메뉴 건너뛰기




Volumn 15, Issue 4, 1996, Pages 827-838

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

Author keywords

Apoptosis; G1 arrest; p53; Transcriptional activation; Tumor suppression

Indexed keywords

PROTEIN P53;

EID: 0030021748     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00418.x     Document Type: Article
Times cited : (295)

References (84)
  • 2
    • 0028946766 scopus 로고
    • 2 arrest-dependent immunoglobulin κ light chain gene expression
    • 2 arrest-dependent immunoglobulin κ light chain gene expression. EMBO J., 14, 1392-1401.
    • (1995) EMBO J. , vol.14 , pp. 1392-1401
    • Aloni-Grinstein, R.1    Schwartz, D.2    Rotter, V.3
  • 3
    • 0025040233 scopus 로고
    • Suppression of human colorectal carcinoma cell growth by wild-type p53
    • Baker, S.J., Markowitz, S., Fearon, E.R , Willson, J K V. and Vogelstein, B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science, 249, 912-915.
    • (1990) Science , vol.249 , pp. 912-915
    • Baker, S.J.1    Markowitz, S.2    Fearon, E.R.3    Willson, J.K.V.4    Vogelstein, B.5
  • 4
    • 0027459198 scopus 로고
    • mdm-2 expression is induced by wild type p53 activity
    • Barak, Y., Juven, T, Haffner, R. and Oren, M. (1993) mdm-2 expression is induced by wild type p53 activity. EMBO J., 12, 461-468.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 6
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles, C., Helmberg, A. and Karin, M (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature, 370, 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 7
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • Canman, C.E., Gilmer, T.M., Coutts, S.B. and Kastan, M.B. (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev., 9, 600-611.
    • (1995) Genes Dev. , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 8
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen, J.D., Marechal, V. and Levine, A.J. (1993a) Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol., 13, 4107-1114.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4107-11114
    • Chen, J.D.1    Marechal, V.2    Levine, A.J.3
  • 9
    • 0027203117 scopus 로고
    • Heterogeneity of transcriptional activity of mutant p53 protein and p53 DNA target sequences
    • Chen, J.Y., Funk, W.D., Wright, W.E., Shay, J.W. and Minna, J.D (1993b) Heterogeneity of transcriptional activity of mutant p53 protein and p53 DNA target sequences. Oncogene, 8, 2159-2166.
    • (1993) Oncogene , vol.8 , pp. 2159-2166
    • Chen, J.Y.1    Funk, W.D.2    Wright, W.E.3    Shay, J.W.4    Minna, J.D.5
  • 10
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor-suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho, Y., Gorina, S., Jeffery, P.D. and Pavletich, N.P (1994) Crystal structure of a p53 tumor-suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffery, P.D.3    Pavletich, N.P.4
  • 11
    • 0026731894 scopus 로고
    • Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents
    • Collins, M.K.L., Marvel, J., Malde, P. and Lopez-Rivas, A. (1992) Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J. Exp. Med., 176, 1043-1051.
    • (1992) J. Exp. Med. , vol.176 , pp. 1043-1051
    • Collins, M.K.L.1    Marvel, J.2    Malde, P.3    Lopez-Rivas, A.4
  • 12
    • 0029028158 scopus 로고
    • A direct effect of activated human p53 on nuclear DNA replication
    • Cox, L.S., Hupp, T., Midgley, C.A. and Lane, D.P. (1995) A direct effect of activated human p53 on nuclear DNA replication. EMBO J., 14, 2099-2105.
    • (1995) EMBO J. , vol.14 , pp. 2099-2105
    • Cox, L.S.1    Hupp, T.2    Midgley, C.A.3    Lane, D.P.4
  • 13
    • 0026070670 scopus 로고
    • Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression
    • Crook, T., Fisher, C. and Vousden, K.H. (1991) Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression. J. Virol, 65, 505-511.
    • (1991) J. Virol , vol.65 , pp. 505-511
    • Crook, T.1    Fisher, C.2    Vousden, K.H.3
  • 14
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., Marston, N.J., Sara, E.A. and Vousden, K.H. (1994) Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell, 79, 817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 16
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M and White, E. (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev., 7, 546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 17
    • 0028325483 scopus 로고
    • Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7
    • Demers, G.W., Foster, S.A., Halbert, C.L. and Galloway, D.A. (1994) Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc. Natl Acad. Sci. USA, 91, 4382-4386.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 4382-4386
    • Demers, G.W.1    Foster, S.A.2    Halbert, C.L.3    Galloway, D.A.4
  • 18
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell, 82, 675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 19
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo, A., Linke, S.P., Clarkin, K. and Wahl, G.M (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts Genes Dev., 8, 2540-2551.
    • (1994) Genes Dev. , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 20
    • 0025086953 scopus 로고
    • p53 functions as a cell cycle control protein in osteosarcomas
    • Diller, L. et al. (1990) p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell. Biol., 10, 5772-5781.
    • (1990) Mol Cell. Biol. , vol.10 , pp. 5772-5781
    • Diller, L.1
  • 22
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., Kaufmann, W.K., Wilson, S.J., Tlsty, T.D., Lees, E., Harper, J.W., Elledge, S.J. and Reed, S.I. (1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell, 76, 1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 24
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumour suppression
    • El-Deiry, W. et al. (1993) WAF1, a potential mediator of p53 tumour suppression. Cell, 75, 817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.1
  • 25
    • 0027500246 scopus 로고
    • Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
    • Fritsche, M., Haessler, C. and Brandner, G (1993) Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene, 8, 307-318.
    • (1993) Oncogene , vol.8 , pp. 307-318
    • Fritsche, M.1    Haessler, C.2    Brandner, G.3
  • 26
    • 0026650531 scopus 로고
    • A transcriptionally active DNA-binding site for human p53 protein complexes
    • Funk, W.D., Pak, D.T. Karas, R.H., Wright, W.E. and Shay, J.W. (1992) A transcriptionally active DNA-binding site for human p53 protein complexes Mol Cell. Biol., 12, 2866-2871.
    • (1992) Mol Cell. Biol. , vol.12 , pp. 2866-2871
    • Funk, W.D.1    Pak, D.T.2    Karas, R.H.3    Wright, W.E.4    Shay, J.W.5
  • 27
    • 0028294898 scopus 로고
    • Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3 dependent hematopoietic cells following IL-3 withdrawal
    • Gottlieb, E., Haffner, R., von Ruden, T, Wagner, E.F. and Oren, M. (1994) Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3 dependent hematopoietic cells following IL-3 withdrawal. EMBO J., 13, 1368-1374
    • (1994) EMBO J. , vol.13 , pp. 1368-1374
    • Gottlieb, E.1    Haffner, R.2    Von Ruden, T.3    Wagner, E.F.4    Oren, M.5
  • 28
    • 0029023560 scopus 로고
    • Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: Blocking p53-induced apoptosis unmasks G1 arrest
    • Guillouf, C., Grana, X., Selvakumaran, M., De Luca, A., Giordano, A., Hoffman, B. and Liebermann, D.A. (1995) Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest. Blood, 85, 2691-2698.
    • (1995) Blood , vol.85 , pp. 2691-2698
    • Guillouf, C.1    Grana, X.2    Selvakumaran, M.3    De Luca, A.4    Giordano, A.5    Hoffman, B.6    Liebermann, D.A.7
  • 29
    • 0019401161 scopus 로고
    • Monoclonal antibodies specific for simian virus 40 tumor antigens
    • Harlow, E., Crawford, L.V., Pim, D.C. and Williamson, N.M. (1981) Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol., 39, 861-869.
    • (1981) J. Virol. , vol.39 , pp. 861-869
    • Harlow, E.1    Crawford, L.V.2    Pim, D.C.3    Williamson, N.M.4
  • 30
    • 0028999429 scopus 로고
    • p53-mediated apoptosis in HeLa cells can be overcome by excess pRB
    • Haupt, Y., Rowan, S. and Oren, M. (1995a) p53-mediated apoptosis in HeLa cells can be overcome by excess pRB Oncogene, 10, 1563-1571.
    • (1995) Oncogene , vol.10 , pp. 1563-1571
    • Haupt, Y.1    Rowan, S.2    Oren, M.3
  • 31
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by transactivation deficient p53
    • Haupt, Y., Rowan, S., Shaulian, E., Vousden, K.H. and Oren, M. (1995b) Induction of apoptosis in HeLa cells by transactivation deficient p53. Genes Dev., 9, 2170-2183.
    • (1995) Genes Dev. , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 32
    • 0028239976 scopus 로고
    • Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation
    • Hickman, E.S., Picksley, S.M. and Vousden, K.H. (1994) Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation. Oncogene, 9, 2177-2181.
    • (1994) Oncogene , vol.9 , pp. 2177-2181
    • Hickman, E.S.1    Picksley, S.M.2    Vousden, K.H.3
  • 33
    • 0029060982 scopus 로고
    • A temperature sensitive mutant of the human p53, Val 138, arrests rat cell growth without inducing expression of cip1/waf1/sdi1 after temperature shift-down
    • Hirano, Y., Yamato, K. and Tsuchida, N. (1995) A temperature sensitive mutant of the human p53, Val 138, arrests rat cell growth without inducing expression of cip1/waf1/sdi1 after temperature shift-down. Oncogene, 10, 1879-1885.
    • (1995) Oncogene , vol.10 , pp. 1879-1885
    • Hirano, Y.1    Yamato, K.2    Tsuchida, N.3
  • 34
    • 0028108985 scopus 로고
    • Database of p53 gene somatic mutations in human tumors and cell lines
    • Hollstein, M. et al. (1994) Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res., 22, 3551-3555.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 3551-3555
    • Hollstein, M.1
  • 35
    • 0028227260 scopus 로고
    • Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
    • Howes, K.A., Ransom, L.N., Papermaster, D.S., Lasudry, J.G.H., Albert, D.M. and Windle, J.J. (1994) Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev., 8, 1300-1310.
    • (1994) Genes Dev. , vol.8 , pp. 1300-1310
    • Howes, K.A.1    Ransom, L.N.2    Papermaster, D.S.3    Lasudry, J.G.H.4    Albert, D.M.5    Windle, J.J.6
  • 36
    • 0029028352 scopus 로고
    • Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo
    • Ishioka, C., Englert, C., Winge, P., Yan, Y.-X., Engelstein, M. and Friend, S.H. (1995) Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo. Oncogene, 10, 1485-1492.
    • (1995) Oncogene , vol.10 , pp. 1485-1492
    • Ishioka, C.1    Englert, C.2    Winge, P.3    Yan, Y.-X.4    Engelstein, M.5    Friend, S.H.6
  • 38
    • 0027501841 scopus 로고
    • Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
    • Juven, T., Barak, Y., Zauberman, A., George, D.L. and Oren, M. (1993) Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene, 8, 3411-3416.
    • (1993) Oncogene , vol.8 , pp. 3411-3416
    • Juven, T.1    Barak, Y.2    Zauberman, A.3    George, D.L.4    Oren, M.5
  • 39
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B. and Craig, R.W. (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res , 51, 6304-6311.
    • (1991) Cancer Res , vol.51 , pp. 6304-6311
    • Kastan, M.B.1    Onyekwere, O.2    Sidransky, D.3    Vogelstein, B.4    Craig, R.W.5
  • 40
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • Kastan, M.B. et al. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71, 587-597.
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1
  • 43
    • 0026656853 scopus 로고
    • Wild-type p53 is a cell cycle checkpoint determinant following irradiation
    • Kuerbitz, S.J., Plunkett, B.S., Walsh, W.V. and Kastan, M.B. (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl Acad Sci. USA, 89, 7491-7495.
    • (1992) Proc. Natl Acad Sci. USA , vol.89 , pp. 7491-7495
    • Kuerbitz, S.J.1    Plunkett, B.S.2    Walsh, W.V.3    Kastan, M.B.4
  • 44
    • 0027316813 scopus 로고
    • An E2F-binding site mediates cell-cycle regulation repression of mouse B-myb transcription
    • Lam, E.W.F. and Waston, R.J. (1993) An E2F-binding site mediates cell-cycle regulation repression of mouse B-myb transcription. EMBO J., 12, 2705-2713.
    • (1993) EMBO J. , vol.12 , pp. 2705-2713
    • Lam, E.W.F.1    Waston, R.J.2
  • 45
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D.P. (1992) p53, guardian of the genome. Nature, 358, 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 46
    • 0028231086 scopus 로고
    • The regulation of p53 function
    • Lane, D.P. (1994) The regulation of p53 function. Int. J. Cancer, 57, 623-627.
    • (1994) Int. J. Cancer , vol.57 , pp. 623-627
    • Lane, D.P.1
  • 47
    • 0026680464 scopus 로고
    • Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription
    • Lechner, M.S., Mack, D.H., Finicle, A.B., Crook, T., Vousden, K.H. and Laimins, L.A (1992) Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. EMBO J., 11, 3045-3052.
    • (1992) EMBO J. , vol.11 , pp. 3045-3052
    • Lechner, M.S.1    Mack, D.H.2    Finicle, A.B.3    Crook, T.4    Vousden, K.H.5    Laimins, L.A.6
  • 48
    • 0026756737 scopus 로고
    • Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase
    • Lin, D., Shields, M.T., Ullrich, S.J., Appella, E. and Mercer, W.E. (1992) Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase. Proc. Natl Acad. Sci. USA, 89, 9210-9214.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 9210-9214
    • Lin, D.1    Shields, M.T.2    Ullrich, S.J.3    Appella, E.4    Mercer, W.E.5
  • 49
    • 0026801062 scopus 로고
    • Altered cell-cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone, L.R., White, A., Sprouse, J., Livanos, E., Jacks, T. and Tlsty, T.D. (1992) Altered cell-cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell, 70, 923-935.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 50
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S.W, Schmitt, E.M., Smith, S.W., Osborne, B.A. and Jacks, T. (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 51
    • 0026093164 scopus 로고
    • Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein
    • Martinez, J., Georgoff, I. and Levine, A.J. (1991) Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev., 5, 151-159
    • (1991) Genes Dev. , vol.5 , pp. 151-159
    • Martinez, J.1    Georgoff, I.2    Levine, A.J.3
  • 52
    • 0025292735 scopus 로고
    • Wild type human p53 is antiproliferative in SV40-transformed hamster cells
    • Mercer, W.E, Amim, M., Sauve, G.J., Appella, E., Ullrich, S.J and Romano, J W. (1990) Wild type human p53 is antiproliferative in SV40-transformed hamster cells. Oncogene, 5, 973-980.
    • (1990) Oncogene , vol.5 , pp. 973-980
    • Mercer, W.E.1    Amim, M.2    Sauve, G.J.3    Appella, E.4    Ullrich, S.J.5    Romano, J.W.6
  • 53
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz, D., Halevy, O. and Oren, M (1990) Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell, 62, 671-680.
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 54
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 55
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita, T. et al. (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9, 1799-1805.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1
  • 56
    • 0027944251 scopus 로고
    • Cyclin G is a transcriptional target of the p53 tumor-suppressor protein
    • Okamoto, K. and Beach, D. (1994) Cyclin G is a transcriptional target of the p53 tumor-suppressor protein. EMBO J., 13, 4816-4822.
    • (1994) EMBO J. , vol.13 , pp. 4816-4822
    • Okamoto, K.1    Beach, D.2
  • 57
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • Oltvai, Z., Lilliman, C L. and Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell, 74, 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.1    Lilliman, C.L.2    Korsmeyer, S.J.3
  • 58
    • 0028456527 scopus 로고
    • Relationship of p53 to the control of apoptotic cell death
    • Oren, M. (1994) Relationship of p53 to the control of apoptotic cell death. Sem. Cancer Biol., 5, 3051-3057.
    • (1994) Sem. Cancer Biol. , vol.5 , pp. 3051-3057
    • Oren, M.1
  • 59
    • 0027994037 scopus 로고
    • Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation
    • Ory, K., Legros, Y., Auguin, C. and Soussi, T. (1994) Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J., 13, 3496-3504.
    • (1994) EMBO J. , vol.13 , pp. 3496-3504
    • Ory, K.1    Legros, Y.2    Auguin, C.3    Soussi, T.4
  • 60
    • 0029003501 scopus 로고
    • Wild-type human p53 and a temperature sensitive mutant induce Fas/APO-1 expression
    • Owen-Schaub, L.B. et al. (1995) Wild-type human p53 and a temperature sensitive mutant induce Fas/APO-1 expression. Mol. Cell. Biol., 15, 3032-3040.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3032-3040
    • Owen-Schaub, L.B.1
  • 61
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor-suppressor gene function in development
    • Pan, H.C. and Griep, A.E. (1994) Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor-suppressor gene function in development. Genes Dev., 8, 1285-1299
    • (1994) Genes Dev. , vol.8 , pp. 1285-1299
    • Pan, H.C.1    Griep, A.E.2
  • 63
    • 0028775245 scopus 로고
    • p21 inhibits cyclin shock
    • Pines, J. (1994) p21 inhibits cyclin shock. Nature, 369, 520-521.
    • (1994) Nature , vol.369 , pp. 520-521
    • Pines, J.1
  • 64
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X.-Q., Livingston, D.M., Kaelin, W.G. and Adams, P.D. (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl Acad. Sci. USA, 91, 10918-10922.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 10918-10922
    • Qin, X.-Q.1    Livingston, D.M.2    Kaelin, W.G.3    Adams, P.D.4
  • 65
    • 0029143395 scopus 로고
    • Essential role for p53-mediated transcription in apoptosis but not growth suppression
    • Sabbatini, P., Lin, J., Levine, A.J. and White, E. (1995) Essential role for p53-mediated transcription in apoptosis but not growth suppression. Genes Dev., 9, 2184-2192.
    • (1995) Genes Dev. , vol.9 , pp. 2184-2192
    • Sabbatini, P.1    Lin, J.2    Levine, A.J.3    White, E.4
  • 66
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B. and Lee, W.H. (1994) Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis Mol. Cell. Biol., 14, 8166-8173.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 67
    • 0026523778 scopus 로고
    • Induction of apoptosis by wild type p53 in a human colon tumor-derived cell line
    • Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, R. and Costa, J. (1992) Induction of apoptosis by wild type p53 in a human colon tumor-derived cell line. Proc. Natl Acad. Sci. USA, 89, 4495-4499.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 4495-4499
    • Shaw, P.1    Bovey, R.2    Tardy, S.3    Sahli, R.4    Sordat, R.5    Costa, J.6
  • 68
    • 0028177401 scopus 로고
    • p53-dependent G(1) arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
    • Slebos, R.J.C. et al. (1994) p53-dependent G(1) arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl Acad. Sci. USA, 91, 5320-5324.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 5320-5324
    • Slebos, R.J.C.1
  • 69
    • 0028813528 scopus 로고
    • Evidence for a second cell cycle block at G2/M by p53
    • Stewart, N., Hicks, G.G., Paraskevas, F. and Mowat, M. (1995) Evidence for a second cell cycle block at G2/M by p53. Oncogene, 10, 109-115.
    • (1995) Oncogene , vol.10 , pp. 109-115
    • Stewart, N.1    Hicks, G.G.2    Paraskevas, F.3    Mowat, M.4
  • 71
    • 0026535237 scopus 로고
    • p53: A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer
    • Unger, T., Nau, M.M., Segal, S. and Minna, J.D. (1992) p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. EMBO J., 11, 1383-1390.
    • (1992) EMBO J. , vol.11 , pp. 1383-1390
    • Unger, T.1    Nau, M.M.2    Segal, S.3    Minna, J.D.4
  • 72
    • 0027182946 scopus 로고
    • Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression
    • Unger, T., Mietz, J.A., Scheffner, M., Yee, C.L. and Howley, P.M. (1993) Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression. Mol. Cell. Biol., 13, 5186-5194.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5186-5194
    • Unger, T.1    Mietz, J.A.2    Scheffner, M.3    Yee, C.L.4    Howley, P.M.5
  • 73
    • 0026769713 scopus 로고
    • An immunochemical analysis of the human nuclear phosphoprotein p53
    • Vojtesek, B, Bartek, J., Midgley, C.A. and Lane, D.P. (1992) An immunochemical analysis of the human nuclear phosphoprotein p53. J. Immunol. Meth., 151, 237-244
    • (1992) J. Immunol. Meth. , vol.151 , pp. 237-244
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3    Lane, D.P.4
  • 74
    • 0029283913 scopus 로고
    • Regulation of the cell cycle by viral oncoproteins
    • Vousden, K.H. (1995) Regulation of the cell cycle by viral oncoproteins. Sem Cancer Biol., 6, 109-116.
    • (1995) Sem Cancer Biol. , vol.6 , pp. 109-116
    • Vousden, K.H.1
  • 76
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X.W and Levine, A.J. (1994) p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad. Sci. USA, 91, 3602-3606.
    • (1994) Proc Natl Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.W.1    Levine, A.J.2
  • 77
    • 0027244853 scopus 로고
    • The p53 mdm-2 Autoregulatory Feedback Loop
    • Wu, X.W., Bayle, J.H., Olson, D and Levine, A.J. (1993) The p53 mdm-2 Autoregulatory Feedback Loop. Genes Dev., 7, 1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.W.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 78
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L.C. and Wahl, G.M. (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell, 70, 937-948.
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 79
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach, E., Resnitzky, D, Lotem, J., Sachs, L., Kimchi, A. and Oren, M. (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature, 353, 345-347.
    • (1991) Nature , vol.353 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 80
    • 0028115501 scopus 로고
    • Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines
    • Yonish-Rouach, E., Borde, J., Gotteland, M., Mishal, Z., Viron, A. and May, E. (1994) Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. Cell Death Diff., 1, 39-47.
    • (1994) Cell Death Diff. , vol.1 , pp. 39-47
    • Yonish-Rouach, E.1    Borde, J.2    Gotteland, M.3    Mishal, Z.4    Viron, A.5    May, E.6
  • 81
    • 0027944228 scopus 로고
    • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
    • Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D.A., O'Connor, P.M. and Fornace, A.J. (1994) Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene, 9, 3743-3751.
    • (1994) Oncogene , vol.9 , pp. 3743-3751
    • Zhan, Q.1    Fan, S.2    Bae, I.3    Guillouf, C.4    Liebermann, D.A.5    O'Connor, P.M.6    Fornace, A.J.7
  • 83
    • 0027248782 scopus 로고
    • Sequence-specific DNA binding by p53 - Identification of target sites and lack of binding to p53-MDM2 complexes
    • Zauberman, A., Barak, Y., Ragimov, N., Levy, N. and Oren, M. (1993) Sequence-specific DNA binding by p53 - identification of target sites and lack of binding to p53-MDM2 complexes. EMBO J., 12, 2799-2808
    • (1993) EMBO J. , vol.12 , pp. 2799-2808
    • Zauberman, A.1    Barak, Y.2    Ragimov, N.3    Levy, N.4    Oren, M.5
  • 84
    • 0029006743 scopus 로고
    • Identification of p53 target genes through immune selection of genomic DNA. the cyclin G gene contains two distinct p53 binding sites
    • Zauberman, A., Lupo, A. and Oren, M. (1995) Identification of p53 target genes through immune selection of genomic DNA. the cyclin G gene contains two distinct p53 binding sites. Oncogene, 10, 2361-2366.
    • (1995) Oncogene , vol.10 , pp. 2361-2366
    • Zauberman, A.1    Lupo, A.2    Oren, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.