Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

Molecular Microbiology

Volumn 43, Issue 5, 2002, Pages 1215-1225

  Long, Paul F ^a,d   Wilkinson, Christopher J ^a   Bisang, Christian P ^a,e   Cortés, Jesús ^a,f   Dunster, Nicholas ^a,g   Oliynyk, Marko ^a   McCormick, Ellen ^b   McArthur, Hamish ^b   Mendez, Carmen ^c   Salas, José A ^c   Staunton, James ^a   Leadlay, Peter F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PFIZER INC   (United States)

^c DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^f GLAXOSMITHKLINE   (United Kingdom)

^g PanTherix Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACYLTRANSFERASE; ARGININE; CARBOXYLYASE; DICARBOXYLIC ACID; ERYTHROMYCIN; LACTONE; OLEANDOMYCIN; PANTETHEINE PHOSPHATE; POLYKETIDE SYNTHASE; PROPIONIC ACID; RAPAMYCIN; TYLOSIN;

ACYLATION; ARTICLE; CATALYSIS; DECARBOXYLATION; DRUG SYNTHESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ERYTHROMYCIN; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; OLEANDOMYCIN; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN ENGINEERING; SACCHAROPOLYSPORA; STREPTOMYCES; SUBSTRATE SPECIFICITY;

ILEX COOKII;

EID: 0036223415     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02815.x     Document Type: Article

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