Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase

Journal of Industrial Microbiology and Biotechnology

Volumn 34, Issue 1, 2007, Pages 9-15

  Ward, Shannon L ^a   Desai, Ruchir P ^a   Hu, Zhihao ^a   Gramajo, Hugo ^b   Katz, Leonard ^a  

^a KOSAN BIOSCIENCES INC   (United States)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Erythromycin; Genetic engineering; Polyketide

Indexed keywords

CYSTEAMINE DERIVATIVE; ERYTHROMYCIN DERIVATIVE; ERYTHRONOLIDE DERIVATIVE; POLYKETIDE SYNTHASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; ENZYME ACTIVE SITE; MODULATION; MUTATION; NONHUMAN; PRECURSOR; SACCHAROPOLYSPORA; STREPTOMYCES COELICOLOR; STREPTOMYCES ERYTHRAEUS;

CATALYTIC DOMAIN; ERYTHROMYCIN; MACROLIDES; POLYKETIDE SYNTHASES; PROTEIN ENGINEERING; SEQUENCE DELETION; STREPTOMYCES; STREPTOMYCES COELICOLOR;

SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES COELICOLOR;

EID: 33845621530     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-006-0156-6     Document Type: Article

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