Spatiotemporal control of cell signalling using a light-switchable protein interaction

Nature

Volumn 461, Issue 7266, 2009, Pages 997-1001

  Levskaya, Anselm ^a,b,c   Weiner, Orion D ^a,d   Lim, Wendell A ^a,e   Voigt, Christopher A ^a,c  

^a UCSF/UCB NIH Nanomedicine Development Center

^b Graduate Program in Biochemistry and Structural Biology   (United States)

^c Department of Pharmaceutical Chemistry ^*

^d Cardiovascular Research Institute

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHODOPSIN;

CYTOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; LIGHT EFFECT; MEMBRANE; OPTICAL METHOD; PROTEIN; SPATIOTEMPORAL ANALYSIS; TIMESCALE;

ARABIDOPSIS; ARTICLE; CELL FUNCTION; CELL SIZE; CELL STRUCTURE; CHROMATOPHORE; CONTROLLED STUDY; CYTOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ANIMALS; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL MEMBRANE; CELL SHAPE; COLOR; CYTOSKELETON; INFRARED RAYS; KINETICS; LIGHT; MICE; NIH 3T3 CELLS; PHOTOCHEMISTRY; PHYTOCHROME B; PROTEIN BINDING; PROTEIN TRANSPORT; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TIME FACTORS;

ARABIDOPSIS THALIANA; MAMMALIA;

EID: 70350070364     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08446     Document Type: Article

References (26)

1. Szobota, S. et al. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron 54, 535-545 (2007).
2. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neurosci. 8, 1263-1268 (2005).
3. Han, X. & Boyden, E. S. Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. PLoS One 2, e299 (2007).
4. Mettetal, J. T., Muzzey, D., Gómez-Uribe, C. & van Oudenaarden, A. The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science 319, 482-484 (2008).
5. Bennett, M. R. et al. Metabolic gene regulation in a dynamically changing environment. Nature 454, 1119-1122 (2008).
6. Ghosh, M. et al. Cofilin promotes actin polymerization and defines the direction of cell motility. Science 304, 743-746 (2004).
7. Gorostiza, P. & Isacoff, E. Y. Optical switches for remote and noninvasive control of cell signaling. Science 322, 395-399 (2008).
8. Levskaya, A. et al. Synthetic biology: engineering Escherichia coli to see light. Nature 438, 441-442 (2005).
9. Lee, J. et al. Surface sites for engineering allosteric control in proteins. Science 322, 438-442 (2008).
10. Shimizu-Sato, S., Huq, E., Tepperman, J. M. & Quail, P. H. A light-switchable gene promoter system. Nature Biotechnol. 20, 1041-1044 (2002).
11. Quail, P. H. Phytochrome photosensory signalling networks. Nature Rev. Mol. Cell Biol. 3, 85-93 (2002).
12. Ni, M., Tepperman, J. M. & Quail, P. H. Binding of phytochrome B to its nuclear signalling partner PIF3 is reversibly induced by light. Nature 400, 781-784 (1999).
13. Khanna, R. et al. A novel molecular recognition motif necessary for targeting photoactivated phytochrome signaling to specific basic helix-loop-helix transcription factors. Plant Cell 16, 3033-3044 (2004).
14. Tyszkiewicz, A. B. & Muir, T. W. Activation of protein splicing with light in yeast. Nature Methods 5, 303-305 (2008).
15. Leung, D. W., Otomo, C., Chory, J. & Rosen, M. K. Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway. Proc. Natl Acad. Sci. USA 105, 12797-12802 (2008).
16. Su, Y. & Lagarias, J. C. Light-independent phytochrome signaling mediated by dominant GAF domain tyrosine mutants of Arabidopsis phytochromes in transgenic plants. Plant Cell 19, 2124-2139 (2007).
17. Heo, W. D. et al. PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314, 1458-1461 (2006).
18. Al-Sady, B., Ni, W., Kircher, S., Schäfer, E. & Quail, P. H. Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation. Mol. Cell 23, 439-446 (2006).
19. Genoud, T. et al. FHY1 mediates nuclear import of the light-activated phytochrome A photoreceptor. PLoS Genet. 4, e1000143 (2008).
20. Chen, M., Tao, Y., Lim, J., Shaw, A. & Chory, J. Regulation of phytochrome B nuclear localization through light-dependent unmasking of nuclear-localization signals. Curr. Biol. 15, 637-642 (2005).
21. Inoue, T., Heo, W. D., Grimley, J. S., Wandless, T. J. & Meyer, T. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nature Methods 2, 415-418 (2005).
22. Wang, S. et al. All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Lett. 7, 3859-3863 (2007).
23. Castellano, F. et al. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation. Curr. Biol. 9, 351-361 (1999).
24. Suh, B., Inoue, T., Meyer, T. & Hille, B. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science 314, 1454-1457 (2006).
25. Inoue, T. & Meyer, T. Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One 3, e3068 (2008).
26. Gambetta, G. A. & Lagarias, J. C. Genetic engineering of phytochrome biosynthesis in bacteria. Proc. Natl Acad. Sci. USA 98, 10566-10571 (2001).