Gene regulation by tetracyclines: Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

European Journal of Biochemistry

Volumn 270, Issue 15, 2003, Pages 3109-3121

  Berens, Christian ^a   Hillen, Wolfgang ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Antibiotic resistance; Disease models; Fusion protein; Inducible gene expression; Ligand binding specificity; Mammalian cell lines; Protein engineering; Structure activity relationship; Tet repressor; Transgenic organism

Indexed keywords

MEMBRANE PROTEIN; PROTEIN TETA; REPRESSOR PROTEIN; TET REPRESSOR PROTEIN; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; BINDING AFFINITY; DIFFUSION; DRUG PENETRATION; DRUG STRUCTURE; EUKARYOTE; GENE CONTROL; GENE EXPRESSION REGULATION; GRAM NEGATIVE BACTERIUM; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; REPRESSOR GENE; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; EUKARYOTIC CELLS; GENE EXPRESSION REGULATION; GRAM-NEGATIVE BACTERIA; MODELS, GENETIC; ORGANISMS, GENETICALLY MODIFIED; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TETRACYCLINE RESISTANCE; TETRACYCLINES; TRANSCRIPTION FACTORS;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; NEGIBACTERIA;

EID: 0042268512     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03694.x     Document Type: Review

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