Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 26, 2009, Pages 10638-10643

  Gitzinger, Marc ^a   Kemmer, Christian ^a   El Baba, Marie Daoud ^b   Weber, Wilfried ^a,c   Fussenegger, Martin ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Biopharmaceutical manufacturing; Gene therapy; Synthetic biology; Synthetic gene networks; Transdermal gene regulation

Indexed keywords

ALGINATE POLYLYSINE ALGINATE; ALKALINE PHOSPHATASE; PHLORETIN; SECRETED ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LOTION; MOUSE; NONHUMAN; OPERON; PHLORETIN ADJUSTABLE CONTROL ELEMENT; PRIORITY JOURNAL; PSEUDOMONAS PUTIDA; TRANSGENE; TTGR OPERON;

ALKALINE PHOSPHATASE; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL TRANSPLANTATION; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DERMATOLOGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GENE EXPRESSION REGULATION; GENETIC VECTORS; HUMANS; MALUS; MICE; NIH 3T3 CELLS; OPERON; PHLORETIN; PSEUDOMONAS PUTIDA; RESPONSE ELEMENTS; TRANSFECTION; TRANSGENES;

MALUS X DOMESTICA; MAMMALIA; MUS; PSEUDOMONAS PUTIDA;

EID: 67649819663     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901501106     Document Type: Article

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