-
1
-
-
0028350106
-
Topoisomerase I inhibitors: An overview of the camptothecin analogs
-
Burris HA, Fields SM: Topoisomerase I inhibitors: An overview of the camptothecin analogs. Hematol Oncol Clin North Am 8:333-355, 1994.
-
(1994)
Hematol Oncol Clin North Am
, vol.8
, pp. 333-355
-
-
Burris, H.A.1
Fields, S.M.2
-
2
-
-
0027972726
-
Topoisomerase I inhibitors: Topotecan and irinotecan
-
Creemers GJ, Lund B, Verweij J: Topoisomerase I inhibitors: Topotecan and irinotecan. Cancer Treat Rev 20:73-96, 1994.
-
(1994)
Cancer Treat Rev
, vol.20
, pp. 73-96
-
-
Creemers, G.J.1
Lund, B.2
Verweij, J.3
-
3
-
-
0028267240
-
Camptothecins: From bench research to hospital wards
-
Potmesil M: Camptothecins: From bench research to hospital wards. Cancer Res 54:1431-1439, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 1431-1439
-
-
Potmesil, M.1
-
4
-
-
0000760112
-
The Camptothecins
-
Chabner BA, Longo DL (eds): Philadelphia, Lippincott-Raven
-
Takimoto CH, Arbuck SG: The Camptothecins. in: Chabner BA, Longo DL (eds): Cancer Chemotherapy and Biotherapy: Principles and Practice, pp 463-484. Philadelphia, Lippincott-Raven, 1996.
-
(1996)
Cancer Chemotherapy and Biotherapy: Principles and Practice
, pp. 463-484
-
-
Takimoto, C.H.1
Arbuck, S.G.2
-
5
-
-
0024560495
-
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase 1 : Evidence for a specific receptor site and a relation to antitumor activity
-
Jaxel C, Kohn KW, Wani MC, et al: Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase 1 : Evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 49:1465-1469, 1989.
-
(1989)
Cancer Res
, vol.49
, pp. 1465-1469
-
-
Jaxel, C.1
Kohn, K.W.2
Wani, M.C.3
-
6
-
-
0024537205
-
Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity
-
Hertzberg KP, Caranfa MJ, Holden KG, et al: Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity. J Med Chem 32:715-720, 1989.
-
(1989)
J Med Chem
, vol.32
, pp. 715-720
-
-
Hertzberg, K.P.1
Caranfa, M.J.2
Holden, K.G.3
-
7
-
-
0027501814
-
Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat gen-n in the presence and absence of camptothecin
-
Tamzawa A, Kohn KW, Pommier Y: Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat gen-n in the presence and absence of camptothecin. Nucleic Acids Res 21:5157-5166, 1993.
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 5157-5166
-
-
Tamzawa, A.1
Kohn, K.W.2
Pommier, Y.3
-
8
-
-
0027096415
-
A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
-
Fassberg J, Stella VJ: A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 81:676-684, 1992.
-
(1992)
J Pharm Sci
, vol.81
, pp. 676-684
-
-
Fassberg, J.1
Stella, V.J.2
-
9
-
-
0028697603
-
Roles of DNA topoisomerases in chromosomal replication and segregation
-
Nitiss JL: Roles of DNA topoisomerases in chromosomal replication and segregation. Adv Pharmacol 29:103-134, 1994.
-
(1994)
Adv Pharmacol
, vol.29
, pp. 103-134
-
-
Nitiss, J.L.1
-
10
-
-
0028726953
-
DNA topoisomerase-mediated illegitimate recombination
-
Ikeda H: DNA topoisomerase-mediated illegitimate recombination. Adv Pharmacol 29:147-165, 1994.
-
(1994)
Adv Pharmacol
, vol.29
, pp. 147-165
-
-
Ikeda, H.1
-
11
-
-
0028711871
-
Roles of DNA topoisomerases in transcription
-
Drolet M, Wu HY, Liu LF: Roles of DNA topoisomerases in transcription. Adv Pharmacol 29:135-146, 1994.
-
(1994)
Adv Pharmacol
, vol.29
, pp. 135-146
-
-
Drolet, M.1
Wu, H.Y.2
Liu, L.F.3
-
12
-
-
0025719903
-
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin
-
Jaxel C, Capranico G, Kerrigan D, et al: Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin. J Biol Chem 266:20418-20423, 1991.
-
(1991)
J Biol Chem
, vol.266
, pp. 20418-20423
-
-
Jaxel, C.1
Capranico, G.2
Kerrigan, D.3
-
13
-
-
0027290438
-
Specific interaction of camptothecin, a topoi- Somerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm
-
Leteurtre F, Fesen M, Koblhagen G, et al: Specific interaction of camptothecin, a topoi- somerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm. Biochemistry 32:8955-8962, 1993.
-
(1993)
Biochemistry
, vol.32
, pp. 8955-8962
-
-
Leteurtre, F.1
Fesen, M.2
Koblhagen, G.3
-
14
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
Hslang YH, Lihou MG, Liu LF: Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 49:5077-5082, 1989.
-
(1989)
Cancer Res
, vol.49
, pp. 5077-5082
-
-
Hslang, Y.H.1
Lihou, M.G.2
Liu, L.F.3
-
15
-
-
0024388737
-
Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells
-
Holm C, Covey JM, Kerrigan D, et al: Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells. Cancer Res 49:6365-6368, 1989.
-
(1989)
Cancer Res
, vol.49
, pp. 6365-6368
-
-
Holm, C.1
Covey, J.M.2
Kerrigan, D.3
-
16
-
-
0026489662
-
Apoptotic cell death triggered by camptothecin or temposide: The cell cycle specificity and effects of ionizing radiation
-
Del Bino G, Bruno S, Yi PN, et al: Apoptotic cell death triggered by camptothecin or temposide: The cell cycle specificity and effects of ionizing radiation. Cell Prolif 25:531-548, 1992.
-
(1992)
Cell Prolif
, vol.25
, pp. 531-548
-
-
Del Bino, G.1
Bruno, S.2
Yi, P.N.3
-
17
-
-
0027168859
-
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors
-
Bertrand R, Solary E, Jenkins J, et al: Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. Exp Cell Res 207:388-397, 1993.
-
(1993)
Exp Cell Res
, vol.207
, pp. 388-397
-
-
Bertrand, R.1
Solary, E.2
Jenkins, J.3
-
18
-
-
0025133118
-
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
-
D'Arpa P, Beardmore C, Liu LF: Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res 50:6919-6924, 1990.
-
(1990)
Cancer Res
, vol.50
, pp. 6919-6924
-
-
D'Arpa, P.1
Beardmore, C.2
Liu, L.F.3
-
19
-
-
0028357995
-
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen
-
Hochster H. Liebes L, Speyer J, et al: Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen. J Clin Oncol 12:553-559, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 553-559
-
-
Hochster, H.1
Liebes, L.2
Speyer, J.3
-
20
-
-
9544234452
-
Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer
-
Creemers GJ, Gerrits CJ, Schellens JH, et al: Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer. J Clin Oncol 14:2540-2545, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 2540-2545
-
-
Creemers, G.J.1
Gerrits, C.J.2
Schellens, J.H.3
-
21
-
-
0000360615
-
Phase II study of topotecan (TPT) 21-day infusion in platinum-treated ovarian cancer: A highly active regimen
-
Hochster H, Speyer J, Wadler S, et al: Phase II study of topotecan (TPT) 21-day infusion in platinum-treated ovarian cancer: A highly active regimen. Proc Am Soc Clin Oncol 15:285, 1996.
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 285
-
-
Hochster, H.1
Speyer, J.2
Wadler, S.3
-
22
-
-
0024305936
-
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: Restoration of sensitivity of the cells to the antitumor drug camptothecin
-
Bjornsti MA, Benedetti P, Viglianti GA, et al: Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: Restoration of sensitivity of the cells to the antitumor drug camptothecin. Cancer Res 49:6318-6323, 1989.
-
(1989)
Cancer Res
, vol.49
, pp. 6318-6323
-
-
Bjornsti, M.A.1
Benedetti, P.2
Viglianti, G.A.3
-
23
-
-
0028090410
-
Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia
-
Rowinsky EK, Adjel A, Donehower RC, et al: Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia. J Clin Oncol 12:2193-2203, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2193-2203
-
-
Rowinsky, E.K.1
Adjel, A.2
Donehower, R.C.3
-
24
-
-
0024358188
-
DNA topoisomerase 1-targeted chemotherapy of human colon cancer in xenografts
-
Glovanella BC, Stehlin JS, Wall ME, et al: DNA topoisomerase 1-targeted chemotherapy of human colon cancer in xenografts. Science 246:1046-1048, 1989.
-
(1989)
Science
, vol.246
, pp. 1046-1048
-
-
Glovanella, B.C.1
Stehlin, J.S.2
Wall, M.E.3
-
25
-
-
0028862978
-
Topoisomerase I activity in squamous cell carcinoma of the head and neck
-
Masin JS, Berger SJ, Setrakian S, et al: Topoisomerase I activity in squamous cell carcinoma of the head and neck. Laryngoscope 105:1191-1196, 1995.
-
(1995)
Laryngoscope
, vol.105
, pp. 1191-1196
-
-
Masin, J.S.1
Berger, S.J.2
Setrakian, S.3
-
26
-
-
0028006314
-
Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy
-
Husain I, Mohler JL, Seigler HF, et al: Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. Cancer Res 54:539-546, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 539-546
-
-
Husain, I.1
Mohler, J.L.2
Seigler, H.F.3
-
27
-
-
0026503077
-
Overexpression of human topoisomerase I in baby hamster kidney cells: Hypersensitivity of clonal isolates to camptothecin
-
Madden KR, Champoux JJ: Overexpression of human topoisomerase I in baby hamster kidney cells: Hypersensitivity of clonal isolates to camptothecin. Cancer Res 52:525-532, 1992.
-
(1992)
Cancer Res
, vol.52
, pp. 525-532
-
-
Madden, K.R.1
Champoux, J.J.2
-
28
-
-
0028067913
-
Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types
-
Perego P, Capranico G, Supino R, et al: Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types. Anticancer Drugs 5:645-649, 1994.
-
(1994)
Anticancer Drugs
, vol.5
, pp. 645-649
-
-
Perego, P.1
Capranico, G.2
Supino, R.3
-
29
-
-
0029029436
-
Topolsomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
-
Goldwasser F, Bae I, Valenti M, et al: Topolsomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. Cancer Res 55:2116-2121, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 2116-2121
-
-
Goldwasser, F.1
Bae, I.2
Valenti, M.3
-
30
-
-
0029036445
-
The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors
-
Dubrez L, Goldwasser F, Genne P, et al: The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors. Leukemia 9:1013-1024, 1995.
-
(1995)
Leukemia
, vol.9
, pp. 1013-1024
-
-
Dubrez, L.1
Goldwasser, F.2
Genne, P.3
-
31
-
-
0000536643
-
DNA topoisomerase-targeting antitumor drugs can be studied in yeast
-
Nitiss J, Wang JC: DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc Natl Acad Sci USA 85:7501-7505, 1988.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 7501-7505
-
-
Nitiss, J.1
Wang, J.C.2
-
32
-
-
0030057744
-
Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines
-
Beadler DR, Chang JY, Zhou BS, et al: Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines. Cancer Res 56:345-353, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 345-353
-
-
Beadler, D.R.1
Chang, J.Y.2
Zhou, B.S.3
-
33
-
-
0028033906
-
Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors
-
Pommier Y, Leteurtre F, Fesen MR, et al: Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors. Cancer Invest 12:530-542, 1994.
-
(1994)
Cancer Invest
, vol.12
, pp. 530-542
-
-
Pommier, Y.1
Leteurtre, F.2
Fesen, M.R.3
-
34
-
-
0024318022
-
Nonproductive rearrangement of DNA topoisomerase I and II genes: Correlation with resistance to topoisomerase inhibitors
-
Tan KB, Mattem MR, Eng WK, et al: Nonproductive rearrangement of DNA topoisomerase I and II genes: Correlation with resistance to topoisomerase inhibitors. J Natl Cancer Inst 81:1732-1735, 1989.
-
(1989)
J Natl Cancer Inst
, vol.81
, pp. 1732-1735
-
-
Tan, K.B.1
Mattem, M.R.2
Eng, W.K.3
-
35
-
-
0027005977
-
Camptothecin hyper-resistant P388 cells: Drug-dependent reduction in topoisomerase I content
-
Woessner RD, Eng WK, Hofmann GA, et al: Camptothecin hyper-resistant P388 cells: Drug-dependent reduction in topoisomerase I content. Oncol Res 4:481-488, 1992.
-
(1992)
Oncol Res
, vol.4
, pp. 481-488
-
-
Woessner, R.D.1
Eng, W.K.2
Hofmann, G.A.3
-
36
-
-
0028030721
-
Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitrocamptothecin
-
Rubin E, Pantazis P, Bharti A, et al: Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitrocamptothecin. J Biol Chem 269:2433-2439, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 2433-2439
-
-
Rubin, E.1
Pantazis, P.2
Bharti, A.3
-
37
-
-
0027881702
-
Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine
-
Benedetti P, Fiorani P, Capuani L, et al: Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine. Cancer Res 53:4343-4348, 1993.
-
(1993)
Cancer Res
, vol.53
, pp. 4343-4348
-
-
Benedetti, P.1
Fiorani, P.2
Capuani, L.3
-
38
-
-
0026032557
-
Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites
-
Tamura H, Kohchi C, Yamada R, et al: Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. Nucleic Acids Res 19:69-75, 1991.
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 69-75
-
-
Tamura, H.1
Kohchi, C.2
Yamada, R.3
-
39
-
-
0026497895
-
Detection of topoisomerase 1 gene point mutation in CPT-11 resistant lung cancer cell line
-
Kubota N, Kanzawa F, Nishio K, et al: Detection of topoisomerase 1 gene point mutation in CPT-11 resistant lung cancer cell line. Biochem Biophys Res Commun 188:571-577, 1992.
-
(1992)
Biochem Biophys Res Commun
, vol.188
, pp. 571-577
-
-
Kubota, N.1
Kanzawa, F.2
Nishio, K.3
-
40
-
-
0029003314
-
Altered topoisomerase I expression in two sub-clones of human CEM leukemia selected for resistance to Camptothecin
-
Kapoor R, Slade DL, Fujimori A, et al: Altered topoisomerase I expression in two sub-clones of human CEM leukemia selected for resistance to Camptothecin. Oncol Res 7:83-95, 1995.
-
(1995)
Oncol Res
, vol.7
, pp. 83-95
-
-
Kapoor, R.1
Slade, D.L.2
Fujimori, A.3
-
41
-
-
0028957974
-
Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to Camptothecin
-
Fujimori A, Harker WG, Kohlhagen G, et al: Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to Camptothecin. Cancer Res 55:1339-1346, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 1339-1346
-
-
Fujimori, A.1
Harker, W.G.2
Kohlhagen, G.3
-
42
-
-
0028030329
-
7-Ethyl-10-[4-(1 -piperidino)-1-piperidino] carbonyloxy Camptothecin: Mechanism of resistance and clinical trials
-
Saijo N, Nishio K, Kubota N, et al: 7-Ethyl-10-[4-(1 -piperidino)-1-piperidino] carbonyloxy Camptothecin: Mechanism of resistance and clinical trials. Cancer Chemother Pharmacol 34(suppl):S112-117, 1994.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, Issue.SUPPL.
-
-
Saijo, N.1
Nishio, K.2
Kubota, N.3
-
43
-
-
0028970266
-
A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons
-
Knab AM, Fertala J, Bjomsti MA: A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons. J Biol Chem 270:6141-6148, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 6141-6148
-
-
Knab, A.M.1
Fertala, J.2
Bjomsti, M.A.3
-
44
-
-
0029091756
-
Cross-resistance to Camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations
-
Yang CJ, Horton JK, Cowan KH, et al: Cross-resistance to Camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations. Cancer Res 55:4004-4009, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 4004-4009
-
-
Yang, C.J.1
Horton, J.K.2
Cowan, K.H.3
-
45
-
-
0026742287
-
Characterization of camptothecin-resistant Chinese hamster lung cells
-
Chang JY, Dethlefsen LA, Barley LR, et al: Characterization of camptothecin-resistant Chinese hamster lung cells, Biochem Pharmacol 43:2443-2452, 1992.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 2443-2452
-
-
Chang, J.Y.1
Dethlefsen, L.A.2
Barley, L.R.3
-
46
-
-
0026339352
-
Camptothecin overcomes MDR1-medialed resistance in human KB carcinoma cells
-
Chen AY, Yu C, Potmesil M, et al: Camptothecin overcomes MDR1-medialed resistance in human KB carcinoma cells. Cancer Res 51:6039-6044, 1991.
-
(1991)
Cancer Res
, vol.51
, pp. 6039-6044
-
-
Chen, A.Y.1
Yu, C.2
Potmesil, M.3
-
47
-
-
0026772298
-
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue
-
Hendricks CB, Rowinsky EK, Grochow LB, et al: Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Cancer Res 52:2268-2278, 1992.
-
(1992)
Cancer Res
, vol.52
, pp. 2268-2278
-
-
Hendricks, C.B.1
Rowinsky, E.K.2
Grochow, L.B.3
-
48
-
-
0027813132
-
In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells
-
Mattern MR, Hofmann GA, Polsky RM, et al: In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells. Oncol Res 5:467-474, 1993.
-
(1993)
Oncol Res
, vol.5
, pp. 467-474
-
-
Mattern, M.R.1
Hofmann, G.A.2
Polsky, R.M.3
-
50
-
-
0028122271
-
International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents
-
Anderson RD, Borger NA: International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents. Mutat Res 309:109-142, 1994.
-
(1994)
Mutat Res
, vol.309
, pp. 109-142
-
-
Anderson, R.D.1
Borger, N.A.2
-
51
-
-
0030248750
-
Concentration and timing dependence of lethality enhancement between topotecan, a topoisomerase I inhibitor, and ionizing radiation
-
Lamond JP, Wang M, Kinsella TJ, et al: Concentration and timing dependence of lethality enhancement between topotecan, a topoisomerase I inhibitor, and ionizing radiation. Int J Radiat Oncol Biol Phys 36:361-368, 1996.
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.36
, pp. 361-368
-
-
Lamond, J.P.1
Wang, M.2
Kinsella, T.J.3
-
52
-
-
0001431415
-
Phase I clinical and pharmacokinetic study of dally topotecan with thoracic irradiation
-
Berlin J, Schiller JH, Hutson PR, et al: Phase I clinical and pharmacokinetic study of dally topotecan with thoracic irradiation. Proc Am Assoc Cancer Res 37:164, 1996.
-
(1996)
Proc Am Assoc Cancer Res
, vol.37
, pp. 164
-
-
Berlin, J.1
Schiller, J.H.2
Hutson, P.R.3
-
53
-
-
0026537874
-
Phase I and pharmacologic study of topotecan: A novel topoisomerase I inhibitor
-
Rowinsky EK, Grochow LB, Hendricks CB, et al: Phase I and pharmacologic study of topotecan: A novel topoisomerase I inhibitor. J Clin Oncol 10:647-656, 1992.
-
(1992)
J Clin Oncol
, vol.10
, pp. 647-656
-
-
Rowinsky, E.K.1
Grochow, L.B.2
Hendricks, C.B.3
-
54
-
-
0027323646
-
Phase I clinical and pharmacology study of topotecan given dally for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor
-
Saltz L, Sirott M, Young C, et al: Phase I clinical and pharmacology study of topotecan given dally for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor. J Natl Cancer Inst 85:1499-1507, 1993.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 1499-1507
-
-
Saltz, L.1
Sirott, M.2
Young, C.3
-
55
-
-
0027454410
-
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor
-
Verweij J, Lund B, Beijnen J, et al: Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor. Ann Oncol 4:673-678, 1993.
-
(1993)
Ann Oncol
, vol.4
, pp. 673-678
-
-
Verweij, J.1
Lund, B.2
Beijnen, J.3
-
56
-
-
0027935576
-
Phase I and pharmacokinetic studies of topotecan administered as a 72 or 120 hour continuous infusion
-
Burris HA, Awada A, Kuhn JG, et al: Phase I and pharmacokinetic studies of topotecan administered as a 72 or 120 hour continuous infusion. Anticancer Drugs 5:394-402, 1994.
-
(1994)
Anticancer Drugs
, vol.5
, pp. 394-402
-
-
Burris, H.A.1
Awada, A.2
Kuhn, J.G.3
-
57
-
-
0027501999
-
Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia
-
Kantarjian HM, Beran M, Ellis A, et al: Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia. Blood 81:1146-1151, 1993.
-
(1993)
Blood
, vol.81
, pp. 1146-1151
-
-
Kantarjian, H.M.1
Beran, M.2
Ellis, A.3
-
58
-
-
0026697849
-
A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days
-
Wall JG, Burris HA, Von Hoff DD, et al: A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days. Anticancer Drugs 3:337-345, 1992.
-
(1992)
Anticancer Drugs
, vol.3
, pp. 337-345
-
-
Wall, J.G.1
Burris, H.A.2
Von Hoff, D.D.3
-
59
-
-
0010267346
-
Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly
-
Haas NB, LaCreta FP, Walczak J, et al: Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly. Cancer Res 54:1220-1226, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 1220-1226
-
-
Haas, N.B.1
LaCreta, F.P.2
Walczak, J.3
-
60
-
-
0029030737
-
Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion
-
van Warmerdam LJ, ten Bokkel Humink WW, Rodenhuis S, et al: Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion. J Clin Oncol 13:1768-1776, 1995.
-
(1995)
J Clin Oncol
, vol.13
, pp. 1768-1776
-
-
Van Warmerdam, L.J.1
Ten Bokkel Humink, W.W.2
Rodenhuis, S.3
-
61
-
-
0027407637
-
Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continu- Ous infusion
-
Blaney SM, Balis FM, Cole DE, et al: Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continu- ous infusion. Cancer Res 53:1032-1036, 1993.
-
(1993)
Cancer Res
, vol.53
, pp. 1032-1036
-
-
Blaney, S.M.1
Balis, F.M.2
Cole, D.E.3
-
62
-
-
0028357993
-
Phase I study of topotecan for pediatric patients with malignant solid tumors
-
Pratt CB, Stewart C, Santana VM, et al: Phase I study of topotecan for pediatric patients with malignant solid tumors. J Clin Oncol 12:539-543, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 539-543
-
-
Pratt, C.B.1
Stewart, C.2
Santana, V.M.3
-
63
-
-
0031056424
-
Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors
-
Creemers GJ, Gerrits CJH, Eckardt JR, et al: Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors. J Clin Oncol 15:1087-1093, 1997.
-
(1997)
J Clin Oncol
, vol.15
, pp. 1087-1093
-
-
Creemers, G.J.1
Gerrits, C.J.H.2
Eckardt, J.R.3
-
65
-
-
0026646768
-
Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer
-
Grochow LB, Rowinsky EK, Johnson R, et al: Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer. Drug Metab Dispos 20:706-713, 1992.
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 706-713
-
-
Grochow, L.B.1
Rowinsky, E.K.2
Johnson, R.3
-
66
-
-
0001459009
-
Phase I & pharmacologic study of topotecan, an inhibitor of topoisomerase I, with granulocyte colony-stimulating factor (G-CSF): Toxicologic differences between concurrent & post-treatment C-CSF administration
-
Rowinsky E, Sartorius S, Grochow L, et al: Phase I & pharmacologic study of topotecan, an inhibitor of topoisomerase I, with granulocyte colony-stimulating factor (G-CSF): Toxicologic differences between concurrent & post-treatment C-CSF administration. Proc Am Soc Clin Oncol 11: 116, 1992.
-
(1992)
Proc Am Soc Clin Oncol
, vol.11
, pp. 116
-
-
Rowinsky, E.1
Sartorius, S.2
Grochow, L.3
-
68
-
-
0028036827
-
Recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based, clinical practice guidelines
-
American Society of Clinical Oncology: Recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based, clinical practice guidelines. J Clin Oncol 12:2471-2508, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2471-2508
-
-
-
69
-
-
0344405536
-
Update of recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based clinical practice guidelines
-
American Society of Clinical Oncology: Update of recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based clinical practice guidelines. J Clin Oncol 14:1957-1960, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1957-1960
-
-
-
70
-
-
0010243242
-
Oral topotecan for 10 days b.i.d. every 3 weeks, results of a phase I and pharmacologic study in adults with solid tumors
-
Gerrits CJ, Eckardt JR, Schellens JHM, et al: Oral topotecan for 10 days b.i.d. every 3 weeks, results of a phase I and pharmacologic study in adults with solid tumors. Ann Oncol 7(suppl 1):132, 1996.
-
(1996)
Ann Oncol
, vol.7
, Issue.1 SUPPL.
, pp. 132
-
-
Gerrits, C.J.1
Eckardt, J.R.2
Schellens, J.H.M.3
-
71
-
-
0028147296
-
Phase II study of topotecan in metastatic non-small-cel lung cancer
-
Lynch Jr. TJ, Kalish L, Strauss G, et al: Phase II study of topotecan in metastatic non-small-cel lung cancer. J Clin Oncol 12:347-352, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 347-352
-
-
Lynch Jr., T.J.1
Kalish, L.2
Strauss, G.3
-
72
-
-
0028130504
-
Clinical pharmacodynamics of continuous infusion topotecan in children: Systemic exposure predicts hematologic toxicity
-
Stewart CF, Baker SD, Heideman RL, et al: Clinical pharmacodynamics of continuous infusion topotecan in children: Systemic exposure predicts hematologic toxicity. J Clin Oncol 12:1946-1954, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 1946-1954
-
-
Stewart, C.F.1
Baker, S.D.2
Heideman, R.L.3
-
73
-
-
0010236583
-
Bioavailability of oral topotecan, a new topoisomerase I inhibitor
-
Creemers GJ, Schellens JHM, Beijnen JH, et al: Bioavailability of oral topotecan, a new topoisomerase I inhibitor. Proc Am Soc Clin Oncol 13:132, 1995.
-
(1995)
Proc Am Soc Clin Oncol
, vol.13
, pp. 132
-
-
Creemers, G.J.1
Schellens, J.H.M.2
Beijnen, J.H.3
-
75
-
-
0028012774
-
The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability
-
Burke TG, Mi Z: The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability. J Med Chem 37:40-46, 1994.
-
(1994)
J Med Chem
, vol.37
, pp. 40-46
-
-
Burke, T.G.1
Mi, Z.2
-
76
-
-
0028844445
-
Reduced albumin binding promotes the stability and activity of topotecan in human blood
-
Mi Z, Malak H, Burke TG: Reduced albumin binding promotes the stability and activity of topotecan in human blood. Biochemistry 34:13722-13728, 1995.
-
(1995)
Biochemistry
, vol.34
, pp. 13722-13728
-
-
Mi, Z.1
Malak, H.2
Burke, T.G.3
-
77
-
-
0029656180
-
Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors
-
Baker SD, Heideman RL, Crom WR, et al: Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors. Cancer Chemother Phannacol 37:195-202, 1996.
-
(1996)
Cancer Chemother Phannacol
, vol.37
, pp. 195-202
-
-
Baker, S.D.1
Heideman, R.L.2
Crom, W.R.3
-
78
-
-
0028796513
-
Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks
-
van Warmerdam LJ, Verweij J, Schellens JH, et al: Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks. Cancer Chemother Pharmacol 35:237-245, 1995.
-
(1995)
Cancer Chemother Pharmacol
, vol.35
, pp. 237-245
-
-
Van Warmerdam, L.J.1
Verweij, J.2
Schellens, J.H.3
-
79
-
-
0029966916
-
Phase I and pharmacologic studies of topotecan in patients with impaired renal function
-
O'Reilly S, Rowinsky E, Slichenmyer W, et al: Phase I and pharmacologic studies of topotecan in patients with impaired renal function. J Clin Oncol 14:3062-3073, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 3062-3073
-
-
O'Reilly, S.1
Rowinsky, E.2
Slichenmyer, W.3
-
80
-
-
15844424667
-
Phase I and pharmacologic studies of topotecan in patients with impaired hepatic function
-
O'Reilly S, Rowinsky E, Slichenmyer W, et al: Phase I and pharmacologic studies of topotecan in patients with impaired hepatic function. J Natl Cancer Inst 88:817-824, 1996.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 817-824
-
-
O'Reilly, S.1
Rowinsky, E.2
Slichenmyer, W.3
-
81
-
-
0030900145
-
Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer
-
Ten Bokkel Huinink W, Gore M, Carmichael J, et al: Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J Clin Oncol 15:2183-2193, 1997.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2183-2193
-
-
Ten Bokkel Huinink, W.1
Gore, M.2
Carmichael, J.3
-
82
-
-
0000391321
-
Efficacy of topotecan in advanced epithelial ovarian cancer after failure of platinum and paclitaxel: International Topotecan Study Group trial
-
Gordon A, Bookman M, Malstrom H, et al: Efficacy of topotecan in advanced epithelial ovarian cancer after failure of platinum and paclitaxel: International Topotecan Study Group trial. Proc Am Soc Clin Oncol 15:282, 1996.
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 282
-
-
Gordon, A.1
Bookman, M.2
Malstrom, H.3
-
83
-
-
9244247616
-
Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma
-
Kudelka AP, Tresukosol D, Edwards CL, et al: Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma. J Clin Oncol 14:1552-1557, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1552-1557
-
-
Kudelka, A.P.1
Tresukosol, D.2
Edwards, C.L.3
-
84
-
-
10544229791
-
Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: Results of a large European phase II study
-
Creemers GJ, Bolis G, Gore M, et al: Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: Results of a large European phase II study. J Clin Oncol 14:3056-3061, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 3056-3061
-
-
Creemers, G.J.1
Bolis, G.2
Gore, M.3
-
85
-
-
0029790139
-
Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: An Eastem Cooperative Oncology Group Trial
-
Schiller JH, Kim K, Hutson P, et al: Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: An Eastem Cooperative Oncology Group Trial. J Clin Oncol 14:2345-2352, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 2345-2352
-
-
Schiller, J.H.1
Kim, K.2
Hutson, P.3
-
86
-
-
0000582724
-
Phase II study of topotecan in patients with small cell lung cancer (SCLC) refractory to etoposide
-
Perez-Soler R, Glission BS, Lee JS, et al: Phase II study of topotecan in patients with small cell lung cancer (SCLC) refractory to etoposide. Proc Am Soc Clin Oncol 14:355, 1995.
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 355
-
-
Perez-Soler, R.1
Glission, B.S.2
Lee, J.S.3
-
87
-
-
0001401883
-
Phase II study of topotecan in refractory and sensitive small cell lung cancer (SCLC)
-
Wanders J, Ardizzoni A, Hansen HH, et al: Phase II study of topotecan in refractory and sensitive small cell lung cancer (SCLC). Proc Am Assoc Cancer Res 36:237, 1995.
-
(1995)
Proc Am Assoc Cancer Res
, vol.36
, pp. 237
-
-
Wanders, J.1
Ardizzoni, A.2
Hansen, H.H.3
-
88
-
-
0030913459
-
Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: A phase II study in patients with refractory and sensitive disease
-
Ardizzoni A, Hansen H, Dombemoswsky P, et al: Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: A phase II study in patients with refractory and sensitive disease. J Clin Oncol 15:2090-2096, 1997.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2090-2096
-
-
Ardizzoni, A.1
Hansen, H.2
Dombemoswsky, P.3
-
89
-
-
0000339156
-
Randomized phase II trial of two schedules of topotecan for the treatment of advanced stage non-small cell lung carcinoma (NSCLC): A North Central Cancer Treatment Group (NCCTG) trial
-
Weitz JJ, Jung SH, Marschke FF, et al: Randomized phase II trial of two schedules of topotecan for the treatment of advanced stage non-small cell lung carcinoma (NSCLC): A North Central Cancer Treatment Group (NCCTG) trial. Proc Am Soc Clin Oncol 14:348, 1995.
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 348
-
-
Weitz, J.J.1
Jung, S.H.2
Marschke, F.F.3
-
90
-
-
0004484604
-
Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy
-
Perez-Soler R, Fossella FV, Glisson BS, et al: Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy. J Clin Oncol 14:503-513, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 503-513
-
-
Perez-Soler, R.1
Fossella, F.V.2
Glisson, B.S.3
-
91
-
-
10144234806
-
Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myclomonocytic leukemia
-
Beran M, Kantarjian H, O'Brien S, et al: Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myclomonocytic leukemia. Blood 88:2473-2479, 1996.
-
(1996)
Blood
, vol.88
, pp. 2473-2479
-
-
Beran, M.1
Kantarjian, H.2
O'Brien, S.3
-
92
-
-
0000347726
-
Myelodysplastic syndrome
-
Hoffman R, Benz EJ, Shattil SJ, et al (eds). New York, Churchill Livingstone
-
Greenberg PL: Myelodysplastic syndrome, in: Hoffman R, Benz EJ, Shattil SJ, et al (eds). Hematology: Basic Principles and Practice, pp 1109. New York, Churchill Livingstone, 1995.
-
(1995)
Hematology: Basic Principles and Practice
, pp. 1109
-
-
Greenberg, P.L.1
-
93
-
-
0029991006
-
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia
-
Furman WL, Baker SD, Prall CB, et al: Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia. J Clin Oncol 14:1504-1511, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1504-1511
-
-
Furman, W.L.1
Baker, S.D.2
Prall, C.B.3
-
94
-
-
0028930068
-
Topotecan in chronic lymphocytic leukemia
-
O'Brien S, Kantarjian H, Ellis A, et al: Topotecan in chronic lymphocytic leukemia. Cancer 75:1104-1108, 1995.
-
(1995)
Cancer
, vol.75
, pp. 1104-1108
-
-
O'Brien, S.1
Kantarjian, H.2
Ellis, A.3
-
95
-
-
0003225587
-
Preliminary results of a phase II trial of topotecan in patients with relapsing lymphoma
-
Preti HA, Plunkett W, Sarris AH: Preliminary results of a phase II trial of topotecan in patients with relapsing lymphoma. Blood 86:820a, 1995.
-
(1995)
Blood
, vol.86
-
-
Preti, H.A.1
Plunkett, W.2
Sarris, A.H.3
-
96
-
-
12644290823
-
The camptothecin topoisomerase I inhibitors: An update
-
Hortobagyi GN, Khayat D (eds): Oxford, Blackwell Science Ltd
-
Arbuck SG, Blaylock BA, Christian MC, et al: The camptothecin topoisomerase I inhibitors: An update, in: Hortobagyi GN, Khayat D (eds): Progress in Anti-Cancer Chemotherapy, pp 1-27. Oxford, Blackwell Science Ltd, 1997.
-
(1997)
Progress in Anti-Cancer Chemotherapy
, pp. 1-27
-
-
Arbuck, S.G.1
Blaylock, B.A.2
Christian, M.C.3
-
97
-
-
0031027077
-
Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia
-
Seiter K, Feldman EJ, Halicka HD, et al: Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia. J Clin Oncol 15:44-51, 1997.
-
(1997)
J Clin Oncol
, vol.15
, pp. 44-51
-
-
Seiter, K.1
Feldman, E.J.2
Halicka, H.D.3
-
98
-
-
0001146173
-
Up front phase II therapy with TAXOL (Tx1) and topotecan in untreated children (> 365 days) with disseminated (INSS stage 4) neuroblastoma
-
Kretschmar C, Kletzel M, Murray K, et al: Up front phase II therapy with TAXOL (Tx1) and topotecan in untreated children (> 365 days) with disseminated (INSS stage 4) neuroblastoma. Med Pediat Oncol 25:243, 1995.
-
(1995)
Med Pediat Oncol
, vol.25
, pp. 243
-
-
Kretschmar, C.1
Kletzel, M.2
Murray, K.3
-
99
-
-
0003326033
-
Topotecan window in patients with rhabdomyosarcoma (RMS): An IRSG study
-
Vietti T, Crist W, Ruby E, et al: Topotecan window in patients with rhabdomyosarcoma (RMS): An IRSG study. Proc Am Soc Clin Oncol 16:510a, 1997.
-
(1997)
Proc Am Soc Clin Oncol
, vol.16
-
-
Vietti, T.1
Crist, W.2
Ruby, E.3
-
100
-
-
0028829131
-
Topotecan in colorcctal cancer: A phase II study of the EORTC early clinical trials group
-
Creemers GJ, Wanders J, Gamucci T, et al: Topotecan in colorcctal cancer: A phase II study of the EORTC early clinical trials group. Ann Oncol 6:844-846, 1995.
-
(1995)
Ann Oncol
, vol.6
, pp. 844-846
-
-
Creemers, G.J.1
Wanders, J.2
Gamucci, T.3
-
101
-
-
0001730741
-
A Phase II trial of topotecan (TPT) for the treatment of advanced, measurable colorectal cancer
-
Sugarman SM, Ajani JA, Daugherty K, et al. A Phase II trial of topotecan (TPT) for the treatment of advanced, measurable colorectal cancer. Proc Am Soc Clin Oncol 13:225, 1994.
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 225
-
-
Sugarman, S.M.1
Ajani, J.A.2
Daugherty, K.3
-
102
-
-
0010458798
-
Evaluation of topolecan in recurrent or metastatic head and neck cancer. SWOG-9305
-
Smith RE, Lew D, Rodriguez GI, et al: Evaluation of topolecan in recurrent or metastatic head and neck cancer. SWOG-9305. Proc Am Soc Clin Oncol 15.310, 1996
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 310
-
-
Smith, R.E.1
Lew, D.2
Rodriguez, G.I.3
-
103
-
-
0029915134
-
Phase II study of topotecan in patients with recurrent malignant glioma
-
National Clinical Institute of Canada Clinical Trials Group
-
MacDonald D, Cairncross G, Stewart D, et al: Phase II study of topotecan in patients with recurrent malignant glioma. National Clinical Institute of Canada Clinical Trials Group. Ann Oncol 7:205-207, 1996.
-
(1996)
Ann Oncol
, vol.7
, pp. 205-207
-
-
MacDonald, D.1
Cairncross, G.2
Stewart, D.3
-
104
-
-
0013590606
-
A North Central Cancer Treatment Group phase II trial of topotecan in relapsed gliomas
-
Burch PA, Novotony PJ, Bemath AM, et al: A North Central Cancer Treatment Group phase II trial of topotecan in relapsed gliomas. Proc Am Assoc Cancer Res 37:169-170, 1996.
-
(1996)
Proc Am Assoc Cancer Res
, vol.37
, pp. 169-170
-
-
Burch, P.A.1
Novotony, P.J.2
Bemath, A.M.3
-
105
-
-
0000050035
-
Phase II trial of topotecan for cervical cancer of the uterus
-
Noda K, Sasaki H, Yamamoto K, et al: Phase II trial of topotecan for cervical cancer of the uterus. Proc Am Soc Clin Oncol 15:280, 1996.
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 280
-
-
Noda, K.1
Sasaki, H.2
Yamamoto, K.3
-
106
-
-
0028860716
-
Phase II trial of topotecan in patients with cisplatinrefractory germ cell tumors
-
Puc HS, Bajorin DF, Bosl GJ, et al: Phase II trial of topotecan in patients with cisplatinrefractory germ cell tumors. Invest New Drugs 13:163-165, 1995.
-
(1995)
Invest New Drugs
, vol.13
, pp. 163-165
-
-
Puc, H.S.1
Bajorin, D.F.2
Bosl, G.J.3
-
107
-
-
9344262852
-
Phase II trial of topotecan in pleural mesothelioma: North Central Cancer Treatment Group (NCCTG) trial
-
Maksymiuk AW, Jung S, Marschke RF, et al: Phase II trial of topotecan in pleural mesothelioma: North Central Cancer Treatment Group (NCCTG) trial Proc Am Soc Clin Oncol 14:435, 1995.
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 435
-
-
Maksymiuk, A.W.1
Jung, S.2
Marschke, R.F.3
-
109
-
-
0029551032
-
Phase II study of topotecan in metastatic hormone-refractory prostate cancer
-
Hudes GR, Kosierowski R, Greenberg R, et al: Phase II study of topotecan in metastatic hormone-refractory prostate cancer. Invest New Drugs 13:235-240, 1995.
-
(1995)
Invest New Drugs
, vol.13
, pp. 235-240
-
-
Hudes, G.R.1
Kosierowski, R.2
Greenberg, R.3
-
110
-
-
0010421429
-
Phase II study of topotecan (TT) for hormone-refractory prostate cancer (HRPC)
-
Giantomo BJ, Kosierowski R, Ramsey HE: Phase II study of topotecan (TT) for hormone-refractory prostate cancer (HRPC). Proc Am Soc Clin Oncol 12:A774, 1993.
-
(1993)
Proc Am Soc Clin Oncol
, vol.12
-
-
Giantomo, B.J.1
Kosierowski, R.2
Ramsey, H.E.3
-
111
-
-
0001730741
-
A Phase II trial of topotecan (TPT) for the treatment of unresectable pancreatic cancer
-
Sugannan SM, Pazdur R, Daugherty K, et al: A Phase II trial of topotecan (TPT) for the treatment of unresectable pancreatic cancer. Proc Am Soc Clin Oncol 13:224, 1994.
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 224
-
-
Sugannan, S.M.1
Pazdur, R.2
Daugherty, K.3
-
112
-
-
0029556666
-
Phase II trial of topotecan in advanced or metastatic adenocarcinomaof the pancreas
-
Scher RM, Kosierowski R, Lusch C, et al: Phase II trial of topotecan in advanced or metastatic adenocarcinomaof the pancreas. Invest New Drugs 13:347-354, 1996.
-
(1996)
Invest New Drugs
, vol.13
, pp. 347-354
-
-
Scher, R.M.1
Kosierowski, R.2
Lusch, C.3
-
113
-
-
0028793342
-
Phase II study of topotecan (NSC 609 699) in patients with recurrent or metastatic soft tissue sarcoma
-
Bramwell VH, Eisenhauer EA, Elacksteln M, et al: Phase II study of topotecan (NSC 609 699) in patients with recurrent or metastatic soft tissue sarcoma. Ann Oncol 6:847-849, 1995.
-
(1995)
Ann Oncol
, vol.6
, pp. 847-849
-
-
Bramwell, V.H.1
Eisenhauer, E.A.2
Elacksteln, M.3
-
114
-
-
0028054333
-
Phase II triai of topotecan in patients with advanced renal cell carcinoma
-
Law TM, Ilson DU, Motzer RJ: Phase II triai of topotecan in patients with advanced renal cell carcinoma. Invest New Drugs 12:143-145, 1994.
-
(1994)
Invest New Drugs
, vol.12
, pp. 143-145
-
-
Law, T.M.1
Ilson, D.U.2
Motzer, R.J.3
-
115
-
-
0342748911
-
Comparison of intermittent and continuous exposure to topotecan in medulloblastoma cells
-
Danks MK, Marion RC: Comparison of intermittent and continuous exposure to topotecan in medulloblastoma cells. Proc Am Assoc Cancer Res 37:436, 1996.
-
(1996)
Proc Am Assoc Cancer Res
, vol.37
, pp. 436
-
-
Danks, M.K.1
Marion, R.C.2
-
116
-
-
0027999967
-
Phase I study of topotecan and cisplatin in patients with advanced solid tumors: A cancer and leukemia group B study
-
Miller AA, Hargis JB, Lilenbaum RC, et al: Phase I study of topotecan and cisplatin in patients with advanced solid tumors: A cancer and leukemia group B study. J Clin Oncol 12:2743-2750, 1994.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2743-2750
-
-
Miller, A.A.1
Hargis, J.B.2
Lilenbaum, R.C.3
-
117
-
-
10544249871
-
Sequences of topotecan and cisplatin: Phase 1, pharmacologie, and in vitro studies to examine sequence dependence
-
Rowinsky EK, Kaufmann SH, Baker SD. et al: Sequences of topotecan and cisplatin: Phase 1, pharmacologie, and in vitro studies to examine sequence dependence. J Clin Oncol 14:3074-3084, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 3074-3084
-
-
Rowinsky, E.K.1
Kaufmann, S.H.2
Baker, S.D.3
-
118
-
-
0029163002
-
Phase I study of paclitaxel and topotecan in patients with advanced tumors: A cancer and leukemia group B study
-
Lilenbaum RC, Ratain MJ, Miller AA, et al: Phase I study of paclitaxel and topotecan in patients with advanced tumors: A cancer and leukemia group B study. J Clin Oncol 13:2230-2237, 1995.
-
(1995)
J Clin Oncol
, vol.13
, pp. 2230-2237
-
-
Lilenbaum, R.C.1
Ratain, M.J.2
Miller, A.A.3
-
119
-
-
0342621658
-
Phase I study of TAXOL with 14-day topotecan continuous low-dose infusions
-
Hochster H, Speyer J, Oratz R, et al: Phase I study of TAXOL with 14-day topotecan continuous low-dose infusions. Proc Am Soc Clin Oncol 14:486, 1995.
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 486
-
-
Hochster, H.1
Speyer, J.2
Oratz, R.3
-
120
-
-
0010236301
-
Phase I trial of cyclophosphamide and topotecan in refractory cancer
-
Murren JR, Fedele J, Andersen S, et al Phase I trial of cyclophosphamide and topotecan in refractory cancer. Proc Am Soc Clin Oncol 14:475, 1995.
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 475
-
-
Murren, J.R.1
Fedele, J.2
Andersen, S.3
-
121
-
-
0001234395
-
A phase I study of topotecan (a topoisomerase I inhibitor) in combination with doxorubicm (a topoisomerase II inhibitor)
-
Torcher AW, O'Shaughnessy JA, Weiss RB, et al: A phase I study of topotecan (a topoisomerase I inhibitor) in combination with doxorubicm (a topoisomerase II inhibitor). Proc Am Soc Clinc Oncol 13:157, 1994.
-
(1994)
Proc Am Soc Clinc Oncol
, vol.13
, pp. 157
-
-
Torcher, A.W.1
O'Shaughnessy, J.A.2
Weiss, R.B.3
-
122
-
-
0003029383
-
Measurement of tumor topoisomerase I and II levels during the sequential administration of topotecan and etoposide
-
Eckardt JR, Burris HA, Von Hoff DD, et al: Measurement of tumor topoisomerase I and II levels during the sequential administration of topotecan and etoposide. Proc Am Soc Clin Oncol 13:141, 1994.
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 141
-
-
Eckardt, J.R.1
Burris, H.A.2
Von Hoff, D.D.3
-
123
-
-
0344783315
-
Phase I and pharmacokinetic study of topotecan in combination with oral etoposide
-
Herben VMM, ten Bokkel Huinink WW, Rodenhuls S, et al: Phase I and pharmacokinetic study of topotecan in combination with oral etoposide. Ann Oncol 1 (suppl 1).133, 1996.
-
(1996)
Ann Oncol
, vol.1
, Issue.1 SUPPL.
, pp. 133
-
-
Herben, V.M.M.1
Ten Bokkel Huinink, W.W.2
Rodenhuls, S.3
-
124
-
-
0344783314
-
A phase I trial of sequential topotecan and etoposide in adult acute myeloid leukemia
-
Crump M, Lipton J, Medley D, et al: A phase I trial of sequential topotecan and etoposide in adult acute myeloid leukemia. Proc Am Soc Clin Oncol 15:357, 1996.
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 357
-
-
Crump, M.1
Lipton, J.2
Medley, D.3
-
125
-
-
0028099895
-
Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens
-
Cheng MF, Chatterjee S, Berger NA. Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens. Oncol Res 6:269-279, 1994.
-
(1994)
Oncol Res
, vol.6
, pp. 269-279
-
-
Cheng, M.F.1
Chatterjee, S.2
Berger, N.A.3
-
126
-
-
0029993118
-
Treatment-related fatal sepsis from topotecan/cisplatin and topotecan/paclitaxel
-
Miller AA, Lilenbaum RC, Lynch TJ, et al: Treatment-related fatal sepsis from topotecan/cisplatin and topotecan/paclitaxel. J Clin Oncol 14:1964-1965, 1996.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1964-1965
-
-
Miller, A.A.1
Lilenbaum, R.C.2
Lynch, T.J.3
|