Uncoupling of Cell Growth and Proliferation Results in Enhancement of Productivity in p21CIP1-Arrested CHO Cells

Biotechnology and Bioengineering

Volumn 85, Issue 7, 2004, Pages 741-749

  Bi, Jing Xiu ^a   Shuttleworth, John ^a   Al Rubeai, Mohamed ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Cell cycle arrest; Cyclin dependent kinase; Growth control; Metabolic engineering

Indexed keywords

ANTIBODIES; ENZYME INHIBITION; GENETIC ENGINEERING; METABOLISM; PARAMETER ESTIMATION; PHYSIOLOGY;

CELL PRODUCTIVITY; MITOCHONDRIA;

CYTOLOGY;

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P21; PROTEIN S6;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL CYCLE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL VOLUME; CHO CELL; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENETIC ENGINEERING; GROWTH REGULATION; METABOLIC ENGINEERING; MITOCHONDRION; MITOSIS INHIBITION; NONHUMAN;

ANIMALS; ANTIBODIES; CELL CYCLE; CELL DIVISION; CELL SIZE; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; GENETIC ENHANCEMENT; PROTEIN ENGINEERING;

CRICETINAE; CRICETULUS GRISEUS;

EID: 1542410260     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20025     Document Type: Article

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