Tyrosine phosphorylation of lactate dehydrogenase a is important for NADH/NAD + redox homeostasis in cancer cells

Molecular and Cellular Biology

Volumn 31, Issue 24, 2011, Pages 4938-4950

  Fan, Jun ^a   Hitosugi, Taro ^a   Chung, Tae Wook ^a,d   Xie, Jianxin ^b   Ge, Qingyuan ^b   Gu, Ting Le ^b   Polakiewicz, Roberto D ^b   Chen, Georgia Z ^a   Boggon, Titus J ^c   Lonial, Sagar ^a   Khuri, Fadlo R ^a   Kang, Sumin ^a   Chen, Jing ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 1; LACTATE DEHYDROGENASE; LACTIC ACID; MYC PROTEIN; PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL HYPOXIA; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GLYCOLYSIS; HOMEOSTASIS; HUMAN; HUMAN CELL; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; MOUSE; MUTANT; NONHUMAN; NUDE MOUSE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL RESPIRATION; GLYCOLYSIS; HOMEOSTASIS; HUMANS; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; MICE; MICE, NUDE; MITOCHONDRIA; NAD; NEOPLASMS; OXIDATION-REDUCTION; PHOSPHORYLATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; TYROSINE;

EID: 83255171153     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06120-11     Document Type: Article

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