-
1
-
-
13644264181
-
Secondgeneration tetracycline-regulatable promoter: Repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness
-
Agha-Mohammadi S, O'Malley M, Etemad A, Wang Z, Xiao X, Lotze MT (2004) Secondgeneration tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness. J Gene Med 6:817-828
-
(2004)
J Gene Med
, vol.6
, pp. 817-828
-
-
Agha-Mohammadi, S.1
O'Malley, M.2
Etemad, A.3
Wang, Z.4
Xiao, X.5
Lotze, M.T.6
-
2
-
-
0032485869
-
Overexpression of a cytosolic chaperone to improve solubility and secretion of a recombinant IgG protein in insect cells
-
Ailor E, Betenbaugh MJ (1998) Overexpression of a cytosolic chaperone to improve solubility and secretion of a recombinant IgG protein in insect cells. Biotechnol Bioeng 58:196-203
-
(1998)
Biotechnol Bioeng
, vol.58
, pp. 196-203
-
-
Ailor, E.1
Betenbaugh, M.J.2
-
3
-
-
0035866302
-
A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain
-
Akagi K, Kanai M, Saya H, Kozu T, Berns A (2001) A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain. Nucleic Acids Res 29:E23
-
(2001)
Nucleic Acids Res
, vol.29
-
-
Akagi, K.1
Kanai, M.2
Saya, H.3
Kozu, T.4
Berns, A.5
-
4
-
-
0035100475
-
Cellular transformation by SV40 large T antigen: Interaction with host proteins
-
Ali SH, DeCaprio JA (2001) Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 11:15-23
-
(2001)
Semin Cancer Biol
, vol.11
, pp. 15-23
-
-
Ali, S.H.1
DeCaprio, J.A.2
-
5
-
-
1642325279
-
Life and death in mammalian cell culture: Strategies for apoptosis inhibition
-
Arden N, Betenbaugh MJ (2004) Life and death in mammalian cell culture: strategies for apoptosis inhibition. Trends Biotechnol 22:174-180
-
(2004)
Trends Biotechnol
, vol.22
, pp. 174-180
-
-
Arden, N.1
Betenbaugh, M.J.2
-
6
-
-
77950453393
-
Mammalian synthetic biology-from tools to therapies
-
Aubel D, Fussenegger M (2010) Mammalian synthetic biology-from tools to therapies. BioEssays 32:332-345
-
(2010)
BioEssays
, vol.32
, pp. 332-345
-
-
Aubel, D.1
Fussenegger, M.2
-
7
-
-
33846446395
-
Fast set-up of doxycycline-inducible protein expression in human cell lines with a single plasmid based on Epstein-Barr virus replication and the simple tetracycline repressor
-
Bach M, Grigat S, Pawlik B, Fork C, Utermöhlen O, Pal S, Banczyk D, Lazar A, Schömig E, Gründemann D (2007) Fast set-up of doxycycline-inducible protein expression in human cell lines with a single plasmid based on Epstein-Barr virus replication and the simple tetracycline repressor. FEBS J 274:783-790
-
(2007)
FEBS J
, vol.274
, pp. 783-790
-
-
Bach, M.1
Grigat, S.2
Pawlik, B.3
Fork, C.4
Utermöhlen, O.5
Pal, S.6
Banczyk, D.7
Lazar, A.8
Schömig, E.9
Gründemann, D.10
-
8
-
-
53549129978
-
Chemical control of protein stability and function in living mice
-
Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH (2008) Chemical control of protein stability and function in living mice. Nat Med 14:1123-1127
-
(2008)
Nat Med
, vol.14
, pp. 1123-1127
-
-
Banaszynski, L.A.1
Sellmyer, M.A.2
Contag, C.H.3
Wandless, T.J.4
Thorne, S.H.5
-
9
-
-
0029075822
-
Co-regulation of two gene activities by tetracycline via a bidirectional promoter
-
Baron U, Freundlieb S, Gossen M, Bujard H (1995) Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res 23:3605-3606
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 3605-3606
-
-
Baron, U.1
Freundlieb, S.2
Gossen, M.3
Bujard, H.4
-
10
-
-
0030797223
-
Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
-
Baron U, Gossen M, Bujard H (1997) Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res 25:2723-2729
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 2723-2729
-
-
Baron, U.1
Gossen, M.2
Bujard, H.3
-
12
-
-
44149115663
-
An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes
-
Becker E, Florin L, Pfizenmaier K, Kaufmann H (2008) An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes. J Biotechnol 135:217-223
-
(2008)
J Biotechnol
, vol.135
, pp. 217-223
-
-
Becker, E.1
Florin, L.2
Pfizenmaier, K.3
Kaufmann, H.4
-
13
-
-
0034212551
-
Engineering stability in gene networks by autoregulation
-
Becskei A, Serrano L (2000) Engineering stability in gene networks by autoregulation. Nature 405:590-593
-
(2000)
Nature
, vol.405
, pp. 590-593
-
-
Becskei, A.1
Serrano, L.2
-
14
-
-
0042268512
-
Gene regulation by tetracyclines: Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes
-
Berens C, Hillen W (2003) Gene regulation by tetracyclines: constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem 270:3109-3121
-
(2003)
Eur J Biochem
, vol.270
, pp. 3109-3121
-
-
Berens, C.1
Hillen, W.2
-
15
-
-
1542410260
-
Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells
-
Bi JX, Shuttleworth J, Al-Rubeai M (2004) Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells. Biotechnol Bioeng 85:741-749
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 741-749
-
-
Bi, J.X.1
Shuttleworth, J.2
Al-Rubeai, M.3
-
16
-
-
0032866070
-
An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer
-
Binley K, Iqball S, Kingsman A, Kingsman S, Naylor S (1999) An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer. Gene Ther 6:1721-1727
-
(1999)
Gene Ther
, vol.6
, pp. 1721-1727
-
-
Binley, K.1
Iqball, S.2
Kingsman, A.3
Kingsman, S.4
Naylor, S.5
-
17
-
-
2342446492
-
Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer
-
Blesch A (2004) Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer. Methods 33:164-172
-
(2004)
Methods
, vol.33
, pp. 164-172
-
-
Blesch, A.1
-
18
-
-
0034103927
-
Transcriptional augmentation: Modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements)
-
Bode J, Benham C, Knopp A, Mielke C (2000) Transcriptional augmentation: modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements). Crit Rev Eukaryot Gene Expr 10:73-90
-
(2000)
Crit Rev Eukaryot Gene Expr
, vol.10
, pp. 73-90
-
-
Bode, J.1
Benham, C.2
Knopp, A.3
Mielke, C.4
-
19
-
-
13544251527
-
Temperature reduction in cultures of hGM-CSF-expressing CHO cells: Effect on productivity and product quality
-
Bollati-Fogolin M, Forno G, Nimtz M, Conradt HS, Etcheverrigaray M, Kratje R (2005) Temperature reduction in cultures of hGM-CSF-expressing CHO cells: effect on productivity and product quality. Biotechnol Prog 21:17-21
-
(2005)
Biotechnol Prog
, vol.21
, pp. 17-21
-
-
Bollati-Fogolin, M.1
Forno, G.2
Nimtz, M.3
Conradt, H.S.4
Etcheverrigaray, M.5
Kratje, R.6
-
20
-
-
0034006644
-
A temperature-regulated replicon-based DNA expression system
-
Boorsma M, Nieba L, Koller D, Bachmann MF, Bailey JE, Renner WA (2000) A temperature-regulated replicon-based DNA expression system. Nat Biotechnol 18:429-432
-
(2000)
Nat Biotechnol
, vol.18
, pp. 429-432
-
-
Boorsma, M.1
Nieba, L.2
Koller, D.3
Bachmann, M.F.4
Bailey, J.E.5
Renner, W.A.6
-
21
-
-
0037144081
-
Bioprocess applications of a Sindbis virus-based temperature-inducible expression system
-
Boorsma M, Hoenke S, Marrero A, Fischer R, Bailey JE, Renner WA, Bachmann MF (2002) Bioprocess applications of a Sindbis virus-based temperature-inducible expression system. Biotechnol Bioeng 79:602-609
-
(2002)
Biotechnol Bioeng
, vol.79
, pp. 602-609
-
-
Boorsma, M.1
Hoenke, S.2
Marrero, A.3
Fischer, R.4
Bailey, J.E.5
Renner, W.A.6
Bachmann, M.F.7
-
22
-
-
27144556152
-
Stringent doxycycline-dependent control of gene activities using an episomal one-vector system
-
Bornkamm GW, Berens C, Kuklik-Roos C, Bechet JM, Laux G, Bachl J, Korndoerfer M, Schlee M, Hölzel M, Malamoussi A, Chapman RD, Nimmerjahn F, Mautner J, Hillen W, Bujard H, Feuillard J (2005) Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res 33:1-11
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 1-11
-
-
Bornkamm, G.W.1
Berens, C.2
Kuklik-Roos, C.3
Bechet, J.M.4
Laux, G.5
Bachl, J.6
Korndoerfer, M.7
Schlee, M.8
Hölzel, M.9
Malamoussi, A.10
Chapman, R.D.11
Nimmerjahn, F.12
Mautner, J.13
Hillen, W.14
Bujard, H.15
Feuillard, J.16
-
23
-
-
13544249755
-
Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line
-
Borth N, Mattanovich D, Kunert R, Katinger H (2005) Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line. Biotechnol Prog 21:106-111
-
(2005)
Biotechnol Prog
, vol.21
, pp. 106-111
-
-
Borth, N.1
Mattanovich, D.2
Kunert, R.3
Katinger, H.4
-
24
-
-
0027465481
-
A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins
-
Braselmann S, Graninger P, Busslinger M (1993) A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc Natl Acad Sci U S A 90:1657-1661
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 1657-1661
-
-
Braselmann, S.1
Graninger, P.2
Busslinger, M.3
-
25
-
-
0042827473
-
AAV-based gene transfer
-
Büning H, Nicklin SA, Perabo L, Hallek M, Baker AH (2003) AAV-based gene transfer. Curr Opin Mol Ther 5:367-375
-
(2003)
Curr Opin Mol Ther
, vol.5
, pp. 367-375
-
-
Büning, H.1
Nicklin, S.A.2
Perabo, L.3
Hallek, M.4
Baker, A.H.5
-
27
-
-
0035889772
-
Strategies to modulate BHK cell proliferation by the regulation of IRF-1 expression
-
Carvalhal AV, Moreira JL, Carrondo MJ (2001) Strategies to modulate BHK cell proliferation by the regulation of IRF-1 expression. J Biotechnol 92:47-59
-
(2001)
J Biotechnol
, vol.92
, pp. 47-59
-
-
Carvalhal, A.V.1
Moreira, J.L.2
Carrondo, M.J.3
-
29
-
-
77957727111
-
Transglutaminase 2 inhibits apoptosis induced by calcium overload through downregulation of Bax
-
Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG (2010) Transglutaminase 2 inhibits apoptosis induced by calcium overload through downregulation of Bax. Exp Mol Med 42:639-650
-
(2010)
Exp Mol Med
, vol.42
, pp. 639-650
-
-
Cho, S.Y.1
Lee, J.H.2
Bae, H.D.3
Jeong, E.M.4
Jang, G.Y.5
Kim, C.W.6
Shin, D.M.7
Jeon, J.H.8
Kim, I.G.9
-
30
-
-
1442352043
-
Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells
-
Chung JY, Lim SW, Hong YJ, Hwang SO, Lee GM (2004) Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells. Biotechnol Bioeng 85:539-546
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 539-546
-
-
Chung, J.Y.1
Lim, S.W.2
Hong, Y.J.3
Hwang, S.O.4
Lee, G.M.5
-
31
-
-
77954606202
-
Adjusting transgene expression levels in lymphocytes with a set of inducible promoters
-
Danke C, G€runz X, Wittmann J, Schmidt A, Agha-Mohammadi S, Kutsch O, Jäck HM, Hillen W, Berens C (2010) Adjusting transgene expression levels in lymphocytes with a set of inducible promoters. J Gene Med 12:501-515
-
(2010)
J Gene Med
, vol.12
, pp. 501-515
-
-
Danke, C.1
G€runz, X.2
Wittmann, J.3
Schmidt, A.4
Agha-Mohammadi, S.5
Kutsch, O.6
Jäck, H.M.7
Hillen, W.8
Berens, C.9
-
32
-
-
34347394540
-
LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop
-
Davey RE, Onishi K, Mahdavi A, Zandstra PW (2007) LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop. FASEB J 21:2020-2032
-
(2007)
FASEB J
, vol.21
, pp. 2020-2032
-
-
Davey, R.E.1
Onishi, K.2
Mahdavi, A.3
Zandstra, P.W.4
-
33
-
-
34447505900
-
A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells
-
Deans TL, Cantor CR, Collins JJ (2007) A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells. Cell 130:363-372
-
(2007)
Cell
, vol.130
, pp. 363-372
-
-
Deans, T.L.1
Cantor, C.R.2
Collins, J.J.3
-
34
-
-
0028897720
-
Tetracycline-reversible silencing of eukaryotic promoters
-
Deuschle U, Meyer WKH, Thiesen HJ (1995) Tetracycline-reversible silencing of eukaryotic promoters. Mol Cell Biol 15:1907-1914
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1907-1914
-
-
Deuschle, U.1
Meyer, W.K.H.2
Thiesen, H.J.3
-
35
-
-
0037083193
-
Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: Intracellular pH, cell size, apoptosis, and metabolism
-
deZengotita VM, Schmelzer AE, Miller WM (2002) Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: intracellular pH, cell size, apoptosis, and metabolism. Biotechnol Bioeng 77:369-380
-
(2002)
Biotechnol Bioeng
, vol.77
, pp. 369-380
-
-
deZengotita, V.M.1
Schmelzer, A.E.2
Miller, W.M.3
-
36
-
-
79952198533
-
Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines
-
Dorai H, Ellis D, Keung YS, Campbell M, Zhuang M, Lin C, Betenbaugh MJ (2010) Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines. Biotechnol Prog 26:1367-1381
-
(2010)
Biotechnol Prog
, vol.26
, pp. 1367-1381
-
-
Dorai, H.1
Ellis, D.2
Keung, Y.S.3
Campbell, M.4
Zhuang, M.5
Lin, C.6
Betenbaugh, M.J.7
-
37
-
-
48249096827
-
Episomal vectors for gene therapy
-
Ehrhardt A, Haase R, Schepers A, Deutsch MJ, Lipps HJ, Baiker A (2008) Episomal vectors for gene therapy. Curr Gene Ther 8:147-161
-
(2008)
Curr Gene Ther
, vol.8
, pp. 147-161
-
-
Ehrhardt, A.1
Haase, R.2
Schepers, A.3
Deutsch, M.J.4
Lipps, H.J.5
Baiker, A.6
-
38
-
-
0024396222
-
Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
-
Eilers M, Picard D, Yamamoto KR, Bishop JM (1989) Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340:66-68
-
(1989)
Nature
, vol.340
, pp. 66-68
-
-
Eilers, M.1
Picard, D.2
Yamamoto, K.R.3
Bishop, J.M.4
-
39
-
-
0037336295
-
Quality control in the endoplasmic reticulum
-
Ellgaard L, Helenius A (2003) Quality control in the endoplasmic reticulum. Nat Rev Mol Cell Biol 4:181-191
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 181-191
-
-
Ellgaard, L.1
Helenius, A.2
-
40
-
-
0034688173
-
A synthetic oscillatory network of transcriptional regulators
-
Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403:335-338
-
(2000)
Nature
, vol.403
, pp. 335-338
-
-
Elowitz, M.B.1
Leibler, S.2
-
41
-
-
58949085528
-
Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality
-
Ertel A, Tozeren A (2008) Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality. BMC Genomics 9:628
-
(2008)
BMC Genomics
, vol.9
, pp. 628
-
-
Ertel, A.1
Tozeren, A.2
-
42
-
-
0031589555
-
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains
-
Feil R, Wagner J, Metzger D, Chambon P (1997) Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 237: 752-757
-
(1997)
Biochem Biophys Res Commun
, vol.237
, pp. 752-757
-
-
Feil, R.1
Wagner, J.2
Metzger, D.3
Chambon, P.4
-
43
-
-
0036736455
-
Reversible G(1) arrest by dimethyl sulfoxide as a new method to synchronize Chinese hamster cells
-
Fiore M, Zanier R, Degrassi F (2002) Reversible G(1) arrest by dimethyl sulfoxide as a new method to synchronize Chinese hamster cells. Mutagenesis 17:419-424
-
(2002)
Mutagenesis
, vol.17
, pp. 419-424
-
-
Fiore, M.1
Zanier, R.2
Degrassi, F.3
-
44
-
-
64549145396
-
Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells
-
Florin L, Pegel A, Becker E, Hausser A, Olayioye MA, Kaufmann H (2009) Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells. J Biotechnol 141:84-90
-
(2009)
J Biotechnol
, vol.141
, pp. 84-90
-
-
Florin, L.1
Pegel, A.2
Becker, E.3
Hausser, A.4
Olayioye, M.A.5
Kaufmann, H.6
-
45
-
-
0033555764
-
Tetracyclineinducible expression systems with reduced basal activity in mammalian cells
-
Forster K, Helbl V, Lederer T, Urlinger S, Wittenburg N, Hillen W (1999) Tetracyclineinducible expression systems with reduced basal activity in mammalian cells. Nucleic Acids Res 27:708-710
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 708-710
-
-
Forster, K.1
Helbl, V.2
Lederer, T.3
Urlinger, S.4
Wittenburg, N.5
Hillen, W.6
-
46
-
-
0942265268
-
Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: Experimental and modeling
-
Fox SR, Patel UA, Yap MG, Wang DI (2004) Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling. Biotechnol Bioeng 85:177-184
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 177-184
-
-
Fox, S.R.1
Patel, U.A.2
Yap, M.G.3
Wang, D.I.4
-
47
-
-
20544446100
-
A detailed understanding of the enhanced hypothermic productivity of interferon-gamma by Chinese-hamster ovary cells
-
Fox SR, Tan HK, Tan MC, Wong SC, Yap MG, Wang DI (2005) A detailed understanding of the enhanced hypothermic productivity of interferon-gamma by Chinese-hamster ovary cells. Biotechnol Appl Biochem 41:255-264
-
(2005)
Biotechnol Appl Biochem
, vol.41
, pp. 255-264
-
-
Fox, S.R.1
Tan, H.K.2
Tan, M.C.3
Wong, S.C.4
Yap, M.G.5
Wang, D.I.6
-
48
-
-
0030152925
-
Precise excision of TTAA-specific lepidopteran transposons piggyBac (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines from two species of Lepidoptera
-
Fraser MJ, Ciszczon T, Elick T, Bauser C (1996) Precise excision of TTAA-specific lepidopteran transposons piggyBac (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines from two species of Lepidoptera. Insect Mol Biol 5:141-151
-
(1996)
Insect Mol Biol
, vol.5
, pp. 141-151
-
-
Fraser, M.J.1
Ciszczon, T.2
Elick, T.3
Bauser, C.4
-
49
-
-
0032600013
-
A tetracycline controlled activation/ repression system with increased potential for gene transfer into mammalian cells
-
Freundlieb S, Schirra-Müller C, Bujard H (1999) A tetracycline controlled activation/ repression system with increased potential for gene transfer into mammalian cells. J Gene Med 1:4-12
-
(1999)
J Gene Med
, vol.1
, pp. 4-12
-
-
Freundlieb, S.1
Schirra-Müller, C.2
Bujard, H.3
-
50
-
-
0035121677
-
The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies
-
Fussenegger M (2001) The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies. Biotechnol Prog 17:1-51
-
(2001)
Biotechnol Prog
, vol.17
, pp. 1-51
-
-
Fussenegger, M.1
-
51
-
-
0343196706
-
A novel cytostatic process enhances the productivity of Chinese hamster ovary cells
-
Fussenegger M, Mazur X, Bailey JE (1997) A novel cytostatic process enhances the productivity of Chinese hamster ovary cells. Biotechnol Bioeng 55:927-939
-
(1997)
Biotechnol Bioeng
, vol.55
, pp. 927-939
-
-
Fussenegger, M.1
Mazur, X.2
Bailey, J.E.3
-
52
-
-
0032484706
-
pTRIDENT, a novel vector family for tricistronic gene expression in mammalian cells
-
Fussenegger M, Mazur X, Bailey JE (1998a) pTRIDENT, a novel vector family for tricistronic gene expression in mammalian cells. Biotechnol Bioeng 57:1-10
-
(1998)
Biotechnol Bioeng
, vol.57
, pp. 1-10
-
-
Fussenegger, M.1
Mazur, X.2
Bailey, J.E.3
-
53
-
-
0031945008
-
Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells
-
Fussenegger M, Schlatter S, Datwyler D, Mazur X, Bailey JE (1998b) Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells. Nat Biotechnol 16:468-472
-
(1998)
Nat Biotechnol
, vol.16
, pp. 468-472
-
-
Fussenegger, M.1
Schlatter, S.2
Datwyler, D.3
Mazur, X.4
Bailey, J.E.5
-
54
-
-
77951645043
-
Defeating randomness-targeted integration as a boost for biotechnology
-
In: Al-Rubeai M (ed), Springer, London
-
Gama-Norton L, Riemer P, Sandhu U, Nehlsen K, Schucht R, Hauser H, Wirth D (2009) Defeating randomness-targeted integration as a boost for biotechnology. In: Al-Rubeai M (ed) Cell engineering. Springer, London
-
(2009)
Cell engineering
-
-
Gama-Norton, L.1
Riemer, P.2
Sandhu, U.3
Nehlsen, K.4
Schucht, R.5
Hauser, H.6
Wirth, D.7
-
55
-
-
77955506625
-
Retroviral vector performance in defined chromosomal loci of modular packaging cell lines
-
Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Low R, Alves PM, Bartholomae CC, Schmidt M, Baum C, Schambach A, Hauser H, Wirth D (2010) Retroviral vector performance in defined chromosomal loci of modular packaging cell lines. Hum Gene Ther 21:979-991
-
(2010)
Hum Gene Ther
, vol.21
, pp. 979-991
-
-
Gama-Norton, L.1
Herrmann, S.2
Schucht, R.3
Coroadinha, A.S.4
Low, R.5
Alves, P.M.6
Bartholomae, C.C.7
Schmidt, M.8
Baum, C.9
Schambach, A.10
Hauser, H.11
Wirth, D.12
-
56
-
-
0034609237
-
Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors
-
Geserick C, Bonarius HP, Kongerslev L, Hauser H, Mueller PP (2000) Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors. Biotechnol Bioeng 69:266-274
-
(2000)
Biotechnol Bioeng
, vol.69
, pp. 266-274
-
-
Geserick, C.1
Bonarius, H.P.2
Kongerslev, L.3
Hauser, H.4
Mueller, P.P.5
-
57
-
-
36949017502
-
Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media
-
Ghani K, Cottin S, Kamen A, Caruso M (2007) Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media. Gene Ther 14:1705-1711
-
(2007)
Gene Ther
, vol.14
, pp. 1705-1711
-
-
Ghani, K.1
Cottin, S.2
Kamen, A.3
Caruso, M.4
-
58
-
-
77953584054
-
Creation of a bacterial cell controlled by a chemically synthesized genome
-
Gibson DG, Glass JI, Lartigue C, Noskov VN, Chuang RY, Algire MA, Benders GA, Montague MG, Ma L, Moodie MM, Merryman C, Vashee S, Krishnakumar R, Assad-Garcia N, Andrews-Pfannkoch C, Denisova EA, Young L, Qi ZQ, Segall-Shapiro TH, Calvey CH, Parmar PP, Hutchison CA III, Smith HO, Venter JC (2010) Creation of a bacterial cell controlled by a chemically synthesized genome. Science 329:52-56
-
(2010)
Science
, vol.329
, pp. 52-56
-
-
Gibson, D.G.1
Glass, J.I.2
Lartigue, C.3
Noskov, V.N.4
Chuang, R.Y.5
Algire, M.A.6
Benders, G.A.7
Montague, M.G.8
Ma, L.9
Moodie, M.M.10
Merryman, C.11
Vashee, S.12
Krishnakumar, R.13
Assad-Garcia, N.14
Andrews-Pfannkoch, C.15
Denisova, E.A.16
Young, L.17
Qi, Z.Q.18
Segall-Shapiro, T.H.19
Calvey, C.H.20
Parmar, P.P.21
Hutchison III, C.A.22
Smith, H.O.23
Venter, J.C.24
more..
-
59
-
-
0023805741
-
Negative effect of the transcriptional activator GAL4
-
Gill G, Ptashne M (1988) Negative effect of the transcriptional activator GAL4. Nature 334:721-724
-
(1988)
Nature
, vol.334
, pp. 721-724
-
-
Gill, G.1
Ptashne, M.2
-
60
-
-
67649819663
-
Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin
-
Gitzinger M, Kemmer C, El-Baba MD, Weber W, Fussenegger M (2009) Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin. Proc Natl Acad Sci U S A 106:10638-10643
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 10638-10643
-
-
Gitzinger, M.1
Kemmer, C.2
El-Baba, M.D.3
Weber, W.4
Fussenegger, M.5
-
61
-
-
68349116137
-
Conditional and reversible disruption of essential herpesvirus proteins
-
Glaß M, Busche A, Wagner K, Messerle M, Borst EM (2009) Conditional and reversible disruption of essential herpesvirus proteins. Nat Methods 6:577-579
-
(2009)
Nat Methods
, vol.6
, pp. 577-579
-
-
Glaß, M.1
Busche, A.2
Wagner, K.3
Messerle, M.4
Borst, E.M.5
-
62
-
-
0036579880
-
Optimization and direct comparison of the dimerizer and reverse tet transcriptional control systems
-
Go WY, Ho SN (2002) Optimization and direct comparison of the dimerizer and reverse tet transcriptional control systems. J Gene Med 4:258-270
-
(2002)
J Gene Med
, vol.4
, pp. 258-270
-
-
Go, W.Y.1
Ho, S.N.2
-
63
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 89:5547-5551
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
64
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Muller, G.4
Hillen, W.5
Bujard, H.6
-
65
-
-
34347389431
-
Mammalian synthetic biology: Engineering of sophisticated gene networks
-
Greber D, Fussenegger M (2007) Mammalian synthetic biology: engineering of sophisticated gene networks. J Biotechnol 130:329-345
-
(2007)
J Biotechnol
, vol.130
, pp. 329-345
-
-
Greber, D.1
Fussenegger, M.2
-
66
-
-
33845733725
-
Promoter crosstalk effects on gene expression
-
Hampf M, Gossen M (2007) Promoter crosstalk effects on gene expression. J Mol Biol 365:911-920
-
(2007)
J Mol Biol
, vol.365
, pp. 911-920
-
-
Hampf, M.1
Gossen, M.2
-
67
-
-
0347611095
-
Molecular machinery for non-vesicular trafficking of ceramide
-
Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide. Nature 426:803-809
-
(2003)
Nature
, vol.426
, pp. 803-809
-
-
Hanada, K.1
Kumagai, K.2
Yasuda, S.3
Miura, Y.4
Kawano, M.5
Fukasawa, M.6
Nishijima, M.7
-
68
-
-
36749000446
-
An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice
-
Hartenbach S, Daoud-El Baba M, Weber W, Fussenegger M (2007) An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice. Nucleic Acids Res 35:e136
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Hartenbach, S.1
Daoud-El Baba, M.2
Weber, W.3
Fussenegger, M.4
-
69
-
-
0025975704
-
Chinese hamster ovary cell growth and interferon production kinetics in stirred batch culture
-
Hayter PM, Curling EM, Baines AJ, Jenkins N, Salmon I, Strange PG, Bull AT (1991) Chinese hamster ovary cell growth and interferon production kinetics in stirred batch culture. Appl Microbiol Biotechnol 34:559-564
-
(1991)
Appl Microbiol Biotechnol
, vol.34
, pp. 559-564
-
-
Hayter, P.M.1
Curling, E.M.2
Baines, A.J.3
Jenkins, N.4
Salmon, I.5
Strange, P.G.6
Bull, A.T.7
-
70
-
-
79951834881
-
Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range
-
Heinz N, Schambach A, Galla M, Maetzig T, Baum C, Loew R, Schiedlmeier B (2010) Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range. Hum Gene Ther 22:166-176
-
(2010)
Hum Gene Ther
, vol.22
, pp. 166-176
-
-
Heinz, N.1
Schambach, A.2
Galla, M.3
Maetzig, T.4
Baum, C.5
Loew, R.6
Schiedlmeier, B.7
-
71
-
-
18244367173
-
Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: A cell cycle phases analysis
-
Hendrick V, Winnepenninckx P, Abdelkafi C, Vandeputte O, Cherlet M, Marique T, Renemann G, Loa A, Kretzmer G, Werenne J (2001) Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: a cell cycle phases analysis. Cytotechnology 36:71-83
-
(2001)
Cytotechnology
, vol.36
, pp. 71-83
-
-
Hendrick, V.1
Winnepenninckx, P.2
Abdelkafi, C.3
Vandeputte, O.4
Cherlet, M.5
Marique, T.6
Renemann, G.7
Loa, A.8
Kretzmer, G.9
Werenne, J.10
-
72
-
-
0030001394
-
Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette
-
Hofmann A, Nolan GP, Blau HM (1996) Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette. Proc Natl Acad Sci U S A 93:5185-5190
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 5185-5190
-
-
Hofmann, A.1
Nolan, G.P.2
Blau, H.M.3
-
73
-
-
0023666091
-
The inducible lac operator-repressor system is functional in mammalian cells
-
Hu MC, Davidson N (1987) The inducible lac operator-repressor system is functional in mammalian cells. Cell 48:555-566
-
(1987)
Cell
, vol.48
, pp. 555-566
-
-
Hu, M.C.1
Davidson, N.2
-
75
-
-
0037274318
-
Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NS0 cells
-
Ibarra N, Watanabe S, Bi JX, Shuttleworth J, Al-Rubeai M (2003) Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NS0 cells. Biotechnol Prog 19:224-228
-
(2003)
Biotechnol Prog
, vol.19
, pp. 224-228
-
-
Ibarra, N.1
Watanabe, S.2
Bi, J.X.3
Shuttleworth, J.4
Al-Rubeai, M.5
-
76
-
-
0030775881
-
Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells
-
Ito K, Ueda Y, Kokubun M, Urabe M, Inaba T, Mano H, Hamada H, Kitamura T, Mizoguchi H, Sakata T, Hasegawa M, Ozawa K (1997) Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells. Blood 90:3884-3892
-
(1997)
Blood
, vol.90
, pp. 3884-3892
-
-
Ito, K.1
Ueda, Y.2
Kokubun, M.3
Urabe, M.4
Inaba, T.5
Mano, H.6
Hamada, H.7
Kitamura, T.8
Mizoguchi, H.9
Sakata, T.10
Hasegawa, M.11
Ozawa, K.12
-
77
-
-
0030662074
-
Molecular reconstruction of sleeping beauty, a Tc1-like transposon from fish, and its transposition in human cells
-
Ivics Z, Hackett PB, Plasterk RH, Izsvák Z (1997) Molecular reconstruction of sleeping beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91:501-510
-
(1997)
Cell
, vol.91
, pp. 501-510
-
-
Ivics, Z.1
Hackett, P.B.2
Plasterk, R.H.3
Izsvák, Z.4
-
78
-
-
70349779189
-
Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors
-
Izsvák Z, Chuah MKL, VandenDriessche T, Ivics Z (2009) Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors. Methods 49:287-297
-
(2009)
Methods
, vol.49
, pp. 287-297
-
-
Izsvák, Z.1
Chuah, M.K.L.2
VandenDriessche, T.3
Ivics, Z.4
-
79
-
-
0026047651
-
Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse
-
Jat PS, Noble MD, Ataliotis P, Tanaka Y, Yannoutsos N, Larsen L, Kioussis D (1991) Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A 88:5096-5100
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 5096-5100
-
-
Jat, P.S.1
Noble, M.D.2
Ataliotis, P.3
Tanaka, Y.4
Yannoutsos, N.5
Larsen, L.6
Kioussis, D.7
-
80
-
-
67649664208
-
Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells
-
Jenkins N, Meleady P, Tyther R, Murphy L (2009) Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells. Biotechnol Appl Biochem 53:73-83
-
(2009)
Biotechnol Appl Biochem
, vol.53
, pp. 73-83
-
-
Jenkins, N.1
Meleady, P.2
Tyther, R.3
Murphy, L.4
-
81
-
-
0033526546
-
Influence of low temperature on productivity, proteome and protein phosphorylation ofCHOcells
-
Kaufmann H, Mazur X, Fussenegger M, Bailey JE (1999) Influence of low temperature on productivity, proteome and protein phosphorylation ofCHOcells. BiotechnolBioeng 63:573-582
-
(1999)
BiotechnolBioeng
, vol.63
, pp. 573-582
-
-
Kaufmann, H.1
Mazur, X.2
Fussenegger, M.3
Bailey, J.E.4
-
82
-
-
0029874029
-
Regulation of Cre recombinase activity by the synthetic steroid RU 486
-
Kellendonk C, Tronche F, Monaghan AP, Angrand PO, Stewart F, Schutz G (1996) Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res 24:1404-1411
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 1404-1411
-
-
Kellendonk, C.1
Tronche, F.2
Monaghan, A.P.3
Angrand, P.O.4
Stewart, F.5
Schutz, G.6
-
83
-
-
77950676224
-
Self-sufficient control of urate homeostasis in mice by a synthetic circuit
-
Kemmer C, Gitzinger M, Daoud-El Baba M, Djonov V, Stelling J, Fussenegger M (2010) Self-sufficient control of urate homeostasis in mice by a synthetic circuit. Nat Biotechnol 28:355-360
-
(2010)
Nat Biotechnol
, vol.28
, pp. 355-360
-
-
Kemmer, C.1
Gitzinger, M.2
Daoud-El Baba, M.3
Djonov, V.4
Stelling, J.5
Fussenegger, M.6
-
84
-
-
73149117995
-
Engineering signal transduction pathways
-
Kiel C, Yus E, Serrano L (2010) Engineering signal transduction pathways. Cell 140:33-47
-
(2010)
Cell
, vol.140
, pp. 33-47
-
-
Kiel, C.1
Yus, E.2
Serrano, L.3
-
85
-
-
0027261245
-
Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes
-
Kirchhoff S, Schaper F, Hauser H (1993) Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes. Nucleic Acids Res 21:2881-2889
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 2881-2889
-
-
Kirchhoff, S.1
Schaper, F.2
Hauser, H.3
-
86
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ (1998) Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
87
-
-
77953633943
-
The discovery of zinc fingers and their applications in gene regulation and genome manipulation
-
Klug A. (2010) The discovery of zinc fingers and their applications in gene regulation and genome manipulation. Annu Rev Biochem 79:213-231
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 213-231
-
-
Klug, A.1
-
88
-
-
0029844292
-
Transposable element in fish [11]
-
Koga A, Suzuki M, Inagaki H, Bessho Y, Hori H (1996) Transposable element in fish [11]. Nature 383:30
-
(1996)
Nature
, vol.383
, pp. 30
-
-
Koga, A.1
Suzuki, M.2
Inagaki, H.3
Bessho, Y.4
Hori, H.5
-
89
-
-
0002382152
-
Proliferation control of mammalian cells by the tumor suppressor IRF-1
-
Köster M, Kirchhoff S, Schaper F, Hauser H (1995) Proliferation control of mammalian cells by the tumor suppressor IRF-1. Cytotechnology18:67-75
-
(1995)
Cytotechnology
, vol.18
, pp. 67-75
-
-
Köster, M.1
Kirchhoff, S.2
Schaper, F.3
Hauser, H.4
-
90
-
-
22144452865
-
Hysteresis in a synthetic mammalian gene network
-
Kramer BP, Fussenegger M (2005) Hysteresis in a synthetic mammalian gene network. Proc Natl Acad Sci U S A 102:9517-9522
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 9517-9522
-
-
Kramer, B.P.1
Fussenegger, M.2
-
91
-
-
0041930790
-
Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells
-
Kramer BP, Weber W, Fussenegger M (2003) Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol Bioeng 83:810-820
-
(2003)
Biotechnol Bioeng
, vol.83
, pp. 810-820
-
-
Kramer, B.P.1
Weber, W.2
Fussenegger, M.3
-
92
-
-
3042822415
-
An engineered epigenetic transgene switch in mammalian cells
-
Kramer BP, Viretta AU, Baba MDE, Aubel D, Weber W, Fussenegger M (2004) An engineered epigenetic transgene switch in mammalian cells. Nat Biotechnol 22:867-870
-
(2004)
Nat Biotechnol
, vol.22
, pp. 867-870
-
-
Kramer, B.P.1
Viretta, A.U.2
Baba, M.D.E.3
Aubel, D.4
Weber, W.5
Fussenegger, M.6
-
93
-
-
24044457608
-
Semi-synthetic mammalian gene regulatory networks
-
Kramer BP, Fischer M, Fussenegger M (2005) Semi-synthetic mammalian gene regulatory networks. Metab Eng 7:241-250
-
(2005)
Metab Eng
, vol.7
, pp. 241-250
-
-
Kramer, B.P.1
Fischer, M.2
Fussenegger, M.3
-
94
-
-
7244231295
-
Self-inactivating retroviral vectors with improved RNA processing
-
Kraunus J, Schaumann DH, Meyer J, Modlich U, Fehse B, Brandenburg G, von Laer D, Klump H, Schambach A, Bohne J, Baum C (2004) Self-inactivating retroviral vectors with improved RNA processing. Gene Ther 11:1568-1578
-
(2004)
Gene Ther
, vol.11
, pp. 1568-1578
-
-
Kraunus, J.1
Schaumann, D.H.2
Meyer, J.3
Modlich, U.4
Fehse, B.5
Brandenburg, G.6
von Laer, D.7
Klump, H.8
Schambach, A.9
Bohne, J.10
Baum, C.11
-
95
-
-
0036182868
-
Activities of IRF-1
-
Kroger A, Koster M, Schroeder K, Hauser H, Mueller PP (2002) Activities of IRF-1. J Interferon Cytokine Res 22:5-14
-
(2002)
J Interferon Cytokine Res
, vol.22
, pp. 5-14
-
-
Kroger, A.1
Koster, M.2
Schroeder, K.3
Hauser, H.4
Mueller, P.P.5
-
96
-
-
2342518183
-
Doxycycline regulation in a single retroviral vector by an autoregulatory loop facilitates controlled gene expression in liver cells
-
Kühnel F, Fritsch C, Krause S, Mundt B, Wirth T, Paul Y, Malek NP, Zender L, Manns MP, Kubicka S (2004) Doxycycline regulation in a single retroviral vector by an autoregulatory loop facilitates controlled gene expression in liver cells. Nucleic Acids Res 32:e30
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Kühnel, F.1
Fritsch, C.2
Krause, S.3
Mundt, B.4
Wirth, T.5
Paul, Y.6
Malek, N.P.7
Zender, L.8
Manns, M.P.9
Kubicka, S.10
-
97
-
-
0142259352
-
In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene
-
Kume A, Koremoto M, Xu R, Okada T, Mizukami H, Hanazono Y, Hasegawa M, Ozawa K (2003) In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene. J Gene Med 5:175-181
-
(2003)
J Gene Med
, vol.5
, pp. 175-181
-
-
Kume, A.1
Koremoto, M.2
Xu, R.3
Okada, T.4
Mizukami, H.5
Hanazono, Y.6
Hasegawa, M.7
Ozawa, K.8
-
98
-
-
0037567495
-
Tissuespecific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis
-
Langley RR, Ramirez KM, Tsan RZ, Van Arsdall M, Nilsson MB, Fidler IJ (2003) Tissuespecific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis. Cancer Res 63:2971-2976
-
(2003)
Cancer Res
, vol.63
, pp. 2971-2976
-
-
Langley, R.R.1
Ramirez, K.M.2
Tsan, R.Z.3
van Arsdall, M.4
Nilsson, M.B.5
Fidler, I.J.6
-
99
-
-
70449384375
-
Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis
-
Langley RR, Fan D, Guo L, Zhang C, Lin Q, Brantley EC, McCarty JH, Fidler IJ (2009) Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis. Int J Oncol 35:665-672
-
(2009)
Int J Oncol
, vol.35
, pp. 665-672
-
-
Langley, R.R.1
Fan, D.2
Guo, L.3
Zhang, C.4
Lin, Q.5
Brantley, E.C.6
McCarty, J.H.7
Fidler, I.J.8
-
100
-
-
70350070364
-
Spatiotemporal control of cell signalling using a light-switchable protein interaction
-
Levskaya A, Weiner OD, Lim WA, Voigt CA (2009) Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 461:997-1001
-
(2009)
Nature
, vol.461
, pp. 997-1001
-
-
Levskaya, A.1
Weiner, O.D.2
Lim, W.A.3
Voigt, C.A.4
-
102
-
-
33749435598
-
RNAi suppression of Bax and Bak enhances viability in fed-batch cultures of CHO cells
-
Lim SF, Chuan KH, Liu S, Loh SO, Chung BY, Ong CC, Song Z (2006) RNAi suppression of Bax and Bak enhances viability in fed-batch cultures of CHO cells. Metab Eng 8: 509-522
-
(2006)
Metab Eng
, vol.8
, pp. 509-522
-
-
Lim, S.F.1
Chuan, K.H.2
Liu, S.3
Loh, S.O.4
Chung, B.Y.5
Ong, C.C.6
Song, Z.7
-
103
-
-
0035110023
-
Pentanoic acid, a novel protein synthesis stimulant for Chinese hamster ovary (CHO) cells
-
Liu C, Chu I, Hwang S (2001) Pentanoic acid, a novel protein synthesis stimulant for Chinese hamster ovary (CHO) cells. J Biosci Bioeng 91:71-75
-
(2001)
J Biosci Bioeng
, vol.91
, pp. 71-75
-
-
Liu, C.1
Chu, I.2
Hwang, S.3
-
104
-
-
0033735339
-
Relationship between cell size, cell cycle and specific recombinant protein productivity
-
Lloyd DR, Holmes P, Jackson LP, Emery AN, Al-Rubeai M (2000) Relationship between cell size, cell cycle and specific recombinant protein productivity. Cytotechnology 34:59-70
-
(2000)
Cytotechnology
, vol.34
, pp. 59-70
-
-
Lloyd, D.R.1
Holmes, P.2
Jackson, L.P.3
Emery, A.N.4
Al-Rubeai, M.5
-
105
-
-
65549143271
-
Retroviral vectors containing Tet-controlled bidirectional transcription units for simultaneous regulation of two gene activities
-
Loew R, Vigna E, Lindemann D, Naldini L, Bujard H (2006) Retroviral vectors containing Tet-controlled bidirectional transcription units for simultaneous regulation of two gene activities. J Mol Genet Med 2:107-118
-
(2006)
J Mol Genet Med
, vol.2
, pp. 107-118
-
-
Loew, R.1
Vigna, E.2
Lindemann, D.3
Naldini, L.4
Bujard, H.5
-
106
-
-
76749155354
-
A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration
-
Loew R, Meyer Y, Kuehlcke K, Gama-Norton L, Wirth D, Hauser H, Stein S, Grez M, Thornhill S, Thrasher A, Baum C, Schambach A (2010) A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration. Gene Ther 17:272-280
-
(2010)
Gene Ther
, vol.17
, pp. 272-280
-
-
Loew, R.1
Meyer, Y.2
Kuehlcke, K.3
Gama-Norton, L.4
Wirth, D.5
Hauser, H.6
Stein, S.7
Grez, M.8
Thornhill, S.9
Thrasher, A.10
Baum, C.11
Schambach, A.12
-
107
-
-
0029043630
-
Ligand-regulated site-specific recombination
-
Logie C, Stewart AF (1995) Ligand-regulated site-specific recombination. Proc Natl Acad Sci U S A 92:5940-5944
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5940-5944
-
-
Logie, C.1
Stewart, A.F.2
-
108
-
-
50549090204
-
Advances in high-capacity extrachromosomal vector technology: Episomal maintenance, vector delivery, and transgene expression
-
Lufino MMP, Edser PAH, Wade-Martins R (2008) Advances in high-capacity extrachromosomal vector technology: episomal maintenance, vector delivery, and transgene expression. Mol Ther 16:1525-1538
-
(2008)
Mol Ther
, vol.16
, pp. 1525-1538
-
-
Lufino, M.M.P.1
Edser, P.A.H.2
Wade-Martins, R.3
-
109
-
-
34249061491
-
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
-
Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT (2007) Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 316:1043-1046
-
(2007)
Science
, vol.316
, pp. 1043-1046
-
-
Major, M.B.1
Camp, N.D.2
Berndt, J.D.3
Yi, X.4
Goldenberg, S.J.5
Hubbert, C.6
Biechele, T.L.7
Gingras, A.C.8
Zheng, N.9
McCoss, M.J.10
Angers, S.11
Moon, R.T.12
-
110
-
-
33745991945
-
Improved transgene expression fine-tuning in mammalian cells using a novel transcription-translation network
-
Malphettes L, Fussenegger M (2006) Improved transgene expression fine-tuning in mammalian cells using a novel transcription-translation network. J Biotechnol 124:732-746
-
(2006)
J Biotechnol
, vol.124
, pp. 732-746
-
-
Malphettes, L.1
Fussenegger, M.2
-
111
-
-
26444488248
-
A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1
-
Malphettes L, Weber CC, El-Baba MD, Schoenmakers RG, Aubel D, Weber W, Fussenegger M (2005) A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1. Nucleic Acids Res 33:e107
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Malphettes, L.1
Weber, C.C.2
El-Baba, M.D.3
Schoenmakers, R.G.4
Aubel, D.5
Weber, W.6
Fussenegger, M.7
-
112
-
-
0028183182
-
Kruppel-associated boxes are potent transcriptional repression domains
-
Margolin JF, Friedman JR, Meyer WKH, Vissing H, Thiesen HJ, Rauscher Iii FJ (1994) Kruppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci U S A 91:4509-4513
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4509-4513
-
-
Margolin, J.F.1
Friedman, J.R.2
Meyer, W.K.H.3
Vissing, H.4
Thiesen, H.J.5
Rauscher Iii, F.J.6
-
113
-
-
77953933421
-
Doxycycline regulated lentiviral vectors
-
Markusic D, Seppen J (2010) Doxycycline regulated lentiviral vectors. Meth Mol Biol 614:69-76
-
(2010)
Meth Mol Biol
, vol.614
, pp. 69-76
-
-
Markusic, D.1
Seppen, J.2
-
114
-
-
28644442724
-
Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter
-
Markusic D, Oude-Elferink R, Das AT, Berkhout B, Seppen J (2005) Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter. Nucleic Acids Res 33:e63
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Markusic, D.1
Oude-Elferink, R.2
Das, A.T.3
Berkhout, B.4
Seppen, J.5
-
115
-
-
77649273815
-
Recent advances in lentiviral vector development and applications
-
Mátrai J, Chuah MK, Vandendriessche T (2010) Recent advances in lentiviral vector development and applications. Mol Ther 18:477-490
-
(2010)
Mol Ther
, vol.18
, pp. 477-490
-
-
Mátrai, J.1
Chuah, M.K.2
Vandendriessche, T.3
-
116
-
-
9144222636
-
Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization
-
May T, Hauser H, Wirth D (2004a) Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization. Nucleic Acids Res 32:5529-5538
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 5529-5538
-
-
May, T.1
Hauser, H.2
Wirth, D.3
-
117
-
-
28444451898
-
Application of a reversible immortalization system for the generation of proliferation-controlled cell lines
-
May T, Lindenmaier W, Wirth D, Mueller PP (2004b) Application of a reversible immortalization system for the generation of proliferation-controlled cell lines. Cytotechnology 46:69-78
-
(2004)
Cytotechnology
, vol.46
, pp. 69-78
-
-
May, T.1
Lindenmaier, W.2
Wirth, D.3
Mueller, P.P.4
-
118
-
-
25644436462
-
Establishment of murine cell lines by constitutive and conditional immortalization
-
May T, Mueller PP, Weich H, Froese N, Deutsch U, Wirth D, Kroger A, Hauser H (2005) Establishment of murine cell lines by constitutive and conditional immortalization. J Biotechnol 120:99-110
-
(2005)
J Biotechnol
, vol.120
, pp. 99-110
-
-
May, T.1
Mueller, P.P.2
Weich, H.3
Froese, N.4
Deutsch, U.5
Wirth, D.6
Kroger, A.7
Hauser, H.8
-
119
-
-
33747350813
-
Current status of transcriptional regulation systems
-
May T, Hauser H, Wirth D (2006) Current status of transcriptional regulation systems. Cytotechnology 50:109-119
-
(2006)
Cytotechnology
, vol.50
, pp. 109-119
-
-
May, T.1
Hauser, H.2
Wirth, D.3
-
120
-
-
48649104164
-
Bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit
-
May T, Eccleston L, Herrmann S, Hauser H, Goncalves J, Wirth D (2008) Bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit. PLoS One 3:e2372
-
(2008)
PLoS One
, vol.3
-
-
May, T.1
Eccleston, L.2
Herrmann, S.3
Hauser, H.4
Goncalves, J.5
Wirth, D.6
-
121
-
-
77049100733
-
Synthetic gene regulation circuits for control of cell expansion
-
May T, Butueva M, Bantner S, Marcusic D, Seppen J, Weich H, Hauser H, Wirth D (2010) Synthetic gene regulation circuits for control of cell expansion. Tissue Eng Part A 16: 441-452
-
(2010)
Tissue Eng Part A
, vol.16
, pp. 441-452
-
-
May, T.1
Butueva, M.2
Bantner, S.3
Marcusic, D.4
Seppen, J.5
Weich, H.6
Hauser, H.7
Wirth, D.8
-
122
-
-
0032170308
-
Higher productivity of growtharrested Chinese hamster ovary cells expressing the cyclin-dependent kinase inhibitor p27
-
Mazur X, Fussenegger M, Renner WA, Bailey JE (1998) Higher productivity of growtharrested Chinese hamster ovary cells expressing the cyclin-dependent kinase inhibitor p27. Biotechnol Prog 14:705-713
-
(1998)
Biotechnol Prog
, vol.14
, pp. 705-713
-
-
Mazur, X.1
Fussenegger, M.2
Renner, W.A.3
Bailey, J.E.4
-
123
-
-
29144433988
-
Ionizing radiation: A genetic switch for cancer therapy
-
Mezhir JJ, Smith KD, Posner MC, Senzer N, Yamini B, Kufe DW, Weichselbaum RR (2006) Ionizing radiation: a genetic switch for cancer therapy. Cancer Gene Ther 13:1-6
-
(2006)
Cancer Gene Ther
, vol.13
, pp. 1-6
-
-
Mezhir, J.J.1
Smith, K.D.2
Posner, M.C.3
Senzer, N.4
Yamini, B.5
Kufe, D.W.6
Weichselbaum, R.R.7
-
125
-
-
0344668818
-
The frog prince: A reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells
-
Miskey C, Izsvák Z, Plasterk RH, Ivics Z (2003) The frog prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells. Nucleic Acids Res 31:6873-6881
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 6873-6881
-
-
Miskey, C.1
Izsvák, Z.2
Plasterk, R.H.3
Ivics, Z.4
-
126
-
-
35048827454
-
Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: Thrombopoietin and antibody
-
Mohan C, Park SH, Chung JY, Lee GM (2007) Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: thrombopoietin and antibody. Biotechnol Bioeng 98:611-615
-
(2007)
Biotechnol Bioeng
, vol.98
, pp. 611-615
-
-
Mohan, C.1
Park, S.H.2
Chung, J.Y.3
Lee, G.M.4
-
127
-
-
0030855387
-
Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor
-
Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W (1997) Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor. Biol Chem 378:669-677
-
(1997)
Biol Chem
, vol.378
, pp. 669-677
-
-
Moosmann, P.1
Georgiev, O.2
Thiesen, H.J.3
Hagmann, M.4
Schaffner, W.5
-
128
-
-
0028280007
-
Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: A model system for the derivation of tissue-specific and mutationspecific cell lines
-
Morgan JE, Beauchamp JR, Pagel CN, Peckham M, Ataliotis P, Jat PS, Noble MD, Farmer K, Partridge TA (1994) Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutationspecific cell lines. Dev Biol 162:486-498
-
(1994)
Dev Biol
, vol.162
, pp. 486-498
-
-
Morgan, J.E.1
Beauchamp, J.R.2
Pagel, C.N.3
Peckham, M.4
Ataliotis, P.5
Jat, P.S.6
Noble, M.D.7
Farmer, K.8
Partridge, T.A.9
-
129
-
-
33751268632
-
The cumate geneswitch: A system for regulated expression in mammalian cells
-
Mullick A, Xu Y, Warren R, Koutroumanis M, Guilbault C, Broussau S, Malenfant F, Bourget L, Lamoureux L, Lo R, Caron AW, Pilotte A, Massie B (2006) The cumate geneswitch: a system for regulated expression in mammalian cells. BMC Biotechnol 6:43
-
(2006)
BMC Biotechnol
, vol.6
, pp. 43
-
-
Mullick, A.1
Xu, Y.2
Warren, R.3
Koutroumanis, M.4
Guilbault, C.5
Broussau, S.6
Malenfant, F.7
Bourget, L.8
Lamoureux, L.9
Lo, R.10
Caron, A.W.11
Pilotte, A.12
Massie, B.13
-
130
-
-
0037298235
-
A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR
-
Neddermann P, Gargioli C, Muraglia E, Sambucini S, Bonelli F, De Francesco R, Cortese R (2003) A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR. EMBO Rep 4:159-165
-
(2003)
EMBO Rep
, vol.4
, pp. 159-165
-
-
Neddermann, P.1
Gargioli, C.2
Muraglia, E.3
Sambucini, S.4
Bonelli, F.5
de Francesco, R.6
Cortese, R.7
-
131
-
-
74749086258
-
Recombinant protein expression by targeting pre-selected chromosomal loci
-
Nehlsen K, Schucht R, da Gama-Norton L, Kromer W, Baer A, Cayli A, Hauser H, Wirth D (2009) Recombinant protein expression by targeting pre-selected chromosomal loci. BMC Biotechnol 9:100
-
(2009)
BMC Biotechnol
, vol.9
, pp. 100
-
-
Nehlsen, K.1
Schucht, R.2
da Gama-Norton, L.3
Kromer, W.4
Baer, A.5
Cayli, A.6
Hauser, H.7
Wirth, D.8
-
132
-
-
0036426628
-
The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy
-
Ngan ESW, Schillinger K, DeMayo F, Tsai SY (2002) The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy. Semin Cell Dev Biol 13:143-149
-
(2002)
Semin Cell Dev Biol
, vol.13
, pp. 143-149
-
-
Ngan, E.S.W.1
Schillinger, K.2
DeMayo, F.3
Tsai, S.Y.4
-
133
-
-
73349085934
-
An auxin-based degron system for the rapid depletion of proteins in nonplant cells
-
Nishimura K, Fukagawa T, Takisawa H, Kakimoto T, Kanemaki M (2009) An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat Methods 6:917-922
-
(2009)
Nat Methods
, vol.6
, pp. 917-922
-
-
Nishimura, K.1
Fukagawa, T.2
Takisawa, H.3
Kakimoto, T.4
Kanemaki, M.5
-
134
-
-
0029865151
-
Ecdysone-inducible gene expression in mammalian cells and transgenic mice
-
No D, Yao TP, Evans RM (1996) Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A 93:3346-3351
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 3346-3351
-
-
No, D.1
Yao, T.P.2
Evans, R.M.3
-
135
-
-
0036811515
-
Antiprogestin-controllable transgene regulation in vivo
-
Nordstrom JL (2002) Antiprogestin-controllable transgene regulation in vivo. Curr Opin Biotechnol 13:453-458
-
(2002)
Curr Opin Biotechnol
, vol.13
, pp. 453-458
-
-
Nordstrom, J.L.1
-
136
-
-
66149102465
-
Targeted transgenesis at the HPRT locus: An efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system
-
Palais G, Cat AND, Friedman H, Panek-Huet N, Millet A, Tronche F, Gellen B, Mercadier JJ, Peterson A, Jaisser F (2009) Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genom 37:140-146
-
(2009)
Physiol Genom
, vol.37
, pp. 140-146
-
-
Palais, G.1
Cat, A.N.D.2
Friedman, H.3
Panek-Huet, N.4
Millet, A.5
Tronche, F.6
Gellen, B.7
Mercadier, J.J.8
Peterson, A.9
Jaisser, F.10
-
137
-
-
0037038696
-
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
-
Pamment J, Ramsay E, Kelleher M, Dornan D, Ball KL (2002) Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. Oncogene 21:7776-7785
-
(2002)
Oncogene
, vol.21
, pp. 7776-7785
-
-
Pamment, J.1
Ramsay, E.2
Kelleher, M.3
Dornan, D.4
Ball, K.L.5
-
138
-
-
73449101112
-
Recent trends in non-viral vector-mediated gene delivery
-
Pathak A, Patnaik S, Gupta KC (2009) Recent trends in non-viral vector-mediated gene delivery. Biotechnol J 4:1559-1572
-
(2009)
Biotechnol J
, vol.4
, pp. 1559-1572
-
-
Pathak, A.1
Patnaik, S.2
Gupta, K.C.3
-
139
-
-
0032442810
-
Variable functions of bcl-2 in mediating bioreactor stress-induced apoptosis in hybridoma cells
-
Perani A, Singh RP, Chauhan R, Al-Rubeai M (1998) Variable functions of bcl-2 in mediating bioreactor stress-induced apoptosis in hybridoma cells. Cytotechnology 28: 177-188
-
(1998)
Cytotechnology
, vol.28
, pp. 177-188
-
-
Perani, A.1
Singh, R.P.2
Chauhan, R.3
Al-Rubeai, M.4
-
140
-
-
0028114235
-
Regulation of protein function through expression of chimaeric proteins
-
Picard D (1994) Regulation of protein function through expression of chimaeric proteins. Curr Opin Biotechnol 5:511-515
-
(1994)
Curr Opin Biotechnol
, vol.5
, pp. 511-515
-
-
Picard, D.1
-
141
-
-
77957343707
-
Chemical vectors for gene delivery: Uptake and intracellular trafficking
-
Pichon C, Billiet L, Midoux P (2010) Chemical vectors for gene delivery: uptake and intracellular trafficking. Curr Opin Biotechnol 21:640-645
-
(2010)
Curr Opin Biotechnol
, vol.21
, pp. 640-645
-
-
Pichon, C.1
Billiet, L.2
Midoux, P.3
-
142
-
-
41149127259
-
Comparison of zinc finger nucleases for use in gene targeting in mammalian cells
-
Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH (2008) Comparison of zinc finger nucleases for use in gene targeting in mammalian cells. Mol Ther 16:707-717
-
(2008)
Mol Ther
, vol.16
, pp. 707-717
-
-
Pruett-Miller, S.M.1
Connelly, J.P.2
Maeder, M.L.3
Joung, J.K.4
Porteus, M.H.5
-
143
-
-
62649096826
-
Designing new cellular signaling pathways
-
Pryciak PM (2009) Designing new cellular signaling pathways. Chem Biol 16:249-254
-
(2009)
Chem Biol
, vol.16
, pp. 249-254
-
-
Pryciak, P.M.1
-
144
-
-
34447310821
-
A universal RNAi-based logic evaluator that operates in mammalian cells
-
Rinaudo K, Bleris L, Maddamsetti R, Subramanian S, Weiss R, Benenson Y (2007) A universal RNAi-based logic evaluator that operates in mammalian cells. Nat Biotechnol 25:795-801
-
(2007)
Nat Biotechnol
, vol.25
, pp. 795-801
-
-
Rinaudo, K.1
Bleris, L.2
Maddamsetti, R.3
Subramanian, S.4
Weiss, R.5
Benenson, Y.6
-
145
-
-
0036182472
-
IRF-1 as a negative regulator of cell proliferation
-
Romeo G, Fiorucci G, Chiantore MV, Percario ZA, Vannucchi S, Affabris E (2002) IRF-1 as a negative regulator of cell proliferation. J Interferon Cytokine Res 22:39-47
-
(2002)
J Interferon Cytokine Res
, vol.22
, pp. 39-47
-
-
Romeo, G.1
Fiorucci, G.2
Chiantore, M.V.3
Percario, Z.A.4
Vannucchi, S.5
Affabris, E.6
-
146
-
-
0030021748
-
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
-
Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH (1996) Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. Embo J 15:827-838
-
(1996)
Embo J
, vol.15
, pp. 827-838
-
-
Rowan, S.1
Ludwig, R.L.2
Haupt, Y.3
Bates, S.4
Lu, X.5
Oren, M.6
Vousden, K.H.7
-
147
-
-
0037507281
-
Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation
-
Rybkin II, Markham DW, Yan Z, Bassel-Duby R, Williams RS, Olson EN (2003) Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. J Biol Chem 278:15927-15934
-
(2003)
J Biol Chem
, vol.278
, pp. 15927-15934
-
-
Rybkin, I.I.1
Markham, D.W.2
Yan, Z.3
Bassel-Duby, R.4
Williams, R.S.5
Olson, E.N.6
-
148
-
-
0034296940
-
Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes
-
Salmon P, Oberholzer J, Occhiodoro T, Morel P, Lou J, Trono D (2000) Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther 2:404-414
-
(2000)
Mol Ther
, vol.2
, pp. 404-414
-
-
Salmon, P.1
Oberholzer, J.2
Occhiodoro, T.3
Morel, P.4
Lou, J.5
Trono, D.6
-
149
-
-
78651322759
-
Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells
-
Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D (2010) Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells. Nucleic acids Res 39:e1
-
(2010)
Nucleic acids Res
, vol.39
-
-
Sandhu, U.1
Cebula, M.2
Behme, S.3
Riemer, P.4
Wodarczyk, C.5
Metzger, D.6
Reimann, J.7
Schirmbeck, R.8
Hauser, H.9
Wirth, D.10
-
150
-
-
0037139754
-
Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants
-
Sauerwald TM, Betenbaugh MJ, Oyler GA (2002) Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants. Biotechnol Bioeng 77:704-716
-
(2002)
Biotechnol Bioeng
, vol.77
, pp. 704-716
-
-
Sauerwald, T.M.1
Betenbaugh, M.J.2
Oyler, G.A.3
-
151
-
-
0037419710
-
Study of caspase inhibitors for limiting death in mammalian cell culture
-
Sauerwald TM, Oyler GA, Betenbaugh MJ (2003) Study of caspase inhibitors for limiting death in mammalian cell culture. Biotechnol Bioeng 81:329-340
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 329-340
-
-
Sauerwald, T.M.1
Oyler, G.A.2
Betenbaugh, M.J.3
-
152
-
-
33744481521
-
Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures
-
Sauerwald TM, Figueroa B Jr, Hardwick JM, Oyler GA, Betenbaugh MJ (2006) Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures. Biotechnol Bioeng 94:362-372
-
(2006)
Biotechnol Bioeng
, vol.94
, pp. 362-372
-
-
Sauerwald, T.M.1
Figueroa Jr., B.2
Hardwick, J.M.3
Oyler, G.A.4
Betenbaugh, M.J.5
-
153
-
-
34249298695
-
Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors
-
Schambach A, Galla M, Maetzig T, Loew R, Baum C (2007) Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors. Mol Ther 15: 1167-1173
-
(2007)
Mol Ther
, vol.15
, pp. 1167-1173
-
-
Schambach, A.1
Galla, M.2
Maetzig, T.3
Loew, R.4
Baum, C.5
-
154
-
-
0142104901
-
Higher expression of Fab antibody fragments in a CHO cell line at reduced temperature
-
Schatz SM, Kerschbaumer RJ, Gerstenbauer G, Kral M, Dorner F, Scheiflinger F (2003) Higher expression of Fab antibody fragments in a CHO cell line at reduced temperature. Biotechnol Bioeng 84:433-438
-
(2003)
Biotechnol Bioeng
, vol.84
, pp. 433-438
-
-
Schatz, S.M.1
Kerschbaumer, R.J.2
Gerstenbauer, G.3
Kral, M.4
Dorner, F.5
Scheiflinger, F.6
-
155
-
-
37649013169
-
Engineering eukaryotic protein factories
-
Schroder M (2008) Engineering eukaryotic protein factories. Biotechnol Lett 30:187-196
-
(2008)
Biotechnol Lett
, vol.30
, pp. 187-196
-
-
Schroder, M.1
-
156
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder M, Kaufman RJ (2005) The mammalian unfolded protein response. Annu Rev Biochem 74:739-789
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
157
-
-
33745668475
-
A new generation of retroviral producer cells: Predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors
-
Schucht R, Coroadinha AS, Zanta-Boussif MA, Verhoeyen E, Carrondo MJ, Hauser H, Wirth D (2006) A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors. Mol Ther 14: 285-292
-
(2006)
Mol Ther
, vol.14
, pp. 285-292
-
-
Schucht, R.1
Coroadinha, A.S.2
Zanta-Boussif, M.A.3
Verhoeyen, E.4
Carrondo, M.J.5
Hauser, H.6
Wirth, D.7
-
158
-
-
76749095812
-
Precise regulation of transgene expression level and control of cell physiology
-
Schucht R, Wirth D, May T (2009) Precise regulation of transgene expression level and control of cell physiology. Cell Biol Toxicol 26:29-42
-
(2009)
Cell Biol Toxicol
, vol.26
, pp. 29-42
-
-
Schucht, R.1
Wirth, D.2
May, T.3
-
159
-
-
0021986710
-
Building a metal-responsive promoter with synthetic regulatory elements
-
Searle PF, Stuart GW, Palmiter RD (1985) Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol 5:1480-1489
-
(1985)
Mol Cell Biol
, vol.5
, pp. 1480-1489
-
-
Searle, P.F.1
Stuart, G.W.2
Palmiter, R.D.3
-
160
-
-
3142658576
-
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
-
Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee AH, Qian SB, Zhao H, Yu X, Yang L, Tan BK, Rosenwald A, Hurt EM, Petroulakis E, Sonenberg N, Yewdell JW, Calame K, Glimcher LH, Staudt LM (2004) XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21:81-93
-
(2004)
Immunity
, vol.21
, pp. 81-93
-
-
Shaffer, A.L.1
Shapiro-Shelef, M.2
Iwakoshi, N.N.3
Lee, A.H.4
Qian, S.B.5
Zhao, H.6
Yu, X.7
Yang, L.8
Tan, B.K.9
Rosenwald, A.10
Hurt, E.M.11
Petroulakis, E.12
Sonenberg, N.13
Yewdell, J.W.14
Calame, K.15
Glimcher, L.H.16
Staudt, L.M.17
-
161
-
-
46349096298
-
Regulated gene insertion by steroid-induced PhiC31 integrase
-
Sharma N, Moldt B, Dalsgaard T, Jensen TG, Mikkelsen JG (2008) Regulated gene insertion by steroid-induced PhiC31 integrase. Nucleic Acids Res 36:e67
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Sharma, N.1
Moldt, B.2
Dalsgaard, T.3
Jensen, T.G.4
Mikkelsen, J.G.5
-
162
-
-
77649275761
-
Novel RNA-based strategies for therapeutic gene silencing
-
Sibley CR, Seow Y, Wood MJ (2010) Novel RNA-based strategies for therapeutic gene silencing. Mol Ther 18:466-476
-
(2010)
Mol Ther
, vol.18
, pp. 466-476
-
-
Sibley, C.R.1
Seow, Y.2
Wood, M.J.3
-
163
-
-
33846820101
-
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas
-
Siddiqui F, Li CY, Larue SM, Poulson JM, Avery PR, Pruitt AF, Zhang X, Ullrich RL, Thrall DE, Dewhirst MW, Hauck ML (2007) A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Mol Cancer Ther 6:380-389
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 380-389
-
-
Siddiqui, F.1
Li, C.Y.2
Larue, S.M.3
Poulson, J.M.4
Avery, P.R.5
Pruitt, A.F.6
Zhang, X.7
Ullrich, R.L.8
Thrall, D.E.9
Dewhirst, M.W.10
Hauck, M.L.11
-
165
-
-
22744455256
-
Gene therapy progress and prospects: Development of improved lentiviral and retroviral vectors-design, biosafety, and production
-
Sinn PL, Sauter SL, McCray PB Jr (2005) Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors-design, biosafety, and production. Gene Ther 12:1089-1098
-
(2005)
Gene Ther
, vol.12
, pp. 1089-1098
-
-
Sinn, P.L.1
Sauter, S.L.2
McCray Jr., P.B.3
-
166
-
-
33344477324
-
An improved Tet-On regulatable FasL-adenovirus vector system for lung cancer therapy
-
Sipo I, Hurtado Pico A, Wang X, Eberle J, Petersen I, Weger S, Poller W, Fechner H (2006) An improved Tet-On regulatable FasL-adenovirus vector system for lung cancer therapy. J Mol Med 84:215-225
-
(2006)
J Mol Med
, vol.84
, pp. 215-225
-
-
Sipo, I.1
Hurtado Pico, A.2
Wang, X.3
Eberle, J.4
Petersen, I.5
Weger, S.6
Poller, W.7
Fechner, H.8
-
167
-
-
35548970476
-
Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent
-
Strathdee D, Ibbotson H, Grant SGN (2006) Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent. PLoS ONE 1:e4
-
(2006)
PLoS ONE
, vol.1
-
-
Strathdee, D.1
Ibbotson, H.2
Grant, S.G.N.3
-
168
-
-
29044436756
-
Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin
-
Sung YH, Hwang SJ, Lee GM (2005) Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin. Metab Eng 7:457-466
-
(2005)
Metab Eng
, vol.7
, pp. 457-466
-
-
Sung, Y.H.1
Hwang, S.J.2
Lee, G.M.3
-
169
-
-
35549010214
-
Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin
-
Sung YH, Lee JS, Park SH, Koo J, Lee GM (2007) Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin. Metab Eng 9:452-464
-
(2007)
Metab Eng
, vol.9
, pp. 452-464
-
-
Sung, Y.H.1
Lee, J.S.2
Park, S.H.3
Koo, J.4
Lee, G.M.5
-
170
-
-
77949566751
-
Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest
-
Sunley K, Butler M (2010) Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest. Biotechnol Adv 28:385-394
-
(2010)
Biotechnol Adv
, vol.28
, pp. 385-394
-
-
Sunley, K.1
Butler, M.2
-
171
-
-
0034281735
-
Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells
-
Sunstrom NA, Gay RD, Wong DC, Kitchen NA, DeBoer L, Gray PP (2000) Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells. Biotechnol Prog 16:698-702
-
(2000)
Biotechnol Prog
, vol.16
, pp. 698-702
-
-
Sunstrom, N.A.1
Gay, R.D.2
Wong, D.C.3
Kitchen, N.A.4
DeBoer, L.5
Gray, P.P.6
-
172
-
-
0026095725
-
Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins
-
Superti-Furga G, Bergers G, Picard D, Busslinger M (1991) Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc Natl Acad Sci U S A 88:5114-5118
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 5114-5118
-
-
Superti-Furga, G.1
Bergers, G.2
Picard, D.3
Busslinger, M.4
-
173
-
-
51149102891
-
Intron length increases oscillatory periods of gene expression in animal cells
-
Swinburne IA, Miguez DG, Landgraf D, Silver PA (2008) Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev 22:2342-2346
-
(2008)
Genes Dev
, vol.22
, pp. 2342-2346
-
-
Swinburne, I.A.1
Miguez, D.G.2
Landgraf, D.3
Silver, P.A.4
-
174
-
-
0028276685
-
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
-
Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lamphier MS, Aizawa S, Mak TW, Taniguchi T (1994) Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77:829-839
-
(1994)
Cell
, vol.77
, pp. 829-839
-
-
Tanaka, N.1
Ishihara, M.2
Kitagawa, M.3
Harada, H.4
Kimura, T.5
Matsuyama, T.6
Lamphier, M.S.7
Aizawa, S.8
Mak, T.W.9
Taniguchi, T.10
-
175
-
-
16044362508
-
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
-
Tanaka N, Ishihara M, Lamphier MS, Nozawa H, Matsuyama T, Mak TW, Aizawa S, Tokino T, Oren M, Taniguchi T (1996) Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature 382:816-818
-
(1996)
Nature
, vol.382
, pp. 816-818
-
-
Tanaka, N.1
Ishihara, M.2
Lamphier, M.S.3
Nozawa, H.4
Matsuyama, T.5
Mak, T.W.6
Aizawa, S.7
Tokino, T.8
Oren, M.9
Taniguchi, T.10
-
176
-
-
2442681626
-
Stringent rosiglitazone-dependent gene switch in muscle cells without effect on myogenic differentiation
-
Tascou S, Sorensen TK, Glenat V, Wang M, Lakich MM, Darteil R, Vigne E, Thuillier V (2004) Stringent rosiglitazone-dependent gene switch in muscle cells without effect on myogenic differentiation. Mol Ther 9:637-649
-
(2004)
Mol Ther
, vol.9
, pp. 637-649
-
-
Tascou, S.1
Sorensen, T.K.2
Glenat, V.3
Wang, M.4
Lakich, M.M.5
Darteil, R.6
Vigne, E.7
Thuillier, V.8
-
178
-
-
77950435582
-
A synthetic low-frequency mammalian oscillator
-
Tigges M, Denervaud N, Greber D, Stelling J, Fussenegger M (2010) A synthetic low-frequency mammalian oscillator. Nucleic Acids Res 38:2702-2711
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 2702-2711
-
-
Tigges, M.1
Denervaud, N.2
Greber, D.3
Stelling, J.4
Fussenegger, M.5
-
179
-
-
78049239445
-
A synthetic-natural hybrid oscillator in human cells
-
Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G (2010) A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A 107:17047-17052
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 17047-17052
-
-
Toettcher, J.E.1
Mock, C.2
Batchelor, E.3
Loewer, A.4
Lahav, G.5
-
180
-
-
33747144131
-
Process parameter shifting: Part II. Biphasic-a tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells
-
Trummer E, Fauland K, Seidinger S, Schriebl K, Lattenmayer C, Kunert R, Vorauer-Uhl K, Weik R, Borth N, Katinger H, Müller D (2006) Process parameter shifting: part II. Biphasic-a tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells. Biotechnol Bioeng 94:1045-1052
-
(2006)
Biotechnol Bioeng
, vol.94
, pp. 1045-1052
-
-
Trummer, E.1
Fauland, K.2
Seidinger, S.3
Schriebl, K.4
Lattenmayer, C.5
Kunert, R.6
Vorauer-Uhl, K.7
Weik, R.8
Borth, N.9
Katinger, H.10
Müller, D.11
-
181
-
-
0035190644
-
Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes
-
Unsinger J, Kröger A, Hauser H, Wirth D (2001) Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes. Mol Ther 4:484-489
-
(2001)
Mol Ther
, vol.4
, pp. 484-489
-
-
Unsinger, J.1
Kröger, A.2
Hauser, H.3
Wirth, D.4
-
182
-
-
2942527253
-
Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer
-
Unsinger J, Lindenmaier W, May T, Hauser H, Wirth D (2004) Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer. Biochem Biophys Res Commun 319: 879-887
-
(2004)
Biochem Biophys Res Commun
, vol.319
, pp. 879-887
-
-
Unsinger, J.1
Lindenmaier, W.2
May, T.3
Hauser, H.4
Wirth, D.5
-
183
-
-
0034608802
-
Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
-
Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A 97:7963-7968
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7963-7968
-
-
Urlinger, S.1
Baron, U.2
Thellmann, M.3
Hasan, M.T.4
Bujard, H.5
Hillen, W.6
-
184
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD (2010) Genome editing with engineered zinc finger nucleases. Nat Rev Genet 11:636-646
-
(2010)
Nat Rev Genet
, vol.11
, pp. 636-646
-
-
Urnov, F.D.1
Rebar, E.J.2
Holmes, M.C.3
Zhang, H.S.4
Gregory, P.D.5
-
185
-
-
0026653659
-
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor
-
Vegeto E, Allan GF, Schrader WT, Tsai MJ, McDonnell DP, O'Malley BW (1992) The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 69:703-713
-
(1992)
Cell
, vol.69
, pp. 703-713
-
-
Vegeto, E.1
Allan, G.F.2
Schrader, W.T.3
Tsai, M.J.4
McDonnell, D.P.5
O'Malley, B.W.6
-
186
-
-
4644258829
-
Adenoviral vectors for gene transfer and therapy
-
Volpers C, Kochanek S (2004) Adenoviral vectors for gene transfer and therapy. J Gene Med 6:S164-S171
-
(2004)
J Gene Med
, vol.6
-
-
Volpers, C.1
Kochanek, S.2
-
187
-
-
0028282633
-
Tissue and serum levels of steroid hormones and RU 486 after administration of mifepristone
-
Wang JD, Shi WL, Zhang GQ, Bai XM (1994) Tissue and serum levels of steroid hormones and RU 486 after administration of mifepristone. Contraception 49:245-253
-
(1994)
Contraception
, vol.49
, pp. 245-253
-
-
Wang, J.D.1
Shi, W.L.2
Zhang, G.Q.3
Bai, X.M.4
-
188
-
-
33645318751
-
Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
-
Wang GG, Calvo KR, Pasillas MP, Sykes DB, Hacker H, Kamps MP (2006) Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods 3:287-293
-
(2006)
Nat Methods
, vol.3
, pp. 287-293
-
-
Wang, G.G.1
Calvo, K.R.2
Pasillas, M.P.3
Sykes, D.B.4
Hacker, H.5
Kamps, M.P.6
-
189
-
-
0348133603
-
A stable murine-based RD114 retroviral packaging line efficiently transduces human hematopoietic cells
-
Ward M, Sattler R, Grossman IR, Bell AJ Jr, Skerrett D, Baxi L, Bank A (2003) A stable murine-based RD114 retroviral packaging line efficiently transduces human hematopoietic cells. Mol Ther 8:804-812
-
(2003)
Mol Ther
, vol.8
, pp. 804-812
-
-
Ward, M.1
Sattler, R.2
Grossman, I.R.3
Bell Jr., A.J.4
Skerrett, D.5
Baxi, L.6
Bank, A.7
-
190
-
-
0037021802
-
Regulation of cell cycle and productivity in NS0 cells by the over-expression of p21CIP1
-
Watanabe S, Shuttleworth J, Al-Rubeai M (2002) Regulation of cell cycle and productivity in NS0 cells by the over-expression of p21CIP1. Biotechnol Bioeng 77:1-7
-
(2002)
Biotechnol Bioeng
, vol.77
, pp. 1-7
-
-
Watanabe, S.1
Shuttleworth, J.2
Al-Rubeai, M.3
-
191
-
-
77957369335
-
Synthetic gene networks in mammalian cells
-
Weber W, Fussenegger M (2010) Synthetic gene networks in mammalian cells. Curr Opin Biotechnol 21:690-696
-
(2010)
Curr Opin Biotechnol
, vol.21
, pp. 690-696
-
-
Weber, W.1
Fussenegger, M.2
-
193
-
-
0038239238
-
Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system
-
Weber W, Marty RR, Link N, Ehrbar M, Keller B, Weber CC, Zisch AH, Heinzen C, Djonov V, Fussenegger M (2003a) Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system. Nucleic Acids Res 31:e69
-
(2003)
Nucleic Acids Res
, vol.31
-
-
Weber, W.1
Marty, R.R.2
Link, N.3
Ehrbar, M.4
Keller, B.5
Weber, C.C.6
Zisch, A.H.7
Heinzen, C.8
Djonov, V.9
Fussenegger, M.10
-
194
-
-
0242348870
-
Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice
-
Weber W, Schoenmakers R, Spielmann M, El-Baba MD, Folcher M, Keller B, Weber CC, Link N, van de Wetering P, Heinzen C, Jolivet B, Sequin U, Aubel D, Thompson CJ, Fussenegger M (2003b) Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice. Nucleic Acids Res 31:e71
-
(2003)
Nucleic Acids Res
, vol.31
-
-
Weber, W.1
Schoenmakers, R.2
Spielmann, M.3
El-Baba, M.D.4
Folcher, M.5
Keller, B.6
Weber, C.C.7
Link, N.8
van de Wetering, P.9
Heinzen, C.10
Jolivet, B.11
Sequin, U.12
Aubel, D.13
Thompson, C.J.14
Fussenegger, M.15
-
195
-
-
60949111303
-
A biotin-triggered genetic switch in mammalian cells and mice
-
Weber W, Lienhart C, Baba MD, Fussenegger M (2009a) A biotin-triggered genetic switch in mammalian cells and mice. Metab Eng 11:117-124
-
(2009)
Metab Eng
, vol.11
, pp. 117-124
-
-
Weber, W.1
Lienhart, C.2
Baba, M.D.3
Fussenegger, M.4
-
196
-
-
67650360436
-
A synthetic metabolite-based mammalian inter-cell signaling system
-
Weber W, Schuetz M, Denervaud N, Fussenegger M (2009b) A synthetic metabolite-based mammalian inter-cell signaling system. Mol Biosyst 5:757-763
-
(2009)
Mol Biosyst
, vol.5
, pp. 757-763
-
-
Weber, W.1
Schuetz, M.2
Denervaud, N.3
Fussenegger, M.4
-
197
-
-
62549134078
-
A synthetic mammalian electro-genetic transcription circuit
-
Weber W, Luzi S, Karlsson M, Sanchez-Bustamante CD, Frey U, Hierlemann A, Fussenegger M (2009c) A synthetic mammalian electro-genetic transcription circuit. Nucleic Acids Res 37:e33
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Weber, W.1
Luzi, S.2
Karlsson, M.3
Sanchez-Bustamante, C.D.4
Frey, U.5
Hierlemann, A.6
Fussenegger, M.7
-
198
-
-
76749135226
-
Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo
-
Wells DJ (2010) Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo. Cell Biol Toxicol 26:21-28
-
(2010)
Cell Biol Toxicol
, vol.26
, pp. 21-28
-
-
Wells, D.J.1
-
199
-
-
17444369067
-
Remote control of gene transcription
-
West AG, Fraser P (2005) Remote control of gene transcription. Hum Mol Genet 14: R101-R111
-
(2005)
Hum Mol Genet
, vol.14
-
-
West, A.G.1
Fraser, P.2
-
200
-
-
36148961543
-
Road to precision: Recombinase-based targeting technologies for genome engineering
-
Wirth D, Gama-Norton L, Riemer P, Sandhu U, Schucht R, Hauser H (2007) Road to precision: recombinase-based targeting technologies for genome engineering. Curr Opin Biotechnol 18:411-419
-
(2007)
Curr Opin Biotechnol
, vol.18
, pp. 411-419
-
-
Wirth, D.1
Gama-Norton, L.2
Riemer, P.3
Sandhu, U.4
Schucht, R.5
Hauser, H.6
-
201
-
-
33744455813
-
Targeting early apoptotic genes in batch and fed-batch CHO cell cultures
-
Wong DC, Wong KT, Nissom PM, Heng CK, Yap MG (2006) Targeting early apoptotic genes in batch and fed-batch CHO cell cultures. Biotechnol Bioeng 95:350-361
-
(2006)
Biotechnol Bioeng
, vol.95
, pp. 350-361
-
-
Wong, D.C.1
Wong, K.T.2
Nissom, P.M.3
Heng, C.K.4
Yap, M.G.5
-
203
-
-
69949104482
-
A genetically encoded photoactivatable Rac controls the motility of living cells
-
Wu YI, Frey D, Lungu OI, Jaehrig A, Schlichting I, Kuhlman B, Hahn KM (2009) A genetically encoded photoactivatable Rac controls the motility of living cells. Nature 461:104-108
-
(2009)
Nature
, vol.461
, pp. 104-108
-
-
Wu, Y.I.1
Frey, D.2
Lungu, O.I.3
Jaehrig, A.4
Schlichting, I.5
Kuhlman, B.6
Hahn, K.M.7
-
204
-
-
2942533342
-
Illegitimate DNA integration in mammalian cells
-
Würtele H, Little KCE, Chartrand P (2003) Illegitimate DNA integration in mammalian cells. Gene Ther 10:1791-1799
-
(2003)
Gene Ther
, vol.10
, pp. 1791-1799
-
-
Würtele, H.1
Little, K.C.E.2
Chartrand, P.3
-
205
-
-
0025985356
-
Hepatocyte cell lines established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene
-
Yanai N, Suzuki M, Obinata M (1991) Hepatocyte cell lines established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene. Exp Cell Res 197:50-56
-
(1991)
Exp Cell Res
, vol.197
, pp. 50-56
-
-
Yanai, N.1
Suzuki, M.2
Obinata, M.3
-
206
-
-
33845621580
-
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells
-
Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC Jr, Zhou C, Liu J (2007) Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis 28:174-182
-
(2007)
Carcinogenesis
, vol.28
, pp. 174-182
-
-
Yang, G.1
Rosen, D.G.2
Mercado-Uribe, I.3
Colacino, J.A.4
Mills, G.B.5
Bast Jr., R.C.6
Zhou, C.7
Liu, J.8
-
207
-
-
0032170171
-
Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells
-
Yao F, Svensjo T, Winkler T, Lu M, Eriksson C, Eriksson E (1998) Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells. Hum Gene Ther 9:1939-1950
-
(1998)
Hum Gene Ther
, vol.9
, pp. 1939-1950
-
-
Yao, F.1
Svensjo, T.2
Winkler, T.3
Lu, M.4
Eriksson, C.5
Eriksson, E.6
-
208
-
-
43149108161
-
A bistable Rb-E2F switch underlies the restriction point
-
Yao G, Lee TJ, Mori S, Nevins JR, You L (2008) A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 10:476-482
-
(2008)
Nat Cell Biol
, vol.10
, pp. 476-482
-
-
Yao, G.1
Lee, T.J.2
Mori, S.3
Nevins, J.R.4
You, L.5
-
210
-
-
0041476091
-
Effect of low culture temperature on specific productivity and transcription level of anti-4-1BB antibody in recombinant Chinese hamster ovary cells
-
Yoon SK, Kim SH, Lee GM (2003a) Effect of low culture temperature on specific productivity and transcription level of anti-4-1BB antibody in recombinant Chinese hamster ovary cells. Biotechnol Prog 19:1383-1386
-
(2003)
Biotechnol Prog
, vol.19
, pp. 1383-1386
-
-
Yoon, S.K.1
Kim, S.H.2
Lee, G.M.3
-
211
-
-
0037420754
-
Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells
-
Yoon SK, Song JY, Lee GM (2003b) Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells. Biotechnol Bioeng 82:289-298
-
(2003)
Biotechnol Bioeng
, vol.82
, pp. 289-298
-
-
Yoon, S.K.1
Song, J.Y.2
Lee, G.M.3
-
212
-
-
10044226092
-
Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: Clonal variation
-
Yoon SK, Hwang SO, Lee GM (2004) Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: clonal variation. Biotechnol Prog 20:1683-1688
-
(2004)
Biotechnol Prog
, vol.20
, pp. 1683-1688
-
-
Yoon, S.K.1
Hwang, S.O.2
Lee, G.M.3
-
213
-
-
33645358361
-
Adaptation of Chinese hamster ovary cells to low culture temperature: Cell growth and recombinant protein production
-
Yoon SK, Hong JK, Choo SH, Song JY, Park HW, Lee GM (2006) Adaptation of Chinese hamster ovary cells to low culture temperature: cell growth and recombinant protein production. J Biotechnol 122:463-472
-
(2006)
J Biotechnol
, vol.122
, pp. 463-472
-
-
Yoon, S.K.1
Hong, J.K.2
Choo, S.H.3
Song, J.Y.4
Park, H.W.5
Lee, G.M.6
-
214
-
-
0346132122
-
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells
-
Yu SF, von Ruden T, Kantoff PW, Garber C, Seiberg M, Ruther U, Anderson WF, Wagner EF, Gilboa E (1986) Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci U S A 83:3194-3198
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 3194-3198
-
-
Yu, S.F.1
von Ruden, T.2
Kantoff, P.W.3
Garber, C.4
Seiberg, M.5
Ruther, U.6
Anderson, W.F.7
Wagner, E.F.8
Gilboa, E.9
-
215
-
-
0344010997
-
A coumermycin/novobiocin-regulated gene expression system
-
Zhao HF, Boyd J, Jolicoeur N, Shen SH (2003) A coumermycin/novobiocin-regulated gene expression system. Hum Gene Ther 14:1619-1629
-
(2003)
Hum Gene Ther
, vol.14
, pp. 1619-1629
-
-
Zhao, H.F.1
Boyd, J.2
Jolicoeur, N.3
Shen, S.H.4
-
216
-
-
0035816681
-
Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice
-
Zhu Z, Ma B, Homer RJ, Zheng T, Elias JA (2001) Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J Biol Chem 276:25222-25229
-
(2001)
J Biol Chem
, vol.276
, pp. 25222-25229
-
-
Zhu, Z.1
Ma, B.2
Homer, R.J.3
Zheng, T.4
Elias, J.A.5
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