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Volumn 70, Issue , 2005, Pages 159-166

The von Hippel-Lindau tumor suppressor protein: Roles in cancer and oxygen sensing

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GENE PRODUCT; HETERODIMER; LIGASE; NERVE GROWTH FACTOR; PROTEIN C JUN; TRANSCRIPTION FACTOR; VON HIPPEL LINDAU PROTEIN; DNA 26S; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR; OXYGEN; PROTEIN TYROSINE KINASE A; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE E3; VASCULOTROPIN;

EID: 33746427905     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2005.70.001     Document Type: Conference Paper
Times cited : (61)

References (116)
  • 1
    • 0034213624 scopus 로고    scopus 로고
    • Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
    • Adryan B., Decker H.-J.H., Papas T.S., and Hsu T. 2000. Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila. Oncogene 19: 2803.
    • (2000) Oncogene , vol.19 , pp. 2803
    • Adryan, B.1    Decker, H.-J.H.2    Papas, T.S.3    Hsu, T.4
  • 2
    • 0036712736 scopus 로고    scopus 로고
    • Rapid and durable recovery of visual function in a patient with von Hippel-Lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416
    • Aiello L.P., George D.J., Cahill M.T., Wong J.S., Cavallerano J., Hannah A.L., and Kaelin W.G., Jr. 2002. Rapid and durable recovery of visual function in a patient with von Hippel-Lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416. Ophthalmology 109: 1745.
    • (2002) Ophthalmology , vol.109 , pp. 1745
    • Aiello, L.P.1    George, D.J.2    Cahill, M.T.3    Wong, J.S.4    Cavallerano, J.5    Hannah, A.L.6    Kaelin Jr., W.G.7
  • 4
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin L.E., Golijanin D., Itin A., Pode D., and Keshet E. 1999. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103: 159.
    • (1999) J. Clin. Invest. , vol.103 , pp. 159
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 5
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., and Hanahan D. 2003. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111: 1287.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 6
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
    • Berra E., Benizri E., Ginouves A., Volmat V., Roux D., and Pouyssegur J. 2003. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22: 4082.
    • (2003) EMBO J. , vol.22 , pp. 4082
    • Berra, E.1    Benizri, E.2    Ginouves, A.3    Volmat, V.4    Roux, D.5    Pouyssegur, J.6
  • 8
    • 0033602089 scopus 로고    scopus 로고
    • Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
    • Blankenship C., Naglich J., Whaley J., Seizinger B., and Kley N. 1999. Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 18: 1529.
    • (1999) Oncogene , vol.18 , pp. 1529
    • Blankenship, C.1    Naglich, J.2    Whaley, J.3    Seizinger, B.4    Kley, N.5
  • 9
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick R. and McKnight S. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337.
    • (2001) Science , vol.294 , pp. 1337
    • Bruick, R.1    McKnight, S.2
  • 13
    • 0037432686 scopus 로고    scopus 로고
    • Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
    • Cioffi C.L., Liu X.Q., Kosinski P.A., and Bowen B.R. 2003. Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem. Biophys. Res. Commun. 303: 947.
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 947
    • Cioffi, C.L.1    Liu, X.Q.2    Kosinski, P.A.3    Bowen, B.R.4
  • 14
    • 0035339044 scopus 로고    scopus 로고
    • Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
    • Clifford S., Cockman M., Smallwood A., Mole D., Woodward E., Maxwell P., Ratcliffe P., and Maher E. 2001. Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum. Mol. Genet. 10: 1029.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1029
    • Clifford, S.1    Cockman, M.2    Smallwood, A.3    Mole, D.4    Woodward, E.5    Maxwell, P.6    Ratcliffe, P.7    Maher, E.8
  • 16
    • 0030948396 scopus 로고    scopus 로고
    • Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues
    • Corless C.L., Kibel A., Iliopoulos O., and Kaelin W.G., Jr. 1997. Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues. Hum. Pathol. 28: 459.
    • (1997) Hum. Pathol. , vol.28 , pp. 459
    • Corless, C.L.1    Kibel, A.2    Iliopoulos, O.3    Kaelin Jr., W.G.4
  • 17
    • 1642603441 scopus 로고    scopus 로고
    • von Hippel-Lindau tumor suppressor: Not only HIF's executioner
    • Czyzyk-Krzeska M.F. and Meller J. 2004. von Hippel-Lindau tumor suppressor: Not only HIF's executioner. Trends Mol. Med. 10: 146.
    • (2004) Trends Mol. Med. , vol.10 , pp. 146
    • Czyzyk-Krzeska, M.F.1    Meller, J.2
  • 18
    • 0035136533 scopus 로고    scopus 로고
    • VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling
    • Davidowitz E., Schoenfeld A., and Burk R. 2001. VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol. Cell. Biol. 21: 865.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 865
    • Davidowitz, E.1    Schoenfeld, A.2    Burk, R.3
  • 19
    • 0027485950 scopus 로고
    • Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
    • Deckwerth T.L. and Johnson E.M., Jr. 1993. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123: 1207.
    • (1993) J. Cell Biol. , vol.123 , pp. 1207
    • Deckwerth, T.L.1    Johnson Jr., E.M.2
  • 20
    • 1542300383 scopus 로고    scopus 로고
    • The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
    • del Peso L., Castellanos M.C., Temes E., Martin-Puig S., Cuevas Y., Olmos G., and Landazuri M.O. 2003. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 278: 48690.
    • (2003) J. Biol. Chem. , vol.278 , pp. 48690
    • Del Peso, L.1    Castellanos, M.C.2    Temes, E.3    Martin-Puig, S.4    Cuevas, Y.5    Olmos, G.6    Landazuri, M.O.7
  • 23
    • 0028123667 scopus 로고
    • Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal
    • Edwards S.N. and Tolkovsky A.M. 1994. Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal. J. Cell Biol. 124: 537.
    • (1994) J. Cell Biol. , vol.124 , pp. 537
    • Edwards, S.N.1    Tolkovsky, A.M.2
  • 26
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus S., Zaks W.J., Freeman R.S., Gruda M., Bravo R., and Johnson, E.M., Jr. 1994. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127: 1717.
    • (1994) J. Cell Biol. , vol.127 , pp. 1717
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson Jr., E.M.6
  • 27
    • 0031870653 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha
    • Flamme I., Krieg M., and Plate K. 1998. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. Am. J. Pathol. 153: 25.
    • (1998) Am. J. Pathol. , vol.153 , pp. 25
    • Flamme, I.1    Krieg, M.2    Plate, K.3
  • 28
    • 0028812223 scopus 로고
    • Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: Implications for the potential organization of the human von Hippel-Lindau disease gene
    • Gao J., Naglich J.G., Laidlaw J., Whaley J.M., Seizinger B.R., and Kley N. 1995. Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: Implications for the potential organization of the human von Hippel-Lindau disease gene. Cancer Res. 55: 743.
    • (1995) Cancer Res. , vol.55 , pp. 743
    • Gao, J.1    Naglich, J.G.2    Laidlaw, J.3    Whaley, J.M.4    Seizinger, B.R.5    Kley, N.6
  • 30
    • 0038015673 scopus 로고    scopus 로고
    • Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas
    • Girmens J.F., Erginay A., Massin P., Scigalla P., Gaudric A., and Richard S. 2003. Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas. Am. J. Ophthalmol. 136: 194.
    • (2003) Am. J. Ophthalmol. , vol.136 , pp. 194
    • Girmens, J.F.1    Erginay, A.2    Massin, P.3    Scigalla, P.4    Gaudric, A.5    Richard, S.6
  • 33
    • 0036314978 scopus 로고    scopus 로고
    • Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
    • Groulx I. and Lee S. 2002. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 22: 5319.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5319
    • Groulx, I.1    Lee, S.2
  • 35
    • 0035852668 scopus 로고    scopus 로고
    • Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
    • Haase V., Glickman J., Socolovsky M., and Jaenisch R. 2001. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. 98: 1583.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 1583
    • Haase, V.1    Glickman, J.2    Socolovsky, M.3    Jaenisch, R.4
  • 36
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J., Babij C., Whitfield J., Pfarr C.M., Lallemand D., Yaniv M., and Rubin L.L. 1995. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14: 927.
    • (1995) Neuron , vol.14 , pp. 927
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6    Rubin, L.L.7
  • 37
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • Hirsila M., Koivunen P., Gunzler V., Kivirikko K.I., and Myllyharju J. 2003. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278: 30772.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30772
    • Hirsila, M.1    Koivunen, P.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 38
    • 0035336706 scopus 로고    scopus 로고
    • von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
    • Hoffman M., Ohh M., Yang H., Klco J., Ivan M., and Kaelin W.G., Jr. 2001. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum. Mol. Genet. 10: 1019.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1019
    • Hoffman, M.1    Ohh, M.2    Yang, H.3    Klco, J.4    Ivan, M.5    Kaelin Jr., W.G.6
  • 40
    • 0032578357 scopus 로고    scopus 로고
    • pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
    • Iliopoulos O., Ohh M., and Kaelin W. 1998. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc. Natl. Acad. Sci. 95: 11661.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 11661
    • Iliopoulos, O.1    Ohh, M.2    Kaelin, W.3
  • 41
    • 0029090338 scopus 로고
    • Tumor suppression by the human von Hippel-Lindau gene product
    • Iliopoulos O., Kibel A., Gray S., and Kaelin W.G. 1995. Tumor suppression by the human von Hippel-Lindau gene product. Nat. Med. 1: 822.
    • (1995) Nat. Med. , vol.1 , pp. 822
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin, W.G.4
  • 47
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin W.G., Jr. 2002. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2: 673.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 673
    • Kaelin Jr., W.G.1
  • 48
    • 4644363095 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene and kidney cancer
    • _. 2004. The von Hippel-Lindau tumor suppressor gene and kidney cancer. Clin. Cancer Res. 10: 6290S.
    • (2004) Clin. Cancer Res. , vol.10
  • 51
  • 52
    • 0029147430 scopus 로고
    • Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C
    • Kibel A., Iliopoulos O., DeCaprio J.D., and Kaelin W.G. 1995. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 269: 1444.
    • (1995) Science , vol.269 , pp. 1444
    • Kibel, A.1    Iliopoulos, O.2    DeCaprio, J.D.3    Kaelin, W.G.4
  • 54
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim W.Y. and Kaelin W.G. 2004. Role of VHL gene mutation in human cancer. J. Clin. Oncol. 22: 4991.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4991
    • Kim, W.Y.1    Kaelin, W.G.2
  • 55
    • 0028826589 scopus 로고
    • Cellular proteins that bind the von Hippel-Lindau disease gene product: Mapping of binding domains and the effect of missense mutations
    • Kishida T., Stackhouse T.M., Chen F., Lerman M.I., and Zbar B. 1995. Cellular proteins that bind the von Hippel-Lindau disease gene product: Mapping of binding domains and the effect of missense mutations. Cancer Res. 55: 4544.
    • (1995) Cancer Res. , vol.55 , pp. 4544
    • Kishida, T.1    Stackhouse, T.M.2    Chen, F.3    Lerman, M.I.4    Zbar, B.5
  • 56
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth
    • Kondo K., Kim W.Y., Lechpammer M., and Kaelin W.G., Jr. 2003. Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 1: E83.
    • (2003) PLoS Biol. , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr., W.G.4
  • 57
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K., Klco J., Nakamura E., Lechpammer M., and Kaelin W.G. 2002. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1: 237.
    • (2002) Cancer Cell , vol.1 , pp. 237
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin, W.G.5
  • 59
    • 0034676331 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M., Haas R., Brauch H., Acker T., Flamme I., and Plate K. 2000. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19: 5435.
    • (2000) Oncogene , vol.19 , pp. 5435
    • Krieg, M.1    Haas, R.2    Brauch, H.3    Acker, T.4    Flamme, I.5    Plate, K.6
  • 61
    • 0029946004 scopus 로고    scopus 로고
    • Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density
    • Lee S., Chen D.Y.T., Humphrey J.S., Gnarra J.R., Linehan W.M., and Klausner R.D. 1996. Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density. Proc. Natl. Acad. Sci. 93: 1770.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 1770
    • Lee, S.1    Chen, D.Y.T.2    Humphrey, J.S.3    Gnarra, J.R.4    Linehan, W.M.5    Klausner, R.D.6
  • 62
    • 0344026345 scopus 로고    scopus 로고
    • Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
    • Lee S., Neumann M., Stearman R., Stauber R., Pause A., Pavlakis G., and Klausner R. 1999. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 19: 1486.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1486
    • Lee, S.1    Neumann, M.2    Stearman, R.3    Stauber, R.4    Pause, A.5    Pavlakis, G.6    Klausner, R.7
  • 64
    • 0032211360 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
    • Lieubeau-Teillet B., Rak J., Jothy S., Iliopoulos O., Kaelin W., and Kerbel R. 1998. von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res. 58: 4957.
    • (1998) Cancer Res. , vol.58 , pp. 4957
    • Lieubeau-Teillet, B.1    Rak, J.2    Jothy, S.3    Iliopoulos, O.4    Kaelin, W.5    Kerbel, R.6
  • 65
    • 0035895928 scopus 로고    scopus 로고
    • SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons
    • Lipscomb E.A., Sarmiere P.D., and Freeman R.S. 2001. SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. J. Biol. Chem. 276: 5085.
    • (2001) J. Biol. Chem. , vol.276 , pp. 5085
    • Lipscomb, E.A.1    Sarmiere, P.D.2    Freeman, R.S.3
  • 66
    • 0033066605 scopus 로고    scopus 로고
    • Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons
    • Lipscomb E., Sarmiere P., Crowder R., and Freeman R. 1999. Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons. J. Neurochem. 73: 429.
    • (1999) J. Neurochem. , vol.73 , pp. 429
    • Lipscomb, E.1    Sarmiere, P.2    Crowder, R.3    Freeman, R.4
  • 67
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau protein requires binding to complexes containing elongins B/C and Cul2
    • Lonergan K.M., Iliopoulos O., Ohh M., Kamura T., Conaway R.C., Conaway J.W., and Kaelin W.G. 1998. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell. Biol. 18: 732.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 732
    • Lonergan, K.M.1    Iliopoulos, O.2    Ohh, M.3    Kamura, T.4    Conaway, R.C.5    Conaway, J.W.6    Kaelin, W.G.7
  • 68
    • 0029847090 scopus 로고    scopus 로고
    • Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients
    • Lubensky I.A., Gnarra J.R., Bertheau P., Walther M.M., Linehan W.M., and Zhuang Z. 1996. Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients. Am. J. Pathol. 149: 2089.
    • (1996) Am. J. Pathol. , vol.149 , pp. 2089
    • Lubensky, I.A.1    Gnarra, J.R.2    Bertheau, P.3    Walther, M.M.4    Linehan, W.M.5    Zhuang, Z.6
  • 71
    • 0036798174 scopus 로고    scopus 로고
    • The pressure rises: Update on the genetics of phaeochromocytoma
    • Maher E.R. and Eng C. 2002. The pressure rises: Update on the genetics of phaeochromocytoma. Hum. Mol. Genet. 11: 2347.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2347
    • Maher, E.R.1    Eng, C.2
  • 74
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
    • Maranchie J.K., Vasselli J.R., Riss J., Bonifacino J.S., Linehan W.M., and Klausner R.D. 2002. The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1: 247.
    • (2002) Cancer Cell , vol.1 , pp. 247
    • Maranchie, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacino, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 76
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
    • Masson N., Willam C., Maxwell P., Pugh C., and Ratcliffe P. 2001. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J. 20: 5197.
    • (2001) EMBO J. , vol.20 , pp. 5197
    • Masson, N.1    Willam, C.2    Maxwell, P.3    Pugh, C.4    Ratcliffe, P.5
  • 77
    • 0033587146 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits
    • Maxwell P., Weisner M., Chang G.-W., Clifford S., Vaux E., Pugh C., Maher E., and Ratcliffe P. 1999. The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits. Nature 399: 271.
    • (1999) Nature , vol.399 , pp. 271
    • Maxwell, P.1    Weisner, M.2    Chang, G.-W.3    Clifford, S.4    Vaux, E.5    Pugh, C.6    Maher, E.7    Ratcliffe, P.8
  • 78
    • 0037035851 scopus 로고    scopus 로고
    • Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling
    • Min J.H., Yang H., Ivan M., Gertler F., Kaelin W.G., Jr., and Pavletich N.P. 2002. Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling. Science 296: 1886.
    • (2002) Science , vol.296 , pp. 1886
    • Min, J.H.1    Yang, H.2    Ivan, M.3    Gertler, F.4    Kaelin Jr., W.G.5    Pavletich, N.P.6
  • 84
    • 0035941291 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
    • Okuda H., Saitoh K., Hirai S., Iwai K., Takaki Y., Baba M., Minato N., Ohno S., and Shuin T. 2001. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J. Biol. Chem. 276: 43611.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43611
    • Okuda, H.1    Saitoh, K.2    Hirai, S.3    Iwai, K.4    Takaki, Y.5    Baba, M.6    Minato, N.7    Ohno, S.8    Shuin, T.9
  • 86
    • 0030735367 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways
    • Pal S., Claffey K., Dvorak H., and Mukhopadhyay D. 1997. The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J. Biol. Chem. 272: 27509.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27509
    • Pal, S.1    Claffey, K.2    Dvorak, H.3    Mukhopadhyay, D.4
  • 87
    • 0032477788 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    • Pause A., Lee S., Lonergan K.M., and Klausner R.D. 1998. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc. Natl. Acad. Sci. 95: 993.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 993
    • Pause, A.1    Lee, S.2    Lonergan, K.M.3    Klausner, R.D.4
  • 88
    • 0033578405 scopus 로고    scopus 로고
    • Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
    • Pause A., Peterson B., Schaffar G., Stearman R., and Klausner R. 1999. Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. Proc. Natl. Acad. Sci. 96: 9533.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 9533
    • Pause, A.1    Peterson, B.2    Schaffar, G.3    Stearman, R.4    Klausner, R.5
  • 89
    • 0030953635 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    • Pause A., Lee S., Worrell R.A., Chen D.Y.T., Burgess W.H., Linehan W.M., and Klausner R.D. 1997. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. 94: 2156.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 2156
    • Pause, A.1    Lee, S.2    Worrell, R.A.3    Chen, D.Y.T.4    Burgess, W.H.5    Linehan, W.M.6    Klausner, R.D.7
  • 90
    • 16244381736 scopus 로고    scopus 로고
    • Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice
    • Rankin E.B., Higgins D.F., Walisser J.A., Johnson R.S., Bradfield C.A., and Haase V.H. 2005. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol. Cell. Biol. 25: 3163.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 3163
    • Rankin, E.B.1    Higgins, D.F.2    Walisser, J.A.3    Johnson, R.S.4    Bradfield, C.A.5    Haase, V.H.6
  • 91
    • 0029153743 scopus 로고
    • Coexpression of transforming growth factor-alpha and epidermal growth factor receptor in capillary hemangioblastomas of the central nervous system
    • Reifenberger G., Reifenberger J., Bilzer T., Wechsler W., and Collins V. 1995. Coexpression of transforming growth factor-alpha and epidermal growth factor receptor in capillary hemangioblastomas of the central nervous system. Am. J. Pathol. 147: 245.
    • (1995) Am. J. Pathol. , vol.147 , pp. 245
    • Reifenberger, G.1    Reifenberger, J.2    Bilzer, T.3    Wechsler, W.4    Collins, V.5
  • 92
    • 0029859624 scopus 로고    scopus 로고
    • Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene
    • Renbaum P., Duh F.-M., Latif F., Zbar B., Lerman M., and Kuzmin I. 1996. Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene. Hum. Genet. 98: 666.
    • (1996) Hum. Genet. , vol.98 , pp. 666
    • Renbaum, P.1    Duh, F.-M.2    Latif, F.3    Zbar, B.4    Lerman, M.5    Kuzmin, I.6
  • 93
    • 0031837459 scopus 로고    scopus 로고
    • Haemangioblastoma of the central nervous system in von Hippel-Lindau disease
    • Richard S., Campello C., Taillandier L., Parker F., and Resche F. 1998. Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. J. Int. Med. 243: 547.
    • (1998) J. Int. Med. , vol.243 , pp. 547
    • Richard, S.1    Campello, C.2    Taillandier, L.3    Parker, F.4    Resche, F.5
  • 94
    • 0028631458 scopus 로고
    • The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo
    • Schlingensiepen K.H., Wollnik F., Kunst M., Schlingensiepen R., Herdegen T., and Brysch W. 1994. The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo. Cell. Mol. Neurobiol. 14: 487.
    • (1994) Cell. Mol. Neurobiol. , vol.14 , pp. 487
    • Schlingensiepen, K.H.1    Wollnik, F.2    Kunst, M.3    Schlingensiepen, R.4    Herdegen, T.5    Brysch, W.6
  • 95
    • 0032555217 scopus 로고    scopus 로고
    • A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
    • Schoenfeld A., Davidowitz E., and Burk R. 1998. A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc. Natl. Acad. Sci. 95: 8817.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 8817
    • Schoenfeld, A.1    Davidowitz, E.2    Burk, R.3
  • 96
    • 0035865958 scopus 로고    scopus 로고
    • Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region
    • _. 2001. Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region. Int. J. Cancer 91: 457.
    • (2001) Int. J. Cancer , vol.91 , pp. 457
  • 99
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • Semenza G. 2000. HIF-1 and human disease: One highly involved factor. Genes Dev. 14: 1983.
    • (2000) Genes Dev. , vol.14 , pp. 1983
    • Semenza, G.1
  • 101
    • 0029920054 scopus 로고    scopus 로고
    • Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
    • Siemeister G., Weindel K., Mohrs K., Barleon B., Martiny-Baron G., and Marme D. 1996. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56: 2299.
    • (1996) Cancer Res. , vol.56 , pp. 2299
    • Siemeister, G.1    Weindel, K.2    Mohrs, K.3    Barleon, B.4    Martiny-Baron, G.5    Marme, D.6
  • 102
    • 2942737069 scopus 로고    scopus 로고
    • Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia
    • Simon M.C. 2004. Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia. Cell 117: 851-3.
    • (2004) Cell , vol.117 , pp. 851-853
    • Simon, M.C.1
  • 103
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function
    • Stebbins C.E., Kaelin W.G., Jr., and Pavletich N.P. 1999. Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function. Science 284: 455.
    • (1999) Science , vol.284 , pp. 455
    • Stebbins, C.E.1    Kaelin Jr., W.G.2    Pavletich, N.P.3
  • 105
    • 0030831655 scopus 로고    scopus 로고
    • Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene
    • Stratmann R., Krieg M., Haas R., and Plate K. 1997. Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. J. Neuropathol. Exp. Neurol. 56: 1242.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 1242
    • Stratmann, R.1    Krieg, M.2    Haas, R.3    Plate, K.4
  • 106
    • 0345269184 scopus 로고    scopus 로고
    • Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death
    • Straub J.A., Lipscomb E.A., Yoshida E.S., and Freeman R.S. 2003. Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death. J. Neurochem. 85: 318.
    • (2003) J. Neurochem. , vol.85 , pp. 318
    • Straub, J.A.1    Lipscomb, E.A.2    Yoshida, E.S.3    Freeman, R.S.4
  • 107
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto K., Makino Y., Pereira T., and Poellinger L. 2000. Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19: 4298.
    • (2000) EMBO J. , vol.19 , pp. 4298
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 108
    • 0029120950 scopus 로고
    • Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons
    • Vogel K.S., Brannan C.I., Jenkins N.A., Copeland N.G., and Parada L.F. 1995. Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell 82: 733.
    • (1995) Cell , vol.82 , pp. 733
    • Vogel, K.S.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4    Parada, L.F.5
  • 109
    • 0030958304 scopus 로고    scopus 로고
    • von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease
    • Vortmeyer A., Gnarra J., Emmert-Buck M., Katz D., Linehan W., Oldfield E., and Zhuang Z. 1997. von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum. Pathol. 28: 540.
    • (1997) Hum. Pathol. , vol.28 , pp. 540
    • Vortmeyer, A.1    Gnarra, J.2    Emmert-Buck, M.3    Katz, D.4    Linehan, W.5    Oldfield, E.6    Zhuang, Z.7
  • 110
    • 0028929991 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
    • Wizigmann-Voos S., Breier G., Risau W., and Plate K. 1995. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55: 1358.
    • (1995) Cancer Res. , vol.55 , pp. 1358
    • Wizigmann-Voos, S.1    Breier, G.2    Risau, W.3    Plate, K.4
  • 111
    • 0034649507 scopus 로고    scopus 로고
    • Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
    • Wykoff C., Pugh C., Maxwell P., Harris A., and Ratcliffe P. 2000. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 19: 6297.
    • (2000) Oncogene , vol.19 , pp. 6297
    • Wykoff, C.1    Pugh, C.2    Maxwell, P.3    Harris, A.4    Ratcliffe, P.5
  • 112
    • 0031869573 scopus 로고    scopus 로고
    • Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent
    • Ye Y., Vasavada S., Kuzmin I., Stackhouse T., Zbar B., and Williams B. 1998. Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent. Int. J. Cancer 78: 62.
    • (1998) Int. J. Cancer , vol.78 , pp. 62
    • Ye, Y.1    Vasavada, S.2    Kuzmin, I.3    Stackhouse, T.4    Zbar, B.5    Williams, B.6
  • 113
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu F., White S., Zhao Q., and Lee F. 2001. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. 98: 9630.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 9630
    • Yu, F.1    White, S.2    Zhao, Q.3    Lee, F.4
  • 114
    • 0036645091 scopus 로고    scopus 로고
    • Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease
    • Zatyka M., da Silva N.F., Clifford S.C., Morris M.R., Wiesener M.S., Eckardt K.U., Houlston R.S., Richards F.M., Latif F., and Maher E.R. 2002. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res. 62: 3803.
    • (2002) Cancer Res. , vol.62 , pp. 3803
    • Zatyka, M.1    Da Silva, N.F.2    Clifford, S.C.3    Morris, M.R.4    Wiesener, M.S.5    Eckardt, K.U.6    Houlston, R.S.7    Richards, F.M.8    Latif, F.9    Maher, E.R.10
  • 115
    • 0028954688 scopus 로고
    • A microscopic dissection technique for archival DNA analysis of specific cell populations in lesions <1mm in size
    • Zhuang Z., Bertheau P., Emmert-Buck M., Liotta L., Gnarra J., Linehan W., and Lubensky I. 1995. A microscopic dissection technique for archival DNA analysis of specific cell populations in lesions <1mm in size. Am. J. Pathol. 146: 620.
    • (1995) Am. J. Pathol. , vol.146 , pp. 620
    • Zhuang, Z.1    Bertheau, P.2    Emmert-Buck, M.3    Liotta, L.4    Gnarra, J.5    Linehan, W.6    Lubensky, I.7
  • 116
    • 1342280515 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
    • Zimmer M., Doucette D., Siddiqui N., and Iliopoulos O. 2004. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2: 89.
    • (2004) Mol. Cancer Res. , vol.2 , pp. 89
    • Zimmer, M.1    Doucette, D.2    Siddiqui, N.3    Iliopoulos, O.4


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