Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

Journal of Bacteriology

Volumn 179, Issue 20, 1997, Pages 6416-6425

  Ruan, Xiaoan ^a   Pereda, Ana ^a   Stassi, Diane L ^a   Zeidner, David ^a   Summers, Richard G ^a   Jackson, Marianna ^a   Shivakumar, Annapur ^a   Kakavas, Stephan ^a   Staver, Michael J ^a   Donadio, Stefano ^a,b   Katz, Leonard ^a  

^a ABBOTT LABORATORIES   (United States)

^b Vicuron Pharmaceuticals (formerly Biosearch Italia SpA)   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ERYTHROMYCIN DERIVATIVE; METHYLMALONYL COENZYME A MUTASE; POLYKETIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERICIDAL ACTIVITY; CHROMATIN CONDENSATION; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENE CLUSTER; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE;

EID: 0030763125     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.20.6416-6425.1997     Document Type: Article

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