Cellular transformation by SV40 large T antigen: Interaction with host proteins

Seminars in Cancer Biology

Volumn 11, Issue 1, 2001, Pages 15-22

  Ali, Syed Hamid ^a   DeCaprio, James A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

p53; pRB; SV40; T antigen

Indexed keywords

ONCOPROTEIN; PROTEIN; PROTEIN CBP; PROTEIN P300; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN;

ANTIGEN BINDING; ARTICLE; CELL TRANSFORMATION; HUMAN; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIMIAN VIRUS 40; TUMOR SUPPRESSOR GENE;

EID: 0035100475     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0342     Document Type: Article

References (78)

1. The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions
2. Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53
3. Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations
4. Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen
5. Association of p300 and CBP with simian virus 40 large T antigen
6. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
7. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
8. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120
9. Chaperone power in a virus?
10. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication
11. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
12. Cellular targets for transformation by the adenovirus E1A proteins
13. p53: Puzzle and paradigm
14. Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen
15. TAF-like function of SV40 large T antigen
16. The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300
17. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
18. The RB family of cell cycle regulatory factors
19. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
20. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
21. Identification of a growth suppression domain within the retinoblastoma gene product
22. Subunit composition determines E2F DNA-binding site specificity
23. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
24. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
25. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo
26. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
27. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations
28. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product
29. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins
30. Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40
31. Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen
32. Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation
33. Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107
34. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
35. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
36. T antigen is bound to a host protein in SV40-transformed cells
37. p53, the cellular gatekeeper for growth and division
38. p53 function and dysfunction
39. Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
40. p53 and cell-cycle control: A finger in every pie
41. Abrogation of p53-mediated transactivation by SV40 large T antigen
42. SV40 T antigen abrogates p53-mediated transcriptional activity
43. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein
44. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53
45. Wild-type p53 activates transcription in vitro
46. Functions of the MDM2 oncoprotein
47. MDM2 function
48. MDM2 - Arbiter of p53's destruction
49. Mdm2: The ups and downs
50. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
51. Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells
52. A subset of cells expressing SV40 large T antigen contain elevated p53 levels and have an altered cell cycle phenotype
53. The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein
54. MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection
55. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
56. Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
57. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
58. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
59. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
60. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
61. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
62. p53-dependent apoptosis suppresses tumor growth and progression in vivo
63. p53 and E2F-1 cooperate to mediate apoptosis
64. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
65. Phosphorylated CREB binds specifically to the nuclear protein CBP
66. Binding and modulation of p53 by p300/CBP coactivators
67. Synergistic activation of transcription by CBP and p53
68. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
69. CBP/p300 in cell growth, transformation, and development
70. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
71. p300 gene alterations in colorectal and gastric carcinomas
72. Mutations truncating the EP300 acetylase in human cancers
73. Recruitment of p300/CBP in p53-dependent signal pathways
74. Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products
75. The CBP co-activator stimulates E2F1/DP1 activity
76. Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein
77. Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm
78. Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen