-
1
-
-
79955497173
-
Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells
-
A. Ahmad, A. Aboukameel, D. Kong, Z. Wang, S. Sethi, W. Chen, F.H. Sarkar, and A. Raz Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells Cancer Res 71 2011 3400 3409
-
(2011)
Cancer Res
, vol.71
, pp. 3400-3409
-
-
Ahmad, A.1
Aboukameel, A.2
Kong, D.3
Wang, Z.4
Sethi, S.5
Chen, W.6
Sarkar, F.H.7
Raz, A.8
-
2
-
-
0003880161
-
-
Garland Publishers New York
-
B. Alberts, A. Johnson, A. Lewis, M. Raff, K. Roberts, and P. Walter Molecular biology of the cell 2002 Garland Publishers New York
-
(2002)
Molecular Biology of the Cell
-
-
Alberts, B.1
Johnson, A.2
Lewis, A.3
Raff, M.4
Roberts, K.5
Walter, P.6
-
3
-
-
6044239439
-
The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2′-deoxycytidine
-
W.G. Alleman, R.L. Tabios, G.V. Chandramouli, O.N. Aprelikova, C. Torres-Cabala, A. Mendoza, C. Rogers, N.A. Sopko, W.M. Linehan, and J.R. Vasselli The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2′-deoxycytidine Clin Cancer Res 10 2004 7011 7021
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7011-7021
-
-
Alleman, W.G.1
Tabios, R.L.2
Chandramouli, G.V.3
Aprelikova, O.N.4
Torres-Cabala, C.5
Mendoza, A.6
Rogers, C.7
Sopko, N.A.8
Linehan, W.M.9
Vasselli, J.R.10
-
4
-
-
0034802887
-
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression
-
B.P. Ashburner, S.D. Westerheide, and A.S. Baldwin Jr. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression Mol Cell Biol 21 2001 7065 7077
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7065-7077
-
-
Ashburner, B.P.1
Westerheide, S.D.2
Baldwin, Jr.A.S.3
-
5
-
-
0034964421
-
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
-
D. Astuti, F. Latif, A. Dallol, P.L. Dahia, F. Douglas, E. George, F. Skoldberg, E.S. Husebye, C. Eng, and E.R. Maher Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma Am J Hum Genet 69 2001 49 54
-
(2001)
Am J Hum Genet
, vol.69
, pp. 49-54
-
-
Astuti, D.1
Latif, F.2
Dallol, A.3
Dahia, P.L.4
Douglas, F.5
George, E.6
Skoldberg, F.7
Husebye, E.S.8
Eng, C.9
Maher, E.R.10
-
6
-
-
0030884480
-
Increases in mRNA levels of glucose transporters types 1 and 3 in Ehrlich ascites tumor cells during tumor development
-
K.K. Au, E. Liong, J.Y. Li, P.S. Li, C.C. Liew, T.T. Kwok, Y.M. Choy, C.Y. Lee, and K.P. Fung Increases in mRNA levels of glucose transporters types 1 and 3 in Ehrlich ascites tumor cells during tumor development J Cell Biochem 67 1997 131 135
-
(1997)
J Cell Biochem
, vol.67
, pp. 131-135
-
-
Au, K.K.1
Liong, E.2
Li, J.Y.3
Li, P.S.4
Liew, C.C.5
Kwok, T.T.6
Choy, Y.M.7
Lee, C.Y.8
Fung, K.P.9
-
7
-
-
80052848190
-
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin
-
V. Ayyasamy, K.M. Owens, M.M. Desouki, P. Liang, A. Bakin, K. Thangaraj, D.J. Buchsbaum, A.F. LoBuglio, and K.K. Singh Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin PLoS One 6 2011
-
(2011)
PLoS One
, vol.6
-
-
Ayyasamy, V.1
Owens, K.M.2
Desouki, M.M.3
Liang, P.4
Bakin, A.5
Thangaraj, K.6
Buchsbaum, D.J.7
Lobuglio, A.F.8
Singh, K.K.9
-
8
-
-
23844517036
-
Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer
-
H. Bando, T. Atsumi, T. Nishio, H. Niwa, S. Mishima, C. Shimizu, N. Yoshioka, R. Bucala, and T. Koike Phosphorylation of the 6-phosphofructo-2- kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer Clin Cancer Res 11 2005 5784 5792
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5784-5792
-
-
Bando, H.1
Atsumi, T.2
Nishio, T.3
Niwa, H.4
Mishima, S.5
Shimizu, C.6
Yoshioka, N.7
Bucala, R.8
Koike, T.9
-
9
-
-
18844440190
-
Chronic myeloid leukaemia: An investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation
-
K. Barnes, E. McIntosh, A.D. Whetton, G.Q. Daley, J. Bentley, and S.A. Baldwin Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation Oncogene 24 2005 3257 3267
-
(2005)
Oncogene
, vol.24
, pp. 3257-3267
-
-
Barnes, K.1
McIntosh, E.2
Whetton, A.D.3
Daley, G.Q.4
Bentley, J.5
Baldwin, S.A.6
-
10
-
-
35448982216
-
Hypoxia, glucose metabolism and the Warburg's effect
-
R. Bartrons, and J. Caro Hypoxia, glucose metabolism and the Warburg's effect J Bioenerg Biomembr 39 2007 223 229
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 223-229
-
-
Bartrons, R.1
Caro, J.2
-
11
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
B.E. Baysal, R.E. Ferrell, J.E. Willett-Brozick, E.C. Lawrence, D. Myssiorek, A. Bosch, M.e.A. van der, P.E. Taschner, W.S. Rubinstein, E.N. Myers, C.W. Richard III, C.J. Cornelisse, P. Devilee, and B. Devlin Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma Science 287 2000 848 851
-
(2000)
Science
, vol.287
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
Bosch, A.6
Van Der, M.E.A.7
Taschner, P.E.8
Rubinstein, W.S.9
Myers, E.N.10
Richard Iii, C.W.11
Cornelisse, C.J.12
Devilee, P.13
Devlin, B.14
-
12
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
K. Bensaad, A. Tsuruta, M.A. Selak, M.N. Vidal, K. Nakano, R. Bartrons, E. Gottlieb, and K.H. Vousden TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 2006 107 120
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
14
-
-
0019808551
-
Competitive inhibition of rat brain hexokinase by 2-deoxyglucose, glucosamine, and metrizamide
-
J.M. Bertoni Competitive inhibition of rat brain hexokinase by 2-deoxyglucose, glucosamine, and metrizamide J Neurochem 37 1981 1523 1528
-
(1981)
J Neurochem
, vol.37
, pp. 1523-1528
-
-
Bertoni, J.M.1
-
15
-
-
0028978268
-
High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose
-
M. Board, A. Colquhoun, and E.A. Newsholme High Km glucose- phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose Cancer Res 55 1995 3278 3285
-
(1995)
Cancer Res
, vol.55
, pp. 3278-3285
-
-
Board, M.1
Colquhoun, A.2
Newsholme, E.A.3
-
16
-
-
80054782483
-
The dual role of sirtuins in cancer
-
L. Bosch-Presegue, and A. Vaquero The dual role of sirtuins in cancer Genes Cancer 2 2011 648 662
-
(2011)
Genes Cancer
, vol.2
, pp. 648-662
-
-
Bosch-Presegue, L.1
Vaquero, A.2
-
17
-
-
0027489912
-
Overexpression of GLUT-1 glucose transporter in human breast cancer. An immunohistochemical study
-
R.S. Brown, and R.L. Wahl Overexpression of GLUT-1 glucose transporter in human breast cancer. An immunohistochemical study Cancer 72 1993 2979 2985
-
(1993)
Cancer
, vol.72
, pp. 2979-2985
-
-
Brown, R.S.1
Wahl, R.L.2
-
18
-
-
80053597754
-
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
-
U. Bruning, L. Cerone, Z. Neufeld, S.F. Fitzpatrick, A. Cheong, C.C. Scholz, D.A. Simpson, M.O. Leonard, M.M. Tambuwala, E.P. Cummins, and C.T. Taylor MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia Mol Cell Biol 31 2011 4087 4096
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4087-4096
-
-
Bruning, U.1
Cerone, L.2
Neufeld, Z.3
Fitzpatrick, S.F.4
Cheong, A.5
Scholz, C.C.6
Simpson, D.A.7
Leonard, M.O.8
Tambuwala, M.M.9
Cummins, E.P.10
Taylor, C.T.11
-
19
-
-
53449092586
-
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression
-
C.L. Buller, R.D. Loberg, M.H. Fan, Q. Zhu, J.L. Park, E. Vesely, K. Inoki, K.L. Guan, and F.C. Brosius III A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression Am J Physiol Cell Physiol 295 2008 C836 C843
-
(2008)
Am J Physiol Cell Physiol
, vol.295
-
-
Buller, C.L.1
Loberg, R.D.2
Fan, M.H.3
Zhu, Q.4
Park, J.L.5
Vesely, E.6
Inoki, K.7
Guan, K.L.8
Brosius Iii, F.C.9
-
21
-
-
34547225129
-
Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
-
R.A. Cairns, I. Papandreou, P.D. Sutphin, and N.C. Denko Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy Proc Natl Acad Sci U S A 104 2007 9445 9450
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9445-9450
-
-
Cairns, R.A.1
Papandreou, I.2
Sutphin, P.D.3
Denko, N.C.4
-
22
-
-
33846270366
-
Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
-
X. Cao, L. Fang, S. Gibbs, Y. Huang, Z. Dai, P. Wen, X. Zheng, W. Sadee, and D. Sun Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia Cancer Chemother Pharmacol 59 2007 495 505
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 495-505
-
-
Cao, X.1
Fang, L.2
Gibbs, S.3
Huang, Y.4
Dai, Z.5
Wen, P.6
Zheng, X.7
Sadee, W.8
Sun, D.9
-
23
-
-
70349478990
-
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
-
S.Y. Chan, Y.Y. Zhang, C. Hemann, C.E. Mahoney, J.L. Zweier, and J. Loscalzo MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2 Cell Metab 10 2009 273 284
-
(2009)
Cell Metab
, vol.10
, pp. 273-284
-
-
Chan, S.Y.1
Zhang, Y.Y.2
Hemann, C.3
Mahoney, C.E.4
Zweier, J.L.5
Loscalzo, J.6
-
24
-
-
33845526182
-
Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model
-
J.M. Chang, J.W. Chung, H.J. Jae, H. Eh, K.R. Son, K.C. Lee, and J.H. Park Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: in vivo investigation in normal rabbit model Acad Radiol 14 2007 85 92
-
(2007)
Acad Radiol
, vol.14
, pp. 85-92
-
-
Chang, J.M.1
Chung, J.W.2
Jae, H.J.3
Eh, H.4
Son, K.R.5
Lee, K.C.6
Park, J.H.7
-
25
-
-
0026459805
-
The inhibition of bovine heart hexokinase by 2-deoxy-d-glucose-6- phosphate: Characterization by 31P NMR and metabolic implications
-
W. Chen, and M. Gueron The inhibition of bovine heart hexokinase by 2-deoxy-d-glucose-6-phosphate: characterization by 31P NMR and metabolic implications Biochimie 74 1992 867 873
-
(1992)
Biochimie
, vol.74
, pp. 867-873
-
-
Chen, W.1
Gueron, M.2
-
26
-
-
62249137047
-
Role of miR-143 targeting KRAS in colorectal tumorigenesis
-
X. Chen, X. Guo, H. Zhang, Y. Xiang, J. Chen, Y. Yin, X. Cai, K. Wang, G. Wang, Y. Ba, L. Zhu, J. Wang, R. Yang, Y. Zhang, Z. Ren, K. Zen, J. Zhang, and C.Y. Zhang Role of miR-143 targeting KRAS in colorectal tumorigenesis Oncogene 28 2009 1385 1392
-
(2009)
Oncogene
, vol.28
, pp. 1385-1392
-
-
Chen, X.1
Guo, X.2
Zhang, H.3
Xiang, Y.4
Chen, J.5
Yin, Y.6
Cai, X.7
Wang, K.8
Wang, G.9
Ba, Y.10
Zhu, L.11
Wang, J.12
Yang, R.13
Zhang, Y.14
Ren, Z.15
Zen, K.16
Zhang, J.17
Zhang, C.Y.18
-
28
-
-
67449128222
-
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
-
W. Chen, Z. Sun, X.J. Wang, T. Jiang, Z. Huang, D. Fang, and D.D. Zhang Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response Mol Cell 34 2009 663 673
-
(2009)
Mol Cell
, vol.34
, pp. 663-673
-
-
Chen, W.1
Sun, Z.2
Wang, X.J.3
Jiang, T.4
Huang, Z.5
Fang, D.6
Zhang, D.D.7
-
29
-
-
80054776840
-
Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer
-
M. Chen, J. Zhang, N. Li, Z. Qian, M. Zhu, Q. Li, J. Zheng, X. Wang, and G. Shi Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer PLoS One 6 2011
-
(2011)
PLoS One
, vol.6
-
-
Chen, M.1
Zhang, J.2
Li, N.3
Qian, Z.4
Zhu, M.5
Li, Q.6
Zheng, J.7
Wang, X.8
Shi, G.9
-
30
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
-
J. Cheng, X. Kang, S. Zhang, and E.T. Yeh SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia Cell 131 2007 584 595
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.4
-
31
-
-
84861158967
-
Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death
-
G. Cheng, J. Zielonka, B.P. Dranka, D. McAllister, A.C. Mackinnon Jr., J. Joseph, and B. Kalyanaraman Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death Cancer Res 72 2012 2634 2644
-
(2012)
Cancer Res
, vol.72
, pp. 2634-2644
-
-
Cheng, G.1
Zielonka, J.2
Dranka, B.P.3
McAllister, D.4
MacKinnon, Jr.A.C.5
Joseph, J.6
Kalyanaraman, B.7
-
32
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
H.R. Christofk, M.G. Vander Heiden, M.H. Harris, A. Ramanathan, R.E. Gerszten, R. Wei, M.D. Fleming, S.L. Schreiber, and L.C. Cantley The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Nature 452 2008 230 233
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
33
-
-
38349183620
-
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
-
B. Clem, S. Telang, A. Clem, A. Yalcin, J. Meier, A. Simmons, M.A. Rasku, S. Arumugam, W.L. Dean, J. Eaton, A. Lane, J.O. Trent, and J. Chesney Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth Mol Cancer Ther 7 2008 110 120
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 110-120
-
-
Clem, B.1
Telang, S.2
Clem, A.3
Yalcin, A.4
Meier, J.5
Simmons, A.6
Rasku, M.A.7
Arumugam, S.8
Dean, W.L.9
Eaton, J.10
Lane, A.11
Trent, J.O.12
Chesney, J.13
-
34
-
-
0023157214
-
Control of phosphofructokinase by fructose 2,6-bisphosphate in B-lymphocytes and B-chronic lymphocytic leukemia cells
-
D. Colomer, J.L. Vives-Corrons, A. Pujades, and R. Bartrons Control of phosphofructokinase by fructose 2,6-bisphosphate in B-lymphocytes and B-chronic lymphocytic leukemia cells Cancer Res 47 1987 1859 1862
-
(1987)
Cancer Res
, vol.47
, pp. 1859-1862
-
-
Colomer, D.1
Vives-Corrons, J.L.2
Pujades, A.3
Bartrons, R.4
-
36
-
-
35448937135
-
A message emerging from development: The repression of mitochondrial beta-F1-ATPase expression in cancer
-
J.M. Cuezva, M. Sanchez-Arago, S. Sala, A. Blanco-Rivero, and A.D. Ortega A message emerging from development: the repression of mitochondrial beta-F1-ATPase expression in cancer J Bioenerg Biomembr 39 2007 259 265
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 259-265
-
-
Cuezva, J.M.1
Sanchez-Arago, M.2
Sala, S.3
Blanco-Rivero, A.4
Ortega, A.D.5
-
37
-
-
0036795899
-
Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
-
R. Dagher, M. Cohen, G. Williams, M. Rothmann, J. Gobburu, G. Robbie, A. Rahman, G. Chen, A. Staten, D. Griebel, and R. Pazdur Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors Clin Cancer Res 8 2002 3034 3038
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3034-3038
-
-
Dagher, R.1
Cohen, M.2
Williams, G.3
Rothmann, M.4
Gobburu, J.5
Robbie, G.6
Rahman, A.7
Chen, G.8
Staten, A.9
Griebel, D.10
Pazdur, R.11
-
38
-
-
77958492734
-
Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
-
C.V. Dang Glutaminolysis: supplying carbon or nitrogen or both for cancer cells? Cell Cycle 9 2010 3884 3886
-
(2010)
Cell Cycle
, vol.9
, pp. 3884-3886
-
-
Dang, C.V.1
-
40
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and C.B. Thompson The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab 7 2008 11 20
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
41
-
-
76649137960
-
Cancer proliferation and therapy: The Warburg effect and quantum metabolism
-
L.A. Demetrius, J.F. Coy, and J.A. Tuszynski Cancer proliferation and therapy: the Warburg effect and quantum metabolism Theor Biol Med Model 7 2010 2
-
(2010)
Theor Biol Med Model
, vol.7
, pp. 2
-
-
Demetrius, L.A.1
Coy, J.F.2
Tuszynski, J.A.3
-
42
-
-
50149097983
-
Hypoxia, HIF1 and glucose metabolism in the solid tumour
-
N.C. Denko Hypoxia, HIF1 and glucose metabolism in the solid tumour Nat Rev Cancer 8 2008 705 713
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 705-713
-
-
Denko, N.C.1
-
43
-
-
0030748651
-
Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
-
J. Deprez, D. Vertommen, D.R. Alessi, L. Hue, and M.H. Rider Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades J Biol Chem 272 1997 17269 17275
-
(1997)
J Biol Chem
, vol.272
, pp. 17269-17275
-
-
Deprez, J.1
Vertommen, D.2
Alessi, D.R.3
Hue, L.4
Rider, M.H.5
-
44
-
-
0020377044
-
Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography
-
G. Di Chiro, R.L. DeLaPaz, R.A. Brooks, L. Sokoloff, P.L. Kornblith, B.H. Smith, N.J. Patronas, C.V. Kufta, R.M. Kessler, G.S. Johnston, R.G. Manning, and A.P. Wolf Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography Neurology 32 1982 1323 1329
-
(1982)
Neurology
, vol.32
, pp. 1323-1329
-
-
Di Chiro, G.1
Delapaz, R.L.2
Brooks, R.A.3
Sokoloff, L.4
Kornblith, P.L.5
Smith, B.H.6
Patronas, N.J.7
Kufta, C.V.8
Kessler, R.M.9
Johnston, G.S.10
Manning, R.G.11
Wolf, A.P.12
-
45
-
-
33645130721
-
Clinical evidence supporting the role of lonidamine for the treatment of BPH
-
P. Ditonno, M. Battaglia, O. Selvaggio, L. Garofalo, V. Lorusso, and F.P. Selvaggi Clinical evidence supporting the role of lonidamine for the treatment of BPH Rev Urol 7 Suppl. 7 2005 S27 S33
-
(2005)
Rev Urol
, vol.7
, Issue.SUPPL. 7
-
-
Ditonno, P.1
Battaglia, M.2
Selvaggio, O.3
Garofalo, L.4
Lorusso, V.5
Selvaggi, F.P.6
-
46
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
K. Duvel, J.L. Yecies, S. Menon, P. Raman, A.I. Lipovsky, A.L. Souza, E. Triantafellow, Q. Ma, R. Gorski, S. Cleaver, M.G. Vander Heiden, J.P. MacKeigan, P.M. Finan, C.B. Clish, L.O. Murphy, and B.D. Manning Activation of a metabolic gene regulatory network downstream of mTOR complex 1 Mol Cell 39 2010 171 183
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
Vander Heiden, M.G.11
MacKeigan, J.P.12
Finan, P.M.13
Clish, C.B.14
Murphy, L.O.15
Manning, B.D.16
-
47
-
-
58149350343
-
MiR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells
-
A. El Ouaamari, N. Baroukh, G.A. Martens, P. Lebrun, D. Pipeleers, and E. van Obberghen miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells Diabetes 57 2008 2708 2717
-
(2008)
Diabetes
, vol.57
, pp. 2708-2717
-
-
El Ouaamari, A.1
Baroukh, N.2
Martens, G.A.3
Lebrun, P.4
Pipeleers, D.5
Van Obberghen, E.6
-
48
-
-
38649105459
-
MiR-122 targeting with LNA/2′-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates
-
M.M. Fabani, and M.J. Gait miR-122 targeting with LNA/2′-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates RNA 14 2008 336 346
-
(2008)
RNA
, vol.14
, pp. 336-346
-
-
Fabani, M.M.1
Gait, M.J.2
-
49
-
-
83255171153
-
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
-
J. Fan, T. Hitosugi, T.W. Chung, J. Xie, Q. Ge, T.L. Gu, R.D. Polakiewicz, G.Z. Chen, T.J. Boggon, S. Lonial, F.R. Khuri, S. Kang, and J. Chen Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells Mol Cell Biol 31 2011 4938 4950
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4938-4950
-
-
Fan, J.1
Hitosugi, T.2
Chung, T.W.3
Xie, J.4
Ge, Q.5
Gu, T.L.6
Polakiewicz, R.D.7
Chen, G.Z.8
Boggon, T.J.9
Lonial, S.10
Khuri, F.R.11
Kang, S.12
Chen, J.13
-
50
-
-
84863316020
-
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene
-
R. Fang, T. Xiao, Z. Fang, Y. Sun, F. Li, Y. Gao, Y. Feng, L. Li, Y. Wang, X. Liu, H. Chen, X.Y. Liu, and H. Ji MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene J Biol Chem 29 2012 23227 23235
-
(2012)
J Biol Chem
, vol.29
, pp. 23227-23235
-
-
Fang, R.1
Xiao, T.2
Fang, Z.3
Sun, Y.4
Li, F.5
Gao, Y.6
Feng, Y.7
Li, L.8
Wang, Y.9
Liu, X.10
Chen, H.11
Liu, X.Y.12
Ji, H.13
-
51
-
-
77956402239
-
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU
-
E. Favaro, A. Ramachandran, R. McCormick, H. Gee, C. Blancher, M. Crosby, C. Devlin, C. Blick, F. Buffa, J.L. Li, B. Vojnovic, N.e.R. Pires das, P. Glazer, F. Iborra, M. Ivan, J. Ragoussis, and A.L. Harris MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU PLoS One 5 2010
-
(2010)
PLoS One
, vol.5
-
-
Favaro, E.1
Ramachandran, A.2
McCormick, R.3
Gee, H.4
Blancher, C.5
Crosby, M.6
Devlin, C.7
Blick, C.8
Buffa, F.9
Li, J.L.10
Vojnovic, B.11
Pires Das, N.E.R.12
Glazer, P.13
Iborra, F.14
Ivan, M.15
Ragoussis, J.16
Harris, A.L.17
-
52
-
-
48149114282
-
New roles for pyruvate kinase M2: Working out the Warburg effect
-
E.C. Ferguson, and J.C. Rathmell New roles for pyruvate kinase M2: working out the Warburg effect Trends Biochem Sci 33 2008 359 362
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 359-362
-
-
Ferguson, E.C.1
Rathmell, J.C.2
-
53
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization
-
L.W. Finley, A. Carracedo, J. Lee, A. Souza, A. Egia, J. Zhang, J. Teruya-Feldstein, P.I. Moreira, S.M. Cardoso, C.B. Clish, P.P. Pandolfi, and M.C. Haigis SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization Cancer Cell 19 2011 416 428
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
Carracedo, A.2
Lee, J.3
Souza, A.4
Egia, A.5
Zhang, J.6
Teruya-Feldstein, J.7
Moreira, P.I.8
Cardoso, S.M.9
Clish, C.B.10
Pandolfi, P.P.11
Haigis, M.C.12
-
54
-
-
0029101515
-
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
-
J.D. Firth, B.L. Ebert, and P.J. Ratcliffe Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements J Biol Chem 270 1995 21021 21027
-
(1995)
J Biol Chem
, vol.270
, pp. 21021-21027
-
-
Firth, J.D.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
55
-
-
0019868629
-
Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells
-
A. Floridi, M.G. Paggi, S. D'Atri, C. De Martino, M.L. Marcante, B. Silvestrini, and A. Caputo Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells Cancer Res 41 1981 4661 4666
-
(1981)
Cancer Res
, vol.41
, pp. 4661-4666
-
-
Floridi, A.1
Paggi, M.G.2
D'Atri, S.3
De Martino, C.4
Marcante, M.L.5
Silvestrini, B.6
Caputo, A.7
-
56
-
-
0034676303
-
Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival
-
P. Flynn, M. Wongdagger, M. Zavar, N.M. Dean, and D. Stokoe Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival Curr Biol 10 2000 1439 1442
-
(2000)
Curr Biol
, vol.10
, pp. 1439-1442
-
-
Flynn, P.1
Wongdagger, M.2
Zavar, M.3
Dean, N.M.4
Stokoe, D.5
-
57
-
-
77953773201
-
MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
-
F. Fornari, M. Milazzo, P. Chieco, M. Negrini, G.A. Calin, G.L. Grazi, D. Pollutri, C.M. Croce, L. Bolondi, and L. Gramantieri MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells Cancer Res 70 2010 5184 5193
-
(2010)
Cancer Res
, vol.70
, pp. 5184-5193
-
-
Fornari, F.1
Milazzo, M.2
Chieco, P.3
Negrini, M.4
Calin, G.A.5
Grazi, G.L.6
Pollutri, D.7
Croce, C.M.8
Bolondi, L.9
Gramantieri, L.10
-
58
-
-
75149139875
-
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death
-
S. Ganapathy-Kanniappan, J.F. Geschwind, R. Kunjithapatham, M. Buijs, J.A. Vossen, I. Tchernyshyov, R.N. Cole, L.H. Syed, P.P. Rao, S. Ota, and M. Vali Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death Anticancer Res 29 2009 4909 4918
-
(2009)
Anticancer Res
, vol.29
, pp. 4909-4918
-
-
Ganapathy-Kanniappan, S.1
Geschwind, J.F.2
Kunjithapatham, R.3
Buijs, M.4
Vossen, J.A.5
Tchernyshyov, I.6
Cole, R.N.7
Syed, L.H.8
Rao, P.P.9
Ota, S.10
Vali, M.11
-
59
-
-
33744969828
-
Energy deregulation: Licensing tumors to grow
-
K. Garber Energy deregulation: licensing tumors to grow Science 312 2006 1158 1159
-
(2006)
Science
, vol.312
, pp. 1158-1159
-
-
Garber, K.1
-
60
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
R.A. Gatenby, and R.J. Gillies Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4 2004 891 899
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
61
-
-
67049096242
-
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
-
A.K. Ghosh, T.D. Shanafelt, A. Cimmino, C. Taccioli, S. Volinia, C.G. Liu, G.A. Calin, C.M. Croce, D.A. Chan, A.J. Giaccia, C. Secreto, L.E. Wellik, Y.K. Lee, D. Mukhopadhyay, and N.E. Kay Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells Blood 113 2009 5568 5574
-
(2009)
Blood
, vol.113
, pp. 5568-5574
-
-
Ghosh, A.K.1
Shanafelt, T.D.2
Cimmino, A.3
Taccioli, C.4
Volinia, S.5
Liu, C.G.6
Calin, G.A.7
Croce, C.M.8
Chan, D.A.9
Giaccia, A.J.10
Secreto, C.11
Wellik, L.E.12
Lee, Y.K.13
Mukhopadhyay, D.14
Kay, N.E.15
-
62
-
-
78049424494
-
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis
-
(LID - 10.1172/JCI)
-
G. Ghosh, I.V. Subramanian, N. Adhikari, X. Zhang, H.P. Joshi, D. Basi, Y.S. Chandrashekhar, J.L. Hall, S. Roy, Y. Zeng, and S. Ramakrishnan Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis J Clin Invest 120 2010 4141 4154 (LID - 10.1172/JCI)
-
(2010)
J Clin Invest
, vol.120
, pp. 4141-4154
-
-
Ghosh, G.1
Subramanian, I.V.2
Adhikari, N.3
Zhang, X.4
Joshi, H.P.5
Basi, D.6
Chandrashekhar, Y.S.7
Hall, J.L.8
Roy, S.9
Zeng, Y.10
Ramakrishnan, S.11
-
63
-
-
46749121459
-
Causes and consequences of increased glucose metabolism of cancers
-
R.J. Gillies, I. Robey, and R.A. Gatenby Causes and consequences of increased glucose metabolism of cancers J Nucl Med 49 Suppl. 2 2008 24S 42S
-
(2008)
J Nucl Med
, vol.49
, Issue.SUPPL. 2
-
-
Gillies, R.J.1
Robey, I.2
Gatenby, R.A.3
-
64
-
-
0031969042
-
Hypoxia and the regulation of gene expression
-
J.M. Gleadle, and P.J. Ratcliffe Hypoxia and the regulation of gene expression Mol Med Today 4 1998 122 129
-
(1998)
Mol Med Today
, vol.4
, pp. 122-129
-
-
Gleadle, J.M.1
Ratcliffe, P.J.2
-
65
-
-
77649259296
-
MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells
-
J. Godlewski, M.O. Nowicki, A. Bronisz, G. Nuovo, J. Palatini, M. De Lay, J. Van Brocklyn, M.C. Ostrowski, E.A. Chiocca, and S.E. Lawler MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells Mol Cell 37 2010 620 632
-
(2010)
Mol Cell
, vol.37
, pp. 620-632
-
-
Godlewski, J.1
Nowicki, M.O.2
Bronisz, A.3
Nuovo, G.4
Palatini, J.5
De Lay, M.6
Van Brocklyn, J.7
Ostrowski, M.C.8
Chiocca, E.A.9
Lawler, S.E.10
-
66
-
-
0038012340
-
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression
-
A. Goel, S.P. Mathupala, and P.L. Pedersen Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression J Biol Chem 278 2003 15333 15340
-
(2003)
J Biol Chem
, vol.278
, pp. 15333-15340
-
-
Goel, A.1
Mathupala, S.P.2
Pedersen, P.L.3
-
67
-
-
41149105722
-
Mitochondria in cancer cells: What is so special about them?
-
V. Gogvadze, S. Orrenius, and B. Zhivotovsky Mitochondria in cancer cells: what is so special about them? Trends Cell Biol 18 2008 165 173
-
(2008)
Trends Cell Biol
, vol.18
, pp. 165-173
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
68
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
J.D. Gordan, J.A. Bertout, C.J. Hu, J.A. Diehl, and M.C. Simon HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity Cancer Cell 11 2007 335 347
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
69
-
-
34547580590
-
HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
-
J.D. Gordan, C.B. Thompson, and M.C. Simon HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation Cancer Cell 12 2007 108 113
-
(2007)
Cancer Cell
, vol.12
, pp. 108-113
-
-
Gordan, J.D.1
Thompson, C.B.2
Simon, M.C.3
-
70
-
-
28544446058
-
Mitochondrial tumour suppressors: A genetic and biochemical update
-
E. Gottlieb, and I.P. Tomlinson Mitochondrial tumour suppressors: a genetic and biochemical update Nat Rev Cancer 5 2005 857 866
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 857-866
-
-
Gottlieb, E.1
Tomlinson, I.P.2
-
71
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
K. Gottlob, N. Majewski, S. Kennedy, E. Kandel, R.B. Robey, and N. Hay Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase Genes Dev 15 2001 1406 1418
-
(2001)
Genes Dev
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
72
-
-
84861961199
-
MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells
-
L.H. Gregersen, A. Jacobsen, L.B. Frankel, J. Wen, A. Krogh, and A.H. Lund microRNA-143 down-regulates Hexokinase 2 in colon cancer cells BMC Cancer 12 2012 232
-
(2012)
BMC Cancer
, vol.12
, pp. 232
-
-
Gregersen, L.H.1
Jacobsen, A.2
Frankel, L.B.3
Wen, J.4
Krogh, A.5
Lund, A.H.6
-
73
-
-
52249096359
-
The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
-
C. Guo, J.F. Sah, L. Beard, J.K. Willson, S.D. Markowitz, and K. Guda The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers Genes Chromosomes Cancer 47 2008 939 946
-
(2008)
Genes Chromosomes Cancer
, vol.47
, pp. 939-946
-
-
Guo, C.1
Sah, J.F.2
Beard, L.3
Willson, J.K.4
Markowitz, S.D.5
Guda, K.6
-
74
-
-
10944247187
-
The AMP-activated protein kinase pathway-new players upstream and downstream
-
D.G. Hardie The AMP-activated protein kinase pathway-new players upstream and downstream J Cell Sci 117 2004 5479 5487
-
(2004)
J Cell Sci
, vol.117
, pp. 5479-5487
-
-
Hardie, D.G.1
-
75
-
-
0003116179
-
Clinical experience with 6-aminonicotinamide
-
F.P. Herter, S.G. Weissman, H.G. Thompson Jr., G. Hyman, and D.S. Martin Clinical experience with 6-aminonicotinamide Cancer Res 21 1961 31 37
-
(1961)
Cancer Res
, vol.21
, pp. 31-37
-
-
Herter, F.P.1
Weissman, S.G.2
Thompson, Jr.H.G.3
Hyman, G.4
Martin, D.S.5
-
77
-
-
67349240804
-
Metabolic defects provide a spark for the epigenetic switch in cancer
-
M.J. Hitchler, and F.E. Domann Metabolic defects provide a spark for the epigenetic switch in cancer Free Radic Biol Med 47 2009 115 127
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 115-127
-
-
Hitchler, M.J.1
Domann, F.E.2
-
78
-
-
84255162057
-
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
-
T. Hitosugi, J. Fan, T.W. Chung, K. Lythgoe, X. Wang, J. Xie, Q. Ge, T.L. Gu, R.D. Polakiewicz, J.L. Roesel, G.Z. Chen, T.J. Boggon, S. Lonial, H. Fu, F.R. Khuri, S. Kang, and J. Chen Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism Mol Cell 44 2011 864 877
-
(2011)
Mol Cell
, vol.44
, pp. 864-877
-
-
Hitosugi, T.1
Fan, J.2
Chung, T.W.3
Lythgoe, K.4
Wang, X.5
Xie, J.6
Ge, Q.7
Gu, T.L.8
Polakiewicz, R.D.9
Roesel, J.L.10
Chen, G.Z.11
Boggon, T.J.12
Lonial, S.13
Fu, H.14
Khuri, F.R.15
Kang, S.16
Chen, J.17
-
79
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
T. Hitosugi, S. Kang, M.G. Vander Heiden, T.W. Chung, S. Elf, K. Lythgoe, S. Dong, S. Lonial, X. Wang, G.Z. Chen, J. Xie, T.L. Gu, R.D. Polakiewicz, J.L. Roesel, T.J. Boggon, F.R. Khuri, D.G. Gilliland, L.C. Cantley, and Kaufm Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth Sci Signal 2 2009
-
(2009)
Sci Signal
, vol.2
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
Chung, T.W.4
Elf, S.5
Lythgoe, K.6
Dong, S.7
Lonial, S.8
Wang, X.9
Chen, G.Z.10
Xie, J.11
Gu, T.L.12
Polakiewicz, R.D.13
Roesel, J.L.14
Boggon, T.J.15
Khuri, F.R.16
Gilliland, D.G.17
Cantley, L.C.18
Kaufm19
-
80
-
-
0034989311
-
Biological consequences of tumor hypoxia
-
M. Hockel, and P. Vaupel Biological consequences of tumor hypoxia Semin Oncol 28 2001 36 41
-
(2001)
Semin Oncol
, vol.28
, pp. 36-41
-
-
Hockel, M.1
Vaupel, P.2
-
81
-
-
70349309314
-
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes
-
T. Horie, K. Ono, H. Nishi, Y. Iwanaga, K. Nagao, M. Kinoshita, Y. Kuwabara, R. Takanabe, K. Hasegawa, T. Kita, and T. Kimura MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes Biochem Biophys Res Commun 389 2009 315 320
-
(2009)
Biochem Biophys Res Commun
, vol.389
, pp. 315-320
-
-
Horie, T.1
Ono, K.2
Nishi, H.3
Iwanaga, Y.4
Nagao, K.5
Kinoshita, M.6
Kuwabara, Y.7
Takanabe, R.8
Hasegawa, K.9
Kita, T.10
Kimura, T.11
-
82
-
-
77953096272
-
Negative regulation of tumor suppressor p53 by microRNA miR-504
-
W. Hu, C.S. Chan, R. Wu, C. Zhang, Y. Sun, J.S. Song, L.H. Tang, A.J. Levine, and Z. Feng Negative regulation of tumor suppressor p53 by microRNA miR-504 Mol Cell 38 2010 689 699
-
(2010)
Mol Cell
, vol.38
, pp. 689-699
-
-
Hu, W.1
Chan, C.S.2
Wu, R.3
Zhang, C.4
Sun, Y.5
Song, J.S.6
Tang, L.H.7
Levine, A.J.8
Feng, Z.9
-
83
-
-
77952212178
-
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
-
W. Hu, C. Zhang, R. Wu, Y. Sun, A. Levine, and Z. Feng Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Proc Natl Acad Sci U S A 107 2010 7455 7460
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7455-7460
-
-
Hu, W.1
Zhang, C.2
Wu, R.3
Sun, Y.4
Levine, A.5
Feng, Z.6
-
84
-
-
33644864991
-
Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: Role of Sp1
-
D.Y. Hwang, and F. Ismail-Beigi Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1 Am J Physiol Cell Physiol 290 2006 C337 C344
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
Hwang, D.Y.1
Ismail-Beigi, F.2
-
85
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
J.S. Isaacs, Y.J. Jung, E.G. Mimnaugh, A. Martinez, F. Cuttitta, and L.M. Neckers Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway J Biol Chem 277 2002 29936 29944
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
86
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
J.S. Isaacs, Y.J. Jung, D.R. Mole, S. Lee, C. Torres-Cabala, Y.L. Chung, M. Merino, J. Trepel, B. Zbar, J. Toro, P.J. Ratcliffe, W.M. Linehan, and L. Neckers HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability Cancer Cell 8 2005 143 153
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.L.6
Merino, M.7
Trepel, J.8
Zbar, B.9
Toro, J.10
Ratcliffe, P.J.11
Linehan, W.M.12
Neckers, L.13
-
87
-
-
10744221423
-
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
-
A. Isidoro, M. Martinez, P.L. Fernandez, A.D. Ortega, G. Santamaria, M. Chamorro, J.C. Reed, and J.M. Cuezva Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer Biochem J 378 2004 17 20
-
(2004)
Biochem J
, vol.378
, pp. 17-20
-
-
Isidoro, A.1
Martinez, M.2
Fernandez, P.L.3
Ortega, A.D.4
Santamaria, G.5
Chamorro, M.6
Reed, J.C.7
Cuezva, J.M.8
-
88
-
-
84862812020
-
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
-
(LID - 10.1038/emb)
-
S. Jiang, L.F. Zhang, H.W. Zhang, S. Hu, M.H. Lu, S. Liang, B. Li, Y. Li, D. Li, E.D. Wang, and M.F. Liu A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells EMBO J 31 2012 1985 1998 (LID - 10.1038/emb)
-
(2012)
EMBO J
, vol.31
, pp. 1985-1998
-
-
Jiang, S.1
Zhang, L.F.2
Zhang, H.W.3
Hu, S.4
Lu, M.H.5
Liang, S.6
Li, B.7
Li, Y.8
Li, D.9
Wang, E.D.10
Liu, M.F.11
-
89
-
-
20044395613
-
RAS is regulated by the let-7 microRNA family
-
S.M. Johnson, H. Grosshans, J. Shingara, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K.L. Reinert, D. Brown, and F.J. Slack RAS is regulated by the let-7 microRNA family Cell 120 2005 635 647
-
(2005)
Cell
, vol.120
, pp. 635-647
-
-
Johnson, S.M.1
Grosshans, H.2
Shingara, J.3
Byrom, M.4
Jarvis, R.5
Cheng, A.6
Labourier, E.7
Reinert, K.L.8
Brown, D.9
Slack, F.J.10
-
90
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
R.G. Jones, D.R. Plas, S. Kubek, M. Buzzai, J. Mu, Y. Xu, M.J. Birnbaum, and C.B. Thompson AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol Cell 18 2005 283 293
-
(2005)
Mol Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
91
-
-
61849135453
-
Tumor suppressors and cell metabolism: A recipe for cancer growth
-
R.G. Jones, and C.B. Thompson Tumor suppressors and cell metabolism: a recipe for cancer growth Genes Dev 23 2009 537 548
-
(2009)
Genes Dev
, vol.23
, pp. 537-548
-
-
Jones, R.G.1
Thompson, C.B.2
-
92
-
-
33746427905
-
The von Hippel-Lindau tumor suppressor protein: Roles in cancer and oxygen sensing
-
W.G. Kaelin The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing Cold Spring Harb Symp Quant Biol 70 2005 159 166
-
(2005)
Cold Spring Harb Symp Quant Biol
, vol.70
, pp. 159-166
-
-
Kaelin, W.G.1
-
93
-
-
2542615352
-
Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-The Warburg effect revisited
-
R. Kannagi Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-The Warburg effect revisited Glycoconj J 20 2004 353 364
-
(2004)
Glycoconj J
, vol.20
, pp. 353-364
-
-
Kannagi, R.1
-
94
-
-
78650126775
-
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells
-
B. Kefas, L. Comeau, N. Erdle, E. Montgomery, S. Amos, and B. Purow Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells Neuro Oncol 12 2010 1102 1112
-
(2010)
Neuro Oncol
, vol.12
, pp. 1102-1112
-
-
Kefas, B.1
Comeau, L.2
Erdle, N.3
Montgomery, E.4
Amos, S.5
Purow, B.6
-
95
-
-
79959425207
-
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
-
T.J. Kelly, A.L. Souza, C.B. Clish, and P. Puigserver A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like Mol Cell Biol 31 2011 2696 2706
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2696-2706
-
-
Kelly, T.J.1
Souza, A.L.2
Clish, C.B.3
Puigserver, P.4
-
96
-
-
78650204499
-
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
-
O.A. Kent, R.R. Chivukula, M. Mullendore, E.A. Wentzel, G. Feldmann, K.H. Lee, S. Liu, S.D. Leach, A. Maitra, and J.T. Mendell Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway Genes Dev 24 2010 2754 2759
-
(2010)
Genes Dev
, vol.24
, pp. 2754-2759
-
-
Kent, O.A.1
Chivukula, R.R.2
Mullendore, M.3
Wentzel, E.A.4
Feldmann, G.5
Lee, K.H.6
Liu, S.7
Leach, S.D.8
Maitra, A.9
Mendell, J.T.10
-
97
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
J.W. Kim, and C.V. Dang Cancer's molecular sweet tooth and the Warburg effect Cancer Res 66 2006 8927 8930
-
(2006)
Cancer Res
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
98
-
-
33846643485
-
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
-
S.H. Kim, and G.M. Lee Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin Appl Microbiol Biotechnol 74 2007 152 159
-
(2007)
Appl Microbiol Biotechnol
, vol.74
, pp. 152-159
-
-
Kim, S.H.1
Lee, G.M.2
-
99
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
J.W. Kim, I. Tchernyshyov, G.L. Semenza, and C.V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metab 3 2006 177 185
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
100
-
-
0000281046
-
Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP
-
E. Kohler, H. Barrach, and D. Neubert Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP FEBS Lett 6 1970 225 228
-
(1970)
FEBS Lett
, vol.6
, pp. 225-228
-
-
Kohler, E.1
Barrach, H.2
Neubert, D.3
-
101
-
-
2542588628
-
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates
-
T. Koike, N. Kimura, K. Miyazaki, T. Yabuta, K. Kumamoto, S. Takenoshita, J. Chen, M. Kobayashi, M. Hosokawa, A. Taniguchi, T. Kojima, N. Ishida, M. Kawakita, H. Yamamoto, H. Takematsu, A. Suzuki, Y. Kozutsumi, and R. Kannagi Hypoxia induces adhesion molecules on cancer cells: a missing link between Warburg effect and induction of selectin-ligand carbohydrates Proc Natl Acad Sci U S A 101 2004 8132 8137
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8132-8137
-
-
Koike, T.1
Kimura, N.2
Miyazaki, K.3
Yabuta, T.4
Kumamoto, K.5
Takenoshita, S.6
Chen, J.7
Kobayashi, M.8
Hosokawa, M.9
Taniguchi, A.10
Kojima, T.11
Ishida, N.12
Kawakita, M.13
Yamamoto, H.14
Takematsu, H.15
Suzuki, A.16
Kozutsumi, Y.17
Kannagi, R.18
-
102
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
H. Kondoh, M.E. Lleonart, J. Gil, J. Wang, P. Degan, G. Peters, D. Martinez, A. Carnero, and D. Beach Glycolytic enzymes can modulate cellular life span Cancer Res 65 2005 177 185
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
103
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
W.H. Koppenol, P.L. Bounds, and C.V. Dang Otto Warburg's contributions to current concepts of cancer metabolism Nat Rev Cancer 11 2011 325 337
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
104
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
M. Koshiji, Y. Kageyama, E.A. Pete, I. Horikawa, J.C. Barrett, and L.E. Huang HIF-1alpha induces cell cycle arrest by functionally counteracting Myc EMBO J 23 2004 1949 1956
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
105
-
-
79951812882
-
Negative regulation of the tumor suppressor p53 gene by microRNAs
-
M. Kumar, Z. Lu, A.A. Takwi, W. Chen, N.S. Callander, K.S. Ramos, K.H. Young, and Y. Li Negative regulation of the tumor suppressor p53 gene by microRNAs Oncogene 30 2011 843 853
-
(2011)
Oncogene
, vol.30
, pp. 843-853
-
-
Kumar, M.1
Lu, Z.2
Takwi, A.A.3
Chen, W.4
Callander, N.S.5
Ramos, K.S.6
Young, K.H.7
Li, Y.8
-
106
-
-
0033739497
-
Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1
-
A. Lagana, J. Vadnais, P.U. Le, T.N. Nguyen, R. Laprade, I.R. Nabi, and J. Noel Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1 J Cell Sci 113 Pt 20 2000 3649 3662
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 20
, pp. 3649-3662
-
-
Lagana, A.1
Vadnais, J.2
Le, P.U.3
Nguyen, T.N.4
Laprade, R.5
Nabi, I.R.6
Noel, J.7
-
107
-
-
0035812284
-
Transcriptional response to hypoxia in human tumors
-
A. Lal, H. Peters, B. St Croix, Z.A. Haroon, M.W. Dewhirst, R.L. Strausberg, J.H. Kaanders, K.o.A. van der, and G.J. Riggins Transcriptional response to hypoxia in human tumors J Natl Cancer Inst 93 2001 1337 1343
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1337-1343
-
-
Lal, A.1
Peters, H.2
St Croix, B.3
Haroon, Z.A.4
Dewhirst, M.W.5
Strausberg, R.L.6
Kaanders, J.H.7
Van Der, K.O.A.8
Riggins, G.J.9
-
108
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
M. Laplante, and D.M. Sabatini An emerging role of mTOR in lipid biosynthesis Curr Biol 19 2009 R1046 R1052
-
(2009)
Curr Biol
, vol.19
-
-
Laplante, M.1
Sabatini, D.M.2
-
109
-
-
64349101658
-
MicroRNA-125b is a novel negative regulator of p53
-
M.T. Le, C. Teh, N. Shyh-Chang, H. Xie, B. Zhou, V. Korzh, H.F. Lodish, and B. Lim MicroRNA-125b is a novel negative regulator of p53 Genes Dev 23 2009 862 876
-
(2009)
Genes Dev
, vol.23
, pp. 862-876
-
-
Le, M.T.1
Teh, C.2
Shyh-Chang, N.3
Xie, H.4
Zhou, B.5
Korzh, V.6
Lodish, H.F.7
Lim, B.8
-
110
-
-
77955175251
-
MicroRNAs induced during ischemic preconditioning
-
S.T. Lee, K. Chu, K.H. Jung, H.J. Yoon, D. Jeon, K.M. Kang, K.H. Park, E.K. Bae, M. Kim, S.K. Lee, and J.K. Roh MicroRNAs induced during ischemic preconditioning Stroke 41 2010 1646 1651
-
(2010)
Stroke
, vol.41
, pp. 1646-1651
-
-
Lee, S.T.1
Chu, K.2
Jung, K.H.3
Yoon, H.J.4
Jeon, D.5
Kang, K.M.6
Park, K.H.7
Bae, E.K.8
Kim, M.9
Lee, S.K.10
Roh, J.K.11
-
111
-
-
75149159101
-
Warburg effect revisited: An epigenetic link between glycolysis and gastric carcinogenesis
-
X. Liu, X. Wang, J. Zhang, E.K. Lam, V.Y. Shin, A.S. Cheng, J. Yu, F.K. Chan, J.J. Sung, and H.C. Jin Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis Oncogene 29 2010 442 450
-
(2010)
Oncogene
, vol.29
, pp. 442-450
-
-
Liu, X.1
Wang, X.2
Zhang, J.3
Lam, E.K.4
Shin, V.Y.5
Cheng, A.S.6
Yu, J.7
Chan, F.K.8
Sung, J.J.9
Jin, H.C.10
-
112
-
-
77952346716
-
MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism
-
H. Lu, R.J. Buchan, and S.A. Cook MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism Cardiovasc Res 86 2010 410 420
-
(2010)
Cardiovasc Res
, vol.86
, pp. 410-420
-
-
Lu, H.1
Buchan, R.J.2
Cook, S.A.3
-
113
-
-
84861534727
-
Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
-
W. Lu, Y. Hu, G. Chen, Z. Chen, H. Zhang, F. Wang, L. Feng, H. Pelicano, H. Wang, M.J. Keating, J. Liu, W. McKeehan, H. Wang, Y. Luo, and P. Huang Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy PLoS Biol 10 5 2012 e1001326
-
(2012)
PLoS Biol
, vol.10
, Issue.5
, pp. 1001326
-
-
Lu, W.1
Hu, Y.2
Chen, G.3
Chen, Z.4
Zhang, H.5
Wang, F.6
Feng, L.7
Pelicano, H.8
Wang, H.9
Keating, M.J.10
Liu, J.11
McKeehan, W.12
Wang, H.13
Luo, Y.14
Huang, P.15
-
114
-
-
80054046029
-
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
-
S.Y. Lunt, and M.G. Vander Heiden Aerobic glycolysis: meeting the metabolic requirements of cell proliferation Annu Rev Cell Dev Biol 27 2011 441 464
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
115
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
W. Luo, H. Hu, R. Chang, J. Zhong, M. Knabel, R. O'Meally, R.N. Cole, A. Pandey, and G.L. Semenza Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 Cell 145 2011 732 744
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'Meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
116
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
L. Lv, D. Li, D. Zhao, R. Lin, Y. Chu, H. Zhang, Z. Zha, Y. Liu, Z. Li, Y. Xu, G. Wang, Y. Huang, Y. Xiong, K.L. Guan, and Q.Y. Lei Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth Mol Cell 42 2011 719 730
-
(2011)
Mol Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
Wang, G.11
Huang, Y.12
Xiong, Y.13
Guan, K.L.14
Lei, Q.Y.15
-
117
-
-
35448940790
-
A pivotal role for p53: Balancing aerobic respiration and glycolysis
-
W. Ma, H.J. Sung, J.Y. Park, S. Matoba, and P.M. Hwang A pivotal role for p53: balancing aerobic respiration and glycolysis J Bioenerg Biomembr 39 2007 243 246
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 243-246
-
-
Ma, W.1
Sung, H.J.2
Park, J.Y.3
Matoba, S.4
Hwang, P.M.5
-
118
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
N.J. Mabjeesh, D. Escuin, T.M. LaVallee, V.S. Pribluda, G.M. Swartz, M.S. Johnson, M.T. Willard, H. Zhong, J.W. Simons, and P. Giannakakou 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF Cancer Cell 3 2003 363 375
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
Lavallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
Willard, M.T.7
Zhong, H.8
Simons, J.W.9
Giannakakou, P.10
-
119
-
-
81855177061
-
Targeting glucose metabolism: An emerging concept for anticancer therapy
-
(LID - 10.1097/COC)
-
B.M. Madhok, S. Yeluri, S.L. Perry, T.A. Hughes, and D.G. Jayne Targeting glucose metabolism: an emerging concept for anticancer therapy Am J Clin Oncol 34 2011 628 635 (LID - 10.1097/COC)
-
(2011)
Am J Clin Oncol
, vol.34
, pp. 628-635
-
-
Madhok, B.M.1
Yeluri, S.2
Perry, S.L.3
Hughes, T.A.4
Jayne, D.G.5
-
120
-
-
29144467160
-
Differential sensitivity to 2-deoxy-d-glucose between two pancreatic cell lines correlates with GLUT-1 expression
-
J.C. Maher, N. Savaraj, W. Priebe, H. Liu, and T.J. Lampidis Differential sensitivity to 2-deoxy-d-glucose between two pancreatic cell lines correlates with GLUT-1 expression Pancreas 30 2005 e34 e39
-
(2005)
Pancreas
, vol.30
-
-
Maher, J.C.1
Savaraj, N.2
Priebe, W.3
Liu, H.4
Lampidis, T.J.5
-
121
-
-
0037163076
-
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
-
A.S. Marsin, C. Bouzin, L. Bertrand, and L. Hue The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase J Biol Chem 277 2002 30778 30783
-
(2002)
J Biol Chem
, vol.277
, pp. 30778-30783
-
-
Marsin, A.S.1
Bouzin, C.2
Bertrand, L.3
Hue, L.4
-
122
-
-
4344645563
-
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases
-
J.H. Marxsen, P. Stengel, K. Doege, P. Heikkinen, T. Jokilehto, T. Wagner, W. Jelkmann, P. Jaakkola, and E. Metzen Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases Biochem J 381 2004 761 767
-
(2004)
Biochem J
, vol.381
, pp. 761-767
-
-
Marxsen, J.H.1
Stengel, P.2
Doege, K.3
Heikkinen, P.4
Jokilehto, T.5
Wagner, T.6
Jelkmann, W.7
Jaakkola, P.8
Metzen, E.9
-
123
-
-
1642494855
-
2-Deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
-
G. Maschek, N. Savaraj, W. Priebe, P. Braunschweiger, K. Hamilton, G.F. Tidmarsh, L.R. De Young, and T.J. Lampidis 2-Deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo Cancer Res 64 2004 31 34
-
(2004)
Cancer Res
, vol.64
, pp. 31-34
-
-
Maschek, G.1
Savaraj, N.2
Priebe, W.3
Braunschweiger, P.4
Hamilton, K.5
Tidmarsh, G.F.6
De Young, L.R.7
Lampidis, T.J.8
-
124
-
-
33746924468
-
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
S.P. Mathupala, Y.H. Ko, and P.L. Pedersen Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria Oncogene 25 2006 4777 4786
-
(2006)
Oncogene
, vol.25
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
125
-
-
77954390677
-
Voltage dependent anion channel-1 (Vdac-1) as an anti-cancer target
-
S.P. Mathupala, and P.L. Pedersen Voltage dependent anion channel-1 (Vdac-1) as an anti-cancer target Cancer Biol Ther 9 2010 1053 1056
-
(2010)
Cancer Biol Ther
, vol.9
, pp. 1053-1056
-
-
Mathupala, S.P.1
Pedersen, P.L.2
-
126
-
-
33745149291
-
P53 Regulates Mitochondrial Respiration
-
S. Matoba, J.G. Kang, W.D. Patino, A. Wragg, M. Boehm, O. Gavrilova, P.J. Hurley, F. Bunz, and P.M. Hwang P53 Regulates Mitochondrial Respiration Science 312 2006 1650 1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
128
-
-
0001283059
-
Properties of particulate hexokinase of the Krebs-2 ascites tumor
-
R.B. McComb, and W.D. Yushok Properties of particulate hexokinase of the Krebs-2 ascites tumor Biochim Biophys Acta 34 1959 515 526
-
(1959)
Biochim Biophys Acta
, vol.34
, pp. 515-526
-
-
McComb, R.B.1
Yushok, W.D.2
-
129
-
-
34547524771
-
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
-
F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658
-
(2007)
Gastroenterology
, vol.133
, pp. 647-658
-
-
Meng, F.1
Henson, R.2
Wehbe-Janek, H.3
Ghoshal, K.4
Jacob, S.T.5
Patel, T.6
-
130
-
-
84856384698
-
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
-
A. Menssen, P. Hydbring, K. Kapelle, J. Vervoorts, J. Diebold, B. Luscher, L.G. Larsson, and H. Hermeking The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop Proc Natl Acad Sci U S A 109 2012 E187 E196
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Menssen, A.1
Hydbring, P.2
Kapelle, K.3
Vervoorts, J.4
Diebold, J.5
Luscher, B.6
Larsson, L.G.7
Hermeking, H.8
-
131
-
-
53049103850
-
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
-
E.D. Michelakis, L. Webster, and J.R. Mackey Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer Br J Cancer 99 2008 989 994
-
(2008)
Br J Cancer
, vol.99
, pp. 989-994
-
-
Michelakis, E.D.1
Webster, L.2
MacKey, J.R.3
-
132
-
-
39449114808
-
Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II
-
S. Miyamoto, A.N. Murphy, and J.H. Brown Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II Cell Death Differ 15 2008 521 529
-
(2008)
Cell Death Differ
, vol.15
, pp. 521-529
-
-
Miyamoto, S.1
Murphy, A.N.2
Brown, J.H.3
-
133
-
-
0036138398
-
Regulation of HIF by the von Hippel-Lindau tumour suppressor: Implications for cellular oxygen sensing
-
D.R. Mole, P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing IUBMB Life 52 2001 43 47
-
(2001)
IUBMB Life
, vol.52
, pp. 43-47
-
-
Mole, D.R.1
Maxwell, P.H.2
Pugh, C.W.3
Ratcliffe, P.J.4
-
135
-
-
70350596499
-
MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines
-
M.K. Muniyappa, P. Dowling, M. Henry, P. Meleady, P. Doolan, P. Gammell, M. Clynes, and N. Barron MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines Eur J Cancer 45 2009 3104 3118
-
(2009)
Eur J Cancer
, vol.45
, pp. 3104-3118
-
-
Muniyappa, M.K.1
Dowling, P.2
Henry, M.3
Meleady, P.4
Doolan, P.5
Gammell, P.6
Clynes, M.7
Barron, N.8
-
136
-
-
75149146772
-
A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer
-
A.K. Nagaraja, C.J. Creighton, Z. Yu, H. Zhu, P.H. Gunaratne, J.G. Reid, E. Olokpa, H. Itamochi, N.T. Ueno, S.M. Hawkins, M.L. Anderson, and M.M. Matzuk A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer Mol Endocrinol 24 2010 447 463
-
(2010)
Mol Endocrinol
, vol.24
, pp. 447-463
-
-
Nagaraja, A.K.1
Creighton, C.J.2
Yu, Z.3
Zhu, H.4
Gunaratne, P.H.5
Reid, J.G.6
Olokpa, E.7
Itamochi, H.8
Ueno, N.T.9
Hawkins, S.M.10
Anderson, M.L.11
Matzuk, M.M.12
-
137
-
-
0023881240
-
Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line
-
R.A. Nakashima, M.G. Paggi, L.J. Scott, and P.L. Pedersen Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line Cancer Res 48 1988 913 919
-
(1988)
Cancer Res
, vol.48
, pp. 913-919
-
-
Nakashima, R.A.1
Paggi, M.G.2
Scott, L.J.3
Pedersen, P.L.4
-
138
-
-
0033767445
-
Mutations in SDHC cause autosomal dominant paraganglioma, type 3
-
S. Niemann, and U. Muller Mutations in SDHC cause autosomal dominant paraganglioma, type 3 Nat Genet 26 2000 268 270
-
(2000)
Nat Genet
, vol.26
, pp. 268-270
-
-
Niemann, S.1
Muller, U.2
-
139
-
-
64749090748
-
Hypothesis: Using the Warburg effect against cancer by reducing glucose and providing lactate
-
M.W. Nijsten, and G.M. van Dam Hypothesis: using the Warburg effect against cancer by reducing glucose and providing lactate Med Hypotheses 73 2009 48 51
-
(2009)
Med Hypotheses
, vol.73
, pp. 48-51
-
-
Nijsten, M.W.1
Van Dam, G.M.2
-
140
-
-
0008269825
-
Inhibition of anaerobic glycolysis in Ehrlich ascites tumor cells by 2-deoxy-d-glucose
-
M.W. Nirenberg, and J.F. Hogg Inhibition of anaerobic glycolysis in Ehrlich ascites tumor cells by 2-deoxy-d-glucose Cancer Res 18 1958 518 521
-
(1958)
Cancer Res
, vol.18
, pp. 518-521
-
-
Nirenberg, M.W.1
Hogg, J.F.2
-
141
-
-
79959749854
-
Epigenetic regulation of glucose transporters in non-small cell lung cancer
-
K.J. O'Byrne, A.M. Baird, L. Kilmartin, J. Leonard, C. Sacevich, and S.G. Gray Epigenetic regulation of glucose transporters in non-small cell lung cancer Cancers 3 2011 1550 1565
-
(2011)
Cancers
, vol.3
, pp. 1550-1565
-
-
O'Byrne, K.J.1
Baird, A.M.2
Kilmartin, L.3
Leonard, J.4
Sacevich, C.5
Gray, S.G.6
-
142
-
-
0032735328
-
Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes
-
D.A. Okar, and A.J. Lange Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes Biofactors 10 1999 1 14
-
(1999)
Biofactors
, vol.10
, pp. 1-14
-
-
Okar, D.A.1
Lange, A.J.2
-
143
-
-
72849120988
-
MiR-19 is a key oncogenic component of mir-17-92
-
V. Olive, M.J. Bennett, J.C. Walker, C. Ma, I. Jiang, C. Cordon-Cardo, Q.J. Li, S.W. Lowe, G.J. Hannon, and L. He miR-19 is a key oncogenic component of mir-17-92 Genes Dev 23 2009 2839 2849
-
(2009)
Genes Dev
, vol.23
, pp. 2839-2849
-
-
Olive, V.1
Bennett, M.J.2
Walker, J.C.3
Ma, C.4
Jiang, I.5
Cordon-Cardo, C.6
Li, Q.J.7
Lowe, S.W.8
Hannon, G.J.9
He, L.10
-
144
-
-
70349484491
-
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis
-
D. Palmieri, D. Fitzgerald, S.M. Shreeve, E. Hua, J.L. Bronder, R.J. Weil, S. Davis, A.M. Stark, M.J. Merino, R. Kurek, H.M. Mehdorn, G. Davis, S.M. Steinberg, P.S. Meltzer, K. Aldape, and P.S. Steeg Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis Mol Cancer Res 7 2009 1438 1445
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1438-1445
-
-
Palmieri, D.1
Fitzgerald, D.2
Shreeve, S.M.3
Hua, E.4
Bronder, J.L.5
Weil, R.J.6
Davis, S.7
Stark, A.M.8
Merino, M.J.9
Kurek, R.10
Mehdorn, H.M.11
Davis, G.12
Steinberg, S.M.13
Meltzer, P.S.14
Aldape, K.15
Steeg, P.S.16
-
145
-
-
54249136806
-
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
-
T. Papagiannakopoulos, A. Shapiro, and K.S. Kosik MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells Cancer Res 68 2008 8164 8172
-
(2008)
Cancer Res
, vol.68
, pp. 8164-8172
-
-
Papagiannakopoulos, T.1
Shapiro, A.2
Kosik, K.S.3
-
146
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
I. Papandreou, R.A. Cairns, L. Fontana, A.L. Lim, and N.C. Denko HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab 3 2006 187 197
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
147
-
-
41149150716
-
NADPH oxidases, reactive oxygen species, and hypertension: Clinical implications and therapeutic possibilities
-
T.M. Paravicini, and R.M. Touyz NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities Diabetes Care 31 Suppl. 2 2008 S170 S180
-
(2008)
Diabetes Care
, vol.31
, Issue.SUPPL. 2
-
-
Paravicini, T.M.1
Touyz, R.M.2
-
148
-
-
52949097303
-
Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions
-
P. Parente, A. Coli, G. Massi, A. Mangoni, M.M. Fabrizi, and G. Bigotti Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions J Exp Clin Cancer Res 27 2008 34
-
(2008)
J Exp Clin Cancer Res
, vol.27
, pp. 34
-
-
Parente, P.1
Coli, A.2
Massi, G.3
Mangoni, A.4
Fabrizi, M.M.5
Bigotti, G.6
-
149
-
-
71549171732
-
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism
-
D. Pathania, M. Millard, and N. Neamati Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism Adv Drug Deliv Rev 61 2009 1250 1275
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 1250-1275
-
-
Pathania, D.1
Millard, M.2
Neamati, N.3
-
150
-
-
35448964610
-
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "warburg Effect", i.e., elevated glycolysis in the presence of oxygen
-
P.L. Pedersen Warburg, me and Hexokinase 2: multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen J Bioenerg Biomembr 39 2007 211 222
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 211-222
-
-
Pedersen, P.L.1
-
151
-
-
33746879141
-
Glycolysis inhibition for anticancer treatment
-
H. Pelicano, D.S. Martin, R.H. Xu, and P. Huang Glycolysis inhibition for anticancer treatment Oncogene 25 2006 4633 4646
-
(2006)
Oncogene
, vol.25
, pp. 4633-4646
-
-
Pelicano, H.1
Martin, D.S.2
Xu, R.H.3
Huang, P.4
-
152
-
-
33845718704
-
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism
-
H. Pelicano, R.H. Xu, M. Du, L. Feng, R. Sasaki, J.S. Carew, Y. Hu, L. Ramdas, L. Hu, M.J. Keating, W. Zhang, W. Plunkett, and P. Huang Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism J Cell Biol 175 2006 913 923
-
(2006)
J Cell Biol
, vol.175
, pp. 913-923
-
-
Pelicano, H.1
Xu, R.H.2
Du, M.3
Feng, L.4
Sasaki, R.5
Carew, J.S.6
Hu, Y.7
Ramdas, L.8
Hu, L.9
Keating, M.J.10
Zhang, W.11
Plunkett, W.12
Huang, P.13
-
153
-
-
84873708461
-
MiR-143 regulates hexokinase 2 expression in cancer cells
-
10.1038/onc.2012.100 (LID)
-
A. Peschiaroli, A. Giacobbe, A. Formosa, E.K. Markert, L. Bongiorno-Borbone, A.J. Levine, E. Candi, A. D'Alessandro, L. Zolla, A. Finazzi Agro, and G. Melino miR-143 regulates hexokinase 2 expression in cancer cells Oncogene 2012 10.1038/onc.2012.100 (LID)
-
(2012)
Oncogene
-
-
Peschiaroli, A.1
Giacobbe, A.2
Formosa, A.3
Markert, E.K.4
Bongiorno-Borbone, L.5
Levine, A.J.6
Candi, E.7
D'Alessandro, A.8
Zolla, L.9
Finazzi Agro, A.10
Melino, G.11
-
154
-
-
26444570010
-
Accumulation of krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
P.J. Pollard, J.J. Briere, N.A. Alam, J. Barwell, E. Barclay, N.C. Wortham, T. Hunt, M. Mitchell, S. Olpin, S.J. Moat, I.P. Hargreaves, S.J. Heales, Y.L. Chung, J.R. Griffiths, A. Dalgleish, J.A. McGrath, M.J. Gleeson, and Hod Accumulation of krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations Hum Mol Genet 14 2005 2231 2239
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
Briere, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
Wortham, N.C.6
Hunt, T.7
Mitchell, M.8
Olpin, S.9
Moat, S.J.10
Hargreaves, I.P.11
Heales, S.J.12
Chung, Y.L.13
Griffiths, J.R.14
Dalgleish, A.15
McGrath, J.A.16
Gleeson, M.J.17
Hod18
-
155
-
-
79960322580
-
MiR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)
-
T.J. Pullen, X.a.G. da Silva, G. Kelsey, and G.A. Rutter miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1) Mol Cell Biol 31 2011 3182 3194
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3182-3194
-
-
Pullen, T.J.1
Da Silva, X.A.G.2
Kelsey, G.3
Rutter, G.A.4
-
156
-
-
0344223439
-
Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle
-
B. Rais, B. Comin, J. Puigjaner, J.L. Brandes, E. Creppy, D. Saboureau, R. Ennamany, W.N. Lee, L.G. Boros, and M. Cascante Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle FEBS Lett 456 1999 113 118
-
(1999)
FEBS Lett
, vol.456
, pp. 113-118
-
-
Rais, B.1
Comin, B.2
Puigjaner, J.3
Brandes, J.L.4
Creppy, E.5
Saboureau, D.6
Ennamany, R.7
Lee, W.N.8
Boros, L.G.9
Cascante, M.10
-
157
-
-
65249185780
-
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha
-
S. Rane, M. He, D. Sayed, H. Vashistha, A. Malhotra, J. Sadoshima, D.E. Vatner, S.F. Vatner, and M. Abdellatif Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes Circ Res 104 2009 879 886
-
(2009)
Circ Res
, vol.104
, pp. 879-886
-
-
Rane, S.1
He, M.2
Sayed, D.3
Vashistha, H.4
Malhotra, A.5
Sadoshima, J.6
Vatner, D.E.7
Vatner, S.F.8
Abdellatif, M.9
-
158
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
A. Rapisarda, B. Uranchimeg, D.A. Scudiero, M. Selby, E.A. Sausville, R.H. Shoemaker, and G. Melillo Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway Cancer Res 62 2002 4316 4324
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
Melillo, G.7
-
159
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
-
A. Rapisarda, B. Uranchimeg, O. Sordet, Y. Pommier, R.H. Shoemaker, and G. Melillo Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications Cancer Res 64 2004 1475 1482
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
160
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
J.C. Rathmell, C.J. Fox, D.R. Plas, P.S. Hammerman, R.M. Cinalli, and C.B. Thompson Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival Mol Cell Biol 23 2003 7315 7328
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
Thompson, C.B.6
-
161
-
-
33847655286
-
Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines
-
M. Rho, J. Kim, C.D. Jee, Y.M. Lee, H.E. Lee, M.A. Kim, H.S. Lee, and W.H. Kim Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines Anticancer Res 27 2007 251 258
-
(2007)
Anticancer Res
, vol.27
, pp. 251-258
-
-
Rho, M.1
Kim, J.2
Jee, C.D.3
Lee, Y.M.4
Lee, H.E.5
Kim, M.A.6
Lee, H.S.7
Kim, W.H.8
-
162
-
-
4344618856
-
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: Head-to-head with a bifunctional enzyme that controls glycolysis
-
M.H. Rider, L. Bertrand, D. Vertommen, P.A. Michels, G.G. Rousseau, and L. Hue 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis Biochem J 381 2004 561 579
-
(2004)
Biochem J
, vol.381
, pp. 561-579
-
-
Rider, M.H.1
Bertrand, L.2
Vertommen, D.3
Michels, P.A.4
Rousseau, G.G.5
Hue, L.6
-
163
-
-
60549111398
-
Is Akt the "warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
-
R.B. Robey, and N. Hay Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis Semin Cancer Biol 19 2009 25 31
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 25-31
-
-
Robey, R.B.1
Hay, N.2
-
164
-
-
0022481177
-
Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: Potential implications for cell death in tumors
-
D. Rotin, B. Robinson, and I.F. Tannock Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors Cancer Res 46 1986 2821 2826
-
(1986)
Cancer Res
, vol.46
, pp. 2821-2826
-
-
Rotin, D.1
Robinson, B.2
Tannock, I.F.3
-
165
-
-
0026476247
-
Compartmentation of hexokinase in rat heart. A critical factor for tracer kinetic analysis of myocardial glucose metabolism
-
R.R. Russell III, J.M. Mrus, J.I. Mommessin, and H. Taegtmeyer Compartmentation of hexokinase in rat heart. A critical factor for tracer kinetic analysis of myocardial glucose metabolism J Clin Invest 90 1992 1972 1977
-
(1992)
J Clin Invest
, vol.90
, pp. 1972-1977
-
-
Russell Iii, R.R.1
Mrus, J.M.2
Mommessin, J.I.3
Taegtmeyer, H.4
-
166
-
-
79954607456
-
Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase
-
T. Sakamoto, D. Niiya, and M. Seiki Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase J Biol Chem 286 2011 14691 14704
-
(2011)
J Biol Chem
, vol.286
, pp. 14691-14704
-
-
Sakamoto, T.1
Niiya, D.2
Seiki, M.3
-
167
-
-
65549123260
-
Mitochondrial uncoupling and the Warburg effect: Molecular basis for the reprogramming of cancer cell metabolism
-
I. Samudio, M. Fiegl, and M. Andreeff Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism Cancer Res 69 2009 2163 2166
-
(2009)
Cancer Res
, vol.69
, pp. 2163-2166
-
-
Samudio, I.1
Fiegl, M.2
Andreeff, M.3
-
168
-
-
48549088300
-
The Warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation
-
I. Samudio, M. Fiegl, T. McQueen, K. Clise-Dwyer, and M. Andreeff The Warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation Cancer Res 68 2008 5198 5205
-
(2008)
Cancer Res
, vol.68
, pp. 5198-5205
-
-
Samudio, I.1
Fiegl, M.2
McQueen, T.3
Clise-Dwyer, K.4
Andreeff, M.5
-
169
-
-
52949145307
-
Glycolytic enzyme inhibitors in cancer treatment
-
R. Scatena, P. Bottoni, A. Pontoglio, L. Mastrototaro, and B. Giardina Glycolytic enzyme inhibitors in cancer treatment Expert Opin Investig Drugs 17 2008 1533 1545
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1533-1545
-
-
Scatena, R.1
Bottoni, P.2
Pontoglio, A.3
Mastrototaro, L.4
Giardina, B.5
-
170
-
-
0037348402
-
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors
-
P.A. Schornack, and R.J. Gillies Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors Neoplasia 5 2003 135 145
-
(2003)
Neoplasia
, vol.5
, pp. 135-145
-
-
Schornack, P.A.1
Gillies, R.J.2
-
171
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
M.A. Selak, S.M. Armour, E.D. MacKenzie, H. Boulahbel, D.G. Watson, K.D. Mansfield, Y. Pan, M.C. Simon, C.B. Thompson, and E. Gottlieb Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase Cancer Cell 7 2005 77 85
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
172
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
G.L. Semenza Targeting HIF-1 for cancer therapy Nat Rev Cancer 3 2003 721 732
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
173
-
-
76049100577
-
HIF-1: Upstream and downstream of cancer metabolism
-
G.L. Semenza HIF-1: upstream and downstream of cancer metabolism Curr Opin Genet Dev 20 2010 51 56
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
174
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
G.L. Semenza, P.H. Roth, H.M. Fang, and G.L. Wang Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 J Biol Chem 269 1994 23757 23763
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
175
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
S. Sengupta, T.R. Peterson, and D.M. Sabatini Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress Mol Cell 40 2010 310 322
-
(2010)
Mol Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
176
-
-
33751117499
-
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
-
L.A. Shimoda, M. Fallon, S. Pisarcik, J. Wang, and G.L. Semenza HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes Am J Physiol Lung Cell Mol Physiol 291 2006 L941 L949
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Shimoda, L.A.1
Fallon, M.2
Pisarcik, S.3
Wang, J.4
Semenza, G.L.5
-
177
-
-
84859463632
-
Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways
-
M.L. Silviera, B.P. Smith, J. Powell, and C. Sapienza Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways Cancer Prev Res (Phila) 5 2012 374 384
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 374-384
-
-
Silviera, M.L.1
Smith, B.P.2
Powell, J.3
Sapienza, C.4
-
179
-
-
79955777637
-
Posttranslational modification of 6-phosphofructo-1-kinase as an important feature of cancer metabolism
-
A. Smerc, E. Sodja, and M. Legisa Posttranslational modification of 6-phosphofructo-1-kinase as an important feature of cancer metabolism PLoS One 6 2011
-
(2011)
PLoS One
, vol.6
-
-
Smerc, A.1
Sodja, E.2
Legisa, M.3
-
180
-
-
84863229770
-
MiR-138 suppresses expression of hypoxia-inducible factor 1alpha (HIF-1alpha) in clear cell renal cell carcinoma 786-O cells
-
T. Song, X. Zhang, C. Wang, Y. Wu, W. Cai, J. Gao, and B. Hong MiR-138 suppresses expression of hypoxia-inducible factor 1alpha (HIF-1alpha) in clear cell renal cell carcinoma 786-O cells Asian Pac J Cancer Prev 12 2011 1307 1311
-
(2011)
Asian Pac J Cancer Prev
, vol.12
, pp. 1307-1311
-
-
Song, T.1
Zhang, X.2
Wang, C.3
Wu, Y.4
Cai, W.5
Gao, J.6
Hong, B.7
-
181
-
-
0023233164
-
Subunit composition, regulatory properties, and phosphorylation of phosphofructokinase from human gliomas
-
G.E. Staal, A. Kalff, E.C. Heesbeen, C.W. van Veelen, and G. Rijksen Subunit composition, regulatory properties, and phosphorylation of phosphofructokinase from human gliomas Cancer Res 47 1987 5047 5051
-
(1987)
Cancer Res
, vol.47
, pp. 5047-5051
-
-
Staal, G.E.1
Kalff, A.2
Heesbeen, E.C.3
Van Veelen, C.W.4
Rijksen, G.5
-
182
-
-
79952749503
-
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
-
Q. Sun, X. Chen, J. Ma, H. Peng, F. Wang, X. Zha, Y. Wang, Y. Jing, H. Yang, R. Chen, L. Chang, Y. Zhang, J. Goto, H. Onda, T. Chen, M.R. Wang, Y. Lu, H. You, D. Kwiatkowski, and H. Zhang Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Proc Natl Acad Sci U S A 108 2011 4129 4134
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4129-4134
-
-
Sun, Q.1
Chen, X.2
Ma, J.3
Peng, H.4
Wang, F.5
Zha, X.6
Wang, Y.7
Jing, Y.8
Yang, H.9
Chen, R.10
Chang, L.11
Zhang, Y.12
Goto, J.13
Onda, H.14
Chen, T.15
Wang, M.R.16
Lu, Y.17
You, H.18
Kwiatkowski, D.19
Zhang, H.20
more..
-
183
-
-
84866450306
-
MiR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect
-
(LID - 10.3892/or)
-
Y. Sun, X. Zhao, Y. Zhou, and Y. Hu miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect Oncol Rep 28 2012 1346 1352 (LID - 10.3892/or)
-
(2012)
Oncol Rep
, vol.28
, pp. 1346-1352
-
-
Sun, Y.1
Zhao, X.2
Zhou, Y.3
Hu, Y.4
-
184
-
-
0033152102
-
Enhanced expression of glucose transporter GLUT3 in tumorigenic HeLa cell hybrids associated with tumor suppressor dysfunction
-
T. Suzuki, A. Iwazaki, H. Katagiri, Y. Oka, J.L. Redpath, E.J. Stanbridge, and T. Kitagawa Enhanced expression of glucose transporter GLUT3 in tumorigenic HeLa cell hybrids associated with tumor suppressor dysfunction Eur J Biochem 262 1999 534 540
-
(1999)
Eur J Biochem
, vol.262
, pp. 534-540
-
-
Suzuki, T.1
Iwazaki, A.2
Katagiri, H.3
Oka, Y.4
Redpath, J.L.5
Stanbridge, E.J.6
Kitagawa, T.7
-
185
-
-
30344440802
-
TT232, a novel signal transduction inhibitory compound in the therapy of cancer and inflammatory diseases
-
O. Szokoloczi, R. Schwab, I. Petak, L. Orfi, A. Pap, A.N. Eberle, T. Szuts, and G. Keril TT232, a novel signal transduction inhibitory compound in the therapy of cancer and inflammatory diseases J Recept Signal Transduct Res 25 2005 217 235
-
(2005)
J Recept Signal Transduct Res
, vol.25
, pp. 217-235
-
-
Szokoloczi, O.1
Schwab, R.2
Petak, I.3
Orfi, L.4
Pap, A.5
Eberle, A.N.6
Szuts, T.7
Keril, G.8
-
186
-
-
48649102010
-
Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster
-
A. Taguchi, K. Yanagisawa, M. Tanaka, K. Cao, Y. Matsuyama, H. Goto, and T. Takahashi Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster Cancer Res 68 2008 5540 5545
-
(2008)
Cancer Res
, vol.68
, pp. 5540-5545
-
-
Taguchi, A.1
Yanagisawa, K.2
Tanaka, M.3
Cao, K.4
Matsuyama, Y.5
Goto, H.6
Takahashi, T.7
-
188
-
-
84868282332
-
Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems
-
H. Tang, M. Lee, O. Sharpe, L. Salamone, E.J. Noonan, C.D. Hoang, S. Levine, W.H. Robinson, and J.B. Shrager Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems FASEB J 26 2012 4710 4721
-
(2012)
FASEB J
, vol.26
, pp. 4710-4721
-
-
Tang, H.1
Lee, M.2
Sharpe, O.3
Salamone, L.4
Noonan, E.J.5
Hoang, C.D.6
Levine, S.7
Robinson, W.H.8
Shrager, J.B.9
-
189
-
-
66749160812
-
The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras
-
W.P. Tsang, and T.T. Kwok The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras Carcinogenesis 30 2009 953 959
-
(2009)
Carcinogenesis
, vol.30
, pp. 953-959
-
-
Tsang, W.P.1
Kwok, T.T.2
-
190
-
-
32544451943
-
Modification of thiamine pyrophosphate dependent enzyme activity by oxythiamine in Saccharomyces cerevisiae cells
-
A. Tylicki, J. Czerniecki, P. Dobrzyn, A. Matanowska, A. Olechno, and S. Strumilo Modification of thiamine pyrophosphate dependent enzyme activity by oxythiamine in Saccharomyces cerevisiae cells Can J Microbiol 51 2005 833 839
-
(2005)
Can J Microbiol
, vol.51
, pp. 833-839
-
-
Tylicki, A.1
Czerniecki, J.2
Dobrzyn, P.3
Matanowska, A.4
Olechno, A.5
Strumilo, S.6
-
191
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
-
M.S. Ullah, A.J. Davies, and A.P. Halestrap The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism J Biol Chem 281 2006 9030 9037
-
(2006)
J Biol Chem
, vol.281
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
192
-
-
23644437291
-
Radiosensitization by 6-aminonicotinamide and 2-deoxy-d-glucose in human cancer cells
-
R. Varshney, B. Dwarakanath, and V. Jain Radiosensitization by 6-aminonicotinamide and 2-deoxy-d-glucose in human cancer cells Int J Radiat Biol 81 2005 397 408
-
(2005)
Int J Radiat Biol
, vol.81
, pp. 397-408
-
-
Varshney, R.1
Dwarakanath, B.2
Jain, V.3
-
193
-
-
12444279265
-
On the origin of cancer cells
-
O. Warburg On the origin of cancer cells Science 123 1956 309 314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
194
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
-
P.S. Ward, and C.B. Thompson Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate Cancer Cell 21 2012 297 308
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
195
-
-
77952737658
-
Mitochondrial metabolism and ros generation are essential for kras-mediated tumorigenicity
-
F. Weinberg, R. Hamanaka, W.W. Wheaton, S. Weinberg, J. Joseph, M. Lopez, B. Kalyanaraman, G.M. Mutlu, G.R. Budinger, and N.S. Chandel Mitochondrial metabolism and ros generation are essential for kras-mediated tumorigenicity Proc Natl Acad Sci U S A 107 2010 8788 8793
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8788-8793
-
-
Weinberg, F.1
Hamanaka, R.2
Wheaton, W.W.3
Weinberg, S.4
Joseph, J.5
Lopez, M.6
Kalyanaraman, B.7
Mutlu, G.M.8
Budinger, G.R.9
Chandel, N.S.10
-
196
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
S. Welsh, R. Williams, L. Kirkpatrick, G. Paine-Murrieta, and G. Powis Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha Mol Cancer Ther 3 2004 233 244
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
197
-
-
84858710602
-
Using the "reverse Warburg effect" to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
-
A.K. Witkiewicz, D. Whitaker-Menezes, A. Dasgupta, N.J. Philp, Z. Lin, R. Gandara, S. Sneddon, U.E. Martinez-Outschoorn, F. Sotgia, and M.P. Lisanti Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers Cell Cycle 11 2012 1108 1117
-
(2012)
Cell Cycle
, vol.11
, pp. 1108-1117
-
-
Witkiewicz, A.K.1
Whitaker-Menezes, D.2
Dasgupta, A.3
Philp, N.J.4
Lin, Z.5
Gandara, R.6
Sneddon, S.7
Martinez-Outschoorn, U.E.8
Sotgia, F.9
Lisanti, M.P.10
-
198
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
A. Wolf, S. Agnihotri, J. Micallef, J. Mukherjee, N. Sabha, R. Cairns, C. Hawkins, and A. Guha Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme J Exp Med 208 2011 313 326
-
(2011)
J Exp Med
, vol.208
, pp. 313-326
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
Cairns, R.6
Hawkins, C.7
Guha, A.8
-
199
-
-
79961127669
-
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
-
A. Wolf, S. Agnihotri, D. Munoz, and A. Guha Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme Neurobiol Dis 44 2011 84 91
-
(2011)
Neurobiol Dis
, vol.44
, pp. 84-91
-
-
Wolf, A.1
Agnihotri, S.2
Munoz, D.3
Guha, A.4
-
201
-
-
44949142045
-
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
-
T.S. Wong, X.B. Liu, A. Chung-Wai Ho, A. Po-Wing Yuen, R. Wai-Man Ng, and W. Ignace Wei Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling Int J Cancer 123 2008 251 257
-
(2008)
Int J Cancer
, vol.123
, pp. 251-257
-
-
Wong, T.S.1
Liu, X.B.2
Chung-Wai Ho, A.3
Po-Wing Yuen, A.4
Wai-Man Ng, R.5
Ignace Wei, W.6
-
202
-
-
56249134557
-
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
-
T.E. Wood, S. Dalili, C.D. Simpson, R. Hurren, X. Mao, F.S. Saiz, M. Gronda, Y. Eberhard, M.D. Minden, P.J. Bilan, A. Klip, R.A. Batey, and A.D. Schimmer A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death Mol Cancer Ther 7 2008 3546 3555
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3546-3555
-
-
Wood, T.E.1
Dalili, S.2
Simpson, C.D.3
Hurren, R.4
Mao, X.5
Saiz, F.S.6
Gronda, M.7
Eberhard, Y.8
Minden, M.D.9
Bilan, P.J.10
Klip, A.11
Batey, R.A.12
Schimmer, A.D.13
-
203
-
-
39749163245
-
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
-
C. Xiao, L. Srinivasan, D.P. Calado, H.C. Patterson, B. Zhang, J. Wang, J.M. Henderson, J.L. Kutok, and K. Rajewsky Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes Nat Immunol 9 2008 405 414
-
(2008)
Nat Immunol
, vol.9
, pp. 405-414
-
-
Xiao, C.1
Srinivasan, L.2
Calado, D.P.3
Patterson, H.C.4
Zhang, B.5
Wang, J.6
Henderson, J.M.7
Kutok, J.L.8
Rajewsky, K.9
-
204
-
-
33745856925
-
Regulation of rat hepatic l-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist
-
J. Xu, B. Christian, and D.B. Jump Regulation of rat hepatic l-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist J Biol Chem 281 2006 18351 18362
-
(2006)
J Biol Chem
, vol.281
, pp. 18351-18362
-
-
Xu, J.1
Christian, B.2
Jump, D.B.3
-
206
-
-
0346689991
-
Hexokinase II and VEGF expression in liver tumors: Correlation with hypoxia-inducible factor 1 alpha and its significance
-
S. Yasuda, S. Arii, A. Mori, N. Isobe, W. Yang, H. Oe, A. Fujimoto, Y. Yonenaga, H. Sakashita, and M. Imamura Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance J Hepatol 40 2004 117 123
-
(2004)
J Hepatol
, vol.40
, pp. 117-123
-
-
Yasuda, S.1
Arii, S.2
Mori, A.3
Isobe, N.4
Yang, W.5
Oe, H.6
Fujimoto, A.7
Yonenaga, Y.8
Sakashita, H.9
Imamura, M.10
-
207
-
-
63549129144
-
SUMOylation and De-SUMOylation: Wrestling with life's processes
-
E.T. Yeh SUMOylation and De-SUMOylation: wrestling with life's processes J Biol Chem 284 2009 8223 8227
-
(2009)
J Biol Chem
, vol.284
, pp. 8223-8227
-
-
Yeh, E.T.1
-
208
-
-
77955033963
-
MiRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer
-
S. Yu, Z. Lu, C. Liu, Y. Meng, Y. Ma, W. Zhao, J. Liu, J. Yu, and J. Chen miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer Cancer Res 70 2010 6015 6025
-
(2010)
Cancer Res
, vol.70
, pp. 6015-6025
-
-
Yu, S.1
Lu, Z.2
Liu, C.3
Meng, Y.4
Ma, Y.5
Zhao, W.6
Liu, J.7
Yu, J.8
Chen, J.9
-
209
-
-
78651397296
-
Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis
-
X. Zha, F. Wang, Y. Wang, S. He, Y. Jing, X. Wu, and H. Zhang Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis Cancer Res 71 2011 13 18
-
(2011)
Cancer Res
, vol.71
, pp. 13-18
-
-
Zha, X.1
Wang, F.2
Wang, Y.3
He, S.4
Jing, Y.5
Wu, X.6
Zhang, H.7
-
210
-
-
33750713059
-
Effect of 2-deoxy-d-glucose on various malignant cell lines in vitro
-
X.D. Zhang, E. Deslandes, M. Villedieu, L. Poulain, M. Duval, P. Gauduchon, L. Schwartz, and P. Icard Effect of 2-deoxy-d-glucose on various malignant cell lines in vitro Anticancer Res 26 2006 3561 3566
-
(2006)
Anticancer Res
, vol.26
, pp. 3561-3566
-
-
Zhang, X.D.1
Deslandes, E.2
Villedieu, M.3
Poulain, L.4
Duval, M.5
Gauduchon, P.6
Schwartz, L.7
Icard, P.8
-
211
-
-
80053635472
-
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
-
C. Zhang, M. Lin, R. Wu, X. Wang, B. Yang, A.J. Levine, W. Hu, and Z. Feng Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect Proc Natl Acad Sci U S A 108 2011 16259 16264
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 16259-16264
-
-
Zhang, C.1
Lin, M.2
Wu, R.3
Wang, X.4
Yang, B.5
Levine, A.J.6
Hu, W.7
Feng, Z.8
-
212
-
-
84866260153
-
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity
-
Q. Zhang, J. Pan, P.E. North, S. Yang, R.A. Lubet, Y. Wang, and M. You Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity Cancer Prev Res (Phila) 5 2012 717 725
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 717-725
-
-
Zhang, Q.1
Pan, J.2
North, P.E.3
Yang, S.4
Lubet, R.A.5
Wang, Y.6
You, M.7
-
213
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
H. Zhang, D.Z. Qian, Y.S. Tan, K. Lee, P. Gao, Y.R. Ren, S. Rey, H. Hammers, D. Chang, R. Pili, C.V. Dang, J.O. Liu, and G.L. Semenza Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth Proc Natl Acad Sci U S A 105 2008 19579 19586
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
Ren, Y.R.6
Rey, S.7
Hammers, H.8
Chang, D.9
Pili, R.10
Dang, C.V.11
Liu, J.O.12
Semenza, G.L.13
-
214
-
-
77957762440
-
The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS
-
W.G. Zhao, S.N. Yu, Z.H. Lu, Y.H. Ma, Y.M. Gu, and J. Chen The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS Carcinogenesis 31 2010 1726 1733
-
(2010)
Carcinogenesis
, vol.31
, pp. 1726-1733
-
-
Zhao, W.G.1
Yu, S.N.2
Lu, Z.H.3
Ma, Y.H.4
Gu, Y.M.5
Chen, J.6
|