-
1
-
-
0022226658
-
Single-stranded hexameric linkers: A system for in-phase insertion mutagenesis and protein engineering
-
Barany, F. (1985) Single-stranded hexameric linkers: a system for in-phase insertion mutagenesis and protein engineering. Gene 37, 111-123.
-
(1985)
Gene
, vol.37
, pp. 111-123
-
-
Barany, F.1
-
2
-
-
0029087375
-
A mutant generated by expression of an engineered DEBS1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter acid
-
Brown, M.J.B., Cortes, J., Cutter, A.L., Leadlay, P.F. and Staunton, J. (1995) A mutant generated by expression of an engineered DEBS1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter acid. J. Chem. Soc. Chem. Commun., 1517-1518.
-
(1995)
J. Chem. Soc. Chem. Commun.
, pp. 1517-1518
-
-
Brown, M.J.B.1
Cortes, J.2
Cutter, A.L.3
Leadlay, P.F.4
Staunton, J.5
-
3
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
-
Cortes, J., Haydock, S.F., Roberts, G.A., Bevitt, D.J. and Leadlay, P.F. (1990) An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 348, 176-178.
-
(1990)
Nature
, vol.348
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.F.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
4
-
-
0029027352
-
Respositioning of a domain in a modular polyketide synthase to promote specific chain cleavage
-
Cortes, J., Wiesmann, K.E.H., Roberts, G.A., Brown, M.J.B., Staunton, J. and Leadlay, P.F. (1995) Respositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science 268, 1487-1489.
-
(1995)
Science
, vol.268
, pp. 1487-1489
-
-
Cortes, J.1
Wiesmann, K.E.H.2
Roberts, G.A.3
Brown, M.J.B.4
Staunton, J.5
Leadlay, P.F.6
-
5
-
-
0021760092
-
A comprehensive set of sequence analysis programs for the VAX
-
Devereux, J., Haeberli, P. and Smithies, O.: A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12, 387-395.
-
Nucleic Acids Res.
, vol.12
, pp. 387-395
-
-
Devereux, J.1
Haeberli, P.2
Smithies, O.3
-
6
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio, S., Staver, M.J., McAlpine, J.B., Swanson, S.J. and Katz, L. (1991) Modular organization of genes required for complex polyketide biosynthesis. Science 252, 675-679.
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
Swanson, S.J.4
Katz, L.5
-
7
-
-
0026559262
-
Organization of the enzymatic domains in the multifuncitonal polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea
-
Donadio, S. and Katz, L. (1992) Organization of the enzymatic domains in the multifuncitonal polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. Gene 111, 51-60.
-
(1992)
Gene
, vol.111
, pp. 51-60
-
-
Donadio, S.1
Katz, L.2
-
8
-
-
0027234764
-
An erythromycin analog produced by reprogramming polyketide synthesis
-
Donadio, S., McAlpine, J.B., Sheldon, P.J., Jackson, M. and Katz, L. (1993) An erythromycin analog produced by reprogramming polyketide synthesis. Proc. Natl. Acad. Sci. USA 90, 7119-7123.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 7119-7123
-
-
Donadio, S.1
McAlpine, J.B.2
Sheldon, P.J.3
Jackson, M.4
Katz, L.5
-
9
-
-
0016835201
-
Studies on the biosynthesis of basic 16-membered macrolide antibiotics, platenolides. III. production, isolation, and stuctures of platenolides I and II
-
Furumai, T. and Suzuki, M. (1975) Studies on the biosynthesis of basic 16-membered macrolide antibiotics, platenolides. III. production, isolation, and stuctures of platenolides I and II. J. Antibiotics 28, 783-788.
-
(1975)
J. Antibiotics
, vol.28
, pp. 783-788
-
-
Furumai, T.1
Suzuki, M.2
-
10
-
-
0026633027
-
Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens
-
Geistlich, M., Losick, R., Turner, J.R. and Rao, R.N. (1992) Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens. Mol. Microbiol. 6, 2019-2029.
-
(1992)
Mol. Microbiol.
, vol.6
, pp. 2019-2029
-
-
Geistlich, M.1
Losick, R.2
Turner, J.R.3
Rao, R.N.4
-
11
-
-
0018967043
-
Isolation and structure of nitrogen-free platenolide glycosides I. The 5-o-(deoxy-3′-C-acetyl-β-D-hexopyranosyl)-platenolides I and II
-
Grafe, U., Schade, W., Inn, W., Reinhardt, G., Dornberger, K. and Thrum, H. (1980) Isolation and structure of nitrogen-free platenolide glycosides I. the 5-O-(deoxy-3′-C-acetyl-β-D-hexopyranosyl)-platenolides I and II. J. Antibiotics 33, 566-573.
-
(1980)
J. Antibiotics
, vol.33
, pp. 566-573
-
-
Grafe, U.1
Schade, W.2
Inn, W.3
Reinhardt, G.4
Dornberger, K.5
Thrum, H.6
-
12
-
-
0028841535
-
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:Acyl carrier protein transacylase domains in modular polyketide synthases
-
Haydock, S.F., Aparicio, J.F., Molnar, I., Schwecke, T., Khaw, L.E., Konig, A., Marsden, A.F.A., Galloway, I.S., Staunton, J. and Leadlay, P.F. (1995) Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett. 374, 246-248.
-
(1995)
FEBS Lett.
, vol.374
, pp. 246-248
-
-
Haydock, S.F.1
Aparicio, J.F.2
Molnar, I.3
Schwecke, T.4
Khaw, L.E.5
Konig, A.6
Marsden, A.F.A.7
Galloway, I.S.8
Staunton, J.9
Leadlay, P.F.10
-
13
-
-
0027932534
-
Engineered biosynthesis of a complete macrolactone in a heterologous host
-
Kao, C.M., Katz, L. and Khosla, C. (1994) Engineered biosynthesis of a complete macrolactone in a heterologous host. Science 265, 509-512.
-
(1994)
Science
, vol.265
, pp. 509-512
-
-
Kao, C.M.1
Katz, L.2
Khosla, C.3
-
14
-
-
0028857296
-
Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase
-
Kao, C.M., Luo, G., Katz, L., Cane, D.E. and Khosla, C. (1995) Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase. J. Am. Chem. Soc. 117, 9105-9106.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 9105-9106
-
-
Kao, C.M.1
Luo, G.2
Katz, L.3
Cane, D.E.4
Khosla, C.5
-
15
-
-
0027382486
-
Polyketide synthesis: Prospects for hybrid antibiotics
-
Katz, L. and Donadio, S. (1993) Polyketide synthesis: prospects for hybrid antibiotics. Annu. Rev. Microbiol. 47, 875-912.
-
(1993)
Annu. Rev. Microbiol.
, vol.47
, pp. 875-912
-
-
Katz, L.1
Donadio, S.2
-
16
-
-
0026318809
-
Analysis of the integration function of the streptomycete bacteriophage φC31
-
Kuhstoss, S. and Rao, R.N. (1991) Analysis of the integration function of the streptomycete bacteriophage φC31. J. Mol. Biol, 222, 897-908.
-
(1991)
J. Mol. Biol
, vol.222
, pp. 897-908
-
-
Kuhstoss, S.1
Rao, R.N.2
-
17
-
-
0025967413
-
Plasmid cloning vectors that integrate site-specifically in streptomycetes
-
Kuhstoss, S., Richardson, M.A. and Rao, R.N. (1991) Plasmid cloning vectors that integrate site-specifically in streptomycetes. Gene 97, 143-146.
-
(1991)
Gene
, vol.97
, pp. 143-146
-
-
Kuhstoss, S.1
Richardson, M.A.2
Rao, R.N.3
-
18
-
-
0026667294
-
Complex organization of the Streptomyces avermitilis genes encoding avermectin polyketide synthase
-
MacNeil, D.J., Occi, J.L., Gewain, K.M., MacNeil, T., Gibbons, P.H., Ruby, C.L. and Danis, S.J. (1992) Complex organization of the Streptomyces avermitilis genes encoding avermectin polyketide synthase. Gene 115, 119-125.
-
(1992)
Gene
, vol.115
, pp. 119-125
-
-
MacNeil, D.J.1
Occi, J.L.2
Gewain, K.M.3
MacNeil, T.4
Gibbons, P.H.5
Ruby, C.L.6
Danis, S.J.7
-
19
-
-
0028246348
-
Correlation of avermectin polyketide synthase genes to the avermectin structure
-
MacNeil, D.J., Occi, J.L., Gewain, K.M. and MacNeil, T. (1994) Correlation of avermectin polyketide synthase genes to the avermectin structure. Ann. N.Y. Acad. Sci. 721, 123-132.
-
(1994)
Ann. N.y. Acad. Sci.
, vol.721
, pp. 123-132
-
-
Macneil, D.J.1
Occi, J.L.2
Gewain, K.M.3
MacNeil, T.4
-
20
-
-
0028181428
-
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase
-
Marsden, A.F.A., Caffrey, P., Aparico, J.F., Loughran, M.S., Staunton, J. and Leadlay, P.F. (1994) Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science 263, 378-380.
-
(1994)
Science
, vol.263
, pp. 378-380
-
-
Marsden, A.F.A.1
Caffrey, P.2
Aparico, J.F.3
Loughran, M.S.4
Staunton, J.5
Leadlay, P.F.6
-
21
-
-
0023638046
-
New antibiotics from genetically engineered actinomycetes. I. 2-norerythromycins, isolation and structural determinations
-
McAlpine, J.B., Tuan, J.S., Brown, D.P., Grebner, K.D., Whittern, D.N., Buko, A. and Katz, L. (1987) New antibiotics from genetically engineered actinomycetes. I. 2-norerythromycins, isolation and structural determinations. J. Antibiotics 40, 1115-1122.
-
(1987)
J. Antibiotics
, vol.40
, pp. 1115-1122
-
-
McAlpine, J.B.1
Tuan, J.S.2
Brown, D.P.3
Grebner, K.D.4
Whittern, D.N.5
Buko, A.6
Katz, L.7
-
22
-
-
0027908014
-
Engineered biosynthesis of novel polyketides
-
McDaniel, R., Ebert-Khosla, S., Hopwood, D.A. and Khosla, C. (1993a) Engineered biosynthesis of novel polyketides. Science 262, 1546-1550.
-
(1993)
Science
, vol.262
, pp. 1546-1550
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
23
-
-
0027746346
-
Engineered biosynthesis of novel polyketides: Manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities
-
McDaniel, R., Ebert-Khosla, S., Hopwood, D.A. and Khosla, C. (1993b) Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities. J. Am. Chem. Soc. 115, 11671-11675.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 11671-11675
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
24
-
-
0016723630
-
Carbon-13 nuclear magnetic resonance spectral analysis of 16-membered macrolide antibiotics
-
Omura, S., Nakagawa, A., Neszmeli, A., Gero, S.D., Sepulchre, A.M., Piriou, F. and Lukacs, G. (1975a) Carbon-13 nuclear magnetic resonance spectral analysis of 16-membered macrolide antibiotics. J. Am. Chem. Soc. 97, 4001-4009.
-
(1975)
J. Am. Chem. Soc.
, vol.97
, pp. 4001-4009
-
-
Omura, S.1
Nakagawa, A.2
Neszmeli, A.3
Gero, S.D.4
Sepulchre, A.M.5
Piriou, F.6
Lukacs, G.7
-
25
-
-
0016778089
-
A C13 nuclear magnetic resonance study of the biosynthesis of the 16-membered macrolide antibiotic tylosin
-
Omura, S., Nakagawa, A., Takeshima, H., Miyazawa, J. and Kitao, C. (1975b) A C13 nuclear magnetic resonance study of the biosynthesis of the 16-membered macrolide antibiotic tylosin. Tetrahedon Lett. 50, 4503-4506.
-
(1975)
Tetrahedon Lett.
, vol.50
, pp. 4503-4506
-
-
Omura, S.1
Nakagawa, A.2
Takeshima, H.3
Miyazawa, J.4
Kitao, C.5
-
26
-
-
0018340619
-
Bioconversion and biosynthesis of 16-membered macrolide antibiotics. X. Final steps in the biosynthesis of spiramycin, using enzyme inhibitor: Cerulenin
-
Omura, S., Kitao, C., Hamada, H. and Ikeda, H. (1979) Bioconversion and biosynthesis of 16-membered macrolide antibiotics. X. final steps in the biosynthesis of spiramycin, using enzyme inhibitor: cerulenin. Chem. Pharm. Bull. 27, 176-182.
-
(1979)
Chem. Pharm. Bull.
, vol.27
, pp. 176-182
-
-
Omura, S.1
Kitao, C.2
Hamada, H.3
Ikeda, H.4
-
27
-
-
0011314116
-
-
Omura, S. (Eds.), Academic Press, Orlando, FL
-
Omura, S. and Tanaka, Y. (1984) In: Omura, S. (Eds.), Macrolide Antibiotics: Chemistry, Biology, and Practice. Academic Press, Orlando, FL, pp. 199-230.
-
(1984)
Macrolide Antibiotics: Chemistry, Biology, and Practice
, pp. 199-230
-
-
Omura, S.1
Tanaka, Y.2
-
28
-
-
0028784464
-
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
-
Peiper, R., Luo, G., Cane, D.E. and Khosla, C. (1995) Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. Nature 378, 263-266.
-
(1995)
Nature
, vol.378
, pp. 263-266
-
-
Peiper, R.1
Luo, G.2
Cane, D.E.3
Khosla, C.4
-
29
-
-
0011267992
-
Cloning of genes involved in spiramycin biosynthesis from Streptomyces ambofaciens
-
Hershberger, C.L., Queener, S.W. and Hegeman, G. (Eds.), American Society for Microbiology, Washington, DC
-
Richardson, M.A., Kuhstoss, S., Huber, M., Ford, L., Godfrey, O., Turner, J.R. and Rao, R.N. (1989) Cloning of genes involved in spiramycin biosynthesis from Streptomyces ambofaciens. In: Hershberger, C.L., Queener, S.W. and Hegeman, G. (Eds.), Genetics and Molecular Biology of Industrial Microorganisms. American Society for Microbiology, Washington, DC, pp. 40-43.
-
(1989)
Genetics and Molecular Biology of Industrial Microorganisms.
, pp. 40-43
-
-
Richardson, M.A.1
Kuhstoss, S.2
Huber, M.3
Ford, L.4
Godfrey, O.5
Turner, J.R.6
Rao, R.N.7
-
30
-
-
0025299084
-
Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis
-
Richardson, M.A., Kuhstoss, S., Huber, M.L.B., Ford, L., Godfrey, O, Turner, J.R. and Rao, R.N. (1990) Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis. J. Bacteriol. 172, 3790-3798.
-
(1990)
J. Bacteriol.
, vol.172
, pp. 3790-3798
-
-
Richardson, M.A.1
Kuhstoss, S.2
Huber, M.L.B.3
Ford, L.4
Godfrey, O.5
Turner, J.R.6
Rao, R.N.7
-
31
-
-
0026702182
-
Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins
-
Schoner, B., Geistlich, M., Rosteck Jr., P., Rao, R.N., Seno, E., Reynolds, P., Cox, K., Burgett, S. and Hershberger, C. (1992) Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins. Gene 115, 93-96.
-
(1992)
Gene
, vol.115
, pp. 93-96
-
-
Schoner, B.1
Geistlich, M.2
Rosteck P., Jr.3
Rao, R.N.4
Seno, E.5
Reynolds, P.6
Cox, K.7
Burgett, S.8
Hershberger, C.9
-
32
-
-
0029098323
-
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
-
Schwecke, T., Aparicio, J.F., Molnar, I., Konig, A., Khaw, L.E., Haydock, S.F., Oliynyk, M., Caffrey, P., Cortes, J., Lester, J.B., Bohm, G.A., Staunton, J. and Leadlay, P.F. (1995) The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. USA 92, 7839-7843.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7839-7843
-
-
Schwecke, T.1
Aparicio, J.F.2
Molnar, I.3
Konig, A.4
Khaw, L.E.5
Haydock, S.F.6
Oliynyk, M.7
Caffrey, P.8
Cortes, J.9
Lester, J.B.10
Bohm, G.A.11
Staunton, J.12
Leadlay, P.F.13
-
33
-
-
0028044628
-
Characterization of a Streptomyces antibioicus gene encoding a type I polyketide synthase which has an unusual coding sequence
-
Swan, D.G., Rodriguez, A.M., Vilches, C., Mendez, C. and Salas, J.A. (1994) Characterization of a Streptomyces antibioicus gene encoding a type I polyketide synthase which has an unusual coding sequence. Mol. Gen. Genet. 242, 358-362.
-
(1994)
Mol. Gen. Genet.
, vol.242
, pp. 358-362
-
-
Swan, D.G.1
Rodriguez, A.M.2
Vilches, C.3
Mendez, C.4
Salas, J.A.5
-
34
-
-
0024315871
-
Fatty acid synthase, a proficient multifunctional enzyme
-
Wakil, S.J. (1989) Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 28, 4523-4530.
-
(1989)
Biochemistry
, vol.28
, pp. 4523-4530
-
-
Wakil, S.J.1
-
35
-
-
0029360426
-
Polyketide synthesis in vitro on a modular polyketide synthase
-
Wiesmann, K.E.H., Cortes, J., Brown, M.J.B., Cutter, A.L., Staunton, J. and Leadlay, P.F. (1995) Polyketide synthesis in vitro on a modular polyketide synthase. Chem. Biol. 2, 583-589.
-
(1995)
Chem. Biol.
, vol.2
, pp. 583-589
-
-
Wiesmann, K.E.H.1
Cortes, J.2
Brown, M.J.B.3
Cutter, A.L.4
Staunton, J.5
Leadlay, P.F.6
|