-
1
-
-
0025606149
-
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
-
Hopwood, D.A. & Sherman, D.H. (1990). Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 24, 37-66.
-
(1990)
Annu. Rev. Genet.
, vol.24
, pp. 37-66
-
-
Hopwood, D.A.1
Sherman, D.H.2
-
2
-
-
0028811381
-
Polyketide synthase gene manipulation - A structure-function approach in engineering novel antibiotics
-
Hutchinson, C.R. & Fujii, I. (1995). Polyketide synthase gene manipulation - a structure-function approach in engineering novel antibiotics. Annu. Rev. Microbiol. 49, 201-238.
-
(1995)
Annu. Rev. Microbiol.
, vol.49
, pp. 201-238
-
-
Hutchinson, C.R.1
Fujii, I.2
-
3
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
-
Cortes, J., Haydock, S.F., Roberts, G.A., Bevitt, D.J. & Leadlay, P.F. (1990). An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 348, 176-178.
-
(1990)
Nature
, vol.348
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.F.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
4
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio, S., Staver, M.J., McAlpine, J.B., Swanson, S.L. & Katz, L. (1991). Modular organization of genes required for complex polyketide biosynthesis. Science 252, 675-679.
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
Swanson, S.L.4
Katz, L.5
-
5
-
-
0026667294
-
Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase
-
MacNeil, D.J. & Danis, S.J., et al., (1992). Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. Gene 115, 119-125.
-
(1992)
Gene
, vol.115
, pp. 119-125
-
-
MacNeil, D.J.1
Danis, S.J.2
-
6
-
-
0028044628
-
Characterization of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence
-
Swan, D., Rodriguez, A.M., Vilches, C., Mendez, C. & Salas, J.A. (1994). Characterization of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence. Mol. Gen. Genet. 242, 358-362.
-
(1994)
Mol. Gen. Genet.
, vol.242
, pp. 358-362
-
-
Swan, D.1
Rodriguez, A.M.2
Vilches, C.3
Mendez, C.4
Salas, J.A.5
-
7
-
-
0028131912
-
Repeated polyketide synthase modules involved in the biosynthesis of a heptaene macrolide by Streptomyces sp FR-008
-
Hu, Z.H. & Deng, Z.X., et al., (1994). Repeated polyketide synthase modules involved in the biosynthesis of a heptaene macrolide by Streptomyces sp FR-008. Mol. Microbiol. 14, 163-172.
-
(1994)
Mol. Microbiol.
, vol.14
, pp. 163-172
-
-
Hu, Z.H.1
Deng, Z.X.2
-
8
-
-
0028181428
-
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase
-
Marsden, A.F.A., Caffrey, P., Aparicio, J.F., Loughran, M.S., Staunton, J. & Leadlay, P.F. (1994). Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science 263, 378-380.
-
(1994)
Science
, vol.263
, pp. 378-380
-
-
Marsden, A.F.A.1
Caffrey, P.2
Aparicio, J.F.3
Loughran, M.S.4
Staunton, J.5
Leadlay, P.F.6
-
9
-
-
0026697224
-
Identification of DEBS1, DEBS2 and DEBS3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea
-
Caffrey, P., Bevitt, D.J., Staunton, J. & Leadlay, P.F. (1992). Identification of DEBS1, DEBS2 and DEBS3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. FEBS Lett. 304, 225-228.
-
(1992)
FEBS Lett.
, vol.304
, pp. 225-228
-
-
Caffrey, P.1
Bevitt, D.J.2
Staunton, J.3
Leadlay, P.F.4
-
10
-
-
0029098323
-
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
-
Schwecke, T. & Leadlay, P.F., et al., (1995) The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. USA 92, 7839-7843.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7839-7843
-
-
Schwecke, T.1
Leadlay, P.F.2
-
11
-
-
0024449599
-
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcml genes provides key information about the enzymology of polyketide biosynthesis
-
Bibb, M.J., Biro, S., Motamedi, H., Collins, J.F. & Hutchinson, C.R. (1989). Analysis of the nucleotide sequence of the Streptomyces glaucescens tcml genes provides key information about the enzymology of polyketide biosynthesis. EMBO J. 8, 2727-2736.
-
(1989)
EMBO J.
, vol.8
, pp. 2727-2736
-
-
Bibb, M.J.1
Biro, S.2
Motamedi, H.3
Collins, J.F.4
Hutchinson, C.R.5
-
12
-
-
0024438917
-
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22
-
Sherman, D.H., Malpartida, F., Bibb, M.J., Kieser, H.M., Bibb, MJ. & Hopwood, D.A. (1989). Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22. EMBO J. 8, 2717-2725.
-
(1989)
EMBO J.
, vol.8
, pp. 2717-2725
-
-
Sherman, D.H.1
Malpartida, F.2
Bibb, M.J.3
Kieser, H.M.4
Bibb, M.J.5
Hopwood, D.A.6
-
13
-
-
0026657813
-
Nucleotide sequence of a set of cotranscribed genes from Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin
-
Fernandez-Moreno, M.A., Martinez, E., Boto, L., Hopwood, D.A. & Malpartida, F. (1992). Nucleotide sequence of a set of cotranscribed genes from Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. J. Biol. Chem. 267, 19278-19290.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 19278-19290
-
-
Fernandez-Moreno, M.A.1
Martinez, E.2
Boto, L.3
Hopwood, D.A.4
Malpartida, F.5
-
14
-
-
0029934431
-
Characterization of Streptomyces argillaceus genes encoding a PKS involved in the biosynthesis of the antitumor compound mithramycin
-
Lombo, F., Blanco, G., Fernandez, E., Mendez, C. & Salas, J.A. (1996). Characterization of Streptomyces argillaceus genes encoding a PKS involved in the biosynthesis of the antitumor compound mithramycin. Gene 172, 87-91.
-
(1996)
Gene
, vol.172
, pp. 87-91
-
-
Lombo, F.1
Blanco, G.2
Fernandez, E.3
Mendez, C.4
Salas, J.A.5
-
15
-
-
0024996111
-
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in Streptomyces: Clarification of actinorhodin gene functions
-
Bartel, P.L. & Floss, H.G., et al., (1990). Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in Streptomyces: clarification of actinorhodin gene functions. J. Bacteriol. 172, 4816-4826.
-
(1990)
J. Bacteriol.
, vol.172
, pp. 4816-4826
-
-
Bartel, P.L.1
Floss, H.G.2
-
16
-
-
0026515223
-
Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes
-
Strohl, W.R. & Conners, N.C. (1992). Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes. Mol. Microbiol. 6, 147-152.
-
(1992)
Mol. Microbiol.
, vol.6
, pp. 147-152
-
-
Strohl, W.R.1
Conners, N.C.2
-
17
-
-
0027908014
-
Engineered biosynthesis of novel polyketides
-
McDaniel, R., Ebert-Khosla, S., Hopwood, D.A. & Khosla, C. (1993). Engineered biosynthesis of novel polyketides. Science 262, 1546-1550.
-
(1993)
Science
, vol.262
, pp. 1546-1550
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
18
-
-
0027964653
-
Engineered biosynthesis of novel polyketides: Stereochemical course of two reactions catalyzed by a polyketide synthase
-
Fu, H., McDaniel, R., Hopwood, D.A. & Khosla, C. (1994). Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase. Biochemistry 33, 9321-9326.
-
(1994)
Biochemistry
, vol.33
, pp. 9321-9326
-
-
Fu, H.1
McDaniel, R.2
Hopwood, D.A.3
Khosla, C.4
-
19
-
-
0029054128
-
Engineered biosynthesis of novel polyketides - Analysis of TcmN function in tetracenomycin biosynthesis
-
McDaniel, R., Hutchinson, C.R. & Khosla, C. (1994). Engineered biosynthesis of novel polyketides - analysis of TcmN function in tetracenomycin biosynthesis. J. Am. Chem. Soc. 117, 6805-6810.
-
(1994)
J. Am. Chem. Soc.
, vol.117
, pp. 6805-6810
-
-
McDaniel, R.1
Hutchinson, C.R.2
Khosla, C.3
-
20
-
-
0029019944
-
The Streptomyces glaucescens TcmKL polyketide synthase and TcmN polyketide cyclase genes govern the size and shape of aromatic polyketides
-
Shen, B., Summers, R.G., Wendt-Pienkowski, E. & Hutchinson, C.R. (1995). The Streptomyces glaucescens TcmKL polyketide synthase and TcmN polyketide cyclase genes govern the size and shape of aromatic polyketides. J. Am, Chem. Soc. 117, 6811-6821.
-
(1995)
J. Am, Chem. Soc.
, vol.117
, pp. 6811-6821
-
-
Shen, B.1
Summers, R.G.2
Wendt-Pienkowski, E.3
Hutchinson, C.R.4
-
21
-
-
0029064652
-
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits
-
McDaniel, R., Ebert-Khosla, S., Hopwood, D.A. & Khosla, C. (1995), Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature 375, 549-554.
-
(1995)
Nature
, vol.375
, pp. 549-554
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
22
-
-
0029027352
-
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage
-
Cortes, J., Wiesmann, K.E.H., Roberts, G.A., Brown, M.J., Staunton, J. & Leadlay, P.P. (1995). Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science 268, 1487-1489.
-
(1995)
Science
, vol.268
, pp. 1487-1489
-
-
Cortes, J.1
Wiesmann, K.E.H.2
Roberts, G.A.3
Brown, M.J.4
Staunton, J.5
Leadlay, P.P.6
-
23
-
-
0029087375
-
A mutant generated by expression of an engineered DEBS1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coeiicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter unit
-
Brown, M.J.B., Cortés, J., Cutter, A.L., Leadlay, P.P. & Staunton, J. (1995). A mutant generated by expression of an engineered DEBS1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coeiicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter unit. J.C.S. Chem. Commun. 1517-1518.
-
(1995)
J.C.S. Chem. Commun.
, pp. 1517-1518
-
-
Brown, M.J.B.1
Cortés, J.2
Cutter, A.L.3
Leadlay, P.P.4
Staunton, J.5
-
24
-
-
0028784464
-
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
-
Pieper, R., Luo, G.L., Cane, D.E. & Khosla, C. (1995). Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. Nature 378, 263-266.
-
(1995)
Nature
, vol.378
, pp. 263-266
-
-
Pieper, R.1
Luo, G.L.2
Cane, D.E.3
Khosla, C.4
-
25
-
-
0028857296
-
Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase
-
Kao, C.M., Luo, G.L, Katz, L., Cane, D.E. & Khosla, C. (1995). Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase. J. Am. Chem. Soc. 117, 9105-9106.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 9105-9106
-
-
Kao, C.M.1
Luo, G.L.2
Katz, L.3
Cane, D.E.4
Khosla, C.5
-
26
-
-
0028365063
-
Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase
-
Aparicio, J.F., Caffrey, P., Marsden, A.F.A., Staunton, J. & Leadlay, P.F. (1994). Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase. J. Biol, Chem. 269, 8524-8528.
-
(1994)
J. Biol, Chem.
, vol.269
, pp. 8524-8528
-
-
Aparicio, J.F.1
Caffrey, P.2
Marsden, A.F.A.3
Staunton, J.4
Leadlay, P.F.5
-
27
-
-
0030065324
-
Evidence for a double-helical structure for modular polyketide synthases
-
Staunton, J., Caffrey, P., Aparicio, J.F., Roberts, G.A., Bethell, S.S. & Leadlay, P.F. (1996). Evidence for a double-helical structure for modular polyketide synthases. Nat. Struct. Biol. 3, 188-192.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 188-192
-
-
Staunton, J.1
Caffrey, P.2
Aparicio, J.F.3
Roberts, G.A.4
Bethell, S.S.5
Leadlay, P.F.6
-
28
-
-
0029872079
-
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus - Analysis of the enzymatic domains in the modular polyketide synthase
-
Aparicio, J. & Leadlay, P.F., et al., (1996). Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus - analysis of the enzymatic domains in the modular polyketide synthase. Gene 169, 9-16.
-
(1996)
Gene
, vol.169
, pp. 9-16
-
-
Aparicio, J.1
Leadlay, P.F.2
-
29
-
-
0028841535
-
Divergent structural motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases
-
Haydock, S.F. & Leadlay, P.F., et al., (1995). Divergent structural motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett. 374, 246-248.
-
(1995)
FEBS Lett.
, vol.374
, pp. 246-248
-
-
Haydock, S.F.1
Leadlay, P.F.2
-
30
-
-
0028556312
-
Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase
-
Kao, C.M, Luo, G.L., Katz, L., Cane, D.E. & Khosla, C. (1994). Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase. J. Am. Chem. Soc. 116, 11612-11613.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 11612-11613
-
-
Kao, C.M.1
Luo, G.L.2
Katz, L.3
Cane, D.E.4
Khosla, C.5
-
31
-
-
0029360426
-
Polyketide synthesis in vitro on a modular polyketide synthase
-
Wiesmann, K.E.H., Cortes, J., Brown, M.J.B., Cutter, A.L, Staunton, J. & Leadlay, P.F. (1995). Polyketide synthesis in vitro on a modular polyketide synthase. Chemistry & Biology 2, 583-589.
-
(1995)
Chemistry & Biology
, vol.2
, pp. 583-589
-
-
Wiesmann, K.E.H.1
Cortes, J.2
Brown, M.J.B.3
Cutter, A.L.4
Staunton, J.5
Leadlay, P.F.6
-
32
-
-
0028895939
-
Remarkably broad specificity of a modular polyketide synthase in a cell-free system
-
Pieper, R., Luo, G.L., Cane, D.E. & Khosla, C. (1995). Remarkably broad specificity of a modular polyketide synthase in a cell-free system. J. Am. Chem. Soc. 117, 11373-11374.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11373-11374
-
-
Pieper, R.1
Luo, G.L.2
Cane, D.E.3
Khosla, C.4
-
33
-
-
0003903343
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
-
Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (2nd edn), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
-
(1989)
Molecular Cloning: a Laboratory Manual (2nd Edn)
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
35
-
-
0003728297
-
-
The John Innes Foundation, Norwich, United Kingdom.
-
Hopwood, D.A. & Schrempf, H., et al., (1985). Genetic Manipulations of Streptomyces: A Laboratory Manual. The John Innes Foundation, Norwich, United Kingdom.
-
(1985)
Genetic Manipulations of Streptomyces: a Laboratory Manual.
-
-
Hopwood, D.A.1
Schrempf, H.2
-
36
-
-
0023850178
-
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
-
Saiki, T. & Ehrlich, H.A., et al., (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491.
-
(1988)
Science
, vol.239
, pp. 487-491
-
-
Saiki, T.1
Ehrlich, H.A.2
-
37
-
-
3042988525
-
Conformational analysis. 130. MM2. a hydrocarbon force field utilizing V1 and V2 torsional terms
-
Allinger, N.J. (1977) Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms. J. Am. Chem. Soc. 99, 8127-8134.
-
(1977)
J. Am. Chem. Soc.
, vol.99
, pp. 8127-8134
-
-
Allinger, N.J.1
-
38
-
-
84986437005
-
MacroModel - An integrated software system for modelling organic and bioorganic molecules using molecular mechanics
-
Mohamedi, F. & Still, W.C., et al., (1990). MacroModel - an integrated software system for modelling organic and bioorganic molecules using molecular mechanics. J. CompuL Chem. 11, 440-467.
-
(1990)
J. CompuL Chem.
, vol.11
, pp. 440-467
-
-
Mohamedi, F.1
Still, W.C.2
-
39
-
-
20444483055
-
The relationship between proton-proton NMR coupling constants and substituent electronegativities
-
Haasnoot, C.A.G., De Leeuw, F.A.A.M. & Altona, C. (1980). The relationship between proton-proton NMR coupling constants and substituent electronegativities. Tetrahedron 36, 2783-2792.
-
(1980)
Tetrahedron
, vol.36
, pp. 2783-2792
-
-
Haasnoot, C.A.G.1
De Leeuw, F.A.A.M.2
Altona, C.3
|