Cancer proliferation and therapy: The Warburg effect and quantum metabolism

Theoretical Biology and Medical Modelling

Volumn 7, Issue 1, 2010, Pages

  Demetrius, Lloyd A ^a   Coy, Johannes F ^b   Tuszynski, Jack A ^c  

^a HARVARD UNIVERSITY   (United States)

^b Darmstadt and Tavargenix GmbH   (Germany)

^c CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; CELL TRANSFORMATION; ENERGY METABOLISM; GENETIC FITNESS; GLYCOLYSIS; HUMAN; METABOLISM; NEOPLASM; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; PHYSIOLOGY; QUANTUM THEORY;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; ENERGY METABOLISM; GENETIC FITNESS; GLYCOLYSIS; HUMANS; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; QUANTUM THEORY;

EID: 76649137960     PISSN: None     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/1742-4682-7-2     Document Type: Article

References (46)

1. The hallmarks of cancer. D Hanahan R Weinberg, Cell 2000 100 57 70 10.1016/S0092-8674(00)81683-9 10647931
2. The age of cancer. RA DePinho, Nature 2000 408 248 254 10.1038/35041694 11089982
3. The age distribution of cancer and a multi-stage theory of carcinogenesis, International Journal of. P Armitage R Doll, Epidemiology 2004 33 1174 1179 10.1093/ije/dyh216 (Pubitemid 40124910)
4. Angiogenesis and Tumor Metastasis. BR Zetter, Ann Rev Med 1998 49 407 424 10.1146/annurev.med.49.1.407 9509272
5. Vascular-targeting therapies for treatment of malignant disease. DW Siemann DJ Chaplin MR Horsman, Cancer 2004 100 241 249 10.1002/cncr.20299 (Pubitemid 38715753)
6. Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis. JML Ebos CR Lee WGA Cruz-Munoz Bjarnason JG Christensen RS Kerbel, Cancer Cell 2009 15 232 239 10.1016/j.ccr.2009.01.021 19249681
7. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. A Ramanathan G Wang SL Schreiber, Proc Natl Acad Sci USA 2005 102 5992 5997 10.1073/pnas.0502267102 15840712
8. Uber den Stoffwechsel der Carcinomzelle. O Warburg K Posener E Negelein, Biochem Z 1924 152 309 344
9. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. H Pelicano R-H Xu M Du L Feng R Sasaki JS Carew Y Hu L Ramdas L Hu MJ Keating W Zhang W Plunkett P Huang, J Cell Biol 2006 175 913 923 10.1083/jcb.200512100 17158952
10. A genetic model for colorectal tumorigenesis. ER Fearon B Vogelstein, Cell 1991 61 759 767 10.1016/0092-8674(90)90186-I
11. Lineage selection and the evolution of multistage carcinogenesis. L Nunney, Proc R Soc Lond 1999 226 493 498 10.1098/rspb.1999.0664
12. Why do cancers have high aerobic glycolysis? RA Gatenby RJ Gillies, Nature Reviews Cancer 2004 4 891 899 10.1038/nrc1478 15516961
13. Quantum statistics and allometric scaling relations. L Demetrius, Physica A 2003 322 477 490 10.1016/S0378-4371(03)00013-X
14. Quantum metabolism explains the allometric scaling of metabolic rates. L Demetrius J Tuszynski, Jour Royal Soc Interface 2009 7 507 514 March 6, 2010 10.1098/rsif.2009.0310
15. Directionality principles in thermodynamics and evolution. L Demetrius, Proc Natl Acad Sci USA 1997 94 3491 3498 10.1073/pnas.94.8.3491 9108003
16. The problem of life and its relationship to growth and nutrition. M Rubner, Berlin: Oldenberg 1908
17. The fire of life. An introduction to animal energetics. M Kleiber, Wiley, New York 1961
18. Energy metabolism as related to body size and respiratory surfaces, and its evolution. AM Hemmingsen, Rep Steno Mem Hosp Copenhagen 1960 9 1 110
19. Bioenergetics. AL Lehninger, W. A. Benjamin, Inc., New York 1965
20. The way of the cell. FM Harold, Oxford University Press, Oxford 2001
21. The fundamental organization of cardiac mitochondria as a network of coupled oscillators. MA Aon S Cortassa B O'Rourke, Biophys J 2006 91 4317 4327 10.1529/biophysj.106.087817 16980364
22. Collective behavior in gene regulation: Metabolic clocks and cross talking. M Bianchi, FEBS Journal 2008 275 2356 2363 10.1111/j.1742-4658.2008. 06397.x 18410384
23. Collective behavior in gene regulation: The cell is an oscillator, the cell cycle a developmental process. RR Klevecz CM Li I Marcus PH Frankel, FEBS Journal 2008 275 2372 2384 10.1111/j.1742-4658.2008.06399.x 18410382
24. Collective behavior in gene regulation: Post-transcriptional regulation and the temporal compartmentalization of cellular cycles. MC Palumbo L Farina A De Santis A Giuliani A Colosimo G Morelli I Ruberti, FEBS Journal 2008 275 2364 2371 10.1111/j.1742-4658.2008.06398.x 18410383
25. How Enzyme Can Capture and Transmit Free Energy from an Oscillating Electric Field. H Westerhoff TY Tsong PB Chock YD Chen RD Astumian, Proc Natl Acad Sci 1986 83 4734 4738 10.1073/pnas.83.13.4734 2941758
26. Electroconformational Coupling and Membrane Protein Function. TY Tsong, Prog Biophys Mole Biol 1987 50 1 45 10.1016/0079-6107(87)90002-2
27. Electrical Modulation of Membrane Proteins: Enforced Conformational Oscillations and Biological Energy and Signal Transductions. TY Tsong, Annual Review of Biophysics and Biophysical Chemistry 1990 19 83 106 10.1146/annurev.bb.19.060190.000503 2163641
28. Electroconformational Coupling: How Membrane-Bound ATPase Transduces Energy from Dynamic Electric Fields. TY Tsong RD Astumian, Ann Rev Physiol 1988 50 273 290 10.1146/annurev.ph.50.030188.001421
29. Activation of Na+ and K+ pumping modes of (Na,K)-ATPase by an oscillating electric field. DS Liu RD Astumian TY Tsong, J Biol Chem 1990 265 7260 7267 2158997
30. The Proton-Driven Rotor ATP Synthase: Ohmic Conductance (10 fS), and Absence of Voltage Gating. BA Feniouk MA Kozlova DA Knorre DA Cherepanov Y Armen AY Mulkidjanian W Junge, Biophys J 2004 86 4094 4109 10.1529/biophysj.103. 036962 15189903
31. Biochemical Adaptation. PW Hochachka GW Somero, Oxford University Press, Oxford 2000
32. Experimental allometry: effect of size manipulation on metabolic rate of colonial ascidians. F Nakaya Y Saito T Motokawa, Proc Roy Soc B: Biol Sci 2005 272 1963 1969 10.1098/rspb.2005.3143 (Pubitemid 41414649)
33. The Role of Glucose Metabolism and Glucose-Associated Signalling in Cancer. J Coy R Wittig, Persp Medicinal Chem 2007 1 64 84
34. Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype. AJC de Groof MM te Lindert MM van Dommelen M Wu M Willemse AL Smift M Winer F Oerlemans H Pluk JA Fransen B Wieringa, Mol Cancer 2009 8 54 10.1186/1476-4598-8-54 19646236
35. The Genetical Theory of Natural Selection. RA Fisher, Clarendon Press, Oxford 1930
36. Invasion exponents in biological networks. L Demetrius M Gundlach G Ochs, Physica A 2009 388 651 672 10.1016/j.physa.2008.10.048
37. Evolutionary entropy: A predictor of body mass, metabolic rate and maximal life span. L Demetrius S Legendre P Harremöes, Bulletin of Mathematical Biology 2009 9 800 818 10.1007/s11538-008-9382-6
38. Understanding the Warburg effect: the metabolic requirements of cell proliferation. MG Vander Heiden LC Cantley CB Thomson, Science 2009 324 1029 1033 10.1126/science.1160809 19460998
39. Biochemistry. R Roskoski Jr, Elsevier, Amsterdam 1996
40. Selective heat sensitivity of cancer cells. Biochemical and clinical studies. R Cavaliere EC Ciocatto BC Giovanella C Heidelberger RO Johnson M Margottini B Mondovi G Moricca A Rossi-Fanelli, Cancer 209 1351 1381
41. Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil. JL Quiles JR Huertas MM Manas Battino J Mataix, British Journal of Nutrition 1999 81 21 24 10341671
42. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. ED Michelakis L Webster JR Mackey, Br J Cancer 2008 99 989 994 10.1038/sj.bjc.6604554 18766181
43. Regulation analysis of energy metabolism. MD Brand, Journal of Experimental Biology 1997 200 193 202 9050227
44. Internal regulation of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes. EK Ainscow MD Brand, Eur J Biochem 1999 266 737 749 10.1046/j.1432-1327.1999.00856.x 10583367
45. Energy metabolism in tumor cells. R Moreno-Sanchez S Rodriguez-Enriquez A Marin-Hernandez E Saavedra, FEBS J 2007 274 1393 1418 10.1111/j.1742-4658.2007. 05686.x 17302740
46. Energy-modulating vitamins - a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma. SS Perumal P Shanthi P Sachdanandam, British Journal of Nutrition 2005 93 901 909 10.1079/BJN20051439 16022760