The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies

Biotechnology Progress

Volumn 17, Issue 1, 2001, Pages 1-51

  Fussenegger, M ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GENE INDUCTION; GENETIC COMPATIBILITY; GENETIC REGULATION; HETEROLOGOUS EXPRESSION; MAMMALIAN GENETICS; PLEIOTROPY; TRANSACTIVATION; TRANSGENE;

ANIMALS; GENE EXPRESSION REGULATION; GENE THERAPY; GENOME; HUMANS; MAMMALS; METABOLISM;

BACTERIA (MICROORGANISMS); INSECTA; MAMMALIA;

EID: 0035121677     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp000129c     Document Type: Review

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105. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter
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123. Transcriptional activation modulated by homopolymeric glutamine and proline stretches
124. Effect of temperature on the production of human fibroblast interferon
125. Negative effect of the transcriptional activator GAL4
126. Inducible gene expression in the nervous system of transgenic mice
127. Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB
128. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements
129. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
130. Anhydrotetracycline, a novel effector for tetracycline-controlled gene expression systems in eukaryotic cells
131. Transcriptional activation by tetracyclines in mammalian cells
132. Nuclear receptors enhance our understanding of transcription regulation
133. Mapping of RNA-temperature-sensitive mutants of Sindbis virus: Complementation group F mutants have lesions in nsP4
134. Transcriptional repression by the Drosophila even-skipped protein: Definition of a minimal repression domain
135. Inducible control of gene expression: Prospects for gene therapy
136. Mapping of a major surface-exposed site in Herpes simplex virus protein Vmw65 to a region of direct interaction in a transcription complex assembly
137. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
138. Proximity probing of Tet repressor to tet operator by dimethyl sulfate reveals protected and accessible functions for each recognized base-pair in the major groove
139. Stepwise selection of TetR variants recognizing tet operator 4C with high affinity and specificity
140. Stepwise selection of TetR variants recognizing tet operator 6C with high affinity and specificity
141. Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require presence of p53 or Rb; is not affected by large T antigen
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147. Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance
148. Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector
149. Dimeric ligands define a role for transcriptional activation domains in reinitiation
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153. Studies of cloned sequences from four Drosophila heat shock loci
154. Highly controlled heterologous gene expression through combined utilization of the tetracycline-repressible transactivator and the lac repressor
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156. Control of growth and recombinant protein synthesis by heat-schock in a mutant mammalian cell line
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158. The inducible Lac operator-repressor system is functional in mammalian cells
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160. Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter
161. Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system
162. A regulatory network for efficient control of transgene expression
163. Reduced binding of TFIID to transcriptionally compromised mutants of VP16
164. Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptor
165. Genetic regulatory mechanisms in the synthesis of proteins
166. Isolation and characterization of genomic and cDNA clones of human erythropoietin
167. The therapeutic potential of ribozymes
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169. Targeted expansion of genetically modified bone marrow cells
170. In vivo selection using a cell-growth switch
171. Inducible genetic suppression of neuronal excitability
172. An episomal vector for stable tetracycline-regulated gene expression
173. Biochemistry of metallothionein
174. Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein
175. Tetracyclines, chloramphenicol, erythromycin, and miscellaneous antibacterial agents
176. Improved vectors for the stable expression of foreign gene in mammalian cells by use of the untranslated leader sequence from EMC virus
177. Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells
178. Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline-regulated gene expression and productivity
179. Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally
180. Establishment of an apoptosis-resistant and growth-controllable cell line by transfecting with inducible antisensec-jun gene
181. Locus control regions: Overcoming heterochromatin-induced gene inactivation in mammals
182. Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis
183. Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes
184. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR
185. Regulation of cell growth by IRF-1 in BHK-21 cells
186. 2+ reveals mechanisms of antibiotic resistance
187. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
188. An auto-inducible vector conferring high glucocorticoid inducibility uponstable transformant cells
189. Enhanced production of interferon by temperature shift-down from 37 °C to 25 °C in rabbit cell cultures stimulated with Newcastle disease virus
190. Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice
191. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
192. Inducible gene targeting in mice
193. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homologue required for G1 progression
194. Conversion of the Lac repressor into an allosterically regulated transcriptional activator for mammalian cells
195. Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids
196. Exogenous control of cardiac gene therapy: Evidence of regulated myocardial transgene expression after adenovirus and adeno-associated virus transfer of expression cassettes containing corticosteroid response element promoters
197. CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes intransgenic mice
198. Conditional lineage ablation to model human disease
199. Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells
200. A tetracycline-responsive promoter system reveals the role of a secreted binding protein for FGFs during the early phases of tumor growth
201. Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen
202. Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different conditions
203. Alphavirus expression systems
204. A new generation of animal cell expression vectors based on the Semliki forest virus replicon
205. Binding of general transcription factor TFIIB to an acidic activating region
206. Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo
207. Inheritance of resistance to influenza virus in mice
208. Lac/Tet dual-inducible system functions in mammalian cell lines
209. Sequence-selective carbohydrate-DNA interaction: Dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function
210. Ligand-regulated site-specific recombination
211. Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells
212. Suppression of gene expression by tethering KRAB domain to promoter of ER target genes
213. Defining a minimal estrogen receptor DNA binding domain
214. A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells
215. Pharmocologic control of a humanized gene therapy system implanted into nude mice
216. The RXT heterodimers and orphan receptors
217. The nuclear receptor superfamily: The second decade
218. Krüppel-associated boxes are potent transcriptional repression domains
219. Success and problems of long-term levodopa therapy in Parkinson's disease
220. Two silencing subdomains of v-erbA synergize with each other, but not with RXR
221. Creation of ecdysone receptor chimeras in plants for controlled regulation of gene expression
222. Technical advance: Ecdysone agonist inducible transcription in transgenic tobacco plants
223. Regulation of protein activities by fusion to steroid binding domains
224. Control of memory formation through regulated expression of a CaMKII transgene
225. The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells
226. A novel autoregulated proliferation-controlled production process in CHO cells
227. Higher productivity of growth-arrested Chinese hamster ovary cells expressing the cyclin-dependent kinase inhibitor p27
228. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
229. Use of circular dichroism in analysis of mixtures of tetracycline and 4-epitetracycline and its application to assay of commercial products
230. Peptide nucleic acid. DNA strand displacement loops as artificial transcription promoters
231. Effects of temperature shift on cell cycle, apoptosis and nucleotide pools in CHO cell batch cultures
232. Transcriptional repression by RING finger protein TIFβ that interacts with the KRAB repressor domain of KOX1
233. Independent regulation of two separate gene activities in a continuous human cell line
234. Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection
235. An update of pTRIDENT multicistronic expression vectors: pTRIDENTs containing novel streptogramin-responsive promoters
236. Development of an IRF-1 based proliferation control system
237. Sustained expression in proliferation controlled BHK-21 cells
238. Recombinant glycoprotein product quality in proliferation-controlled BHK-21 cells
239. Liver abscesses in feedlot cattle: A review
240. A general strategy to enhance the potency of chimeric transcriptional activators
241. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
242. Purification, cDNA cloning, and expression of UDP-N-acetylglucosamine: β-D-mannoside β-1,4-N-acetylglucosami-nyltransferase III from rat kidney
243. Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene
244. A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth
245. Heat shock induces p53-dependent Cell-cycle arrest at G1/S
246. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
247. Construction and characterization of a one-plasmid system for the controlled expression of genes in mammalian cells by tetracycline
248. Enhancement of Neurospora VS ribozyme cleavage by tuberactinomycin antibiotics
249. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
250. A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo
251. Response of a mouse hybridoma cell line to heat shock, agitation and sparging
252. Regulated expression of foreign genes in vivo after germline transfer
253. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells
254. Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis
255. Transcriptional silencing of human immunodeficiency virus type I long terminal repeat-driven gene expression by the Kruppel-associated box repressor domain targeted to the transactivating response element
256. Will a twist of viral fate lead to a new cancer treatment?
257. Protein-protein interactions: Methods for detection and analysis
258. Regulation of protein function through expression of chimaeric proteins
259. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
260. In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system
261. Structure-based design of transcription factors
262. Nucleotide sequence of the repressor gene of the Tn1O tetracycline resistance determinant
263. Is there a threshold level of fetal hemoglobin that ameliorates morbidity in sickle cell anemia?
264. Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions
265. Activation of hypoxia inducible factor-1; definition of regulatory domains within the α subunit
266. Differential cell cycle effects induced by E2F1 mutants
267. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
268. Application of ex vivo gene therapy in the treatment of Parkinson's disease
269. Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic resistant cells to express recombinant protein
270. Metal regulation of metallothionein gene transcription in mammals
271. Toward autologous ex vivo gene therapy for the central nervous system with human adult astrocytes
272. A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension
273. Pharmacology and toxicology of doxycycline
274. Conditional repression of the E2 transcriptional unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro
275. A humanized system for pharmacologic control of gene expression
276. Long-term regulated expression of growth hormone in mice after intramuscular gene transfer
277. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum
278. A ligand-reversible dimerization system for controlling protein-protein interactions
279. Transiently transfected and stably integrated HIV-1 LTR responds differentially to the silencing activity of the Kruppel-associated box (KRAB) transcriptional repressor domain
280. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
281. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
282. A 46-nucleotide promoter segment from an IFN-α gene renders an unrelated promoter inducible by virus
283. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
284. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
285. Starting at the beginning, middle, and end: Translation initiation in eukaryotes
286. GAL4-VP16 is an unusually potent transcriptional activator
287. Inducible gene expression in mammalian cells and transgenic mice
288. Stress-activated expression of a Streptomyces pristinaespiralis multidrug resistance gene (ptr) in various Streptomyces spp. and Escherichia coli
289. Unusual regulatory mechanism for a Streptomyces multidrug resistance gene, ptr, involving three homologous protein-binding sites overlapping the promoter region
290. Molecular analysis of metallothionein gene regulation
291. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells
292. The p65 subunit is responsible for the strong transcription activating potential of NF-κB
293. Alphavirus vectors for the expression of heterologous genes
294. Determinants of protein-protein recognition by four helix bundles: Changing the dimerization specificity of Tet repressor
295. A modified tetracycline-regulated system provides autoregulatory inducible gene expression in cultured cells and transgenic mice
296. Diverse strategies for tetracycline inducible gene expression
297. The mechanism of action of cyclosporin A and FK506
298. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures
299. A heat-shock-inducible eukaryotic expression vector
300. Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences
301. Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in BHK-21 cells
302. Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells
303. Ribozyme-mediated cleavage of the BCRABL oncogene transcript: In vitro cleavage of RNA and in vivo loss of P210 protein-kinase activity
304. Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription
305. Cytochrome P-450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice
306. Inhibition of c-jun causes reversible proliferation arrest and withdrawal from the cell cycle
307. Rate and proposed mechanism of anhydrotetracycline epimerization in acid solution
308. Creating conditional mutations in mammals
309. Controlling signal transduction with synthetic ligands
310. An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice
311. Synergistic action of the glucocorticoid receptor with transcription factors
312. Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector
313. The alphaviruses: Gene expression, replication and evolution
314. High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor
315. Bombyx EcR (BmEcR) and Bombyx USP (BmCF1) combine to form a functional ecdysone receptor
316. Comparison of the optimal culture conditions for cell growth and tissue plasminogen activator production by human embryo lung cells on microcarriers
317. An IRF-1 dependent pathway of DNA-damage-induced apoptosis in mitogen-activated T lymphocytes
318. Cooperation of the tumour IRF-1 and p53 in response to DNA damage
319. Rational design of allosteric ribozymes
320. Distinct classes of transcriptional activation domains function by different mechanisms
321. Cold shock and adaptation
322. Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle
323. CAAT/enhancer-binding prtein α (C/EBPα) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein
324. The human estrogen receptor has two independent nonacidic transcriptional activation functions
325. Doxycycline control of prion protein transgene expression modulates prion disease in mice
326. Functional dissection of VP16, the transactivator of herpes simplex virus immediate early gene expression
327. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
328. RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase
329. Signal transduction by receptors with tyrosine kinase activity
330. Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity
331. Tetracycline-regulated overexpression of glycosyltransferases in Chinese hamster ovary cells
332. Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity
333. Design, synthesis, and function of therapeutic hammerhead ribozymes
334. The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
335. The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor
336. Development and validation of a sensitive method for tetracycline in gingival crevicular fluid by HPLC using fluorescence detection
337. Isolation and functional analysis of a human 70,000-dalton heat schock protein segment
338. Antibiotic inhibition of group I ribozyme function
339. Induction of apoptosis in neoplastic cells by depletion of vitamin B12
340. Peptide nucleic acid (PNA) binding-mediated induction of human gamma-globin gene expression
341. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
342. Molecular basis of hypoxia-induced erythropoietin expression
343. Ligand-inducible and livet-specific target gene expression in transgenic mice
344. A regulatory system for use in gene therapy
345. Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator
346. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
347. RNA aptamers specifically interact with the prion protein PrP
348. Expression of ribozymes in gene transfer systems to modulate target RNA levels
349. Controlling gene expression in living cells through small molecule-RNA interactions
350. The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression
351. Transcriptional activation by Herpes simplex virus type 1
352. Inducible overproduction of the mouse c-myc protein in mammalian cells
353. Analysis of inducers of the E. coli Lac repressor system in mammalian cells and whole animals
354. Parameters affecting the use of the Lac repressor system in eukaryotic cells and transgenic animals
355. Sindbis virus: An efficient, broad host range vector for gene expression in animal cells
356. Functional ecdysone receptor is the product of the EcR and ultraspiracle genes
357. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
358. Tetracycline repressor, TetR, rather than the TetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells
359. Investigating protein-ligand interactions with a mutant RKBP possessing a designed specificity pocket
360. Regulation of therapeutic proteins after in vivo somatic cell gene transfer
361. BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival afterdrug treatment in HeLa cells
362. Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression
363. Adenovirus-mediated inducible gene expression through tetracycline-controllable transactivator with nuclear localization signal
364. Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells
365. Retroviral delivery and tetracycline-dependent expression of IL-1β-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells
366. Controlled transgene expression in the heart
367. Inducible site-directed recombination in mouse embryonic stem cells
368. Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
369. Nucleotide sequence analysis of the class G tetracycline resistance determinant from Vibrio anguillarum