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Volumn 21, Issue 7, 2003, Pages 796-802

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYMES; ESCHERICHIA COLI; FLAVORS; FRAGRANCES; OLEFINS; SYNTHESIS (CHEMICAL);

EID: 0038391517     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt833     Document Type: Article
Times cited : (1487)

References (43)
  • 1
    • 0031595885 scopus 로고    scopus 로고
    • Paclitaxel (Taxol): A success story with valuable lessons for natural product drug discovery and development
    • Cragg, G.M. Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development. Med. Res. Rev. 18, 315-331 (1998).
    • (1998) Med. Res. Rev. , vol.18 , pp. 315-331
    • Cragg, G.M.1
  • 2
    • 0033554788 scopus 로고    scopus 로고
    • Current status of artemisinin and its derivatives as antimalarial drugs
    • Dhingra, V., Rao, K.V. & Narasu, M.L. Current status of artemisinin and its derivatives as antimalarial drugs. Life Sci. 66, 279-300 (2000).
    • (2000) Life Sci. , vol.66 , pp. 279-300
    • Dhingra, V.1    Rao, K.V.2    Narasu, M.L.3
  • 3
    • 11044223276 scopus 로고    scopus 로고
    • Total synthesis of baccatin III and taxol
    • Danishefsky, S.J. et al. Total synthesis of baccatin III and taxol. J. Amer. Chem. Soc. 118, 2843-2859 (1996).
    • (1996) J. Amer. Chem. Soc. , vol.118 , pp. 2843-2859
    • Danishefsky, S.J.1
  • 4
    • 0031470265 scopus 로고    scopus 로고
    • Total synthesis of eleutherobin
    • Nicolaou, K.C. et al. Total synthesis of eleutherobin. Angew. Chem. Int. Ed. 36, 2520-2524 (1997).
    • (1997) Angew. Chem. Int. Ed. , vol.36 , pp. 2520-2524
    • Nicolaou, K.C.1
  • 5
    • 0026584198 scopus 로고
    • Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L.
    • Avery, M.A., Chong, W.K.M. & Jennings-White, C. Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L. J. Amer. Chem. Soc. 114, 974-979 (1992).
    • (1992) J. Amer. Chem. Soc. , vol.114 , pp. 974-979
    • Avery, M.A.1    Chong, W.K.M.2    Jennings-White, C.3
  • 7
    • 0037034009 scopus 로고    scopus 로고
    • Medical need, scientific opportunity and the drive for antimalarial drugs
    • Ridley, R.G. Medical need, scientific opportunity and the drive for antimalarial drugs. Nature 415, 686-693 (2002).
    • (2002) Nature , vol.415 , pp. 686-693
    • Ridley, R.G.1
  • 8
    • 0035208051 scopus 로고    scopus 로고
    • Artemisinin and derivatives: The future for malaria treatment?
    • Haynes, R.K. Artemisinin and derivatives: the future for malaria treatment? Curr. Opin Infect. Dis. 14, 719-726 (2001).
    • (2001) Curr. Opin Infect. Dis. , vol.14 , pp. 719-726
    • Haynes, R.K.1
  • 9
    • 0033983929 scopus 로고    scopus 로고
    • Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: Proof for the existence of chemotypes
    • Wallaart, T.E., Pras, N., Beekman, A.C. & Quax, W.J. Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes. Planta Med. 66, 57-62 (2000).
    • (2000) Planta Med. , vol.66 , pp. 57-62
    • Wallaart, T.E.1    Pras, N.2    Beekman, A.C.3    Quax, W.J.4
  • 10
    • 0034789998 scopus 로고    scopus 로고
    • Taxol: Biosynthesis, molecular genetics, and biotechnological applications
    • Jennewein, S. & Croteau, R. Taxol: biosynthesis, molecular genetics, and biotechnological applications. Appl. Microbiol. Biotechnol. 57, 13-19 (2001).
    • (2001) Appl. Microbiol. Biotechnol. , vol.57 , pp. 13-19
    • Jennewein, S.1    Croteau, R.2
  • 13
    • 0036830077 scopus 로고    scopus 로고
    • Irofulven, a novel inhibitor of DNA synthesis, in metastatic renal cell cancer
    • Amato, R.J., Perez, C. & Pagliaro, L. Irofulven, a novel inhibitor of DNA synthesis, in metastatic renal cell cancer. Invest. New Drugs 20, 413-417 (2002).
    • (2002) Invest. New Drugs , vol.20 , pp. 413-417
    • Amato, R.J.1    Perez, C.2    Pagliaro, L.3
  • 14
    • 0033859551 scopus 로고    scopus 로고
    • The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways
    • Boucher, Y. & Doolittle, W.F. The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways. Mol. Microbiol. 37, 703-716 (2000).
    • (2000) Mol. Microbiol. , vol.37 , pp. 703-716
    • Boucher, Y.1    Doolittle, W.F.2
  • 15
    • 0037022221 scopus 로고    scopus 로고
    • Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of lsph (LytB) protein
    • Rohdich, F. et al. Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of lsph (LytB) protein. Proc. Natl. Acad. Sci. USA 99, 1158-1163 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1158-1163
    • Rohdich, F.1
  • 16
    • 0024371122 scopus 로고
    • Genetic and physiological relationships among the miaA gene, 2-methylthio-N6-(Δ2-isopentenyl)adenosine transfer RNA modification, and spontaneous mutagenesis in Escherichia coli K-12
    • Connolly, D.M. & Winkler, M.E. Genetic and physiological relationships among the miaA gene, 2-methylthio-N6-(Δ2-isopentenyl)adenosine transfer RNA modification, and spontaneous mutagenesis in Escherichia coli K-12. J. Bacteriol. 171, 3233-3246 (1989).
    • (1989) J. Bacteriol. , vol.171 , pp. 3233-3246
    • Connolly, D.M.1    Winkler, M.E.2
  • 17
    • 0035128694 scopus 로고    scopus 로고
    • Precursor balancing for metabolic engineering of lycopene production in Escherichia coli
    • Farmer, W.R. & Liao, J.C. Precursor balancing for metabolic engineering of lycopene production in Escherichia coli. Biotechnol. Prog. 17, 57-61 (2001).
    • (2001) Biotechnol. Prog. , vol.17 , pp. 57-61
    • Farmer, W.R.1    Liao, J.C.2
  • 18
    • 0030970352 scopus 로고    scopus 로고
    • Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli
    • Kajiwara, S., Fraser, P.D., Kondo, K. & Misawa, N. Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. Biochem. J. 324, 421-426 (1997).
    • (1997) Biochem. J. , vol.324 , pp. 421-426
    • Kajiwara, S.1    Fraser, P.D.2    Kondo, K.3    Misawa, N.4
  • 19
    • 0035916370 scopus 로고    scopus 로고
    • Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production
    • Kim, S.-W. & Keasling, J.D. Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnol. Bioeng. 72, 408-415 (2001).
    • (2001) Biotechnol. Bioeng. , vol.72 , pp. 408-415
    • Kim, S.-W.1    Keasling, J.D.2
  • 20
    • 0034664686 scopus 로고    scopus 로고
    • Molecular cloning, expression, and characterization of amorpha-4,1-dienesynthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L.
    • Mercke, P., Bengtsson, M., Bouwmeester, H.J., Posthumus, M.A. & Brodelius, P.E. Molecular cloning, expression, and characterization of amorpha-4,1-dienesynthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. Arch. Biochem. Biophys. 381, 173-180 (2000).
    • (2000) Arch. Biochem. Biophys. , vol.381 , pp. 173-180
    • Mercke, P.1    Bengtsson, M.2    Bouwmeester, H.J.3    Posthumus, M.A.4    Brodelius, P.E.5
  • 21
    • 0035814339 scopus 로고    scopus 로고
    • The in vivo synthesis of plant sesquiterpenes by Escherichia coli
    • Martin, V.J.J., Yoshikuni, Y. & Keasling, J.D. The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotechnol. Bioeng. 75, 497-503 (2001).
    • (2001) Biotechnol. Bioeng. , vol.75 , pp. 497-503
    • Martin, V.J.J.1    Yoshikuni, Y.2    Keasling, J.D.3
  • 22
    • 0033109071 scopus 로고    scopus 로고
    • Construction and characterization of Escherichia coli disruptants defective in the yaeM gene
    • Kuzuyama, T., Takahashi, S. & Seto, H. Construction and characterization of Escherichia coli disruptants defective in the yaeM gene. Biosci. Biotechnol. Biochem. 63, 776-778 (1999).
    • (1999) Biosci. Biotechnol. Biochem. , vol.63 , pp. 776-778
    • Kuzuyama, T.1    Takahashi, S.2    Seto, H.3
  • 23
    • 0032811818 scopus 로고    scopus 로고
    • Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase
    • Hahn, F.M., Hurlburt, A.P. & Poulter, C.D. Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase. J. Bacteriol. 181, 4499-4504 (1999).
    • (1999) J. Bacteriol. , vol.181 , pp. 4499-4504
    • Hahn, F.M.1    Hurlburt, A.P.2    Poulter, C.D.3
  • 24
    • 0030981836 scopus 로고    scopus 로고
    • State of the art of the production of the antimalarial compound artemisinin in plants
    • Van Geldre, E., Vergauwe, A. & Van den Eeckhout, E. State of the art of the production of the antimalarial compound artemisinin in plants. Plant Mol. Biol. 33, 199-209 (1997).
    • (1997) Plant Mol. Biol. , vol.33 , pp. 199-209
    • Van Geldre, E.1    Vergauwe, A.2    Van den Eeckhout, E.3
  • 25
    • 0033230281 scopus 로고    scopus 로고
    • Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis
    • Bouwmeester, H.J. et al. Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis. Phytochem. 52, 843-854 (1999).
    • (1999) Phytochem. , vol.52 , pp. 843-854
    • Bouwmeester, H.J.1
  • 26
    • 0035129779 scopus 로고    scopus 로고
    • Amorpha-4,11-diene synthase: Cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
    • Wallaart, T.E., Bouwmeester, H.J., Hille, J., Poppinga, L. & Maijers, N.C.A. Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin. Planta 212, 460-465 (2001).
    • (2001) Planta , vol.212 , pp. 460-465
    • Wallaart, T.E.1    Bouwmeester, H.J.2    Hille, J.3    Poppinga, L.4    Maijers, N.C.A.5
  • 27
    • 0034669327 scopus 로고    scopus 로고
    • Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis
    • Chang, Y.J., Song, S.H., Park, S.H. & Kim, S.U. Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis. Arch. Biochem. Biophys. 383, 178-184 (2000).
    • (2000) Arch. Biochem. Biophys. , vol.383 , pp. 178-184
    • Chang, Y.J.1    Song, S.H.2    Park, S.H.3    Kim, S.U.4
  • 28
    • 0032030138 scopus 로고    scopus 로고
    • Codon optimization of the gene encoding a domain from human type 1 neurofibromin protein results in a threefold improvement in expression level in Escherichia coli
    • Hale, R.S. & Thompson, G. Codon optimization of the gene encoding a domain from human type 1 neurofibromin protein results in a threefold improvement in expression level in Escherichia coli. Protein Exper. Purif. 12, 185-188 (1998).
    • (1998) Protein Exper. Purif. , vol.12 , pp. 185-188
    • Hale, R.S.1    Thompson, G.2
  • 29
    • 0036901989 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of carotenoids in a heterologous host: A powerful approach for the biosynthesis of novel structures
    • Sandmann, G. Combinatorial biosynthesis of carotenoids in a heterologous host: a powerful approach for the biosynthesis of novel structures. Chembiochem. 3, 629-635 (2002).
    • (2002) Chembiochem. , vol.3 , pp. 629-635
    • Sandmann, G.1
  • 30
    • 0034838359 scopus 로고    scopus 로고
    • Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
    • Huang, Q.L., Roessner, C.A., Croteau, R. & Scott, A.I. Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol. Bioorgan. Med. Chem. 9, 2237-2242 (2001).
    • (2001) Bioorgan. Med. Chem. , vol.9 , pp. 2237-2242
    • Huang, Q.L.1    Roessner, C.A.2    Croteau, R.3    Scott, A.I.4
  • 31
    • 0034105938 scopus 로고    scopus 로고
    • Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase
    • Matthews, P.D. & Wurtzel, E.T. Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase. Appl. Microbiol. Biotechnol. 53, 396-400 (2000).
    • (2000) Appl. Microbiol. Biotechnol. , vol.53 , pp. 396-400
    • Matthews, P.D.1    Wurtzel, E.T.2
  • 32
    • 0032883216 scopus 로고    scopus 로고
    • Metabolic engineering of the terpenoid biosynthetic pathway of Escherichia coli for production of the carotenoids β-carotene and zeaxanthin
    • Albrecht, M., Misawa, N. & Sandmann, G. Metabolic engineering of the terpenoid biosynthetic pathway of Escherichia coli for production of the carotenoids β-carotene and zeaxanthin. Biotechnol. Lett. 21, 791-795 (1999).
    • (1999) Biotechnol. Lett. , vol.21 , pp. 791-795
    • Albrecht, M.1    Misawa, N.2    Sandmann, G.3
  • 33
    • 0033057722 scopus 로고    scopus 로고
    • Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis
    • Harker, M. & Bramley, P.M. Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis. FEBS Lett. 448, 115-119 (1999).
    • (1999) FEBS Lett. , vol.448 , pp. 115-119
    • Harker, M.1    Bramley, P.M.2
  • 34
    • 0033585443 scopus 로고    scopus 로고
    • Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli
    • Wang, C.-W., Oh, M.-K. & Liao, J.C. Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli. Biotechnol. Bioeng. 62, 235-241 (1999).
    • (1999) Biotechnol. Bioeng. , vol.62 , pp. 235-241
    • Wang, C.-W.1    Oh, M.-K.2    Liao, J.C.3
  • 35
    • 0025677130 scopus 로고
    • Artemisinic acid: A versatile chiral synthon and bioprecursor to natural products
    • Jung, M., ElSohly, H.N. & McChesney, J.D, Artemisinic acid: a versatile chiral synthon and bioprecursor to natural products. Planta Med. 56, 624 (1990).
    • (1990) Planta Med. , vol.56 , pp. 624
    • Jung, M.1    ElSohly, H.N.2    McChesney, J.D.3
  • 36
    • 0030960034 scopus 로고    scopus 로고
    • Biosynthesis of 2-C-methyl-D-erythritol, a putative C-5 intermediate in the mevalonate independent pathway for isoprenoid biosynthesis
    • Duvold, T., Bravo, J.M., Pale-Grosdemange, C. & Rohmer, M. Biosynthesis of 2-C-methyl-D-erythritol, a putative C-5 intermediate in the mevalonate independent pathway for isoprenoid biosynthesis. Tetrahedron Lett. 38, 4769-4772 (1997).
    • (1997) Tetrahedron Lett. , vol.38 , pp. 4769-4772
    • Duvold, T.1    Bravo, J.M.2    Pale-Grosdemange, C.3    Rohmer, M.4
  • 37
    • 0035154356 scopus 로고    scopus 로고
    • Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: A novel system for the genetic analysis of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis
    • Campos, N. et al. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Biochem. J. 353, 59-67 (2001).
    • (2001) Biochem. J. , vol.353 , pp. 59-67
    • Campos, N.1
  • 38
    • 0028485650 scopus 로고
    • Molecular structure and enzymatic function of lycopene cyclase from the Cyanobacterium synechococcus sp. strain PCC7942
    • Cunningham, F.X., Sun, Z., Chamovitz, D., Hirschberg, J. & Gantt, E. Molecular structure and enzymatic function of lycopene cyclase from the Cyanobacterium synechococcus sp. strain PCC7942. Plant Cell 6, 1107-1121 (1994).
    • (1994) Plant Cell , vol.6 , pp. 1107-1121
    • Cunningham, F.X.1    Sun, Z.2    Chamovitz, D.3    Hirschberg, J.4    Gantt, E.5
  • 39
    • 0031962865 scopus 로고    scopus 로고
    • Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast
    • Polakowski, T., Stahl, U. & Lang, C. Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast. Appl. Microbiol. Biotechnol. 49, 66-71 (1998).
    • (1998) Appl. Microbiol. Biotechnol. , vol.49 , pp. 66-71
    • Polakowski, T.1    Stahl, U.2    Lang, C.3
  • 40
    • 0028793123 scopus 로고
    • Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes
    • Kovach, M.E. et al. Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes. Gene 166, 175-176 (1995).
    • (1995) Gene , vol.166 , pp. 175-176
    • Kovach, M.E.1
  • 42
    • 0020482354 scopus 로고
    • Efficient enzymatic hydrolysis of polyprenyl pyrophosphates
    • Fujii, H., Koyama, T. & Ogura, K. Efficient enzymatic hydrolysis of polyprenyl pyrophosphates. Biochem. Biophys. Acta 712, 716-718 (1982).
    • (1982) Biochem. Biophys. Acta , vol.712 , pp. 716-718
    • Fujii, H.1    Koyama, T.2    Ogura, K.3
  • 43
    • 0027327439 scopus 로고
    • Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC
    • Zhang, D.L. & Poulter, C.D. Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC. Anal. Biochem. 213, 356-361 (1993).
    • (1993) Anal. Biochem. , vol.213 , pp. 356-361
    • Zhang, D.L.1    Poulter, C.D.2


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