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Volumn 461, Issue 7260, 2009, Pages 104-108

A genetically encoded photoactivatable Rac controls the motility of living cells

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN; OXYGEN; P21 ACTIVATED KINASE; RAC PROTEIN; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 69949104482     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08241     Document Type: Article
Times cited : (887)

References (29)
  • 2
    • 41449113929 scopus 로고    scopus 로고
    • Photochemical control of endogenous ion channels and cellular excitability
    • Fortin, D. L. et al. Photochemical control of endogenous ion channels and cellular excitability, Nature Methods 5, 331-338 (2008).
    • (2008) Nature Methods , vol.5
    • Fortin, D.L.1
  • 3
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • DOI 10.1016/j.ydbio.2003.06.003
    • 3. Raftopoulou, M. & Hall, A. Cell. migration: Rho GTPases lead the way. Dev. Biol. 265, 23-32 (2004). (Pubitemid 38018819)
    • (2004) Developmental Biology , vol.265 , Issue.1
    • Raftopoulou, M.1    Hall, A.2
  • 4
    • 0344305784 scopus 로고    scopus 로고
    • Cell. migration: Integrating signals from front to back
    • Ridley, A. J. et al. Cell. migration: integrating signals from front to back, Science 302, 1704-1709 (2003).
    • (2003) Science , vol.302
    • Ridley, A.J.1
  • 6
    • 0141707094 scopus 로고    scopus 로고
    • Structural basis of a phototropin light switch
    • Harper, S. M., Neil, L. C. & Gardner, K. H. Structural basis of a phototropin light switch. Science 301, 1541-1544 (2003).
    • (2003) Science , vol.301
    • Harper, S.M.1    Neil, L.C.2    Gardner, K.H.3
  • 7
    • 0034644603 scopus 로고    scopus 로고
    • Localized Rae activation dynamics visualized in living cells
    • Kraynov, V. S. et al. Localized Rae activation dynamics visualized in living cells. Science 290, 333-337 (2000).
    • (2000) Science , vol.290
    • Kraynov, V.S.1
  • 8
    • 33646197411 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of RhoA activity in migrating cells
    • Pertz, O., Hodgson, L., Klemke, R. L. & Hahn, K. M. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 440, 1069-1072 (2006).
    • (2006) Nature , vol.440
    • Pertz, O.1    Hodgson, L.2    Klemke, R.L.3    Hahn, K.M.4
  • 9
    • 0842281652 scopus 로고    scopus 로고
    • And Rac take center stage
    • Burridge, K. & Wennerberg, K. Rho and Rac take center stage, Cell. 116, 167-179 (2004).
    • (2004) Cell. , vol.116
    • Burridge, K.1    Rho, W.K.2
  • 10
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley, A. J., Paterson, H. F., Johnston, C. L. Diekmann, D. & Hall, A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70, 401-410 (1992).
    • (1992) Cell. , vol.70
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 11
    • 0033615966 scopus 로고    scopus 로고
    • Ten Klooster, J. P., van Delft, S.,van der Kammen, R. A. & Collard, J. G. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
    • Sander, E. E., ten Klooster, J. P., van Delft, S.,van der Kammen, R. A. & Collard, J. G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior, J. Cell. Biol. 147, 1009-1022 (1999).
    • (1999) J. Cell. Biol. , vol.147
    • Sander, E.E.1
  • 12
    • 47649085005 scopus 로고    scopus 로고
    • Estimation of the available free energy in a LOV2-Jα photoswitch, Nature
    • Yao, X., Rosen, M. K. & Gardner, K. H. Estimation of the available free energy in a LOV2-Jα photoswitch, Nature Chem. Biol. 4, 491-497 (2008).
    • (2008) Chem. Biol. , vol.4
    • Yao, X.1    Rosen, M.K.2    Gardner, K.H.3
  • 13
    • 0034622586 scopus 로고    scopus 로고
    • Photochemical and mutational analysis of the FMN-binding domains of the plant blue light receptor, phototropin
    • DOI 10.1021/bi000585+
    • 13. Salomon, M., Christie, J. M., Knieb, E., Lempert, U. & Briggs, W. R. Photochemica and mutational analysis of the FMN-binding domains of the plant blue light receptor, phototropin, Biochemistry 39, 9401-9410 (2000). (Pubitemid 30626330)
    • (2000) Biochemistry , vol.39 , Issue.31
    • Salomon, M.1    Christie, J.M.2    Knieb, E.3    Lempert, U.4    Briggs, W.R.5
  • 14
    • 11144344967 scopus 로고    scopus 로고
    • Disruption of the LOV-Jα helix interaction activates phototropin kinase activity
    • Harper, S. M., Christie, J. M. & Gardner, K. H. Disruption of the LOV-Jα helix interaction activates phototropin kinase activity, Biochemistry 43, 16184-16192 (2004).
    • (2004) Biochemistry , vol.43
    • Harper, S.M.1    Christie, J.M.2    Gardner, K.H.3
  • 15
    • 0032568579 scopus 로고    scopus 로고
    • Delineation of the Cdc42/Rac-binding domain of p21-activated kinase
    • DOI 10.1021/bi980140+
    • 15. Thompson, G., Owen, D., Chalk, P. A. & Lowe, P. N. Delineation of the Cdc42/Racbinding domain of p21-activated kinase, Biochemistry 37, 7885-7891 (1998). (Pubitemid 28248649)
    • (1998) Biochemistry , vol.37 , Issue.21
    • Thompson, G.1    Owen, D.2    Chalk, P.A.3    Lowe, P.N.4
  • 16
    • 0037072602 scopus 로고    scopus 로고
    • A photoactivatable GFP for selective photolabeling of proteins and cells
    • Patterson, G. H. & Lippincott-Schwartz, J. A photoactivatable GFP for selective photolabeling of proteins and cells. Science 297, 1873-1877 (2002).
    • (2002) Science , vol.297
    • Patterson, G.H.1    Lippincott-Schwartz, J.2
  • 17
    • 33847354235 scopus 로고    scopus 로고
    • Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells
    • DOI 10.1083/jcb.200612043
    • 17. Vicente-Manzanares, M., Zareno, J., Whitmore, L., Choi, C. K. & Horwitz, A. F. Regulation of protrusion, adhesion dynamics, and polarity by myosins HA and HB in migrating cells. J. Cell. Biol. 176, 573 (2007). (Pubitemid 46333973)
    • (2007) Journal of Cell Biology , vol.176 , Issue.5
    • Vicente-Manzanares, M.1    Zareno, J.2    Whitmore, L.3    Choi, C.K.4    Horwitz, A.F.5
  • 19
    • 33846672361 scopus 로고    scopus 로고
    • Lamellipodial actin mechanically links myosin activity with adhesion-site formation
    • Giannone, G. et al. Lamellipodial actin mechanically links myosin activity with adhesion-site formation, Cell. 128, 561-575 (2007)
    • (2007) Cell. , vol.128
    • Et Al, G.G.1
  • 20
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • DOI 10.1042/0264-6021:3510095
    • 20. Davies, S. P., Reddy, H., Caivano, M. & Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem. J. 351, 95-105 (2000). (Pubitemid 30781561)
    • (2000) Biochemical Journal , vol.351 , Issue.1
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 21
    • 24344482090 scopus 로고    scopus 로고
    • Localized RhoA activation as a requirement for the induction of membrane ruffling
    • DOI 10.1091/mbc.E04-12-1076
    • 21. Kurokawa, K. & Matsuda, M. Localized RhoA activation as a requirement for the induction of membrane ruffling, Mol. Biol. Cell. 16, 4294-4303 (2005). (Pubitemid 41262897)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.9
    • Kurokawa, K.1    Matsuda, M.2
  • 23
    • 37049002915 scopus 로고    scopus 로고
    • And C-terminal flanking regions modulate lightinduced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from
    • Halavaty, A. S. & Moffat, K. N- and C-terminal flanking regions modulate lightinduced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa. Biochemistry 46, 14001-14009 (2007).
    • (2007) Avena Sativa. Biochemistry , vol.46
    • Halavaty, A.S.1    Moffat, K.N.2
  • 24
    • 0028961293 scopus 로고
    • Rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes, C. D. & Hall, A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81, 53-62 (1995).
    • (1995) Cell. , vol.81
    • Nobes, C.D.1    Rho, H.A.2
  • 25
    • 54249105941 scopus 로고    scopus 로고
    • Surface sites for engineering a i losteric control in proteins
    • Lee, J. et al. Surface sites for engineering a I losteric control in proteins, Science 322, 438-442 (2008).
    • (2008) Science , vol.322
    • Lee, J.1
  • 26
    • 58549105950 scopus 로고    scopus 로고
    • And Signaling Mechanism of LightRegulated Histidine Kinases
    • Moglich, A., Ayers, R. A. & Moffat, K. Design and Signaling Mechanism of LightRegulated Histidine Kinases, J. Mol. Biol. 385, 1433-1444 (2008).
    • (2008) J. Mol. Biol. , vol.385
    • Moglich, A.1    Ayers, R.A.2    Design, M.K.3
  • 27
  • 28
    • 51349089700 scopus 로고    scopus 로고
    • Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway
    • Leung, D. W., Otorno, C. Chory, J. & Rosen, M. K. Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway. Proc. Natl Acad. Sci. USA 105, 12797-12802 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105
    • Leung, D.W.1    Otornofnm, C.2    Chory, J.3    Rosen, M.K.4
  • 29
    • 84871826321 scopus 로고    scopus 로고
    • Biosensors for characterizing the dynamics of Rho family GTPases in living cells
    • in the press
    • Hodgson, L., Shen, F. & Hahn, K. M. Biosensors for characterizing the dynamics of Rho family GTPases in living cells. Curr Protoe. Cell. Biol. (in the press).
    • Curr Protoe. Cell. Biol.
    • Hodgson, L.1    Shen, F.2    Hahn, K.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.