Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 13, 1998, Pages 7305-7309

  Stassi, D L ^a   Kakavas, S J ^a   Reynolds, K A ^b   Gunawardana, G ^a   Swanson, S ^a   Zeidner, D ^a   Jackson, M ^a   Liu, H ^b   Buko, A ^a   Katz, L ^a  

^a ABBOTT LABORATORIES   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 NOR 6 ETHYLERYTHROMYCIN A; ACYLTRANSFERASE; ERYTHROMYCIN; ERYTHROMYCIN DERIVATIVE; MALONYL COENZYME A; NIDDAMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; DRUG SYNTHESIS; GENETIC ENGINEERING; GENETIC MANIPULATION; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SACCHAROPOLYSPORA; STRUCTURE ANALYSIS;

ACYL COENZYME A; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ERYTHROMYCIN; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEIN ENGINEERING; RESTRICTION MAPPING; SACCHAROPOLYSPORA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13144249211     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.13.7305     Document Type: Article

References (19)

1. Cortes, J., Haydock, S. F., Roberts, G. A., Bevitt, D. J. & Leadlay, P. F. (1990) Nature (London) 348, 176-178.
2. Donadio, S. & Katz, L. (1992) Gene 111, 51-60.
3. Oliynyk, M., Brown, M. J. B., Cortes, J., Staunton, J. & Leadlay, P. F. (1996) Chem. Biol. 3, 833-839.
4. Kuhstoss, S., Huber, M., Turner, J. R., Paschal, J. W. & Rao, R. N. (1996) Gene 183, 231-236.
5. Ruan, X., Pereda, A., Stassi, D., Zeidner, D., Summers, R., Jackson, M., Shivakumar, A, Kakavas, S. & Katz, L. (1997) J. Bacteriol. 179, 6416-6425.
6. Marsden, A. F. A., Wilkinson, B., Cortes, J., Dunster, N. J., Staunton, J. & Leadlay, P. F. (1998) Science 279, 199-202.
7. Kakavas, S. J., Katz, L. & Stassi, D. (1997) J. Bacteriol. 179, 7515-7522.
8. DeWitt, J. P. (1985) J. Bacteriol. 164, 969-971.
9. Vara J. A., Lewandowska-Skarbek, M., Wang, Y.-G., Donadio, S. & Hutchinson, C. R. (1989) J. Bacteriol. 171, 5872-5881.
10. Maine, G., Post, D., Satter, M. & Stassi, D. (1997) International patent application WO 97/06266 (2/20/97).
11. Yamamoto, H., Maurer, K. H. & Hutchinson, C. R. (1986) J. Antibiot. 39, 1304-1313.
12. Wallace, K. K., Han, L., Lobo, S. & Renolds, K. K. (1997) J. Bacteriol. 179, 3884-3891.
13. Bibb, M. J., White, J., Ward, J. M. & Janssen, G. R. (1994) Mol. Microbiol. 14, 533-545.
14. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
15. Fitzgerald, N. B., English, R. S., Lampel, J. S. & Vanden Boom, T. (1998) Appl. Environ. Microbiol., 64, 1580-1583.
16. Wallace, K. K., Bao, Z.-Y., Dai, H. Digate, R., Schuler, G., Speedie, M. & Reynolds, K. (1995) Eur. J. Biochem. 233, 954-962.
17. Larty, P. A. & Faghih, R. (1993) in Recent Progress in the Chemical Synthesis of Antibiotics, eds. Lukacs, G & Ohno, M. (Springer, New York), p. 121.
18. Gandecha, A. R., Large, S. L. & Cundliffe, E. (1997) Gene 184, 197-203.
19. Weissman, K. J., Timoney, M., Bycroft, M., Grice, P., Hanefeld, U., Staunton, J. & Leadlay, P. F. (1997) Biochemistry 36, 13849-13855.