Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells

Biotechnology and Applied Biochemistry

Volumn 53, Issue 2, 2009, Pages 73-83

  Jenkins, Nigel ^a   Meleady, Paula ^b   Tyther, Raymond ^a   Murphy, Lisa ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Mammalian cell culture; Protein expression; Protein modification; Protein quality; Secretion; Therapeutics

Indexed keywords

MAMMALIAN CELL CULTURE; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN QUALITY; SECRETION; THERAPEUTICS;

ANIMAL CELL CULTURE; CELL MEMBRANES; DRUG PRODUCTS PLANTS; LIGANDS; MAMMALS; MONOCLONAL ANTIBODIES; PROTEINS;

CELL CULTURE;

ASPARAGINE; CHAPERONE; DISULFIDE; METHIONINE; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANALYTIC METHOD; CELL LINE; CHROMATOGRAPHY; CULTURE MEDIUM; DISULFIDE BOND; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG SYNTHESIS; FIELD FLOW FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MAMMAL CELL; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; OSMOTIC PRESSURE; OXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEOMICS; QUALITY CONTROL; REVIEW; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TEMPERATURE; ULTRACENTRIFUGATION; ANIMAL; BIOSYNTHESIS; CELL; GENE EXPRESSION; GENETIC ENGINEERING; GENETICS; HUMAN; METABOLISM; METHODOLOGY; STANDARD;

MAMMALIA;

ANIMALS; CELL LINE; CELLS; GENE EXPRESSION; GENETIC ENGINEERING; HUMANS; PROTEOMICS; RECOMBINANT PROTEINS;

EID: 67649664208     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20080258     Document Type: Review

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