K. M. J. Nat. Prod. 1997, 60, 52-60.
2. Newman, D. J.; Cragg, G. M.; Snader, K. M. J. Nat. Prod. 2003, 66, 1022-1037.
3. Pelish, H. E.; Westwood, N. J.; Feng, Y.; Kirchausen, T.; Shair, M. D. J. Am. Chem. Soc. 2001, 123, 6740-6741.
4. Spring, D. R. Org. Biomol. Chem. 2003, 1, 3867-3870.
5. Burke, M. D.; Schreiber, S. L. Angew. Chem., Int. Ed. 2004, 43, 46-58.
6. Zhonghong, G.; Reddy, P. T.; Quevillion, S.; Couve-Bonnaire, S.; Ayra, P. Angew. Chem., Int. Ed. 2005, 44, 1366-1368.
7. Reayi, A.; Arya, P. Curr. Opin. Chem. Biol. 2005, 9, 240-247.
8. Lipinski, C. A. Drug Discovery Today: Technol. 2004, 1, 337-341.
9. Macarron, R. Drug Discovery Today 2006, 11, 277-279.
10. Keller, T. H.; Pichota, A.; Yin, Z. Curr. Opin. Chem. Biol. 2006, 10, 357-361.
11. Allen, R. C. In Annual Reports in Medicinal Chemistry; Bailey, D. M., Ed.; Academic Press: Orlando, 1984; Vol. 19, pp 313-326.
12. Allen, R. C. In Annual Reports in Medicinal Chemistry; Bailey, D. M., Ed.; Academic Press: Orlando, 1985; Vol. 20, pp 315-325.
13. Allen, R. C. In Annual Reports in Medicinal Chemistry; Bailey, D. M., Ed.; Academic Press: Orlando, 1986; Vol. 21, pp 323-335.
14. Allen, R. C. In Annual Reports in Medicinal Chemistry; Bailey, D. M., Ed.; Academic Press: Orlando, 1987; Vol. 22, pp 315-330.
15. Ong, H. H.; Allen, R. C. In Annual Reports in Medicinal Chemistry; Allen, R. C., Ed.; Academic Press: San Diego, 1988; Vol. 23, pp 325-348.
16. Ong, H. H.; Allen, R. C. In Annual Reports in Medicinal Chemistry; Allen, R. C., Ed.; Academic Press: San Diego, 1989; Vol. 24, pp 295-315.
17. Ong, H. H.; Allen, R. C. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1990; Vol. 25, pp 309-322.
18. Strupczewski, J. D.; Ellis, D. B.; Allen, R. C. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1991; Vol. 26, pp 297-313.
19. Strupczewski, J. D.; Ellis, D. B. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1992; Vol. 27, pp 321-337.
20. Strupczewski, J. D.; Ellis, D. B. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1993; Vol. 28, pp 325-341.
21. Cheng, X.-M. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1994; Vol. 29, pp 331-354.
22. Cheng, X.-M. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1995; Vol. 30, pp 295-317.
23. Cheng, X.-M. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1996; Vol. 31, pp 337-355.
24. Galatsis, P. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1997; Vol. 32, pp 305-326.
25. Galatsis, P. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1998; Vol. 33, pp 327-353.
26. Gaudilliere, B. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: San Diego, 1999; Vol. 34, pp 317-338.
27. Gaudilliere, B.; Berna, P. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: San Diego, 2000; Vol. 35, pp 331-355.
28. Gaudilliere, B.; Bernardelli, P.; Berna, P. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: San Diego, 2001; Vol. 36, pp 293-318.
29. Bernardelli, P.; Gaudilliere, B.; Vergne, F. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2002; Vol. 37, pp 257-277.
30. Boyer-Joubert, C.; Lorthiois, E.; Moreau, F. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2003; Vol. 38, pp 347-374.
31. Hegde, S.; Carter, J. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2004; Vol. 39, pp 337-368.
32. Hegde, S.; Schmidt, M. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic Press: Amsterdam, 2005; Vol. 40, pp 443-473.
33. Prous, J. R. Drug News Perspect. 1990, 3, 19-29.
34. Prous, J. R. Drug News Perspect. 1991, 4, 96-109.
35. Prous, J. R. Drug News Perspect. 1992, 5, 93-101.
36. Prous, J. R. Drug News Perspect. 1993, 6, 95-106.
37. Prous, J. R. Drug News Perspect. 1994, 7, 26-36.
38. Prous, J. R. Drug News Perspect. 1995, 8, 24-37.
39. Prous, J. R. Drug News Perspect. 1996, 9, 19-32.
40. Graul, A. I. Drug News Perspect. 1997, 10, 5-18.
41. Graul, A. I. Drug News Perspect. 1998, 11, 15-32.
42. Graul, A. I. Drug News Perspect. 1999, 12, 27-43.
43. Graul, A. I. Drug News Perspect. 2000, 13, 37-53.
44. Graul, A. I. Drug News Perspect. 2001, 14, 12-31.
45. Graul, A. I. Drug News Perspect. 2002, 15, 29-43.
46. Graul, A. I. Drug News Perspect. 2003, 16, 22-39.
47. Graul, A. I. Drug News Perspect. 2004, 17, 43-57.
48. Graul, A. I. Prous, J. R., Drug News Perspect. 2005, 18, 21-36.
49. Graul, A. I. Prous, J. R., Drug News Perspect. 2006, 19, 33-53.
50. Newman, D. J.; Cragg, G. M.; O'Keefe, B. R. In Modern Biopharmaceuticals, Design, Development and Optimization; Knablein, J., Ed.; Wiley-VCH: Weinheim, 2005; Vol. 2, pp 451-496.
51. Boyd, M. R. In Current Therapy in Oncology; Neiderhuber, J., Ed.; Decker: Philadelphia, 1993; pp 11-22.
52. Sweetman, S. C. Martindale, The Complete Drug Reference, 33 ed.; The Pharmaceutical Press: London, 2002.
53. Hruby, V. J. Nat. Rev., Drug Discovery 2002, 1, 847-858.
54. Wan, Y.; Wallinder, C.; Plouffe, B.; Beaudry, H.; Mahalingam, A. K.; Wu, X.; Johansson, B.; Holm, M.; Botros, M.; Karlen, A.; Petterson, A.; Nyberg, F.; Fandricks, L.; Gallo-Payet, N.; Hallberg, A.; Alterman, M. J. Med. Chem. 2004, 47, 5995-6908.
55. Georgsson, J.; Rosenstrom, U.; Wallinder, C.; Beaudry, H.; Plouffe, B.; Lindeberg, G.; Botros, M.; Nyberg, F.; Karlen, A.; Gallo-Payet, N.; Hallberg, A. Bioorg. Med. Chem. 2006, 14, 5963-5972.
56. Steckelings, U. M.; Kaschina, E.; Unger, T. Peptides 2005, 26, 1401-1409.
57. Newman, D. J.; Cragg, G. M.; Snader, K. M. Nat. Prod. Rep. 2000, 17, 215-234.
58. Breinbauer, R.; Manger, M.; Scheck, M.; Waldmann, H. Curr. Med. Chem. 2002, 9, 2129-2145.
59. Breinbauer, R.; Vetter, I. R.; Waldmann, H. Angew. Chem., Int. Ed. 2002, 41, 2878-2890.
60. Kingston, D. G. I.; Newman, D. J. Curr. Opin. Drug Discovery Dev. 2002, 5, 304-316.
61. Newman, D. J.; Cragg, G. M.; Holbeck, S.; Sausville, E. A. Curr. Cancer Drug Targets 2002, 2, 279-308.
62. Nielsen, J. Curr. Opin. Chem. Biol. 2002, 6, 297-305.
63. Perez, J. J.; Corcho, F.; Llorens, O. Curr. Med. Chem. 2002, 9, 2209-2229.
64. van Huijsduijnen, R. H.; Bombrun, A.; Swinnen, D. Drug Discovery Today 2002, 7, 1013-1019.
65. Barun, O.; Sommer, S.; Waldmann, H. Angew. Chem., Int. Ed. 2004, 43, 3195-3199.
66. Balamurugan, R.; Dekker, F. J.; Waldmann, H. Mol. BioSyst. 2005, 1, 36-45.
67. Ganesan, A. Curr. Opin. Biotech. 2004, 15, 584-590.
68. Shang, S.; Tan, D. S. Curr. Opin. Chem. Biol. 2005, 9, 248-258.
69. Costantino, L.; Barlocco, D. Curr. Med. Chem. 2006, 13, 65-85.
70. Violette, A.; Fournel, S.; Frisch, B.; Briand, J.-P.; Monteil, H.; Guichard, G. Chem. Biol. 2006, 13, 531-538.
71. Baltz, R. H.; Miao, V.; Wrigley, S. K. Nat. Prod. Rep. 2005, 22, 717-741.
72. Melby, T.; Sista, P.; DeMasi, R.; Kirkland, T.; Roberts, N.; Salgo, M.; Heilek-Snyder, G.; Cammack, N.; Matthews, T. J.; Greenberg, M. L. AIDS Res. Hum. Retroviruses 2006, 22, 375-385.
73. Yang, S. S.; Cragg, G. M.; Newman, D. J.; Bader, J. P. J. Nat. Prod. 2001, 64, 265-277.
74. Efferth, T. Drug Res. Updates 2005, 8, 85-97.
75. Carter, S. K.; Bakowski, M. T.; Hellmann, K. Chemotherapy of Cancer; Wiley: New York, 1977; p 350.
76. Cole, W. H. Chemotherapy of Cancer; Lea and Febiger: Philadelphia, 1970; p 349.
77. Iltz, J. L.; Baker, D. E.; Setter, S. M.; Campbell, R. K. Clin. Ther. 2006, 28, 652-665.
78. Borman, S. Chem. Eng. News 2002, Jan 14, 23-24.
79. Wilson, R. M.; Danishefsky, S. J. Acc. Chem. Res. 2006, 39, 539 -549.
80. Klotz, U. Int. J. Clin. Pharmacol. Ther. 2006, 44, 478-483.
81. Wermeling, D. P.; Berger, J. R. Pharmacotherapy 2006, 26, 395-402.
82. Iyamu, E. W.; Turner, E. A.; Asakura, T. Br. J. Haematol. 2003, 122, 1001-1008.
83. Cordeiro, N. J.; Oniyangi, O. Cochrane Database Syst. Rev. 2004, CD004448.
84. Bok, J. W.; Hoffmeister, D.; Maggio-Hall, L. A.; Murillo, R.; Glasner, J. D.; Keller, N. P. Chem. Biol. 2006, 13, 31-37.
85. Challis, G. L.; Ravel, J. FEMS Microbiol. Lett. 2000, 187, 111-114.
86. Lautru, S.; Deeth, R. J.; Bailey, L. M.; Challis, G. L. Nat. Chem. Biol. 2005, 1, 265-269.
87. McAlpine, J. B.; Bachmann, B. O.; Piraee, M.; Tremblay, S.; Alarco, A.-M.; Zazopoulos, E.; Farnet, C. M. J. Nat. Prod. 2005, 68, 493-496.
88. Piel, J. Nat. Prod. Rep. 2004, 21, 519-538.
89. Piel, J. BioSpektrum 2005, 11, 172-173.
90. Piel, J. Curr. Med. Chem. 2006, 13, 39-50.
91. Piel, J.; Butzke, D.; Fusetani, N.; Hui, D.; Platzer, M.; Wen, G.; Matsunaga, S. J. Nat. Prod. 2005, 68, 472-479.
92. Piel, J.; Hui, D.; Wen, G.; Butzke, D.; Platzer, M.; Fusetani, N.; Matsunaga, S. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16222-16227.
93. Newman, D. J.; Hill, R. T. J. Ind. Microbiol. Biotechnol. 2006, 23, 539-544.
94. Puri, S. C.; Verma, V.; Amna, T.; Qazi, G. N.; Spiteller, M. J. Nat. Prod. 2005, 68, 1717-1719.
95. Eyberger, A. L.; Dondapati, R.; Porter, J. R. J. Nat. Prod. 2006, 69, 1121-1124.
96. Yang, X.; Zhang, L.; Guo, B.; Guo, S. Zhong Cao Yao 2004, 35, 79-81.
97. Gunatilaka, A. A. L. J. Nat. Prod. 2006, 69, 509-526.