A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1

Nucleic Acids Research

Volumn 33, Issue 12, 2005, Pages 1-13

  Malphettes, Laetitia ^a   Weber, Cornelia C ^b   El Baba, Marie Daoud ^c   Schoenmakers, Ronald G ^a,d   Aubel, Dominique ^c   Weber, Wilfried ^a   Fussenegger, Martin ^a  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Institut Universitaire de Technologie   (France)

^d EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXY NICOTINE; ALKALINE PHOSPHATASE PLACENTA ISOENZYME; ALKALOID; CARBON; GLYCOPROTEIN; LENTIVIRUS VECTOR; NICOTINE; NICOTINE DERIVATIVE; OXIDOREDUCTASE; UNCLASSIFIED DRUG; VASCULOTROPIN; 6 HYDROXYNICOTINE; 6-HYDROXYNICOTINE; DRUG DERIVATIVE; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTHROBACTER; ARTHROBACTER NICOTINOVORANS; ARTICLE; CATABOLISM; CHICK EMBRYO; CHIMERA; CONTROLLED STUDY; DRUG MANUFACTURE; DRUG RESPONSE; EMBRYO; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE INTERACTION; GENE REPRESSION; GENETIC ENGINEERING; GENETIC TRANSDUCTION; GRAM POSITIVE BACTERIUM; IN VIVO STUDY; MAMMAL CELL; MICROENCAPSULATION; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SOIL MICROFLORA; TRANSACTIVATION; TRANSCRIPTION REGULATION; TRANSGENE; VIRUS INACTIVATION; ANIMAL; CELL LINE; DRUG EFFECT; GENE VECTOR; GENETICS; HAMSTER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; METHODOLOGY; OPERATOR GENE; PLASMID;

ARTHROBACTER NICOTINOVORANS; BACTERIA (MICROORGANISMS); EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; NICOTIANA TABACUM; POSIBACTERIA;

ANIMALS; ARTHROBACTER; CELL LINE; CHICK EMBRYO; CRICETINAE; FEMALE; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETIC VECTORS; HIV-1; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NICOTINE; OPERATOR REGIONS (GENETICS); PLASMIDS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC; TRANSGENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 26444488248     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gni107     Document Type: Article

References (70)

1. Sandu,C., Chiribau,C.B. and Brandsch,R. (2003) Characterization of HdnoR, the transcriptional repressor of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter nicotinovorans pAO1, and its DNA-binding activity in response to L- and D-nicotine derivatives. J. Biol. Chem. 278, 51307-51315.
2. Schmid,A., Dordick,J.S., Hauer,B., Kiener,A., Wubbolts,M. and Witholt,B. (2001) Industrial biocatalysis today and tomorrow. Nature, 409 258-268.
3. Brenik,W. and Rudhard,H. (1982) Patent US4343318.
4. Gravely,L.E., Geiss,V.L. and Gregory,C.F. (1985) United States Patent US4557280.
5. Yildiz,D. (2004) Nicotine, its metabolism and an overview of its biological effects. Toxicon, 43, 619-632.
6. Hillen,W., Klock,G., Kaffenberger,I., Wray,L.V. and Reznikoff,W.S. (1982) Purification of the TET repressor and TET operator from the transposon Tn1O and characterization of their interaction. J. Biol. Chem., 257, 6605-6613.
7. Gossen,M. and Bujard,H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA, 89, 5547-5551.
8. Gossen,M., Freundlieb,S., Bender,G., Muller,G., Hillen,W. and Bujard,H. (1995) Transcriptional activation by tetracyclines in mammalian cells. Science, 268, 1766-1769.
9. Fussenegger,M., Morris,R.P., Fux,C., Rimann,M., von Stockar,B., Thompson,C.J. and Bailey,J.E. (2000) Streptogramin-based gene regulation systems for mammalian cells. Nat. Biotechnol., 18, 1203-1208.
10. Weber,W., Fux,C., Daoud-el Baba,M., Keller,B., Weber,C.C., Kramer,B.P., Heinzen,C., Aubel,D., Bailey,J.E. and Fussenegger,M. (2002) Macrolide-based transgene control in mammalian cells and mice. Nat. Biotechnol., 20, 901-907.
11. Zhao,H.F., Boyd,J., Jolicoeur,N. and Shen,S.H. (2003) A coumermycin/ novobiocin-regulated gene expression system. Hum. Gene Ther., 14, 1619-1629.
12. Rivera,V.M., Clackson,T., Natesan,S., Pollock,R., Amara,J.F., Keenan,T., Magari,S.R., Phillips,T., Courage,N.L, Cerasoli,F.Jr et al. (1996) A humanized system for pharmacologic control of gene expression. Nature Med., 2, 1028-1032.
13. Braselmann,S., Graninger,P. and Busslinger,M. (1993) A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc. Natl Acad. Sci. USA, 90, 1657-1661.
14. Beerli,R.R., Schopfer,U., Dreier,B. and Barbas,C.F.,III (2000) Chemically regulated zinc finger transcription factors. J. Biol. Chem., 275, 32617-32627.
15. No,D., Yao,T.P. and Evans,R.M. (1996) Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl Acad. Sci. USA, 93, 3346-3351.
16. Weber,W., Marty,R.R., Link,N., Ehrbar,M., Keller,B., Weber,C.C., Zisch,A.H., Heirizen,C., Djonov,V. and Fussenegger,M. (2003) Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system. Nucleic Acids Res., 31, e69.
17. Weber,W., Schoenmakers,R., Spielmann,M.. El-Baba,M.D., Folcher,M., Keller,B., Weber,C.C., Link,N., van de Wetering,P., Heinzen,C. et al. (2003) Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice. Nucleic Acids Res., 31, e71.
18. Weber,W., Malphettes,L., de Jesus,M., Schoenmakers,R., El-Baba,M.D., Spielmann,M., Keller,B.. Weber,C.C., van de Wetering,P., Aubel,D. et al. (2004) Engineered Streptomyces quorum-sensing components enable inducible siRNA-mediated translation control in mammalian cells and adjustable transcription control in mice. J. Gene Med., 7 518-525.
19. Tascou,S., Sorensen,T.K., Glenat,V.,Wang,M., Lakich,M.M., Darteil,R., Vigne,E. and Thuillier,V. (2004) Stringent rosiglitazone-dependent gene switch in muscle cells without effect on myogenic differentiation. Mol. Ther., 9, 637-649.
20. Weber,W., Rimann,M., Spielmann,M., Keller,B., Daoud-El Baba,M., Aubel,D., Weber,C.C. and Fussenegger,M. (2004) Gas-inducible transgene expression in mammalian cells and mice. Nat. Bioiechnol., 22 1440-1444.
21. Beck,C., Uramoto,H., Boren,J. and Akyurek,L.M. (2004) Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges. Curr. Gene Ther., 4, 457-467.
22. Aubel,D., Morris,X., Lennon,B., Rimann,M., Kaufmann,H., Folcher,M., Bailey,J.E., Thompson,C.J. and Fussenegger,M. (2001) Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics. J. Antibiot. (Tokyo), 54, 44-55.
23. Gonzalez-Nicolini,V., Fux,C. and Fussenegger,M. (2004) A novel mammalian cell-based approach for the discovery of anticancer drugs with reduced cytotoxicity on non-dividing cells. Invest. New, Drugs, 22, 253-262.
24. Umaña,P., Jean-Mairet,J. and Bailey,J.E. (1999) Tetracycline-regulated overexpression of glycosyltransferases in Chinese hamster ovary cells. Biotechnol. Bioeng., 65, 542-549.
25. Fussenegger,M., Schlatter,S., Datwyler,D., Mazur,X. and Bailey,J.E. (1998) Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells. Nat. Biotechnol., 16, 468-472.
26. Malleret,G., Haditsch,U., Genoux,D., Jones,M.W., Bliss,T.V., Vanhoose,A.M., Weitlaaf,C., Kandel,E.R., Winder,D.G. and Mansuy,I.M. (2001) Inducible and reversible enhancement of learning, inemory, and long-term potentiation by genetic inhibition of calcineurin. Cell, 164, 675-686.
27. Cohlan,S.Q. (1977) Tetracycline staining of teeth. Teratology, 15, 127-129.
28. Lautermann,J., Dehne,N., Schacht,J. and Jahnke,K. (2004) [Aminoglycoside- and cisplatin-ototoxicity: From basic science to clinics.]. Laryngorhinootologie, 83, 317-323.
29. Sartor,O. and Cutler,G.B.,Jr (1996) Mifepristone: Treatment of Cushing's syndrome. Clin. Obstet Gynecol., 39, 506-510.
30. Kramer,B.P., Weber,W. and Fussenegger,M. (2003) Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol. Bioeng., 83, 810-820.
31. Kramer,B.P., Viretta,A.U., Daoud-El-Baba,M., Aubel,D., Weber,W. and Fusseneger,M. (2004) An engineered epigenetic transgene switch in mammalian cells. Nat. Biotechnol., 22, 867-870.
32. Kramer,B.P., Fischer,C. and Fussenegger,M. (2004) BioLogic gates enable logical transcription control in mammalian cells. Biotechnol. Bioeng. 87, 478-484.
33. Mitta,B., Rimann,M., Ebrengruber,M.U., Ehrbar,M., Djonov,V., Kelm,J. and Fussenegger,M. (2002) Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction. Nucleic Acids Res., 30, e113.
34. Reiser,J., Harmison,G., Kluepfel-Stahl,S., Brady,R.O., Karlsson,S. and Schubert,M. (1996) Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles. Proc. Natl Acad. Sci. USA 93, 15266-15271.
35. Mochizuki,H., Schwartz,J.P., Tanaka,K., Brady,R.O. and Reiser,J. (1998) High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. J. Virol., 72, 8873-8883.
36. Djonov,V., Schmid,M., Tschanz,S.A. and Burri,P.H. (2000) Intussusceptive angiogenesis: Its role in embryonic vascular network formation. Circ. Res., 86, 286-292.
37. Djonov,V.G., Galli,A.B. and Burri,P.H. (2000) Intussusceptive arborization contributes to vascular tree formation in the chick chorio-allantoic membrane. Anat. Embryol. (Berl.), 202, 347-357.
38. Herrera,F.J. and Triezenberg,S.J. (2004) VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection. J. Virol., 78, 9689-9696.
39. Boshart,M., Weber,F., Jahn,G., Dorsch-Hasler,K., Fleckenstein,B. and Schaffner,W. (1985) A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell, 41, 521-530.
40. Weber,W. and Fussenegger,M. (2002) Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering. J. Biotechnol., 98, 161-187.
41. Semsey,S., Geanaeopoulos,M., Lewis,D.E. and Adhya,S. (2000) Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding. EMBO J., 21, 4349-4356.
42. Sathya,G., Li,W., Klinge,C.M., Anolik,J.H., Hilf,R. and Bambara,R.A. (1997) Effects of multiple estrogen responsive elements, their spacing. and location on estrogen response of reporter genes. Mol. Endocrinol. 11, 1994-2003.
43. Schreiter,E.R., Sintchak,M.D., Guo,Y., Chivers,P.T., Sauer,R.T. and Drennan,C.L. (2003) Crystal structure of the nickel-responsive transcription factor NikR. Nature Struct. Biol., 10, 794-799.
44. Parkhill,J. and Brown,N.L. (1990) Site-specific insertion and deletion mutants in the mer promoter-operator region of Tn501; the nineteen base-pair spacer is essential for normal induction of the promoter by MerR. Nucleic Acids Res., 18, 5157-5162.
45. Brown,N.L., Stovanov,J.V., Kidd,S.P. and Hobman,J.L. (2003) The MerR family of transcriptional regulators. FEMS Microbiol Rev., 27 145-163.
46. Lewis,D.E. and Adhya,S. (2002) In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators. J. Biol. Chem., 277, 2498-2504.
47. Weber,W., Kramer,B.P., Fux,C., Keller,B. and Fussenegger,M. (2002) Novel promoter/transactivator configurations for macrolide- and streptogramin-responsive transgene expression in mammalian cells. J. Gene. Med., 4, 676-686.
48. Schmitz,M.L., Stelzer,G., Altmann,H., Meisterenst,M. and Baeuerle,P.A. (1995) Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators. J. Biol. Chem., 270, 7219-7226.
49. Urlinger,S., Helbl,V., Guthmann,J., Pook,E., Grimm,S. and Hillen,W. (2000)The p65 domain from NF-kappaB is an efficient human activator in the tetracycline-regulatable gene expression system. Gene, 247 103-110.
50. Akagi,K., Kanai,M., Saya,H., Kozu,T. and Berns,A. (2001) A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain. Nucleic Acids Res., 29, E23.
51. Baron,U., Gossen,M. and Bujard,H. (1997) Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential. Nucleic Acids Res., 25, 2723-2729.
52. Weber,W. and Fussenegger,M. (2004) Inducible gene expression in mammalian cells and mice. Methods Mol. Biol., 267, 451-466.
53. Wang,Y., O'Malley,B.W.,Jr, Tsai,S.Y. and O'Malley,B.W. (1994) A regulatory system for use in gene transfer. Proc. Natl Acad. Sci. USA 91, 8180-8184.
54. Hanson,R.D., Grisolano,J.L. and Ley,T.J. (1993) Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription. Blood, 82, 2749-2757.
55. Dunn,T.M., Hahn,S., Ogden,S. and Schleif,R.F. (1984) An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression. Proc. Natl Acad. Sci. USA, 81 5017-5020.
56. Vilen,B.J., Cogswell,J.P. and Ting,J.P. (1991) Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function. Mol. Cell Biol., 11, 2406-2415.
57. Takahashi,K., Vigneron,M., Matthes,H., Wildeman,A., Zenke,M. and Chambon,P. (1986) Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature, 319 121-126.
58. Rao,E., Dang,W., Tian,G. and Sen,R. (1997) A three-protein-DNA complex on a B cell-specific domain of the immunoglobulin mu heavy chain gene enhancer. J. Biol. Chem., 272, 6722-6732.
59. Ellwood,K., Huang,W., Johnson,R. and Carey,M. (1999) Multiple layers of cooperativity regulate enhanceosome-responsive RNA polymerase II transcription complex assembly. Mol. Cell Biol., 19, 2613-2623.
60. Wang,J., Ellwood,K., Lehman,A., Carey,M.F. and She,Z.S. (1999) A mathematical model for synergistic eukaryotic gene activation. J. Mol. Biol., 286, 315-325.
61. Hebner,C., Lasanen,J., Battle,S. and Aiyar,A. (2003) The spacing between adjacent binding sites in the family of repeats affects the functions of Epstein-Barr nuclear antigen 1 intranscription activation and stable plasmid maintenance. Virology, 311, 263-274.
62. Nikolajczyk,B.S., Nelsen,B. and Sen,R. (1996) Precise alignment of sites required for mu enhancer activation in B cells. Mol. Cell Biol., 16, 4544-4554.
63. Xiong,G. and Maser,E. (2001) Regulation of the steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase gene in Comamonas testosteroni. J. Biol. Chem., 276, 9961-9970.
64. Chi,T., Lieberman,P., Ellwood,K. and Carey,M. (1995) A general mechanism for transcriptional synergy by eukaryotic activators. Nature, 377, 254-257.
65. Lederer,H., Tovar,K., Baer,G., May,R.P., Hillen,W. and Heumann,H. (1989) The quaternary structure of Tet repressors bound to the Tn1O-encoded tet gene control region determined by neutron solution scattering. EMBO J., 8, 1257-1263.
66. Merika,M., Williams,A.J., Chen,G., Collins,T. and Thanos,D. (1998) Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol. Cell, 1, 277-287.
67. Giese,K., Kingsley,C., Kirshner,J.R. and Grosschedl,R. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev., 9, 995-1008.
68. Mitta,B., Weber,C.C., Rimann,M. and Fussenegger,M. (2004) Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression. Nucleic Acids Res., 32, e106.
69. Fussenegger,M., Moser,S., Mazur,X. and Bailey,J.E. (1997) Autoregulated multicistronic expression vectors provide one-step cloning of regulated product gene expression in mammalian cells. Biotechnol. Prog., 13, 733-740.
70. Weber,W., Marty,R.R., Keller,B., Rimann,M., Kramer,B.P. and Fussenegger,M. (2002) Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering. Biotechnol. Bioeng., 80, 691-705.