LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop

FASEB Journal

Volumn 21, Issue 9, 2007, Pages 2020-2032

  Davey, Ryan E ^a   Onishi, Kento ^a   Mahdavi, Alborz ^a,b   Zandstra, Peter W ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cell signaling; Jak STAT; Positive feedback; Systems biology; Threshold

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; AUTOREGULATION; CELL DIFFERENTIATION; CELL FATE; CELL RENEWAL; EMBRYONIC STEM CELL; GENE SWITCHING; MATHEMATICAL MODEL; POSITIVE FEEDBACK; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; AUTOCRINE COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; CYTOKINE RECEPTOR GP130; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; FEEDBACK, BIOCHEMICAL; HOMEODOMAIN PROTEINS; LEUKEMIA INHIBITORY FACTOR; MICE; MODELS, BIOLOGICAL; OCTAMER TRANSCRIPTION FACTOR-3; RECEPTORS, OSM-LIF; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 34347394540     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7852com     Document Type: Article

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